JP2020527599A5 - - Google Patents

Download PDF

Info

Publication number
JP2020527599A5
JP2020527599A5 JP2020522799A JP2020522799A JP2020527599A5 JP 2020527599 A5 JP2020527599 A5 JP 2020527599A5 JP 2020522799 A JP2020522799 A JP 2020522799A JP 2020522799 A JP2020522799 A JP 2020522799A JP 2020527599 A5 JP2020527599 A5 JP 2020527599A5
Authority
JP
Japan
Prior art keywords
alkyl
value
integer
independently
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020522799A
Other languages
English (en)
Japanese (ja)
Other versions
JP7174757B2 (ja
JP2020527599A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2018/000847 external-priority patent/WO2019008441A1/en
Publication of JP2020527599A publication Critical patent/JP2020527599A/ja
Publication of JP2020527599A5 publication Critical patent/JP2020527599A5/ja
Application granted granted Critical
Publication of JP7174757B2 publication Critical patent/JP7174757B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020522799A 2017-07-04 2018-07-03 切断可能なリンカーを含む化合物及びその使用 Active JP7174757B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20170084805 2017-07-04
KR10-2017-0084805 2017-07-04
US201762597226P 2017-12-11 2017-12-11
US62/597,226 2017-12-11
PCT/IB2018/000847 WO2019008441A1 (en) 2017-07-04 2018-07-03 COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2020527599A JP2020527599A (ja) 2020-09-10
JP2020527599A5 true JP2020527599A5 (https=) 2021-08-05
JP7174757B2 JP7174757B2 (ja) 2022-11-17

Family

ID=67702070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020522799A Active JP7174757B2 (ja) 2017-07-04 2018-07-03 切断可能なリンカーを含む化合物及びその使用

Country Status (12)

Country Link
US (2) US11753431B2 (https=)
EP (1) EP3649142A4 (https=)
JP (1) JP7174757B2 (https=)
KR (1) KR102710962B1 (https=)
CN (3) CN120682289A (https=)
AU (2) AU2018295540B2 (https=)
BR (1) BR112019028295A2 (https=)
CA (1) CA3068800A1 (https=)
IL (2) IL271755A (https=)
MX (1) MX2019015940A (https=)
TW (1) TWI801396B (https=)
WO (1) WO2019008441A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008441A1 (en) 2017-07-04 2019-01-10 Intocell, Inc. COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF
MX2020012718A (es) * 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN110845559B (zh) * 2018-08-21 2023-02-28 四川福生源科技有限公司 新型喜树碱衍生物及其制备方法和应用
KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
EP3906064A4 (en) * 2019-01-03 2023-03-08 Intocell, Inc. CLEAVABLE LINKER COMPOUNDS AND USES THEREOF
WO2020141460A2 (en) * 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
US12569438B2 (en) 2019-07-29 2026-03-10 Georgia Tech Research Corporation Nanomaterials containing constrained lipids and uses thereof
AU2020372865A1 (en) * 2019-10-28 2022-05-26 Geron Corporation Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane salts and methods of making the same
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
US12435035B2 (en) 2020-01-09 2025-10-07 Guide Therapeutics, Llc Nanomaterials
CN116829154A (zh) * 2020-05-28 2023-09-29 国家健康科学研究所 用于预防、治疗和诊断血栓的化合物
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
KR20230028793A (ko) * 2020-06-26 2023-03-02 주식회사 인투셀 항-b7-h3 항체를 포함하는 항체-약물 접합체
JP2024503441A (ja) * 2021-01-20 2024-01-25 ビーム セラピューティクス インク. イオン化可能な脂質を含むナノ材料
KR20230131863A (ko) 2021-01-20 2023-09-14 빔 테라퓨틱스, 인크. 나노물질
IL303845A (en) 2021-01-20 2023-08-01 Beam Therapeutics Inc Nanomaterials include a degradable property
CN117769561A (zh) * 2021-04-19 2024-03-26 神经创伤科学有限责任公司 (3E)3-[o-[(膦酰氧基)甲基]肟]-孕烯-4-烯-3,20-二酮的盐和晶型及相关用途
US12565529B2 (en) 2021-05-24 2026-03-03 Provention Bio, Inc. Methods for treating type 1 diabetes
CA3226393A1 (en) * 2021-07-28 2023-02-02 Doron Shabat Water soluble prodrug, conjugates and uses thereof
CN114773433B (zh) * 2022-06-23 2022-09-06 北京肿瘤医院(北京大学肿瘤医院) 一种cd25靶向多肽、分子探针及应用
WO2024019936A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. Nanomaterials comprising triols
GB202306325D0 (en) * 2023-04-28 2023-06-14 Iksuda Therapeutics Ltd Antibody-drug conjugate compounds, and methods of use and treatment
WO2024245421A1 (en) * 2023-05-31 2024-12-05 Full-Life Technologies Hk Limited Radioligands for targeting cell surface receptors and uses thereof
WO2025237246A1 (en) * 2024-05-11 2025-11-20 Westlake Laboratory Of Life Sciences And Biomedicine Novel covalent protein and use thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1182232B (de) 1963-03-08 1964-11-26 Hans J Zimmer Verfahrenstechni Verfahren zur Herstellung von Trialkylaryloxysilanen
CH565791A5 (https=) 1972-07-11 1975-08-29 Sandoz Ag
US4540828A (en) 1982-06-01 1985-09-10 Vista Chemical Company Catalysts for alkoxylation reactions
JPS5978171A (ja) 1982-10-26 1984-05-04 Ikeda Mohandou:Kk 複素環式化合物
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
JP3041736B2 (ja) 1991-11-01 2000-05-15 コニカ株式会社 ハロゲン化銀写真感光材料
JP3061862B2 (ja) 1994-10-14 2000-07-10 山之内製薬株式会社 アゾール誘導体
ATE557013T1 (de) * 2004-03-16 2012-05-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte benzol-derivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE102004012676A1 (de) * 2004-03-16 2005-10-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
JP2005291974A (ja) 2004-03-31 2005-10-20 Kyocera Chemical Corp フェルダジル基を有する磁性有機粒子、粒子固定方法及びマイクロアレイ
WO2006125293A1 (en) 2005-05-27 2006-11-30 Antibe Therapeutics Inc. Derivatives of 4- or 5-aminosalicylic acid
EP1867729A1 (en) 2006-06-14 2007-12-19 Libragen Water soluble phenolics derivatives with dermocosmetic and therapeutic applications
CN101959900A (zh) * 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
MY168297A (en) * 2011-11-17 2018-10-23 Pfizer Cytotoxic Peptides and Antibody Drug Conjugates Thereof
TWI585115B (zh) * 2011-12-15 2017-06-01 普利司通股份有限公司 經穩定之多價陰離子聚合反應引發劑及其製備方法
PL2872157T3 (pl) 2012-07-12 2020-07-13 Hangzhou Dac Biotech Co., Ltd Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
JP6255038B2 (ja) 2013-02-26 2017-12-27 トリアクト セラピューティクス,インク. 癌治療
US9499528B2 (en) 2013-04-08 2016-11-22 The University Of Akron Class of near infrared molecular probes for biological applications
CN105899539B (zh) 2014-01-10 2021-11-09 博笛生物科技有限公司 用于免疫疗法的化合物和组合物
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
WO2016029324A1 (en) * 2014-08-29 2016-03-03 Rsem, Limited Partnership Azasulfurylpeptide-based cd36 modulators and uses thereof
US10035526B2 (en) 2014-12-03 2018-07-31 New York Air Brake, LLC Brake piston assembly
WO2016118770A1 (en) 2015-01-21 2016-07-28 The Regents Of The University Of California Affinity-assisted protein modification and recycling
CN107922375B (zh) 2015-07-30 2020-05-22 正大天晴药业集团股份有限公司 靶向idh2突变的抗肿瘤化合物及其使用方法
WO2017044043A1 (en) * 2015-09-09 2017-03-16 Agency For Science, Technology And Research Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines
KR101766822B1 (ko) 2015-09-10 2017-08-24 서울대학교산학협력단 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물
KR102847350B1 (ko) 2015-11-25 2025-08-19 주식회사 리가켐바이오사이언스 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
WO2018053552A2 (en) 2016-09-19 2018-03-22 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
WO2018124758A2 (ko) 2016-12-28 2018-07-05 주식회사 인투셀 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
WO2019008441A1 (en) 2017-07-04 2019-01-10 Intocell, Inc. COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
WO2020141460A2 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
EP3906064A4 (en) 2019-01-03 2023-03-08 Intocell, Inc. CLEAVABLE LINKER COMPOUNDS AND USES THEREOF

