CA3068800A1 - Compounds comprising cleavable linker and uses thereof - Google Patents
Compounds comprising cleavable linker and uses thereof Download PDFInfo
- Publication number
- CA3068800A1 CA3068800A1 CA3068800A CA3068800A CA3068800A1 CA 3068800 A1 CA3068800 A1 CA 3068800A1 CA 3068800 A CA3068800 A CA 3068800A CA 3068800 A CA3068800 A CA 3068800A CA 3068800 A1 CA3068800 A1 CA 3068800A1
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- Prior art keywords
- antibody
- alkyl
- cancer
- compound
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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| MX2020012718A (es) * | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| CN110845559B (zh) * | 2018-08-21 | 2023-02-28 | 四川福生源科技有限公司 | 新型喜树碱衍生物及其制备方法和应用 |
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| EP3906064A4 (en) * | 2019-01-03 | 2023-03-08 | Intocell, Inc. | CLEAVABLE LINKER COMPOUNDS AND USES THEREOF |
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| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| US12569438B2 (en) | 2019-07-29 | 2026-03-10 | Georgia Tech Research Corporation | Nanomaterials containing constrained lipids and uses thereof |
| AU2020372865A1 (en) * | 2019-10-28 | 2022-05-26 | Geron Corporation | Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane salts and methods of making the same |
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| CN116829154A (zh) * | 2020-05-28 | 2023-09-29 | 国家健康科学研究所 | 用于预防、治疗和诊断血栓的化合物 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| KR20230028793A (ko) * | 2020-06-26 | 2023-03-02 | 주식회사 인투셀 | 항-b7-h3 항체를 포함하는 항체-약물 접합체 |
| JP2024503441A (ja) * | 2021-01-20 | 2024-01-25 | ビーム セラピューティクス インク. | イオン化可能な脂質を含むナノ材料 |
| KR20230131863A (ko) | 2021-01-20 | 2023-09-14 | 빔 테라퓨틱스, 인크. | 나노물질 |
| IL303845A (en) | 2021-01-20 | 2023-08-01 | Beam Therapeutics Inc | Nanomaterials include a degradable property |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| CA3226393A1 (en) * | 2021-07-28 | 2023-02-02 | Doron Shabat | Water soluble prodrug, conjugates and uses thereof |
| CN114773433B (zh) * | 2022-06-23 | 2022-09-06 | 北京肿瘤医院(北京大学肿瘤医院) | 一种cd25靶向多肽、分子探针及应用 |
| WO2024019936A1 (en) | 2022-07-20 | 2024-01-25 | Beam Therapeutics Inc. | Nanomaterials comprising triols |
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| KR101766822B1 (ko) | 2015-09-10 | 2017-08-24 | 서울대학교산학협력단 | 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR102847350B1 (ko) | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법 |
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| WO2022225920A1 (en) * | 2021-04-19 | 2022-10-27 | Neurotrauma Sciences Llc | Salts and crystalline forms of (3e) 3-[o-[(phosphonooxy)methyl]oxime]-pregn-4-ene-3, 20-dione and related uses |
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