JP2020527937A5 - - Google Patents

Download PDF

Info

Publication number
JP2020527937A5
JP2020527937A5 JP2019567571A JP2019567571A JP2020527937A5 JP 2020527937 A5 JP2020527937 A5 JP 2020527937A5 JP 2019567571 A JP2019567571 A JP 2019567571A JP 2019567571 A JP2019567571 A JP 2019567571A JP 2020527937 A5 JP2020527937 A5 JP 2020527937A5
Authority
JP
Japan
Prior art keywords
polypeptide
her1
immunogenic
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019567571A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020527937A (ja
JP7262403B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/036357 external-priority patent/WO2018226897A1/en
Publication of JP2020527937A publication Critical patent/JP2020527937A/ja
Publication of JP2020527937A5 publication Critical patent/JP2020527937A5/ja
Priority to JP2023063807A priority Critical patent/JP7713486B2/ja
Application granted granted Critical
Publication of JP7262403B2 publication Critical patent/JP7262403B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019567571A 2017-06-07 2018-06-06 新規の細胞タグの発現 Active JP7262403B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023063807A JP7713486B2 (ja) 2017-06-07 2023-04-11 新規の細胞タグの発現

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762516639P 2017-06-07 2017-06-07
US62/516,639 2017-06-07
PCT/US2018/036357 WO2018226897A1 (en) 2017-06-07 2018-06-06 Expression of novel cell tags

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023063807A Division JP7713486B2 (ja) 2017-06-07 2023-04-11 新規の細胞タグの発現

Publications (3)

Publication Number Publication Date
JP2020527937A JP2020527937A (ja) 2020-09-17
JP2020527937A5 true JP2020527937A5 (https=) 2021-07-26
JP7262403B2 JP7262403B2 (ja) 2023-04-21

Family

ID=64566601

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019567571A Active JP7262403B2 (ja) 2017-06-07 2018-06-06 新規の細胞タグの発現
JP2023063807A Active JP7713486B2 (ja) 2017-06-07 2023-04-11 新規の細胞タグの発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023063807A Active JP7713486B2 (ja) 2017-06-07 2023-04-11 新規の細胞タグの発現

Country Status (10)

