JP2020533045A - 流体制御デバイス及び流体制御デバイスを使用する方法 - Google Patents
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Abstract
Description
本出願は、2017年9月12日出願の「Fluid Control Devices and Methods of Using the Same(流体制御デバイス及び流体制御デバイスを使用する方法)」と題する米国仮特許出願第62/557,530号の優先権及び利益を主張し、その開示は参照によりその全体が組み込まれる。
Claims (36)
- 入口及び出口を有するハウジングであって、前記入口が、体液源と流体が流通可能に配置されるように構成されており、前記ハウジングが、前記体液源から体液の初期体積を受け入れるように構成された隔離部分を形成する、ハウジングと、
前記ハウジングの前記隔離部分に少なくとも部分的に設けられ、第1の状態から第2の状態に遷移するように構成されたフローコントローラと、
前記出口に流体的に結合されて、負圧差を前記ハウジングの少なくとも一部分内で生成するように構成された流体収集デバイスであって、前記流体収集デバイスによって生成された前記負圧差は、前記フローコントローラが前記第1の状態にあるとき、前記体液の初期体積を前記隔離部分の中に引き込むように動作可能であり、前記流体収集デバイスによって生成された前記負圧差は、前記フローコントローラが前記第2の状態にあるとき、前記体液の検査体積を、前記出口を通って前記流体収集デバイスの中に引き込むように動作可能である、流体収集デバイスと、を備えるシステム。 - 前記フローコントローラが、前記第1の状態から前記第2の状態に自動的に遷移するように構成されている、請求項1に記載のシステム。
- 前記フローコントローラが、前記隔離部分に設けられた前記体液の初期体積の一部分と接触することに応じて、前記第1の状態から前記第2の状態に遷移するように構成されている、請求項1に記載のシステム。
- 前記フローコントローラが、選択的透過性材料を含む、請求項1に記載のシステム。
- 前記第2の状態になる前に、前記フローコントローラが、前記フローコントローラを通る気体が流れることを可能にして前記フローコントローラを通る体液の流れを妨げるように構成されている、請求項4に記載のシステム。
- 前記フローコントローラが、前記第2の状態にあるとき、前記フローコントローラを通る気体及び体液の流れを妨げるように構成されている、請求項5に記載のシステム。
- 前記フローコントローラが、前記体液の初期体積の一部分が前記選択的透過性材料に浸透することに応じて、前記第2の状態になるように構成されている、請求項6に記載のシステム。
- 前記フローコントローラが前記第2の状態に遷移する前に、前記フローコントローラが、前記ハウジングの前記隔離部分に加わる負圧の大きさを調節するように構成されている、請求項1に記載のシステム。
- 前記流体収集デバイスが、前記出口に流体的に結合されたとき、前記負圧差を前記ハウジングの少なくとも前記一部分内で生成するように動作可能な負圧を規定するサンプルリザーバである、請求項1に記載のシステム。
- 前記流体収集デバイスが、前記出口に流体的に結合されて、前記ハウジングの少なくとも一部分内で前記負圧差を生成した後、使用者によって操作されるように構成されたシリンジである、請求項1に記載のシステム。
- 前記ハウジングが、第1の流体流路及び第2の流体流路を規定し、前記フローコントローラが前記第1の状態にあるとき、前記負圧差が、前記第1の流体流路を通る前記体液の初期体積を前記入口から前記隔離部分に引き込むように動作可能であり、前記フローコントローラが前記第2の状態にあるとき、前記負圧差が、前記第2の流体流路を通る前記体液の検査体積を前記入口から前記出口に引き込むように動作可能である、請求項1に記載のシステム。
- 前記ハウジングに結合されたアクチュエータであって、前記負圧差が前記第1の流体流路に加えられる第1のアクチュエータ状態、及び前記負圧差が前記第2の流体流路に加えられる第2のアクチュエータ状態を有する、アクチュエータをさらに含む、請求項11に記載のシステム。
- 前記アクチュエータは、前記フローコントローラが前記第1の状態にあるとき、前記第1のアクチュエータ状態にあり、前記フローコントローラが前記第2の状態に移行した後、前記第1のアクチュエータ状態から前記第2のアクチュエータ状態に移行されるように構成されている、請求項12に記載のシステム。
- 前記フローコントローラが前記第2の状態に移行した後、前記負圧差が、前記アクチュエータを前記第1のアクチュエータ状態から前記第2のアクチュエータ状態に自動的に遷移させる、請求項13に記載のシステム。
- 体液源と流体が流通可能に配置されるように構成された入口及び流体収集デバイスと流体が流通可能に配置されるように構成された出口を有するハウジングであって、前記体液源から体液の初期体積を受け入れるように構成された隔離部分を形成する、ハウジングと、
前記ハウジングに結合されたアクチュエータであって、第1の流体流路が前記入口を前記隔離部分と流体が流通可能に配置する第1の構成、及び第2の流体流路が前記入口を前記出口と流体が流通可能に配置する第2の構成を有する、アクチュエータと、を備え、
前記流体収集デバイスが、前記出口と流体が流通可能に配置されて、(1)前記アクチュエータが前記第1の構成にあるとき、前記体液の初期体積を前記隔離部分の中に引き込むように動作可能な前記第1の流体流路内で負圧差を生成し、(2)前記アクチュエータが前記第2の構成にあるとき、体液の検査体積を前記流体収集デバイスに引き込むように動作可能な前記第2の流体流路内で前記負圧差を生成するように構成されている、装置。 - 前記アクチュエータが前記第2の構成にあるとき、前記体液の初期体積が、前記隔離部分に隔離される、請求項15に記載の装置。
- 前記隔離部分内に前記初期体積を隔離することによって、前記検査体積における汚染を低減する、請求項15に記載の装置。
