JP2021501785A5 - - Google Patents

Download PDF

Info

Publication number
JP2021501785A5
JP2021501785A5 JP2020524812A JP2020524812A JP2021501785A5 JP 2021501785 A5 JP2021501785 A5 JP 2021501785A5 JP 2020524812 A JP2020524812 A JP 2020524812A JP 2020524812 A JP2020524812 A JP 2020524812A JP 2021501785 A5 JP2021501785 A5 JP 2021501785A5
Authority
JP
Japan
Prior art keywords
alkyl
formula
substituted
group
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020524812A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021501785A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/058972 external-priority patent/WO2019090088A1/en
Publication of JP2021501785A publication Critical patent/JP2021501785A/ja
Publication of JP2021501785A5 publication Critical patent/JP2021501785A5/ja
Pending legal-status Critical Current

Links

JP2020524812A 2017-11-02 2018-11-02 統合的ストレス経路の調節剤 Pending JP2021501785A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762580755P 2017-11-02 2017-11-02
US62/580,755 2017-11-02
US201862643075P 2018-03-14 2018-03-14
US62/643,075 2018-03-14
PCT/US2018/058972 WO2019090088A1 (en) 2017-11-02 2018-11-02 Modulators of the integrated stress pathway

Publications (2)

Publication Number Publication Date
JP2021501785A JP2021501785A (ja) 2021-01-21
JP2021501785A5 true JP2021501785A5 (enExample) 2021-12-09

Family

ID=64572460

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524812A Pending JP2021501785A (ja) 2017-11-02 2018-11-02 統合的ストレス経路の調節剤

Country Status (9)

Country Link
US (1) US11939320B2 (enExample)
EP (1) EP3704115A1 (enExample)
JP (1) JP2021501785A (enExample)
CN (1) CN112166113A (enExample)
AU (1) AU2018358160B2 (enExample)
BR (1) BR112020008834A2 (enExample)
CA (1) CA3080971A1 (enExample)
MX (1) MX2020004557A (enExample)
WO (1) WO2019090088A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12157690B2 (en) 2015-12-09 2024-12-03 Microbial Discovery Group Llc Cold temperature-resistant microbials and methods of their use
CN109561712A (zh) 2016-02-29 2019-04-02 微生物发现集团有限责任公司 直接喂饲的微生物
CN111094233B (zh) 2017-08-09 2024-03-15 戴纳立制药公司 化合物、组合物及方法
PT3676297T (pt) 2017-09-01 2023-08-29 Denali Therapeutics Inc Compostos, composições e métodos
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
RU2020122711A (ru) 2017-12-13 2022-01-17 ПРАКСИС БАЙОТЕК ЭлЭлСи Ингибиторы пути интегрированной реакции на стресс
SG11202011014VA (en) 2018-06-05 2020-12-30 Praxis Biotech LLC Inhibitors of integrated stress response pathway
SG11202101486RA (en) 2018-08-16 2021-03-30 Innate Tumor Immunity Inc Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
US12115198B2 (en) 2018-10-02 2024-10-15 ·Microbial Discovery Group, Llc Microbials for animals
TWI832295B (zh) 2018-10-11 2024-02-11 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
CA3129609A1 (en) 2019-02-13 2020-08-20 Denali Therapeutics Inc. Eukaryotic initiation factor 2b modulators
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
US20220177456A1 (en) * 2019-03-06 2022-06-09 Denali Therapeutics Inc. Compounds, compositions and methods
EA202192900A1 (ru) 2019-04-23 2022-03-18 Эвотек Интернешнл Гмбх Модуляторы пути интегрированной реакции на стресс
AU2020261234A1 (en) 2019-04-23 2021-11-11 Evotec International Gmbh Modulators of the integrated stress response pathway
CA3142748A1 (en) 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway
WO2021035137A1 (en) 2019-08-22 2021-02-25 Microbial Discovery Group, Llc Methods of inhibition with microbial strains and antibiotics
KR20220133252A (ko) 2020-01-28 2022-10-04 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절자
JP2023517944A (ja) 2020-03-11 2023-04-27 エヴォテック・インターナショナル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 統合的ストレス応答経路の調節因子
US20230391763A1 (en) 2020-10-22 2023-12-07 Evotec International Gmbh Modulators of the integrated stress response pathway
AU2021366303A1 (en) 2020-10-22 2023-06-22 Evotec International Gmbh Modulators of the integrated stress response pathway
CA3195290A1 (en) * 2020-10-22 2022-04-28 Holly Victoria Atton Modulators of the integrated stress response pathway
KR20240125639A (ko) * 2021-12-23 2024-08-19 신크레스트 가부시키가이샤 유기 구리 화합물, 및 유기 구리 화합물의 제조 방법

