CA3068800A1 - Compounds comprising cleavable linker and uses thereof - Google Patents

Compounds comprising cleavable linker and uses thereof Download PDF

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Publication number
CA3068800A1
CA3068800A1 CA3068800A CA3068800A CA3068800A1 CA 3068800 A1 CA3068800 A1 CA 3068800A1 CA 3068800 A CA3068800 A CA 3068800A CA 3068800 A CA3068800 A CA 3068800A CA 3068800 A1 CA3068800 A1 CA 3068800A1
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Prior art keywords
antibody
alkyl
cancer
compound
integer
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CA3068800A
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English (en)
French (fr)
Inventor
Taekyo Park
Sung Ho Woo
Sunyoung Kim
Suho Park
Jongun Cho
Doohwan Jung
Donghoon Seo
Jaeho Lee
Sangkwang Lee
Sanghyeon Yun
Hyang Sook Lee
Okku Park
Beomseok Seo
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Intocell Inc
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Publication of CA3068800A1 publication Critical patent/CA3068800A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/55Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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