JP2022515885A5 - - Google Patents
Info
- Publication number
- JP2022515885A5 JP2022515885A5 JP2021538388A JP2021538388A JP2022515885A5 JP 2022515885 A5 JP2022515885 A5 JP 2022515885A5 JP 2021538388 A JP2021538388 A JP 2021538388A JP 2021538388 A JP2021538388 A JP 2021538388A JP 2022515885 A5 JP2022515885 A5 JP 2022515885A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- group
- value
- integer
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024178728A JP2025020144A (ja) | 2019-01-03 | 2024-10-11 | 切断可能なリンカーを含む化合物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962788039P | 2019-01-03 | 2019-01-03 | |
| US62/788,039 | 2019-01-03 | ||
| PCT/IB2020/000019 WO2020141460A2 (en) | 2019-01-03 | 2020-01-02 | Compounds comprising cleavable linker and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024178728A Division JP2025020144A (ja) | 2019-01-03 | 2024-10-11 | 切断可能なリンカーを含む化合物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022515885A JP2022515885A (ja) | 2022-02-22 |
| JP2022515885A5 true JP2022515885A5 (https=) | 2023-01-19 |
| JP7657153B2 JP7657153B2 (ja) | 2025-04-04 |
Family
ID=71407384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021538388A Active JP7657153B2 (ja) | 2019-01-03 | 2020-01-02 | 切断可能なリンカーを含む化合物及びその使用 |
| JP2024178728A Withdrawn JP2025020144A (ja) | 2019-01-03 | 2024-10-11 | 切断可能なリンカーを含む化合物及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024178728A Withdrawn JP2025020144A (ja) | 2019-01-03 | 2024-10-11 | 切断可能なリンカーを含む化合物及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12551570B2 (https=) |
| EP (1) | EP3906063A4 (https=) |
| JP (2) | JP7657153B2 (https=) |
| KR (1) | KR20210099658A (https=) |
| CN (2) | CN114306635A (https=) |
| EA (1) | EA202191855A1 (https=) |
| WO (1) | WO2020141460A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120682290A (zh) | 2017-07-04 | 2025-09-23 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
| KR20210099658A (ko) | 2019-01-03 | 2021-08-12 | 주식회사 인투셀 | 절단가능 링커를 포함하는 화합물 및 이의 용도 |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を治療するための方法 |
| CN114874287B (zh) * | 2022-05-20 | 2024-04-02 | 联宁（苏州）生物制药有限公司 | 一种抗体偶联药物-连接子lnd1042的合成方法 |
| WO2025252011A1 (zh) * | 2024-06-03 | 2025-12-11 | 杭州多域生物技术有限公司 | 含Sulfoximine连接子的降解剂及其中间体和应用 |
| CN119462688B (zh) * | 2024-11-08 | 2026-03-10 | 青岛大学 | 一种生物素化氨基酸衍生物的制备方法 |
| CN121494812A (zh) * | 2026-01-14 | 2026-02-10 | 西南林业大学 | 一种基于肉桂酸衍生物的n2h4比率型荧光探针及其合成方法和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1182232B (de) | 1963-03-08 | 1964-11-26 | Hans J Zimmer Verfahrenstechni | Verfahren zur Herstellung von Trialkylaryloxysilanen |
| CH565791A5 (https=) | 1972-07-11 | 1975-08-29 | Sandoz Ag | |
| US4540828A (en) | 1982-06-01 | 1985-09-10 | Vista Chemical Company | Catalysts for alkoxylation reactions |
| JPS5978171A (ja) | 1982-10-26 | 1984-05-04 | Ikeda Mohandou:Kk | 複素環式化合物 |
| DE3632329A1 (de) | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| JP3041736B2 (ja) * | 1991-11-01 | 2000-05-15 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| ATE218132T1 (de) | 1994-10-14 | 2002-06-15 | Yamanouchi Pharma Co Ltd | Azol-derivate |
| JP2005291974A (ja) * | 2004-03-31 | 2005-10-20 | Kyocera Chemical Corp | フェルダジル基を有する磁性有機粒子、粒子固定方法及びマイクロアレイ |
| EP1867729A1 (en) | 2006-06-14 | 2007-12-19 | Libragen | Water soluble phenolics derivatives with dermocosmetic and therapeutic applications |
| CN104185477B (zh) | 2011-11-17 | 2017-05-24 | 辉瑞公司 | 细胞毒性肽及其抗体‑药物缀合物 |
| TWI585115B (zh) | 2011-12-15 | 2017-06-01 | 普利司通股份有限公司 | 經穩定之多價陰離子聚合反應引發劑及其製備方法 |
| ES2781523T3 (es) | 2012-07-12 | 2020-09-02 | Hangzhou Dac Biotech Co Ltd | Conjugados de moléculas de unión celular con agentes citotóxicos |
| US9834575B2 (en) | 2013-02-26 | 2017-12-05 | Triact Therapeutics, Inc. | Cancer therapy |
| US9499528B2 (en) | 2013-04-08 | 2016-11-22 | The University Of Akron | Class of near infrared molecular probes for biological applications |
| DK3092256T3 (da) * | 2014-01-10 | 2022-06-20 | Birdie Biopharmaceuticals Inc | Forbindelser og sammensætninger til immunterapi |
| KR101628872B1 (ko) * | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| WO2016029324A1 (en) | 2014-08-29 | 2016-03-03 | Rsem, Limited Partnership | Azasulfurylpeptide-based cd36 modulators and uses thereof |