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1026506A (en) 1962-10-17 1966-04-20 Du Pont Bicyclodiamines and preparation thereof
US3264351A (en) 1964-07-08 1966-08-02 American Home Prod 1, 4-diaminobicyclo [2.2.2] octanes
US3301827A (en) 1965-05-07 1967-01-31 Du Pont Polymers from polycyclic reactants having functional substituents on bridgehead carbon atoms
US3967629A (en) 1973-10-01 1976-07-06 International Flavors & Fragrances Inc. Bicyclic fragrance materials and processes therefor
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JPH02215779A (ja) 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
EP0495421B1 (en) 1991-01-15 1996-08-21 Alcon Laboratories, Inc. Use of carrageenans in topical ophthalmic compositions
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
JPH0592921A (ja) 1991-05-17 1993-04-16 Yamanouchi Pharmaceut Co Ltd シクロヘキシルアルキルアミド および 該化合物を有効成分とするタキキニン抑制剤
US5852192A (en) 1992-03-11 1998-12-22 Dr. Karl Thomae Gmbh Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
US5506257A (en) 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
CA2166974A1 (en) 1993-07-16 1995-01-26 Mark G. Bock Substituted amide derivatives of piperizinylcamphor sulfonyl and carbonyl oxytocin antagonists
DE4429079A1 (de) 1994-08-17 1996-02-22 Thomae Gmbh Dr K Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO2003065789A2 (en) 2002-02-08 2003-08-14 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
AR038377A1 (es) * 2002-02-08 2005-01-12 Merck & Co Inc Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
GEP20115290B (en) 2002-11-27 2011-09-26 Incyte Corp 3-aminopyrrolidine derivatives as modulators of chemokine receptors
AU2003288994A1 (en) 2002-12-10 2004-06-30 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and medicinal use thereof
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
TW200508224A (en) 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
JP2007517868A (ja) 2004-01-07 2007-07-05 アストラゼネカ アクチボラグ 治療薬i
AU2005212073B2 (en) 2004-02-18 2010-07-08 Kyorin Pharmaceutical Co., Ltd. Bicyclic amide derivatives
US7217838B2 (en) 2005-01-05 2007-05-15 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7517885B2 (en) 2005-06-29 2009-04-14 Janssen Pharmaceutica N.V. Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds
RU2442771C2 (ru) 2005-08-08 2012-02-20 Арджента Дискавери Лтд Производные бицикло[2,2,1]гепт-7-иламина и их применения
JP2009190971A (ja) 2006-06-06 2009-08-27 Mitsubishi Tanabe Pharma Corp 2−シアノピロリジン誘導体
JP2010513263A (ja) 2006-12-15 2010-04-30 ファイザー・プロダクツ・インク ベンズイミダゾール誘導体
CN101878216B (zh) 2007-09-28 2013-07-10 西克拉塞尔有限公司 作为蛋白激酶抑制剂的嘧啶衍生物
SI2310356T1 (sl) 2008-07-25 2014-02-28 H. Lundbeck A/S Adamantil diamid derivati in uporaba le-teh
CA2735420C (en) 2008-09-08 2016-06-28 Merck Patent Gmbh Macrocyclic pyrimidines as protein kinase inhibitors
HRP20090186A2 (hr) 2009-03-31 2010-10-31 Institut Ruđer Bošković Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
MX2011010203A (es) 2009-04-02 2011-10-14 Merck Patent Gmbh Derivados de piperidina y piperazina como inhibidores de autotaxina.
WO2011087758A1 (en) 2009-12-22 2011-07-21 H. Lundbeck A/S Adamantyl amide derivatives and uses of same
UY33288A (es) 2010-03-25 2011-10-31 Glaxosmithkline Llc Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico
MX2012014934A (es) 2010-06-17 2013-05-20 Janssen Pharmaceutica Nv Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2.
AR084457A1 (es) 2010-12-22 2013-05-15 Lundbeck & Co As H Derivados de biciclo[3,2,1]octilamida
WO2013033167A1 (en) 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
TW201348231A (zh) 2012-02-29 2013-12-01 Amgen Inc 雜雙環化合物
WO2013134079A1 (en) 2012-03-05 2013-09-12 Amgen Inc. Oxazolidinone compounds and derivatives thereof
JPWO2013161980A1 (ja) 2012-04-27 2015-12-24 東レ株式会社 シクロヘキサンジアミド誘導体及びその医薬用途
PT2861566T (pt) 2012-06-13 2017-02-08 Hoffmann La Roche Novos diazaspirocicloalcanos e azaspirocicloalcanos
AU2014233520B2 (en) * 2013-03-15 2019-02-21 The Regents Of The University Of California Modulators of the eIF2alpha pathway
US9580459B2 (en) 2013-04-26 2017-02-28 Metselex, Inc. Water-soluble ursodeoxycholic acid prodrugs
WO2015038778A1 (en) 2013-09-11 2015-03-19 The Brigham And Women's Hospital, Inc. SUBSTITUTED UREA EIF2α KINASE ACTIVATORS
JP2015199722A (ja) 2014-04-02 2015-11-12 大日本住友製薬株式会社 イミダゾール誘導体からなる医薬
EP3489232A3 (en) 2014-04-04 2019-07-31 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US20150362847A1 (en) 2014-06-13 2015-12-17 Canon Kabushiki Kaisha Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus
WO2016058544A1 (en) 2014-10-16 2016-04-21 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
CU20170139A7 (es) 2015-05-05 2018-03-13 Bayer Pharma AG Derivados de ciclohexano sustituido con amido
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
US20190022071A1 (en) 2015-08-31 2019-01-24 Proteostasis Therapeutics, Inc. Methods of treating pulmonary diseases and disorders
TW201722958A (zh) 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
PH12018500586B1 (en) 2015-09-16 2023-08-11 Organovo Inc Farnesoid x receptor agonists and uses thereof
TW201808888A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW202506629A (zh) 2016-05-05 2025-02-16 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808903A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
CN109563071B (zh) 2016-06-08 2021-08-03 葛兰素史密斯克莱知识产权发展有限公司 作为atf4途径抑制剂的化学化合物
US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
CN106349130B (zh) 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
JP7299837B2 (ja) 2016-12-23 2023-06-28 アクイナ ファーマシューティカルズ, インコーポレイテッド 化合物、組成物、および使用方法
JP2020522553A (ja) 2017-06-07 2020-07-30 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Atf4経路阻害剤としての化合物
WO2018225093A1 (en) 2017-06-07 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Chemical compounds as atf4 pathway inhibitors
TW201910328A (zh) 2017-07-31 2019-03-16 日商武田藥品工業股份有限公司 雜環化合物
CN111094233B (zh) 2017-08-09 2024-03-15 戴纳立制药公司 化合物、组合物及方法
PT3676297T (pt) 2017-09-01 2023-08-29 Denali Therapeutics Inc Compostos, composições e métodos
JP7307057B2 (ja) 2017-11-02 2023-07-11 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
AU2018358157B2 (en) 2017-11-02 2023-03-09 Abbvie Inc. Modulators of the integrated stress pathway
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
AU2018360847B2 (en) 2017-11-02 2023-07-27 Abbvie Inc. Modulators of the integrated stress pathway
US20200347033A1 (en) 2017-11-02 2020-11-05 Calico Life Sciences Llc Modulators of the integrated stress pathway
KR20200092332A (ko) 2017-11-02 2020-08-03 칼리코 라이프 사이언시스 엘엘씨 통합된 스트레스 경로의 조절제
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
RU2020122711A (ru) 2017-12-13 2022-01-17 ПРАКСИС БАЙОТЕК ЭлЭлСи Ингибиторы пути интегрированной реакции на стресс
US20210130308A1 (en) 2018-03-23 2021-05-06 Denali Therapeutics Inc. Modulators of eukaryotic initiation factor 2
JP2021529814A (ja) 2018-07-09 2021-11-04 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化学化合物
TWI832295B (zh) 2018-10-11 2024-02-11 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
PH12021552759A1 (en) * 2019-04-30 2022-07-04 Abbvie Inc Substituted cycloalkyls as modulators of the integrated stress pathway
AU2020266592A1 (en) 2019-04-30 2021-12-02 Abbvie Inc. Substituted cyclolakyls as modulators of the integrated stress pathway
US20220227785A1 (en) 2019-04-30 2022-07-21 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
EP4237413A1 (en) 2020-10-30 2023-09-06 Calico Life Sciences LLC Modulators of the integrated stress pathway

