CA3080806A1 - Modulators of the integrated stress pathway - Google Patents

Modulators of the integrated stress pathway Download PDF

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Publication number
CA3080806A1
CA3080806A1 CA3080806A CA3080806A CA3080806A1 CA 3080806 A1 CA3080806 A1 CA 3080806A1 CA 3080806 A CA3080806 A CA 3080806A CA 3080806 A CA3080806 A CA 3080806A CA 3080806 A1 CA3080806 A1 CA 3080806A1
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Canada
Prior art keywords
alkyl
disease
syndrome
compound
optionally substituted
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CA3080806A
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English (en)
French (fr)
Inventor
Kathleen Ann MARTIN
Carmela SIDRAUSKI
Jennifer M. Frost
Marina A. Pliushchev
Yunsong Tong
Lawrence A. Black
Xiangdong Xu
Lei Shi
Qingwei Zhang
Seungwon CHUNG
Ramzi Farah Sweis
Michael J. Dart
John T. Randolph
Kathleen MURAUSKI
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AbbVie Inc
Calico Life Sciences LLC
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AbbVie Inc
Calico Life Sciences LLC
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Publication of CA3080806A1 publication Critical patent/CA3080806A1/en
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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