JP2022528840A5 - - Google Patents
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- Publication number
- JP2022528840A5 JP2022528840A5 JP2021557374A JP2021557374A JP2022528840A5 JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5 JP 2021557374 A JP2021557374 A JP 2021557374A JP 2021557374 A JP2021557374 A JP 2021557374A JP 2022528840 A5 JP2022528840 A5 JP 2022528840A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025015181A JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962824136P | 2019-03-26 | 2019-03-26 | |
| US62/824,136 | 2019-03-26 | ||
| US201962826454P | 2019-03-29 | 2019-03-29 | |
| US62/826,454 | 2019-03-29 | ||
| US201962864792P | 2019-06-21 | 2019-06-21 | |
| US62/864,792 | 2019-06-21 | ||
| PCT/US2020/025017 WO2020198509A2 (en) | 2019-03-26 | 2020-03-26 | Modified oligonucleotides with increased stability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Division JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022528840A JP2022528840A (ja) | 2022-06-16 |
| JPWO2020198509A5 JPWO2020198509A5 (https=) | 2023-04-03 |
| JP2022528840A5 true JP2022528840A5 (https=) | 2023-04-03 |
Family
ID=72609530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557374A Pending JP2022528840A (ja) | 2019-03-26 | 2020-03-26 | 安定性が増加した修飾オリゴヌクレオチド |
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025015181A Pending JP2025072451A (ja) | 2019-03-26 | 2025-01-31 | 安定性が増加した修飾オリゴヌクレオチド |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11820985B2 (https=) |
| EP (1) | EP3946369A4 (https=) |
| JP (2) | JP2022528840A (https=) |
| WO (1) | WO2020198509A2 (https=) |
Families Citing this family (21)
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|---|---|---|---|---|
| EP3277811B1 (en) | 2015-04-03 | 2020-12-23 | University of Massachusetts | Fully stabilized asymmetric sirna |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| CN106987604B (zh) * | 2017-03-29 | 2021-05-28 | 北京希诺谷生物科技有限公司 | 一种制备动脉粥样硬化疾病模型犬的方法 |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| JP7627042B2 (ja) | 2018-08-23 | 2025-02-05 | ユニバーシティー オブ マサチューセッツ | Ｏ－メチルリッチ完全安定化オリゴヌクレオチド |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| MX2022001710A (es) | 2019-08-09 | 2022-05-10 | Univ Massachusetts | Oligonucleótidos modificados químicamente dirigidos a los snp. |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| JP7505545B2 (ja) | 2020-03-25 | 2024-06-25 | 株式会社プロテリアル | センサ |
| JP7837560B2 (ja) | 2020-03-26 | 2026-03-31 | ユニバーシティー オブ マサチューセッツ | 安定性の向上を有する修飾オリゴヌクレオチドの合成 |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| US12077758B2 (en) | 2020-05-28 | 2024-09-03 | University Of Massachusetts | Oligonucleotides for SARS-CoV-2 modulation |
| WO2022212231A2 (en) * | 2021-03-29 | 2022-10-06 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| AU2022299169A1 (en) | 2021-06-23 | 2024-02-08 | Beth Israel Deaconess Medical Center, Inc. | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
| US20250223588A1 (en) * | 2021-10-19 | 2025-07-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides |
| US20230313198A1 (en) * | 2021-12-17 | 2023-10-05 | University Of Massachusetts | Oligonucleotides for mlh3 modulation |
| WO2024002007A1 (zh) * | 2022-06-27 | 2024-01-04 | 大睿生物医药科技(上海)有限公司 | 含有可降低脱靶毒性的核苷酸类似物的双链rna |
| WO2025264952A2 (en) * | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
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| WO2010118263A1 (en) | 2009-04-08 | 2010-10-14 | University Of Massachusetts | Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease |
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| SMT202000454T1 (it) | 2015-04-03 | 2020-11-10 | Univ Massachusetts | Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina |
| WO2017132669A1 (en) * | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| US10941402B2 (en) * | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| WO2020033899A1 (en) | 2018-08-10 | 2020-02-13 | University Of Massachusetts | Modified oligonucleotides targeting snps |
| US11820985B2 (en) | 2019-03-26 | 2023-11-21 | University Of Massachusetts | Modified oligonucleotides with increased stability |
| JP7837560B2 (ja) | 2020-03-26 | 2026-03-31 | ユニバーシティー オブ マサチューセッツ | 安定性の向上を有する修飾オリゴヌクレオチドの合成 |
| ES3014076T3 (en) | 2020-03-26 | 2025-04-16 | Nutrivert Inc | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
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2020
- 2020-03-26 US US16/831,470 patent/US11820985B2/en active Active
- 2020-03-26 EP EP20777915.8A patent/EP3946369A4/en active Pending
- 2020-03-26 WO PCT/US2020/025017 patent/WO2020198509A2/en not_active Ceased
- 2020-03-26 JP JP2021557374A patent/JP2022528840A/ja active Pending
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2023
- 2023-09-01 US US18/459,992 patent/US20240141362A1/en active Pending
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2025
- 2025-01-31 JP JP2025015181A patent/JP2025072451A/ja active Pending