MX2019015940A - Compuestos que comprenden un enlazador escindible y sus usos. - Google Patents
Compuestos que comprenden un enlazador escindible y sus usos.Info
- Publication number
- MX2019015940A MX2019015940A MX2019015940A MX2019015940A MX2019015940A MX 2019015940 A MX2019015940 A MX 2019015940A MX 2019015940 A MX2019015940 A MX 2019015940A MX 2019015940 A MX2019015940 A MX 2019015940A MX 2019015940 A MX2019015940 A MX 2019015940A
- Authority
- MX
- Mexico
- Prior art keywords
- cleavable linker
- ligand
- sub
- functional group
- active agent
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 125000000524 functional group Chemical group 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
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Abstract
En la presente se proporciona un compuesto que incluye un enlazador escindible, los usos de este y un compuesto intermedio para prepararlo y más particularmente, el compuesto que incluye un enlazador escindible de la presente invención puede incluir un agente activo (por ejemplo, un fármaco, una toxina, un ligando, una sonda para la detección, etc.) que tiene una función o actividad específica, un grupo funcional SO2 que es capaz de liberar de manera selectiva el agente activo, y un grupo funcional que desencadena una reacción química, una reacción fisioquímica y/o una reacción biológica con estimulación externa, y puede incluir además un ligando (por ejemplo, oligopéptido, polipéptido, anticuerpo, etc.) que tiene especificidad de unión para el receptor objetivo deseado.
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KR20170084805 | 2017-07-04 | ||
US201762597226P | 2017-12-11 | 2017-12-11 | |
PCT/IB2018/000847 WO2019008441A1 (en) | 2017-07-04 | 2018-07-03 | COMPOUNDS COMPRISING A CLIABABLE BIT AND USES THEREOF |
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MX2019015940A true MX2019015940A (es) | 2020-08-17 |
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MX2019015940A MX2019015940A (es) | 2017-07-04 | 2018-07-03 | Compuestos que comprenden un enlazador escindible y sus usos. |
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US (2) | US11753431B2 (es) |
EP (1) | EP3649142A4 (es) |
JP (1) | JP7174757B2 (es) |
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CN (1) | CN111278845A (es) |
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CA (1) | CA3068800A1 (es) |
IL (1) | IL271755A (es) |
MX (1) | MX2019015940A (es) |
TW (1) | TWI801396B (es) |
WO (1) | WO2019008441A1 (es) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111278845A (zh) | 2017-07-04 | 2020-06-12 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
US11084801B2 (en) * | 2018-05-29 | 2021-08-10 | Intocell, Inc. | Benzodiazepine derivatives and uses thereof |
CN110845559B (zh) * | 2018-08-21 | 2023-02-28 | 四川福生源科技有限公司 | 新型喜树碱衍生物及其制备方法和应用 |
CN114306635A (zh) * | 2019-01-03 | 2022-04-12 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
WO2020141459A1 (en) * | 2019-01-03 | 2020-07-09 | Intocell, Inc. | Compounds comprising cleavable linker and uses thereof |
JP7137696B2 (ja) | 2019-05-14 | 2022-09-14 | プロヴェンション・バイオ・インコーポレイテッド | 1型糖尿病を予防するための方法および組成物 |
JP7241605B2 (ja) | 2019-05-31 | 2023-03-17 | 日本製鉄株式会社 | 水浸膨張試験装置 |
CN114728075A (zh) * | 2019-12-02 | 2022-07-08 | 尹图赛利有限公司 | 与分子缀合相关的组合物和方法 |
AU2021287998A1 (en) | 2020-06-11 | 2023-02-02 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
JP2024503441A (ja) * | 2021-01-20 | 2024-01-25 | ビーム セラピューティクス インク. | イオン化可能な脂質を含むナノ材料 |
KR20230131863A (ko) | 2021-01-20 | 2023-09-14 | 빔 테라퓨틱스, 인크. | 나노물질 |
AU2022261742A1 (en) * | 2021-04-19 | 2023-11-02 | Neurotrauma Sciences Llc | Salts and crystalline forms of (3e) 3-[o-[(phosphonooxy)methyl]oxime]-pregn-4-ene-3, 20-dione and related uses |
