JP2019517268A5 - - Google Patents
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- JP2019517268A5 JP2019517268A5 JP2018564259A JP2018564259A JP2019517268A5 JP 2019517268 A5 JP2019517268 A5 JP 2019517268A5 JP 2018564259 A JP2018564259 A JP 2018564259A JP 2018564259 A JP2018564259 A JP 2018564259A JP 2019517268 A5 JP2019517268 A5 JP 2019517268A5
- Authority
- JP
- Japan
- Prior art keywords
- crrna
- synthetic
- guide rna
- guide
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020005004 Guide RNA Proteins 0.000 claims 16
- 238000012986 modification Methods 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 101150013707 HBB gene Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 101150047851 IL2RG gene Proteins 0.000 claims 1
- 108700005078 Synthetic Genes Proteins 0.000 claims 1
- 108091028113 Trans-activating crRNA Proteins 0.000 claims 1
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960005102 foscarnet Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022098789A JP7431891B2 (ja) | 2016-06-08 | 2022-06-20 | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347553P | 2016-06-08 | 2016-06-08 | |
| US62/347,553 | 2016-06-08 | ||
| US15/493,129 | 2017-04-20 | ||
| US15/493,129 US10767175B2 (en) | 2016-06-08 | 2017-04-20 | High specificity genome editing using chemically modified guide RNAs |
| PCT/US2017/036648 WO2017214460A1 (en) | 2016-06-08 | 2017-06-08 | High specificity genome editing using chemically modified guide rnas |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022098789A Division JP7431891B2 (ja) | 2016-06-08 | 2022-06-20 | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517268A JP2019517268A (ja) | 2019-06-24 |
| JP2019517268A5 true JP2019517268A5 (https=) | 2020-07-09 |
| JP7093728B2 JP7093728B2 (ja) | 2022-06-30 |
Family
ID=60573695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564259A Active JP7093728B2 (ja) | 2016-06-08 | 2017-06-08 | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 |
| JP2022098789A Active JP7431891B2 (ja) | 2016-06-08 | 2022-06-20 | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022098789A Active JP7431891B2 (ja) | 2016-06-08 | 2022-06-20 | 化学的に修飾されたガイドｒｎａを使用する高特異性ゲノム編集 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10767175B2 (https=) |
| EP (1) | EP3469084A4 (https=) |
| JP (2) | JP7093728B2 (https=) |
| KR (1) | KR102382772B1 (https=) |
| CN (2) | CN116676305A (https=) |
| AU (1) | AU2017277918B2 (https=) |
| WO (1) | WO2017214460A1 (https=) |
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