SG11202003985YA - Modulators of the integrated stress pathway - Google Patents

Modulators of the integrated stress pathway

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Publication number
SG11202003985YA
SG11202003985YA SG11202003985YA SG11202003985YA SG11202003985YA SG 11202003985Y A SG11202003985Y A SG 11202003985YA SG 11202003985Y A SG11202003985Y A SG 11202003985YA SG 11202003985Y A SG11202003985Y A SG 11202003985YA SG 11202003985Y A SG11202003985Y A SG 11202003985YA
Authority
SG
Singapore
Prior art keywords
modulators
integrated stress
stress pathway
pathway
integrated
Prior art date
Application number
SG11202003985YA
Inventor
Kathleen Martin
Carmela Sidrauski
Marina Pliushchev
Jennifer Frost
Yunsong Tong
Lawrence BLACK
Xiangdong Xu
Lei Shi
Qingwei Zhang
Seungwon Chung
Zhaoming Xiong
Ramzi Sweis
Michael DART
Brian Brown
Kathleen Murauski
Original Assignee
Calico Life Sciences Llc
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calico Life Sciences Llc, Abbvie Inc filed Critical Calico Life Sciences Llc
Publication of SG11202003985YA publication Critical patent/SG11202003985YA/en

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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