CN114773433B (zh) * | 2022-06-23 | 2022-09-06 | 北京肿瘤医院(北京大学肿瘤医院) | 一种cd25靶向多肽、分子探针及应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1182232B (de) | 1963-03-08 | 1964-11-26 | Hans J Zimmer Verfahrenstechni | Verfahren zur Herstellung von Trialkylaryloxysilanen |
CH565791A5 (es) | 1972-07-11 | 1975-08-29 | Sandoz Ag | |
US4540828A (en) | 1982-06-01 | 1985-09-10 | Vista Chemical Company | Catalysts for alkoxylation reactions |
JPS5978171A (ja) | 1982-10-26 | 1984-05-04 | Ikeda Mohandou:Kk | 複素環式化合物 |
DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
JP3041736B2 (ja) | 1991-11-01 | 2000-05-15 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
HUT77609A (hu) | 1994-10-14 | 1998-06-29 | Yamanouchi Pharmaceutical Co. Ltd. | Azolszármazékok, az ezeket tartalmazó gyógyszerkészítmények és a vegyületek intermedierjei |
DE102004012676A1 (de) * | 2004-03-16 | 2005-10-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Glucopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
CN103450129B (zh) * | 2004-03-16 | 2015-08-12 | 贝林格尔.英格海姆国际有限公司 | 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法 |
JP2005291974A (ja) | 2004-03-31 | 2005-10-20 | Kyocera Chemical Corp | フェルダジル基を有する磁性有機粒子、粒子固定方法及びマイクロアレイ |
WO2006125293A1 (en) | 2005-05-27 | 2006-11-30 | Antibe Therapeutics Inc. | Derivatives of 4- or 5-aminosalicylic acid |
EP1867729A1 (en) | 2006-06-14 | 2007-12-19 | Libragen | Water soluble phenolics derivatives with dermocosmetic and therapeutic applications |
US8481696B2 (en) * | 2007-12-26 | 2013-07-09 | Shionogi & Co., Ltd. | Glycosylated glycopeptide antibiotic derivatives |
TWI585115B (zh) * | 2011-12-15 | 2017-06-01 | 普利司通股份有限公司 | 經穩定之多價陰離子聚合反應引發劑及其製備方法 |
HUE061182T2 (hu) | 2012-07-12 | 2023-05-28 | Hangzhou Dac Biotech Co Ltd | Sejtkötõ molekulák konjugátumai citotoxikus szerekkel |
CA2941010A1 (en) | 2013-02-26 | 2014-09-04 | Triact Therapeutics, Inc. | Cancer therapy |
US9499528B2 (en) | 2013-04-08 | 2016-11-22 | The University Of Akron | Class of near infrared molecular probes for biological applications |
WO2015103989A1 (en) | 2014-01-10 | 2015-07-16 | Shanghai Birdie Biotech, Inc. | Compounds and compositions for immunotherapy |
KR101628872B1 (ko) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
WO2016029324A1 (en) | 2014-08-29 | 2016-03-03 | Rsem, Limited Partnership | Azasulfurylpeptide-based cd36 modulators and uses thereof |
US10035526B2 (en) | 2014-12-03 | 2018-07-31 | New York Air Brake, LLC | Brake piston assembly |
US10370407B2 (en) | 2015-01-21 | 2019-08-06 | The Regents Of The University Of California | Affinity-assisted protein modification and recycling |
TW201704203A (zh) | 2015-07-30 | 2017-02-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | 靶向idh2突變的抗腫瘤化合物及其使用方法 |
WO2017044043A1 (en) * | 2015-09-09 | 2017-03-16 | Agency For Science, Technology And Research | Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines |
KR101766822B1 (ko) | 2015-09-10 | 2017-08-24 | 서울대학교산학협력단 | 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN111278845A (zh) | 2017-07-04 | 2020-06-12 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
CN114306635A (zh) | 2019-01-03 | 2022-04-12 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
WO2020141459A1 (en) | 2019-01-03 | 2020-07-09 | Intocell, Inc. | Compounds comprising cleavable linker and uses thereof |
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EP3649142A4 (en) | 2021-09-01 |
KR20200027533A (ko) | 2020-03-12 |
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RU2020104697A3 (es) | 2021-09-21 |
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EP3649142A1 (en) | 2020-05-13 |
WO2019008441A1 (en) | 2019-01-10 |
US20210388017A1 (en) | 2021-12-16 |
CA3068800A1 (en) | 2019-01-10 |
US20230406877A1 (en) | 2023-12-21 |
CN111278845A (zh) | 2020-06-12 |
JP2020527599A (ja) | 2020-09-10 |
BR112019028295A2 (pt) | 2020-07-21 |
IL271755A (en) | 2020-02-27 |
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