JP2020527599A5 - - Google Patents

Download PDF

Info

Publication number
JP2020527599A5
JP2020527599A5 JP2020522799A JP2020522799A JP2020527599A5 JP 2020527599 A5 JP2020527599 A5 JP 2020527599A5 JP 2020522799 A JP2020522799 A JP 2020522799A JP 2020522799 A JP2020522799 A JP 2020522799A JP 2020527599 A5 JP2020527599 A5 JP 2020527599A5
Authority
JP
Japan
Prior art keywords
alkyl
value
integer
independently
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020522799A
Other languages
English (en)
Japanese (ja)
Other versions
JP7174757B2 (ja
JP2020527599A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2018/000847 external-priority patent/WO2019008441A1/en
Publication of JP2020527599A publication Critical patent/JP2020527599A/ja
Publication of JP2020527599A5 publication Critical patent/JP2020527599A5/ja
Application granted granted Critical
Publication of JP7174757B2 publication Critical patent/JP7174757B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020522799A 2017-07-04 2018-07-03 切断可能なリンカーを含む化合物及びその使用 Active JP7174757B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2017-0084805 2017-07-04
KR20170084805 2017-07-04
US201762597226P 2017-12-11 2017-12-11
US62/597,226 2017-12-11
PCT/IB2018/000847 WO2019008441A1 (en) 2017-07-04 2018-07-03 COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2020527599A JP2020527599A (ja) 2020-09-10
JP2020527599A5 true JP2020527599A5 (https=) 2021-08-05
JP7174757B2 JP7174757B2 (ja) 2022-11-17

Family

ID=67702070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020522799A Active JP7174757B2 (ja) 2017-07-04 2018-07-03 切断可能なリンカーを含む化合物及びその使用

Country Status (12)

Country Link
US (2) US11753431B2 (https=)
EP (1) EP3649142A4 (https=)
JP (1) JP7174757B2 (https=)
KR (1) KR102710962B1 (https=)
CN (3) CN120682290A (https=)
AU (2) AU2018295540B2 (https=)
BR (1) BR112019028295A2 (https=)
CA (1) CA3068800A1 (https=)
IL (2) IL271755A (https=)
MX (1) MX2019015940A (https=)
TW (1) TWI801396B (https=)
WO (1) WO2019008441A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) * 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
WO2020038278A1 (zh) * 2018-08-21 2020-02-27 深圳市塔革特生物医药科技有限公司 新型喜树碱衍生物及其制备方法和应用
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
KR20210099658A (ko) * 2019-01-03 2021-08-12 주식회사 인투셀 절단가능 링커를 포함하는 화합물 및 이의 용도
WO2020141459A1 (en) * 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
WO2020232247A1 (en) 2019-05-14 2020-11-19 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
CA3145913A1 (en) 2019-07-29 2021-02-04 James Everett Dahlman Nanomaterials containing constrained lipids and uses thereof
IL292328B2 (en) * 2019-10-28 2025-10-01 Geron Corp Succinylate-converted 3-(amido fatty acid)-2-hydroxy-1-(protected hydroxy)-propane salts, amorphous solids and methods for their preparation
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
IL294318A (en) 2020-01-09 2022-08-01 Guide Therapeutics Llc Nanomaterials
JP2023528825A (ja) * 2020-05-28 2023-07-06 アンセルム 血栓の予防、処置および診断のための化合物
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
BR112022026401A2 (pt) * 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
CN116761888A (zh) 2021-01-20 2023-09-15 比姆医疗股份有限公司 纳米材料
EP4281080A4 (en) 2021-01-20 2025-09-24 Beam Therapeutics Inc NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT
JP2024503441A (ja) * 2021-01-20 2024-01-25 ビーム セラピューティクス インク. イオン化可能な脂質を含むナノ材料
EP4326737A1 (en) * 2021-04-19 2024-02-28 Neurotrauma Sciences LLC Salts and crystalline forms of (3e) 3-[o-[(phosphonooxy)methyl]oxime]-pregn-4-ene-3, 20-dione and related uses
JP2024520444A (ja) 2021-05-24 2024-05-24 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を治療するための方法
EP4377292A1 (en) * 2021-07-28 2024-06-05 Ramot at Tel-Aviv University Ltd. Water soluble prodrug, conjugates and uses thereof
CN114773433B (zh) * 2022-06-23 2022-09-06 北京肿瘤医院(北京大学肿瘤医院) 一种cd25靶向多肽、分子探针及应用
CA3260437A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. NANOMATERIALS INCLUDING TRIOLS
GB202306325D0 (en) * 2023-04-28 2023-06-14 Iksuda Therapeutics Ltd Antibody-drug conjugate compounds, and methods of use and treatment
AU2024282578A1 (en) * 2023-05-31 2025-12-04 Full-Life Technologies Uk Limited Radioligands for targeting cell surface receptors and uses thereof
WO2025237246A1 (en) * 2024-05-11 2025-11-20 Westlake Laboratory Of Life Sciences And Biomedicine Novel covalent protein and use thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1182232B (de) 1963-03-08 1964-11-26 Hans J Zimmer Verfahrenstechni Verfahren zur Herstellung von Trialkylaryloxysilanen
CH565791A5 (https=) 1972-07-11 1975-08-29 Sandoz Ag
US4540828A (en) 1982-06-01 1985-09-10 Vista Chemical Company Catalysts for alkoxylation reactions
JPS5978171A (ja) 1982-10-26 1984-05-04 Ikeda Mohandou:Kk 複素環式化合物
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
JP3041736B2 (ja) 1991-11-01 2000-05-15 コニカ株式会社 ハロゲン化銀写真感光材料
ATE218132T1 (de) 1994-10-14 2002-06-15 Yamanouchi Pharma Co Ltd Azol-derivate
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
DE102004012676A1 (de) * 2004-03-16 2005-10-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2005291974A (ja) 2004-03-31 2005-10-20 Kyocera Chemical Corp フェルダジル基を有する磁性有機粒子、粒子固定方法及びマイクロアレイ
WO2006125293A1 (en) * 2005-05-27 2006-11-30 Antibe Therapeutics Inc. Derivatives of 4- or 5-aminosalicylic acid
EP1867729A1 (en) 2006-06-14 2007-12-19 Libragen Water soluble phenolics derivatives with dermocosmetic and therapeutic applications
CN101959900A (zh) * 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
CN104185477B (zh) * 2011-11-17 2017-05-24 辉瑞公司 细胞毒性肽及其抗体‑药物缀合物
TWI585115B (zh) * 2011-12-15 2017-06-01 普利司通股份有限公司 經穩定之多價陰離子聚合反應引發劑及其製備方法
ES2781523T3 (es) 2012-07-12 2020-09-02 Hangzhou Dac Biotech Co Ltd Conjugados de moléculas de unión celular con agentes citotóxicos
US9834575B2 (en) * 2013-02-26 2017-12-05 Triact Therapeutics, Inc. Cancer therapy
US9499528B2 (en) 2013-04-08 2016-11-22 The University Of Akron Class of near infrared molecular probes for biological applications
DK3092256T3 (da) 2014-01-10 2022-06-20 Birdie Biopharmaceuticals Inc Forbindelser og sammensætninger til immunterapi
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
WO2016029324A1 (en) * 2014-08-29 2016-03-03 Rsem, Limited Partnership Azasulfurylpeptide-based cd36 modulators and uses thereof
US10035526B2 (en) 2014-12-03 2018-07-31 New York Air Brake, LLC Brake piston assembly
US10370407B2 (en) 2015-01-21 2019-08-06 The Regents Of The University Of California Affinity-assisted protein modification and recycling
CN107922375B (zh) 2015-07-30 2020-05-22 正大天晴药业集团股份有限公司 靶向idh2突变的抗肿瘤化合物及其使用方法
WO2017044043A1 (en) * 2015-09-09 2017-03-16 Agency For Science, Technology And Research Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines
KR101766822B1 (ko) * 2015-09-10 2017-08-24 서울대학교산학협력단 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물
AU2016359235B2 (en) 2015-11-25 2022-09-15 Ligachem Biosciences Inc. Antibody-drug conjugates comprising branched linkers and methods related thereto
WO2018053552A2 (en) 2016-09-19 2018-03-22 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
WO2018124758A2 (ko) 2016-12-28 2018-07-05 주식회사 인투셀 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
CN120682290A (zh) 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
WO2020141459A1 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
KR20210099658A (ko) 2019-01-03 2021-08-12 주식회사 인투셀 절단가능 링커를 포함하는 화합물 및 이의 용도

