JP2021501790A5 - - Google Patents

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JP2021501790A5
JP2021501790A5 JP2020524870A JP2020524870A JP2021501790A5 JP 2021501790 A5 JP2021501790 A5 JP 2021501790A5 JP 2020524870 A JP2020524870 A JP 2020524870A JP 2020524870 A JP2020524870 A JP 2020524870A JP 2021501790 A5 JP2021501790 A5 JP 2021501790A5
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JP
Japan
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alkyl
disease
halo
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diseases
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JP2020524870A
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English (en)
Japanese (ja)
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JP7335241B2 (ja
JP2021501790A (ja
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Priority claimed from PCT/US2018/058955 external-priority patent/WO2019090074A1/en
Publication of JP2021501790A publication Critical patent/JP2021501790A/ja
Publication of JP2021501790A5 publication Critical patent/JP2021501790A5/ja
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JP2020524870A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7335241B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580734P 2017-11-02 2017-11-02
US62/580,734 2017-11-02
US201862643061P 2018-03-14 2018-03-14
US62/643,061 2018-03-14
PCT/US2018/058955 WO2019090074A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501790A JP2021501790A (ja) 2021-01-21
JP2021501790A5 true JP2021501790A5 (enExample) 2021-12-09
JP7335241B2 JP7335241B2 (ja) 2023-08-29

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ID=64564979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524870A Active JP7335241B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (12)

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US (2) US20210393599A1 (enExample)
EP (1) EP3704089B1 (enExample)
JP (1) JP7335241B2 (enExample)
KR (1) KR20200092332A (enExample)
CN (1) CN112204006B (enExample)
AU (1) AU2018360855B2 (enExample)
BR (1) BR112020008817B8 (enExample)
CA (1) CA3080804A1 (enExample)
IL (1) IL274367B2 (enExample)
MX (1) MX2020004538A (enExample)
SG (1) SG11202004074TA (enExample)
WO (1) WO2019090074A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL301709B2 (en) 2017-08-09 2025-07-01 Denali Therapeutics Inc Compounds, compositions and methods
TW201920129A (zh) 2017-09-01 2019-06-01 美商戴納立製藥公司 化合物、組合物及方法
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
JP2021508336A (ja) 2017-12-13 2021-03-04 プラクシス バイオテック エルエルシー 統合的ストレス応答経路の阻害剤
US11478461B2 (en) 2018-04-19 2022-10-25 Merck Sharp & Dohme Llc [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
US11166942B2 (en) 2018-06-05 2021-11-09 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
CR20210426A (es) 2019-02-13 2021-09-30 Denali Therapeutics Inc Compuestos, composiciones y métodos
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
WO2020216766A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
CA3162526A1 (en) 2020-01-28 2021-08-05 Christopher John Brown Modulators of the integrated stress response pathway
KR20220151635A (ko) 2020-03-11 2022-11-15 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
MX2023004677A (es) 2020-10-22 2023-05-24 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
ES2997335T3 (en) 2020-10-22 2025-02-17 Evotec Int Gmbh Modulators of the integrated stress response pathway
CA3195290A1 (en) 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
TW202241857A (zh) 2020-12-18 2022-11-01 美商戴納立製藥公司 化合物之固體形式
CN116693529A (zh) * 2023-06-09 2023-09-05 河南师范大学 一种2-氮杂环[2.2.2]辛烷类化合物的合成方法
WO2024263972A2 (en) * 2023-06-21 2024-12-26 Burzynski Stanislaw R Compositions comprising antineoplastons and methods of treating uncommon cancers
AU2025209596A1 (en) * 2024-01-17 2026-08-06 Beijing Tide Pharmaceutical Co., Ltd. Angiotensin ii receptor antagonist and use thereof in treatment of peripherally-induced neuropathic pain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
WO2011075415A1 (en) * 2009-12-14 2011-06-23 Inspire Pharmaceuticals, Inc. Bridged bicyclic rho kinase inhibitor compounds, composition and use
TWI538905B (zh) * 2010-12-22 2016-06-21 H 朗德貝克公司 雙環[3.2.1]辛基醯胺衍生物及其用途
JP2014518267A (ja) * 2011-06-27 2014-07-28 杏林製薬株式会社 細菌感染症の治療のための架橋二環式化合物
WO2014144952A2 (en) * 2013-03-15 2014-09-18 Peter Walter Modulators of the eif2alpha pathway
JP2018520992A (ja) * 2015-05-05 2018-08-02 バイエル ファーマ アクチエンゲゼルシャフト アミドで置換されているシクロヘキサン誘導体
WO2017035408A1 (en) * 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
TW201808903A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑

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