- 前記流体収集デバイスが、前記第1の流体流路及び前記第2の流体流路内で前記負圧差を生成するように動作可能な負圧を規定するサンプルリザーバである、請求項15に記載の装置。
- 前記流体収集デバイスが、前記出口と流体が流通可能に配置されて、前記第1の流体流路及び前記第2の流体流路内で前記負圧差を生成した後、使用者によって操作されるように構成されたシリンジである、請求項15に記載の装置。
- 前記アクチュエータが、前記アクチュエータの一部分に使用者によって加えられる力に応じて、前記第1の構成から前記第2の構成に遷移するように構成されている、請求項15に記載の装置。
- 前記アクチュエータは、前記アクチュエータが前記第1の構成にあるとき、前記第1の流体流路の一部分を規定するように構成された少なくとも1つのシールを含み、前記少なくとも1つのシールは、前記アクチュエータが前記第2の構成にあるとき、前記第2の流体流路の一部分を規定するように構成されている、請求項15に記載の装置。
- 前記アクチュエータは、前記第1の流体流路の一部分内の前記負圧差が負圧の閾値を超えるとき、第1の状態から第2の状態に遷移するように構成された隔膜を含む、請求項15に記載の装置。
- 前記隔膜は、前記隔膜が前記第1の状態にあるとき、前記第1の流体流路の一部分を規定するように構成され、前記隔膜が前記第2の状態にあるとき、前記第2の流体流路の一部分を規定するように構成された少なくとも1つのシールに結合されている、請求項22に記載の装置。
- 前記ハウジングの前記隔離部分に少なくとも部分的に設けられたフローコントローラであって、前記隔離部分と前記アクチュエータとの間に選択的な流体連通を確立するように構成されている、フローコントローラをさらに備える、請求項15に記載の装置。
- 前記フローコントローラが、選択的透過性材料を含む、請求項24に記載の装置。
- 前記フローコントローラは、前記選択的透過性材料が前記フローコントローラを通る気体が流れることを可能にして、前記フローコントローラを通る体液の流れを妨げる第1の状態から、前記選択的透過性材料が前記フローコントローラを通る気体及び体液の流れを妨げる第2の状態に遷移するように構成されている、請求項25に記載の装置。
- 前記フローコントローラが、前記体液の初期体積の一部分が前記選択的透過性材料に浸透することに応じて、前記第2の状態になるように構成されている、請求項26に記載の装置。
- 前記アクチュエータは、前記フローコントローラが前記第2の状態に遷移した後、前記第2の構成に移行されるように構成されている、請求項26に記載の装置。
- 流体制御デバイスを使用して、汚染が低減した体液サンプルを得る方法であって、
体液源と前記流体制御デバイスの入口との間で流体の流通を可能にすることと、
流体収集デバイスを前記流体制御デバイスの出口に結合することであって、前記出口へ前記流体収集デバイスを結合することが、前記流体制御デバイスの少なくとも一部分内で負圧差を生成するように構成されている、結合することと、
前記負圧差に応じて、体液の初期体積を前記入口から前記流体制御デバイスの隔離部分の中に受け入れることと、
前記体液の初期体積の一部分と接触することに応じて、前記隔離部分の中に設けられたフローコントローラを、前記フローコントローラが、前記フローコントローラを通る気体が流れることを可能にして前記フローコントローラを通る体液の流れを妨げる第1の状態から、前記フローコントローラが、前記フローコントローラを通る気体及び体液の流れを妨げる第2の状態に遷移することと、
前記フローコントローラが、前記第2の状態に遷移した後、前記体液の初期体積を前記隔離部分の中に隔離することと、
前記体液の後続体積を、前記入口から、前記出口を通って前記流体収集デバイスに移送することと、を含む、方法。 - 前記フローコントローラが、選択的透過性材料を含む、請求項29に記載の方法。
- 前記フローコントローラが、前記体液の初期体積の少なくとも一部分が選択的透過性材料に浸透することに応じて、前記第2の状態になるように構成されている、請求項29に記載の方法。
- 前記フローコントローラが、前記体液の初期体積の少なくとも前記一部分と接触することに応じて、前記第1の状態から前記第2の状態に自動的に遷移するように構成されている、請求項29に記載の方法。
- 前記流体収集デバイスを前記出口に結合することが、流体リザーバを前記出口に結合して、前記流体制御デバイスの少なくとも前記一部分内で前記負圧差を生成することを含み、前記流体リザーバは、前記流体リザーバが前記出口に結合される前に負圧を規定する、請求項29に記載の方法。
- 前記流体収集デバイスを前記出口に結合することが、シリンジを前記出口に結合することを含み、前記方法が、
前記シリンジを前記出口に結合した後、前記シリンジを操作して、前記流体制御デバイスの少なくとも前記一部分内で前記負圧差を生成することをさらに含む、請求項29に記載の方法。 - 前記フローコントローラを前記第1の状態から前記第2の状態に遷移させた後、前記流体制御デバイスのアクチュエータを第1の構成から第2の構成に移行させることをさらに含み、前記アクチュエータは、前記第1の構成にあるとき、前記入口と前記隔離部分との間の第1の流体流路の少なくとも一部分を規定し、前記アクチュエータは、前記第2の構成にあるとき、前記入口と前記出口との間の第2の流体流路の少なくとも一部分を規定する、請求項29に記載の方法。
- 前記体液の初期体積を隔離することによって、前記体液の後続体積が実質的に汚染物質を含まないように前記隔離部分内の前記汚染物質を隔離する、請求項29に記載の方法。
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CA3074105A1 (en) | 2019-03-21 |
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WO2019055487A1 (en) | 2019-03-21 |
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