Similar Documents

Publication Publication Date Title
JP2020527599A5 (https=)
CN114456186B (zh) 一种喜树碱类衍生物及其配体-药物偶联物
TWI715611B (zh) 抗體藥物偶聯物的共價鍵連接子及其製備方法與應用
JP7393810B2 (ja) 部位特異的抗体コンジュゲーション及びその具体例としての抗体-薬物コンジュゲート
JP2017531028A5 (https=)
CN111643676B (zh) 一种双特异性二聚体、双特异性二聚体-药物偶联物及其应用
CN112543752A (zh) 连接子、含连接子的抗体偶联药物及连接子的用途
EP3186278A1 (en) Internalizing moieties for treatment of cancer
Figini et al. Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor
KR102014383B1 (ko) G 단백질 연결 수용체의 활성 조절 인간 항체
TW202200213A (zh) 抗體藥物複合體
Luca et al. Peptide ligands specifically targeting HER2 Receptor and the role played by a synthetic model system of the receptor extracellular domain: Hypothesized future perspectives
JPWO2020141460A5 (https=)
WO2024109935A1 (zh) 芦竹碱-铂(iv)配合物及其制备方法和抗肿瘤用途
Calce et al. HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor
JPWO2020141459A5 (https=)
WO2023143319A1 (zh) 抗体药物偶联物、药物组合物及用途
JPWO2019229536A5 (https=)
JP2022515880A (ja) Tamおよびmetキナーゼの阻害薬としてのキノリン化合物
AU2004292933B2 (en) Targeting of Erb antigens
RU2020104697A (ru) Соединения, содержащие расщепляемый линкер, и способы их применения
US20150182634A1 (en) Molecular Design and Chemical Synthesis of Pharmaceutical-Ligands and Pharmaceutical-Pharmaceutical Analogs with Multiple Mechanisms of Action
JP7588807B2 (ja) 抗MUC1抗体およびErbB阻害剤を用いた抗がん処置
JPWO2023118961A5 (https=)
Chen et al. Antibody‐Empowered Nanomedicine for Precise Biomedical Applications