JP2023504264A5 - - Google Patents
Info
- Publication number
- JP2023504264A5 JP2023504264A5 JP2022532731A JP2022532731A JP2023504264A5 JP 2023504264 A5 JP2023504264 A5 JP 2023504264A5 JP 2022532731 A JP2022532731 A JP 2022532731A JP 2022532731 A JP2022532731 A JP 2022532731A JP 2023504264 A5 JP2023504264 A5 JP 2023504264A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- nucleotides
- optionally
- stem
- ligase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962943158P | 2019-12-03 | 2019-12-03 | |
| US62/943,158 | 2019-12-03 | ||
| US202063031262P | 2020-05-28 | 2020-05-28 | |
| US63/031,262 | 2020-05-28 | ||
| PCT/US2020/063084 WO2021113494A1 (en) | 2019-12-03 | 2020-12-03 | Synthetic guide rna, compositions, methods, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504264A JP2023504264A (ja) | 2023-02-02 |
| JP2023504264A5 true JP2023504264A5 (https=) | 2023-12-11 |
| JP7826199B2 JP7826199B2 (ja) | 2026-03-09 |
Family
ID=73854975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022532731A Active JP7826199B2 (ja) | 2019-12-03 | 2020-12-03 | 合成ガイドｒｎａ、組成物、方法、およびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230055682A1 (https=) |
| EP (1) | EP4069838A1 (https=) |
| JP (1) | JP7826199B2 (https=) |
| KR (1) | KR20220123398A (https=) |
| CN (2) | CN121759549A (https=) |
| AU (1) | AU2020398213A1 (https=) |
| CA (1) | CA3162908A1 (https=) |
| WO (1) | WO2021113494A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| US20230220379A1 (en) * | 2021-09-24 | 2023-07-13 | Crispr Therapeutics Ag | HIGH PURITY gRNA SYNTHESIS PROCESS |
| EP4441074A2 (en) | 2021-12-03 | 2024-10-09 | The Broad Institute, Inc. | Compositions and methods for efficient in vivo delivery |
| EP4514953A4 (en) * | 2022-04-25 | 2026-04-22 | Huidagene Therapeutics Singapore Pte Ltd | NEW CRISPR-CAS12F SYSTEMS AND THEIR USES |
| CN120303407A (zh) | 2022-05-17 | 2025-07-11 | 恩维洛普治疗有限责任公司 | 用于有效体内递送的组合物和方法 |
| WO2024003810A1 (en) * | 2022-06-30 | 2024-01-04 | Geneditbio Limited | Guide rna with chemical modifications |
| WO2024102434A1 (en) | 2022-11-10 | 2024-05-16 | Senda Biosciences, Inc. | Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs |
| CN121079412A (zh) * | 2023-04-28 | 2025-12-05 | 比姆医疗股份有限公司 | 经修饰的指导rna |
| CN117106782B (zh) * | 2023-10-16 | 2024-04-26 | 吉林凯莱英医药化学有限公司 | gRNA及其生物合成方法 |
| WO2025114441A1 (en) * | 2023-11-30 | 2025-06-05 | F. Hoffmann-La Roche Ag | Single guide rna synthesis |
| WO2025215514A1 (en) * | 2024-04-08 | 2025-10-16 | Crispr Therapeutics Ag | Splint-mediated rna synthesis |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US5846946A (en) | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
| AU2005274948B2 (en) | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
| US8404658B2 (en) | 2007-12-31 | 2013-03-26 | Nanocor Therapeutics, Inc. | RNA interference for the treatment of heart failure |
| US9187746B2 (en) * | 2009-09-22 | 2015-11-17 | Alnylam Pharmaceuticals, Inc. | Dual targeting siRNA agents |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| US10073635B2 (en) | 2014-12-01 | 2018-09-11 | Micron Technology, Inc. | Multiple endianness compatibility |
| EP3274454B1 (en) * | 2015-03-25 | 2021-08-25 | Editas Medicine, Inc. | Crispr/cas-related methods, compositions and components |
| CN105139759B (zh) | 2015-09-18 | 2017-10-10 | 京东方科技集团股份有限公司 | 一种拼接屏 |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3443088B1 (en) * | 2016-04-13 | 2024-09-18 | Editas Medicine, Inc. | Grna fusion molecules, gene editing systems, and methods of use thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| JP6817493B2 (ja) | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖ｒｎａの製造方法 |
| US11920131B2 (en) | 2018-03-30 | 2024-03-05 | Toray Industries, Inc. | Method of producing hairpin single-stranded RNA molecule |
| WO2021113264A1 (en) * | 2019-12-02 | 2021-06-10 | The Regents Of The University Of California | Engineering circular guide rnas |
-
2020
- 2020-12-03 US US17/782,045 patent/US20230055682A1/en active Pending
- 2020-12-03 JP JP2022532731A patent/JP7826199B2/ja active Active
- 2020-12-03 KR KR1020227021479A patent/KR20220123398A/ko active Pending
- 2020-12-03 CN CN202511945638.7A patent/CN121759549A/zh active Pending
- 2020-12-03 EP EP20825383.1A patent/EP4069838A1/en active Pending
- 2020-12-03 AU AU2020398213A patent/AU2020398213A1/en active Pending
- 2020-12-03 CN CN202080091197.8A patent/CN114981426A/zh active Pending
- 2020-12-03 CA CA3162908A patent/CA3162908A1/en active Pending
- 2020-12-03 WO PCT/US2020/063084 patent/WO2021113494A1/en not_active Ceased
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