JP2022527569A5 - - Google Patents
Info
- Publication number
- JP2022527569A5 JP2022527569A5 JP2021559455A JP2021559455A JP2022527569A5 JP 2022527569 A5 JP2022527569 A5 JP 2022527569A5 JP 2021559455 A JP2021559455 A JP 2021559455A JP 2021559455 A JP2021559455 A JP 2021559455A JP 2022527569 A5 JP2022527569 A5 JP 2022527569A5
- Authority
- JP
- Japan
- Prior art keywords
- mito
- linker
- group
- targeted ligand
- ligand cluster
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962821628P | 2019-03-21 | 2019-03-21 | |
| US62/821,628 | 2019-03-21 | ||
| US201962952607P | 2019-12-23 | 2019-12-23 | |
| US62/952,607 | 2019-12-23 | ||
| PCT/US2020/023603 WO2020191183A1 (en) | 2019-03-21 | 2020-03-19 | Multivalent ligand clusters for targeted delivery of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022527569A JP2022527569A (ja) | 2022-06-02 |
| JP2022527569A5 true JP2022527569A5 (https=) | 2023-03-28 |
Family
ID=70285946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021559455A Pending JP2022527569A (ja) | 2019-03-21 | 2020-03-19 | 治療剤の標的化送達のための多価リガンドクラスター |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220175934A1 (https=) |
| EP (1) | EP3923989A1 (https=) |
| JP (1) | JP2022527569A (https=) |
| CN (1) | CN114206389A (https=) |
| AU (1) | AU2020242043A1 (https=) |
| CA (1) | CA3133629A1 (https=) |
| WO (1) | WO2020191183A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230092615A1 (en) | 2020-02-21 | 2023-03-23 | Mitotherapeutix Llc | Compositions and methods for inhibiting expressing of methylation-controlled j-protein (mcj) |
| CN115850358B (zh) * | 2021-03-08 | 2026-04-24 | 南京吉迈生物技术有限公司 | GalNAc簇亚磷酰胺和靶向治疗性核苷 |
| AU2022299173A1 (en) * | 2021-06-24 | 2024-01-18 | Eli Lilly And Company | Novel therapeutic delivery moieties and uses thereof |
| EP4359530A1 (en) * | 2021-06-24 | 2024-05-01 | Eli Lilly and Company | Novel rna therapeutics and uses thereof |
| EP4380624A1 (en) * | 2021-09-23 | 2024-06-12 | Shanghai Argo Biopharmaceutical Co., Ltd. | Multivalent ligand clusters with diamine scaffold for targeted delivery of therapeutic agents |
| IL312811A (en) | 2021-11-16 | 2024-07-01 | Shanghai Argo Biopharmaceutical Co Ltd | Composition and method for inhibiting angiotensinogen (agt) protein expression |
| CA3235672A1 (en) | 2021-11-29 | 2023-06-01 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of hepatitis b virus (hbv) protein |
| TW202345865A (zh) | 2022-01-24 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 抑制LPA(Apo(a))蛋白表達的組合物和方法 |
| WO2024104386A1 (zh) * | 2022-11-16 | 2024-05-23 | 南京明德新药研发有限公司 | 一类含七元杂环的三齿缀合基团 |
| CN116535449B (zh) * | 2023-03-22 | 2025-09-16 | 华东理工大学 | 一种糖基没食子酸类衍生物及其制备方法与在制备乳腺癌靶向诊疗材料中的应用 |
| CN116854753B (zh) * | 2023-06-01 | 2025-12-09 | 北京炫景瑞医药科技有限公司 | 一种化合物、缀合物、组合物以及它们的用途 |
| GB202311334D0 (en) * | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| DK2992098T3 (da) * | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| WO2017111137A1 (ja) * | 2015-12-22 | 2017-06-29 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| CA3020585A1 (en) * | 2016-04-11 | 2017-10-19 | Arbutus Biopharma Corporation | Targeted nucleic acid conjugate compositions |
| WO2017178656A1 (en) * | 2016-04-14 | 2017-10-19 | Roche Innovation Center Copenhagen A/S | TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE |
| SG11201901841TA (en) * | 2016-09-02 | 2019-03-28 | Arrowhead Pharmaceuticals Inc | Targeting ligands |
-
2020
- 2020-03-19 EP EP20719009.1A patent/EP3923989A1/en not_active Withdrawn
- 2020-03-19 US US17/300,676 patent/US20220175934A1/en not_active Abandoned
- 2020-03-19 CA CA3133629A patent/CA3133629A1/en active Pending
- 2020-03-19 CN CN202080037364.0A patent/CN114206389A/zh active Pending
- 2020-03-19 AU AU2020242043A patent/AU2020242043A1/en not_active Withdrawn
- 2020-03-19 JP JP2021559455A patent/JP2022527569A/ja active Pending
- 2020-03-19 WO PCT/US2020/023603 patent/WO2020191183A1/en not_active Ceased
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