AU2018295540B2 - Compounds comprising cleavable linker and uses thereof - Google Patents
Compounds comprising cleavable linker and uses thereof Download PDFInfo
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- AU2018295540B2 AU2018295540B2 AU2018295540A AU2018295540A AU2018295540B2 AU 2018295540 B2 AU2018295540 B2 AU 2018295540B2 AU 2018295540 A AU2018295540 A AU 2018295540A AU 2018295540 A AU2018295540 A AU 2018295540A AU 2018295540 B2 AU2018295540 B2 AU 2018295540B2
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- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140309390A1 (en) * | 2011-12-15 | 2014-10-16 | Stabilized Mult-Valent Anionic Polymerization Initiators /and Methods For Preparing Tne Same Bri | Stabilized Multi-Valent Anionic Polymerization Initiators And Methods For Preparing The Same |
| WO2017044043A1 (en) * | 2015-09-09 | 2017-03-16 | Agency For Science, Technology And Research | Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1182232B (de) | 1963-03-08 | 1964-11-26 | Hans J Zimmer Verfahrenstechni | Verfahren zur Herstellung von Trialkylaryloxysilanen |
| CH565791A5 (https=) | 1972-07-11 | 1975-08-29 | Sandoz Ag | |
| US4540828A (en) | 1982-06-01 | 1985-09-10 | Vista Chemical Company | Catalysts for alkoxylation reactions |
| JPS5978171A (ja) | 1982-10-26 | 1984-05-04 | Ikeda Mohandou:Kk | 複素環式化合物 |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| JP3041736B2 (ja) | 1991-11-01 | 2000-05-15 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| JP3061862B2 (ja) | 1994-10-14 | 2000-07-10 | 山之内製薬株式会社 | アゾール誘導体 |
| ATE557013T1 (de) * | 2004-03-16 | 2012-05-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzol-derivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| DE102004012676A1 (de) * | 2004-03-16 | 2005-10-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| JP2005291974A (ja) | 2004-03-31 | 2005-10-20 | Kyocera Chemical Corp | フェルダジル基を有する磁性有機粒子、粒子固定方法及びマイクロアレイ |
| WO2006125293A1 (en) | 2005-05-27 | 2006-11-30 | Antibe Therapeutics Inc. | Derivatives of 4- or 5-aminosalicylic acid |
| EP1867729A1 (en) | 2006-06-14 | 2007-12-19 | Libragen | Water soluble phenolics derivatives with dermocosmetic and therapeutic applications |
| CN101959900A (zh) * | 2007-12-26 | 2011-01-26 | 盐野义制药株式会社 | 糖肽类抗生素糖基化衍生物 |
| MY168297A (en) * | 2011-11-17 | 2018-10-23 | Pfizer | Cytotoxic Peptides and Antibody Drug Conjugates Thereof |
| PL2872157T3 (pl) | 2012-07-12 | 2020-07-13 | Hangzhou Dac Biotech Co., Ltd | Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi |
| JP6255038B2 (ja) | 2013-02-26 | 2017-12-27 | トリアクト セラピューティクス,インク. | 癌治療 |
| US9499528B2 (en) | 2013-04-08 | 2016-11-22 | The University Of Akron | Class of near infrared molecular probes for biological applications |
| CN105899539B (zh) | 2014-01-10 | 2021-11-09 | 博笛生物科技有限公司 | 用于免疫疗法的化合物和组合物 |
| KR101628872B1 (ko) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| WO2016029324A1 (en) * | 2014-08-29 | 2016-03-03 | Rsem, Limited Partnership | Azasulfurylpeptide-based cd36 modulators and uses thereof |
| US10035526B2 (en) | 2014-12-03 | 2018-07-31 | New York Air Brake, LLC | Brake piston assembly |
| WO2016118770A1 (en) | 2015-01-21 | 2016-07-28 | The Regents Of The University Of California | Affinity-assisted protein modification and recycling |
| CN107922375B (zh) | 2015-07-30 | 2020-05-22 | 正大天晴药业集团股份有限公司 | 靶向idh2突变的抗肿瘤化合物及其使用方法 |
| KR101766822B1 (ko) | 2015-09-10 | 2017-08-24 | 서울대학교산학협력단 | 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR102847350B1 (ko) | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법 |
| WO2018053552A2 (en) | 2016-09-19 | 2018-03-22 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| WO2018124758A2 (ko) | 2016-12-28 | 2018-07-05 | 주식회사 인투셀 | 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물 |
| WO2019008441A1 (en) | 2017-07-04 | 2019-01-10 | Intocell, Inc. | COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF |
| MX2020012718A (es) | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| KR20210068591A (ko) | 2018-10-31 | 2021-06-09 | 주식회사 인투셀 | 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도 |
