JP2020524485A5 - - Google Patents
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- JP2020524485A5 JP2020524485A5 JP2019566839A JP2019566839A JP2020524485A5 JP 2020524485 A5 JP2020524485 A5 JP 2020524485A5 JP 2019566839 A JP2019566839 A JP 2019566839A JP 2019566839 A JP2019566839 A JP 2019566839A JP 2020524485 A5 JP2020524485 A5 JP 2020524485A5
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- JP
- Japan
- Prior art keywords
- composition
- oligonucleotides
- composition according
- base sequence
- oligonucleotide
- Prior art date
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- 108091034117 Oligonucleotide Proteins 0.000 claims 19
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 12
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 4
- 229910052698 phosphorus Inorganic materials 0.000 claims 4
- 239000011574 phosphorus Substances 0.000 claims 4
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 102100031251 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 Human genes 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 101001129184 Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 Proteins 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 208000004930 Fatty Liver Diseases 0.000 claims 1
- 206010019708 Hepatic steatosis Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024071889A JP2024099745A (ja) | 2017-06-02 | 2024-04-25 | オリゴヌクレオチド組成物及びその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762514769P | 2017-06-02 | 2017-06-02 | |
| US62/514,769 | 2017-06-02 | ||
| US201862670698P | 2018-05-11 | 2018-05-11 | |
| US62/670,698 | 2018-05-11 | ||
| PCT/US2018/035721 WO2018223081A1 (en) | 2017-06-02 | 2018-06-01 | Oligonucleotide compositions and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024071889A Division JP2024099745A (ja) | 2017-06-02 | 2024-04-25 | オリゴヌクレオチド組成物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020524485A JP2020524485A (ja) | 2020-08-20 |
| JP2020524485A5 true JP2020524485A5 (https=) | 2021-08-19 |
| JP7557941B2 JP7557941B2 (ja) | 2024-09-30 |
Family
ID=64456268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566839A Active JP7557941B2 (ja) | 2017-06-02 | 2018-06-01 | オリゴヌクレオチド組成物及びその使用方法 |
| JP2024071889A Pending JP2024099745A (ja) | 2017-06-02 | 2024-04-25 | オリゴヌクレオチド組成物及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024071889A Pending JP2024099745A (ja) | 2017-06-02 | 2024-04-25 | オリゴヌクレオチド組成物及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11597927B2 (https=) |
| EP (1) | EP3630789A4 (https=) |
| JP (2) | JP7557941B2 (https=) |
| CN (2) | CN110997692B (https=) |
| CA (1) | CA3065523A1 (https=) |
| TW (1) | TW201904587A (https=) |
| WO (1) | WO2018223081A1 (https=) |
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- 2018-06-01 US US16/618,001 patent/US11597927B2/en active Active
- 2018-06-01 TW TW107119084A patent/TW201904587A/zh unknown
- 2018-06-01 JP JP2019566839A patent/JP7557941B2/ja active Active
- 2018-06-01 WO PCT/US2018/035721 patent/WO2018223081A1/en not_active Ceased
- 2018-06-01 CA CA3065523A patent/CA3065523A1/en active Pending
- 2018-06-01 CN CN201880049516.1A patent/CN110997692B/zh active Active
- 2018-06-01 EP EP18810368.3A patent/EP3630789A4/en active Pending
- 2018-06-01 CN CN202411895814.6A patent/CN120249271A/zh active Pending
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2023
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