CN112543752A - 连接子、含连接子的抗体偶联药物及连接子的用途 - Google Patents

连接子、含连接子的抗体偶联药物及连接子的用途 Download PDF

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CN112543752A
CN112543752A CN201980052214.4A CN201980052214A CN112543752A CN 112543752 A CN112543752 A CN 112543752A CN 201980052214 A CN201980052214 A CN 201980052214A CN 112543752 A CN112543752 A CN 112543752A
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CN112543752B (zh
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周辛波
王彦明
樊士勇
李松
钟武
肖军海
郑志兵
李行舟
肖典
谢云德
王晓奎
曹瑞源
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Institute of Pharmacology and Toxicology of AMMS
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Abstract

提供了一种式I或式I’所示的连接子、含连接子的抗体偶联药物、连接子的用途、包含抗体偶联药物的药物组合物以及所述抗体偶联药物用于治疗和/或预防疾病的用途。
Figure DDA0002936116210000011

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
CN201980052214.4A 2018-08-17 2019-08-15 连接子、含连接子的抗体偶联药物及连接子的用途 Active CN112543752B (zh)

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AU2021388021A1 (en) 2020-11-24 2023-06-22 Novartis Ag Anti-cd48 antibodies, antibody drug conjugates, and uses thereof
CN114106088A (zh) * 2021-04-28 2022-03-01 联宁（苏州）生物制药有限公司 基于溴甲基吡嗪的药物偶联物及adc
WO2023138682A1 (zh) * 2022-01-24 2023-07-27 北京桦冠生物技术有限公司 缀合物及其用途
CN114540454B (zh) * 2022-03-09 2023-10-17 浙江东邦药业有限公司 一种酶法合成盐酸头孢卡品匹酯的方法及其合成中间体
CN114874287B (zh) * 2022-05-20 2024-04-02 联宁（苏州）生物制药有限公司 一种抗体偶联药物-连接子lnd1042的合成方法
WO2024023735A1 (en) * 2022-07-27 2024-02-01 Mediboston Limited Auristatin derivatives and conjugates thereof
CN115364238B (zh) * 2022-08-16 2024-02-02 山东大学 一种阿特珠单抗-mmad结合物及其制备方法与应用

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