| WO2020141460A2 (en) | 2019-01-03 | 2020-07-09 | Intocell, Inc. | Compounds comprising cleavable linker and uses thereof |
| EP3906064A4 (en) | 2019-01-03 | 2023-03-08 | Intocell, Inc. | CLEAVABLE LINKER COMPOUNDS AND USES THEREOF |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140309390A1 (en) * | 2011-12-15 | 2014-10-16 | Stabilized Mult-Valent Anionic Polymerization Initiators /and Methods For Preparing Tne Same Bri | Stabilized Multi-Valent Anionic Polymerization Initiators And Methods For Preparing The Same |
| WO2017044043A1 (en) * | 2015-09-09 | 2017-03-16 | Agency For Science, Technology And Research | Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines |
Non-Patent Citations (16)
| Title |
|---|
| AVER'YANOV, S. F. et al., "Oxidation of aromatic compounds. III. Oxidation of substituted phenols and their O-derivatives in the HSO3F-PbO2 system", Zhurnal Organicheskoi Khimii, (1995), vol. 31, no. 8, ISSN 0514-7492, pages 1197 - 207 * |
| BENASSI, R. et al., "How glucosylation triggers physical-chemical properties of curcumin: an experimental and theoretical study", Journal of Physical Organic Chemistry, (2011-04-30), vol. 24, no. 4, ISSN 0894-3230, pages 299 - 310 * |
| CHEN, J. et al., "Product class 7: aryl hypohalites, aryl peroxides, and aryloxy sulfur compounds", Science of Synthesis, (2007-06-30), vol. 31a, doi:10.1055/sos-SD-031-00501, pages 665 - 704 * |
| COELHO, P. et al., "Adipocyte secretome increases radioresistance of malignant melanocytes by improving cell survival and decreasing oxidative status", Radiation Research, 2017, 187(5), pages 581 - 588 * |
| FINNEGAN, T. et al., "The lipopolysaccharide-induced metabolome signature in Arabidopsis thaliana reveals dynamic reprogramming of phytoalexin and phytoanticipin pathways", PLoS One, (2016), vol. 11, ISSN 1932-6203, pages 1 - 26 * |
| GOUASMAT, A. et al., "Catalytic Iron(III) Chloride Mediated Site-Selective Protection of Mono- and Disaccharides and One Trisaccharide", European Journal of Organic Chemistry, (2017), vol. 2017, no. 23, pages 3355 - 3361 * |
| KAWA, K. et al., "Glycosylation of a newly functionalized orthoester derivative", Molecules, (2014), vol. 19, no. 2, ISSN 1420-3049, pages 2602 - 2611 * |
| PAQUET, V, "Synthesis and in vitro biological properties of novel cationic derivatives of amphotericin B", Chemistry - A European Journal, (2008), vol. 14, no. 8, ISSN 0947-6539, pages 2465 - 2481 * |
| Registry, (1984-11-16), Database accession no. 18001-14-4, URL: STN * |
| Registry, (1984-11-16), Database accession no. 716-42-7, URL: STN * |
| Registry, (1984-11-16), Database accession no. 80858-87-3, URL: STN * |
| Registry, (1984-11-16), Database accession no. 88-75-5, URL: STN * |
| Registry, (2008-12-21), Database accession no. 1087396-71-1, URL: STN * |
| Registry, (2017-05-05), Database accession no. 2094867-09-9, URL: STN * |
| Registry, (2017-05-05), Database accession no. 2094950-01-1, URL: STN * |
| Registry, (2017-05-05), Database accession no. 2094951-37-6, URL: STN * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023216777A1 (en) | 2023-09-07 |
| CN111278845A (zh) | 2020-06-12 |
| JP7174757B2 (ja) | 2022-11-17 |
| AU2023216777C1 (en) | 2024-04-18 |
| JP2020527599A (ja) | 2020-09-10 |
| AU2023216777B2 (en) | 2023-10-05 |
| TWI801396B (zh) | 2023-05-11 |
| EP3649142A1 (en) | 2020-05-13 |
| CN120682289A (zh) | 2025-09-23 |
| KR102710962B1 (ko) | 2024-09-27 |
| CA3068800A1 (en) | 2019-01-10 |
| IL271755A (en) | 2020-02-27 |
| US20230406877A1 (en) | 2023-12-21 |
| IL320635A (en) | 2025-07-01 |
| MX2019015940A (es) | 2020-08-17 |
| TW201919693A (zh) | 2019-06-01 |
| KR20200027533A (ko) | 2020-03-12 |
| US12479927B2 (en) | 2025-11-25 |
| RU2020104697A (ru) | 2021-08-05 |
| RU2020104697A3 (https=) | 2021-09-21 |
| CN120682290A (zh) | 2025-09-23 |
| US20210388017A1 (en) | 2021-12-16 |
| BR112019028295A2 (pt) | 2020-07-21 |
| AU2018295540A1 (en) | 2020-01-30 |
| EP3649142A4 (en) | 2021-09-01 |
| US11753431B2 (en) | 2023-09-12 |
| WO2019008441A1 (en) | 2019-01-10 |
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