Similar Documents

Publication Publication Date Title
JP2021501785A5 (enExample)
JP2021501780A5 (enExample)
JP2021501787A5 (enExample)
JP2021501789A5 (enExample)
JP2021501779A5 (enExample)
JP2021501786A5 (enExample)
JP2021501790A5 (enExample)
JP2021501781A5 (enExample)
JP2021501788A5 (enExample)
RU2020117927A (ru) Модуляторы интегрированного стресса
JP6159484B2 (ja) グレリンo−アシルトランスフェラーゼ阻害剤
RU2020117900A (ru) Модуляторы интегрированного стресса
CN103214484A (zh) 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶
JP2022505525A (ja) Nlrp活性に関連する状態を治療するための化合物及び組成物
JP2016500119A (ja) ブルトン型チロシンキナーゼ阻害剤
JP4551402B2 (ja) ピラゾロ及びイミダゾ−ピリミジン誘導体
JP2021152056A (ja) 疾患を治療するためのmct4阻害剤
HU228962B1 (en) Azolo triazines, pharmaceutical compositions containing them and use of the compounds
TW202015693A (zh) 治療pi3k 相關病症之給藥方案
AU2020331330B2 (en) Fused ring heteroaryl compounds as ripk1 inhibitors
WO2017079753A1 (en) Lysine-specific histone demethylase as a novel therapeutic target in myeloproliferative neoplasms
AU2020299526A1 (en) Bax inhibitors and uses thereof
JP2022512824A (ja) Alk2阻害剤の結晶形
JP7300552B2 (ja) 縮合環ピリミジンアミノ化合物、その調製方法、医薬組成物及び使用
CN102083817A (zh) 作为itpkb抑制剂的化合物和组合物