JP2021501787A5 - - Google Patents

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Publication number
JP2021501787A5
JP2021501787A5 JP2020524825A JP2020524825A JP2021501787A5 JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5 JP 2020524825 A JP2020524825 A JP 2020524825A JP 2020524825 A JP2020524825 A JP 2020524825A JP 2021501787 A5 JP2021501787 A5 JP 2021501787A5
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JP
Japan
Prior art keywords
alkyl
formula
compound
disease
halo
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JP2020524825A
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English (en)
Japanese (ja)
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JP2021501787A (ja
JP7324196B2 (ja
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Priority claimed from PCT/US2018/058965 external-priority patent/WO2019090082A1/en
Publication of JP2021501787A publication Critical patent/JP2021501787A/ja
Publication of JP2021501787A5 publication Critical patent/JP2021501787A5/ja
Application granted granted Critical
Publication of JP7324196B2 publication Critical patent/JP7324196B2/ja
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JP2020524825A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Active JP7324196B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580802P 2017-11-02 2017-11-02
US62/580,802 2017-11-02
US201862643073P 2018-03-14 2018-03-14
US62/643,073 2018-03-14
PCT/US2018/058965 WO2019090082A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (3)

Publication Number Publication Date
JP2021501787A JP2021501787A (ja) 2021-01-21
JP2021501787A5 true JP2021501787A5 (enExample) 2021-12-09
JP7324196B2 JP7324196B2 (ja) 2023-08-09

Family

ID=64661438

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524825A Active JP7324196B2 (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

Country Link
US (1) US20210205277A1 (enExample)
EP (1) EP3704096B1 (enExample)
JP (1) JP7324196B2 (enExample)
CN (1) CN112204012B (enExample)
AU (1) AU2018358157B2 (enExample)
BR (1) BR112020008825A2 (enExample)
CA (1) CA3080964A1 (enExample)
MX (1) MX2020004519A (enExample)
WO (1) WO2019090082A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL301709B2 (en) 2017-08-09 2025-07-01 Denali Therapeutics Inc Compounds, compositions and methods
TW201920129A (zh) 2017-09-01 2019-06-01 美商戴納立製藥公司 化合物、組合物及方法
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
JP2021508336A (ja) 2017-12-13 2021-03-04 プラクシス バイオテック エルエルシー 統合的ストレス応答経路の阻害剤
US11166942B2 (en) 2018-06-05 2021-11-09 Praxis Biotech LLC Inhibitors of integrated stress response pathway
TW202545902A (zh) 2018-10-11 2025-12-01 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. Compounds, compositions and methods
CR20210426A (es) 2019-02-13 2021-09-30 Denali Therapeutics Inc Compuestos, composiciones y métodos
MX2021012904A (es) 2019-04-23 2022-01-18 Evotec Int Gmbh Moduladores de la via de respuesta al estres integrada.
WO2020216766A1 (en) 2019-04-23 2020-10-29 Evotec International Gmbh Modulators of the integrated stress response pathway
JP2022536663A (ja) 2019-06-12 2022-08-18 プラクシス バイオテック エルエルシー 統合的ストレス応答経路のモジュレーター
CA3162526A1 (en) * 2020-01-28 2021-08-05 Christopher John Brown Modulators of the integrated stress response pathway
KR20220151635A (ko) 2020-03-11 2022-11-15 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
ES2997335T3 (en) 2020-10-22 2025-02-17 Evotec Int Gmbh Modulators of the integrated stress response pathway
MX2023004677A (es) * 2020-10-22 2023-05-24 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
CA3195290A1 (en) 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
CN116406359A (zh) * 2020-11-19 2023-07-07 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的双环[1.1.1]戊烷化合物
TW202241857A (zh) 2020-12-18 2022-11-01 美商戴納立製藥公司 化合物之固體形式
CN115453012B (zh) * 2022-10-21 2023-05-12 山东百诺医药股份有限公司 一种同时测定氢溴酸伏硫西汀中多个位置异构体的反相hplc方法
AU2023384649A1 (en) 2022-11-21 2025-05-22 Shenzhen Zhongge Biological Technology Co., Ltd. Compound, pharmaceutical composition containing same, synthesis method therefor and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212A (en) 1847-07-31 Richard m
US162A (en) 1837-04-17 Island
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
JO2397B1 (en) * 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
CN101475538A (zh) * 2002-12-20 2009-07-08 默克公司 用作11-β-羟基类固醇脱氢酶-1抑制剂的三唑衍生物
WO2011087758A1 (en) * 2009-12-22 2011-07-21 H. Lundbeck A/S Adamantyl amide derivatives and uses of same
WO2014144952A2 (en) * 2013-03-15 2014-09-18 Peter Walter Modulators of the eif2alpha pathway
WO2015038778A1 (en) * 2013-09-11 2015-03-19 The Brigham And Women's Hospital, Inc. SUBSTITUTED UREA EIF2α KINASE ACTIVATORS
JP2015199722A (ja) 2014-04-02 2015-11-12 大日本住友製薬株式会社 イミダゾール誘導体からなる医薬
TW201722958A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
TW201808914A (zh) * 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑

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