Country Link
US (4) US11118168B2 (https=)
EP (2) EP3635132A4 (https=)
JP (2) JP7262403B2 (https=)
KR (2) KR102557834B1 (https=)
CN (1) CN110997920A (https=)
AU (2) AU2018281316B2 (https=)
CA (1) CA3065930A1 (https=)
IL (2) IL270990B2 (https=)
WO (1) WO2018226897A1 (https=)
ZA (3) ZA201908215B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
WO2022047417A1 (en) * 2020-08-31 2022-03-03 Exuma Biotech Corp. Anti-idiotype compositions and methods of use thereof
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
KR20190102259A (ko) 2017-01-10 2019-09-03 인트렉손 코포레이션 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP3697438A4 (en) * 2017-10-18 2021-08-18 Intrexon Corporation POLYPEPTIDE COMPOSITIONS WITH SPACERS
WO2019099707A1 (en) * 2017-11-16 2019-05-23 Kite Pharma, Inc Modified chimeric antigen receptors and methods of use
EP3820484A4 (en) 2018-07-10 2022-05-04 Precigen, Inc. ROR-1 SPECIFIC CHIMERA ANTIGEN RECEPTORS AND USES THEREOF
KR20200110576A (ko) * 2019-03-15 2020-09-24 재단법인대구경북과학기술원 사이토카인 기반 면역세포 및 그의 면역 치료 용도
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
GB202007169D0 (en) * 2020-05-14 2020-07-01 Ospedale San Raffaele Srl Epidermal growth factor receptor
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
EP4271817A2 (en) * 2020-12-30 2023-11-08 Alaunos Therapeutics, Inc. Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
MX2023008115A (es) * 2021-01-11 2023-09-11 Precigen Inc Terapia con receptores quiméricos.
WO2022177677A1 (en) * 2021-02-16 2022-08-25 City Of Hope Truncated domain iv egfr and uses thereof
IL305393A (en) * 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
MX2024003250A (es) * 2021-09-22 2024-05-28 Sonoma Biotherapeutics Inc Marcadores de superficie celular il5ra.
EP4435101A4 (en) * 2021-11-17 2025-11-12 Shanghai Juncell Therapeutics Co Ltd MEMBRANE SURFACE PROTEIN CONTAINING A GPI ANCHOR REGION
US20250099612A1 (en) 2022-03-01 2025-03-27 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
US20250388905A1 (en) * 2022-07-10 2025-12-25 Precigen, Inc. POLYCISTRONIC miRNA CONSTRUCTS FOR IMMUNE CHECKPOINT INHIBITION
AU2023400596A1 (en) * 2022-11-29 2025-06-19 Malcorp Biodiscoveries Limited Novel cd20 protein
CN118206620A (zh) * 2022-12-09 2024-06-18 上海细胞治疗集团股份有限公司 一种多肽标签及其应用
CN118557756B (zh) * 2024-05-24 2025-04-29 华中科技大学同济医学院附属协和医院 一种基于aav的遗传性抗凝血酶缺乏的基因疗法
WO2026020171A2 (en) * 2024-07-19 2026-01-22 Aera Therapeutics, Inc. Chimeric antigen receptor constructs
CN121378506A (zh) * 2025-10-21 2026-01-23 北京京科信拓生物技术有限公司 表达car的免疫细胞及其应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US570802A (en) 1896-11-03 Nicholas powell horton
US509002A (en) 1893-11-21 Eleotbic bail way
US10905A (en) 1854-05-16 Lath-machine
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
AU655417B2 (en) 1990-03-22 1994-12-22 Salk Institute For Biological Studies, The Insect retinoid receptor compositions and methods
CA2096222C (en) 1990-11-13 1998-12-29 Stephen D. Lupton Bifunctional selectable fusion genes
US5350674A (en) 1992-09-04 1994-09-27 Becton, Dickinson And Company Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
WO1994028143A1 (en) 1993-05-21 1994-12-08 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
ATE293699T1 (de) 1995-03-03 2005-05-15 Syngenta Participations Ag Kontrolle der pflanzengenexpression durch rezeptor-vermittelte transaktivation in gegenwart von einem chemischen ligand
JP3926842B2 (ja) 1995-03-08 2007-06-06 ザ・スクリプス・リサーチ・インステイチユート 抗原提示系およびt−細胞の活性化方法
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US5885827A (en) 1996-01-23 1999-03-23 The Regents Of The Universtiy Of California Eukaryotic high rate mutagenesis system
AU734051B2 (en) 1996-04-05 2001-05-31 Salk Institute For Biological Studies, The Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
ATE347588T1 (de) 1996-05-23 2006-12-15 Scripps Research Inst Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten
US6489458B2 (en) 1997-03-11 2002-12-03 Regents Of The University Of Minnesota DNA-based transposon system for the introduction of nucleic acid into DNA of a cell
AU738494B2 (en) 1997-07-10 2001-09-20 Salk Institute For Biological Studies, The Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
US6333318B1 (en) 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6790662B1 (en) 1999-03-12 2004-09-14 Ortho-Mcneil Pharmaceutical, Inc. Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides
CA2386270A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
AU1100201A (en) 1999-10-28 2001-05-08 Board Of Trustees Of The Leland Stanford Junior University Methods of in vivo gene transfer using a sleeping beauty transposon system
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
CA2406864A1 (en) 2000-02-24 2001-08-30 Life Technologies Corporation Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
JP5031967B2 (ja) 2000-03-22 2012-09-26 イントレキソン コーポレーション 新規エクジソン受容体ベースの誘導性遺伝子発現系
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
US20020082787A1 (en) 2000-07-07 2002-06-27 Woodworth Robert E. Method and apparatus for monitoring a product during shipping, storage and use
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
WO2002066613A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
US20040071671A1 (en) 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors
EP1373470B1 (en) 2001-02-20 2013-04-24 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
ES2424812T3 (es) 2001-02-20 2013-10-08 Intrexon Corporation Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso
WO2002081649A2 (en) 2001-04-06 2002-10-17 The Trustees Of The University Of Pennsylvania ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2459807C (en) 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
AU2003231048A1 (en) 2002-04-22 2003-11-03 Regents Of The University Of Minnesota Transposon system and methods of use
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
AU2005250408B2 (en) 2004-05-27 2010-09-23 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US8361794B2 (en) 2004-06-29 2013-01-29 Immunocore Limited Cells expressing a modified T cell receptor
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
GB0523954D0 (en) * 2005-11-24 2006-01-04 Ucb Celltech Bioassays
ES2579762T3 (es) 2006-03-01 2016-08-16 Janssen Pharmaceutica N.V. Tratamiento del cáncer combinando agente linfo - reductor con CLTs y citoquinas
BRPI0713272A2 (pt) * 2006-06-12 2017-05-02 Receptor Biologix Inc produtos terapêuticos específicos ao receptor na superfície de pan-células
CA2665568C (en) 2006-10-04 2018-01-09 Janssen Pharmaceutica, N.V. Preparation of inactivated artificial antigen presenting cells and their use in cell therapies
BRPI0807952A2 (pt) 2007-02-20 2014-06-10 Anaptysbio Inc Sistemas de hipermutação somática
EP2160461B1 (en) 2007-07-04 2012-08-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Hyperactive variants of the transposase protein of the transposon system sleeping beauty
KR101666228B1 (ko) 2007-09-28 2016-10-13 인트렉손 코포레이션 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
HUE035406T2 (en) 2007-10-08 2018-05-02 Intrexon Corp Engineered dendritic cells and uses for the treatment of cancer
US7985559B2 (en) 2007-10-19 2011-07-26 Amgen Inc. Methods of selecting epidermal growth factor receptor (EGFR) binding agents
CN102575227A (zh) 2008-10-08 2012-07-11 英特瑞克斯顿股份有限公司 表达多种免疫调节剂的工程改造细胞及其应用
DK2496698T3 (en) 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
JP5508625B2 (ja) 2009-12-14 2014-06-04 トヨタ自動車株式会社 車両の制御装置及び車両の制御方法
CA2794196A1 (en) 2010-03-23 2011-09-29 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
US9331524B1 (en) 2010-07-03 2016-05-03 Best Energy Reduction Technologies, Llc Method, system and apparatus for monitoring and measuring power usage
CN103298489A (zh) * 2010-10-29 2013-09-11 伊缪诺金公司 新型egfr结合分子及其免疫偶联物
SG10201600912SA (en) 2011-03-04 2016-03-30 Intrexon Corp Vectors conditionally expressing protein
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
EP2844267A4 (en) * 2012-04-25 2016-02-24 Ligacept Llc BROAD SPECTRUM ERBB LIGAND BINDING MOLECULES AND METHODS OF USING THE SAME
WO2014159415A1 (en) 2013-03-12 2014-10-02 Bio-Rad Laboratories, Inc. Colloidal coomassie stain
AU2014268364A1 (en) 2013-05-24 2015-12-10 Board Of Regents, The University Of Texas System Chimeric antigen receptor-targeting monoclonal antibodies
CN104341504B (zh) * 2013-08-06 2017-10-24 百奥泰生物科技(广州)有限公司 双特异性抗体
JP2017501712A (ja) 2013-12-18 2017-01-19 イントレキソン コーポレーション 単鎖il−12核酸、ポリペプチド、およびそれらの使用
EP3656864A1 (en) 2014-02-14 2020-05-27 Board of Regents, The University of Texas System Chimeric antigen receptors and methods of making
US9814215B2 (en) 2014-03-11 2017-11-14 Little Big Cat, Inc. Pet toy with telescoping wand with metallic wire
MX383150B (es) 2014-06-02 2025-03-13 Us Health Receptores quiméricos de antígeno que tienen como diana a cd-19.
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-bcma嵌合抗原受體治療癌症
KR20170032244A (ko) 2014-07-26 2017-03-22 선샤인 레이크 파르마 컴퍼니 리미티드 Cdk 저해제로서 2-아미노-피리도[2,3-d]피리미딘-7(8h)-온 유도체 및 그 용도
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
SG11201702295UA (en) 2014-09-22 2017-04-27 Intrexon Corp Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
AU2015343013B2 (en) 2014-11-05 2020-07-16 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
CA2969456A1 (en) * 2014-12-03 2016-06-09 Juno Therapeutics, Inc. Methods and compositions for adoptive cell therapy
ES2869972T3 (es) 2015-01-26 2021-10-26 Cellectis Sistemas de receptores de antígenos quiméricos dirigidos por mAb para clasificar/agotar células inmunitarias genomanipuladas
SG11201802912PA (en) 2015-10-10 2018-05-30 Intrexon Corp Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12
EP4012415A3 (en) 2015-12-04 2022-12-07 Juno Therapeutics, Inc. Methods and compositions related to toxicity associated with cell therapy
SG11201810640RA (en) * 2016-06-08 2018-12-28 Intrexon Corp Cd33 specific chimeric antigen receptors
CN108330133B (zh) 2017-01-20 2020-06-30 上海恒润达生生物科技有限公司 靶向cd19嵌合抗原受体并对其双重修饰的方法及其用途
WO2018197675A1 (en) 2017-04-28 2018-11-01 Julius-Maximilians-Universität Würzburg Ror1-specific chimeric antigen receptors (car) with humanized targeting domains

