JP2020532965A5 - - Google Patents

Info

Publication number

JP2020532965A5

JP2020532965A5 JP2020510103A JP2020510103A JP2020532965A5 JP 2020532965 A5 JP2020532965 A5 JP 2020532965A5 JP 2020510103 A JP2020510103 A JP 2020510103A JP 2020510103 A JP2020510103 A JP 2020510103A JP 2020532965 A5 JP2020532965 A5 JP 2020532965A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

antibody

acid sequence

hvr

Prior art date

2018-08-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 51
• 239000000427 antigen Substances 0.000 claims 32
• 108091007433 antigens Proteins 0.000 claims 32
• 102000036639 antigens Human genes 0.000 claims 32
• 239000012634 fragment Substances 0.000 claims 32
• 125000000539 amino acid group Chemical group 0.000 claims 12
• 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 11
• 229910052757 nitrogen Inorganic materials 0.000 claims 8
• 108091033319 polynucleotide Proteins 0.000 claims 7
• 102000040430 polynucleotide Human genes 0.000 claims 7
• 239000002157 polynucleotide Substances 0.000 claims 7
• 102000050327 human TNFRSF9 Human genes 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims 3
• 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 3
• 210000005260 human cell Anatomy 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000282472 Canis lupus familiaris Species 0.000 claims 1
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 1
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 1
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 1
• 108010057466 NF-kappa B Proteins 0.000 claims 1
• 102000003945 NF-kappa B Human genes 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 108700005077 Viral Genes Proteins 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 229940022399 cancer vaccine Drugs 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229960004397 cyclophosphamide Drugs 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 229960002949 fluorouracil Drugs 0.000 claims 1
• 238000001415 gene therapy Methods 0.000 claims 1
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
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• 230000035772 mutation Effects 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 229910052698 phosphorus Inorganic materials 0.000 claims 1
• 150000003057 platinum Chemical class 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 229960004641 rituximab Drugs 0.000 claims 1
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• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
• 238000002626 targeted therapy Methods 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1