| US10035526B2 (en) | 2014-12-03 | 2018-07-31 | New York Air Brake, LLC | Brake piston assembly |
| US10370407B2 (en) | 2015-01-21 | 2019-08-06 | The Regents Of The University Of California | Affinity-assisted protein modification and recycling |
| CN107922375B (zh) | 2015-07-30 | 2020-05-22 | 正大天晴药业集团股份有限公司 | 靶向idh2突变的抗肿瘤化合物及其使用方法 |
| WO2017044043A1 (en) | 2015-09-09 | 2017-03-16 | Agency For Science, Technology And Research | Process for direct amidation of amines via rh(i)-catalyzed addition of boroxines |
| KR101766822B1 (ko) | 2015-09-10 | 2017-08-24 | 서울대학교산학협력단 | 디페닐설페이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 c형 간염 바이러스 관련 질환의 예방 또는 치료용 약학적 조성물 |
| AU2016359235B2 (en) | 2015-11-25 | 2022-09-15 | Ligachem Biosciences Inc. | Antibody-drug conjugates comprising branched linkers and methods related thereto |
| WO2018053552A2 (en) | 2016-09-19 | 2018-03-22 | Cellerant Therapeutics, Inc. | Isoquinolidinobenzodiazepines |
| WO2018124758A2 (ko) * | 2016-12-28 | 2018-07-05 | 주식회사 인투셀 | 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물 |
| CN120682290A (zh) * | 2017-07-04 | 2025-09-23 | 尹图赛利有限公司 | 包含可裂解接头的化合物及其用途 |
| MX2020012718A (es) | 2018-05-29 | 2021-02-16 | Intocell Inc | Derivados de benzodiazepinas novedosos y usos de los mismos. |
| CN112930350A (zh) | 2018-10-31 | 2021-06-08 | 尹图赛利有限公司 | 稠合杂环苯并二氮杂䓬衍生物及其用途 |
| WO2020141459A1 (en) | 2019-01-03 | 2020-07-09 | Intocell, Inc. | Compounds comprising cleavable linker and uses thereof |
| KR20210099658A (ko) | 2019-01-03 | 2021-08-12 | 주식회사 인투셀 | 절단가능 링커를 포함하는 화합물 및 이의 용도 |
-
2020
- 2020-01-02 KR KR1020217024209A patent/KR20210099658A/ko active Pending
- 2020-01-02 CN CN202111628316.1A patent/CN114306635A/zh active Pending
- 2020-01-02 WO PCT/IB2020/000019 patent/WO2020141460A2/en not_active Ceased
- 2020-01-02 JP JP2021538388A patent/JP7657153B2/ja active Active
- 2020-01-02 EP EP20735849.0A patent/EP3906063A4/en active Pending
- 2020-01-02 US US17/419,435 patent/US12551570B2/en active Active
- 2020-01-02 EA EA202191855A patent/EA202191855A1/ru unknown
- 2020-01-02 CN CN202080007805.2A patent/CN113423431A/zh active Pending
-
2024
- 2024-10-11 JP JP2024178728A patent/JP2025020144A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022515885A5 (https=) | ||
| JP2020527599A5 (https=) | ||
| JP2022515884A5 (https=) | ||
| JP7744104B2 (ja) | 部位特異的抗体コンジュゲーション及びその具体例としての抗体－薬物コンジュゲート | |
| JP5695049B2 (ja) | イマチニブ免疫アッセイ | |
| CN114456186A (zh) | 一种喜树碱类衍生物及其配体-药物偶联物 | |
| WO2017031034A2 (en) | Covalent linkers in antibody-drug conjugates and methods of making and using the same | |
| BR112020023346A2 (pt) | anticorpo capaz de se ligar a muc1 e seu uso, ácido nucleico, cassete ou vetor de expressão, célula hospedeira, conjugado, composição, e, métodos para aumentar a afinidade de ligação a muc1 de um anticorpo e para produzir um anticorpo com afinidade de ligação a muc1 aumentada | |
| KR20200041913A (ko) | 면역자극제로서 톨-유사 수용체 7 (tlr7) 효능제로서의 6-아미노-7,9-디히드로-8h-퓨린-8-온 유도체 | |
| KR20200041914A (ko) | 면역자극제 톨-유사 수용체 7 (tlr7) 효능제로서의 6-아미노-7,9-디히드로-8h-퓨린-8-온 유도체 | |
| EP2356131A1 (en) | Masking ligands for reversible inhibition of multivalent compounds | |
| CN111643676B (zh) | 一种双特异性二聚体、双特异性二聚体-药物偶联物及其应用 | |
| CN105377307A (zh) | 具有改进的稳定性的抗体-药物缀合物及其用途 | |
| KR102014383B1 (ko) | G 단백질 연결 수용체의 활성 조절 인간 항체 | |
| Figini et al. | Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor | |
| US20240059755A1 (en) | Nanolipoprotein-polypeptide conjugates and compositions, systems, and methods using same | |
| CN113490678A (zh) | 荧光gtp类似物和用途 | |
| WO2023028548A2 (en) | Bispecific tetravalent antibody targeting egfr and her3 | |
| JP2023165983A5 (https=) | ||
| Calce et al. | HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor | |
| RU2020104697A (ru) | Соединения, содержащие расщепляемый линкер, и способы их применения | |
| US10114014B2 (en) | Macromolecular conjugates for isolation, immobilization and visualization of proteins | |
| JP2025508868A5 (https=) | ||
| Hellmert et al. | Hybridization of an Aβ-specific antibody fragment with aminopyrazole-based β-sheet ligands displays striking enhancement of target affinity | |
| Colnaghi et al. | Evolution of the therapeutic use of new monoclonal antibodies |