Similar Documents

Publication Publication Date Title
JP2020527937A5 (https=)
JP2023085527A5 (https=)
US12410248B2 (en) Chimeric antigen receptor and its use
US20250101080A1 (en) Chimeric antigen receptors and uses thereof
EP3240805B1 (en) Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
JP2019150066A5 (https=)
JP2021512635A5 (https=)
JP2020530989A5 (https=)
JP2020511949A5 (https=)
JP2019500894A5 (https=)
JPWO2020181094A5 (https=)
JP2017140051A5 (https=)
JP2017527310A5 (https=)
JP2016501535A5 (https=)
JPWO2020014366A5 (https=)
JP2019512215A (ja) 改変細胞及び方法
JPWO2019157533A5 (https=)
CN115403671A (zh) 靶向Claudin18.2的纳米抗体及其用途
JPWO2022133169A5 (https=)
WO2018199595A1 (ko) 4-1bbl 변이체 및 이를 포함하는 융합 단백질
WO2018045034A1 (en) Chimeric antigen receptors having gitr intracellular domain as co-stimulatory domain
CN113795272A (zh) 涉及car工程化的t细胞和细胞因子的治疗
CA3217894A1 (en) Recombinant proteinaceous binding molecules
JP2022521278A (ja) 人工免疫監視キメラ抗原受容体(ai-car)及びそれを発現する細胞
WO2020112529A1 (en) Car-t cells having humanized cd19 scfv with mutation in cdr 1 region