Similar Documents

Publication Publication Date Title
JP2020527599A5 (https=)
JP2022515885A5 (https=)
CN114456186B (zh) 一种喜树碱类衍生物及其配体-药物偶联物
JP2022515884A5 (https=)
TWI715611B (zh) 抗體藥物偶聯物的共價鍵連接子及其製備方法與應用
JP7393810B2 (ja) 部位特異的抗体コンジュゲーション及びその具体例としての抗体-薬物コンジュゲート
JP2017531028A5 (https=)
CN111643676B (zh) 一种双特异性二聚体、双特异性二聚体-药物偶联物及其应用
CN112543752A (zh) 连接子、含连接子的抗体偶联药物及连接子的用途
EP3186278A1 (en) Internalizing moieties for treatment of cancer
IL324591A (en) Improved antibody-drug conjugate production methods
JP2024501894A5 (https=)
Figini et al. Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor
KR102014383B1 (ko) G 단백질 연결 수용체의 활성 조절 인간 항체
TW202200213A (zh) 抗體藥物複合體
JP2025500342A5 (https=)
NL2020121B1 (en) Platinum-based functional moieties for preparing cell targeting conjugates
WO2024109935A1 (zh) 芦竹碱-铂(iv)配合物及其制备方法和抗肿瘤用途
Calce et al. HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor
WO2023143319A1 (zh) 抗体药物偶联物、药物组合物及用途
JP2022515880A (ja) Tamおよびmetキナーゼの阻害薬としてのキノリン化合物
AU2004292933B2 (en) Targeting of Erb antigens
RU2020104697A (ru) Соединения, содержащие расщепляемый линкер, и способы их применения
US20150182634A1 (en) Molecular Design and Chemical Synthesis of Pharmaceutical-Ligands and Pharmaceutical-Pharmaceutical Analogs with Multiple Mechanisms of Action
JP2025508868A5 (https=)