JP2020502046A5 - - Google Patents
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- JP2020502046A5 JP2020502046A5 JP2019523105A JP2019523105A JP2020502046A5 JP 2020502046 A5 JP2020502046 A5 JP 2020502046A5 JP 2019523105 A JP2019523105 A JP 2019523105A JP 2019523105 A JP2019523105 A JP 2019523105A JP 2020502046 A5 JP2020502046 A5 JP 2020502046A5
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- Japan
- Prior art keywords
- polypeptide
- mutation
- region
- antibody
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 88
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 88
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 88
- 230000035772 mutation Effects 0.000 claims description 83
- 239000000203 mixture Substances 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 30
- 230000009827 complement-dependent cellular cytotoxicity Effects 0.000 claims description 16
- -1 RANK Proteins 0.000 claims description 14
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 14
- 239000012636 effector Substances 0.000 claims description 12
- 102000010170 Death domains Human genes 0.000 claims description 10
- 108050001718 Death domains Proteins 0.000 claims description 10
- 239000000427 antigen Substances 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 230000003834 intracellular effect Effects 0.000 claims description 10
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 8
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 8
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 8
- 102100027207 CD27 antigen Human genes 0.000 claims description 8
- 101150013553 CD40 gene Proteins 0.000 claims description 8
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 8
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims description 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 8
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 8
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 8
- 108010052562 RELT Proteins 0.000 claims description 8
- 102000018795 RELT Human genes 0.000 claims description 8
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims description 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 8
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 8
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 8
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 8
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 8
- 239000001825 Polyoxyethene (8) stearate Substances 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 239000004337 magnesium citrate Substances 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims description 4
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims description 4
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims description 4
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 4
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 4
- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 206010057249 Phagocytosis Diseases 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000000052 comparative effect Effects 0.000 claims description 2
- 230000024203 complement activation Effects 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000008782 phagocytosis Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 claims description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 1
- PKWRMUKBEYJEIX-DXXQBUJASA-N Birinapant Chemical compound CN[C@@H](C)C(=O)N[C@@H](CC)C(=O)N1C[C@@H](O)C[C@H]1CC1=C(C2=C(C3=CC=C(F)C=C3N2)C[C@H]2N(C[C@@H](O)C2)C(=O)[C@H](CC)NC(=O)[C@H](C)NC)NC2=CC(F)=CC=C12 PKWRMUKBEYJEIX-DXXQBUJASA-N 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
- 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 239000002147 L01XE04 - Sunitinib Substances 0.000 description 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229940079156 Proteasome inhibitor Drugs 0.000 description 1
- 229940078123 Ras inhibitor Drugs 0.000 description 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
- 239000000611 antibody drug conjugate Substances 0.000 description 1
- 229940049595 antibody-drug conjugate Drugs 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229950004237 birinapant Drugs 0.000 description 1
- 108010063132 birinapant Proteins 0.000 description 1
- 229960001467 bortezomib Drugs 0.000 description 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 190000008236 carboplatin Chemical compound 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 229960004679 doxorubicin Drugs 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 description 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 description 1
- 102000044949 human TNFSF10 Human genes 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 229960005079 pemetrexed Drugs 0.000 description 1
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000003207 proteasome inhibitor Substances 0.000 description 1
- 229960003787 sorafenib Drugs 0.000 description 1
- 229960001796 sunitinib Drugs 0.000 description 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076427A JP7695293B2 (ja) | 2016-11-01 | 2023-05-08 | ポリペプチド変異体およびその使用 |
| JP2025094622A JP2025124873A (ja) | 2016-11-01 | 2025-06-06 | ポリペプチド変異体およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201600674 | 2016-11-01 | ||
| DKPA201600674 | 2016-11-01 | ||
| PCT/EP2017/077971 WO2018083126A1 (en) | 2016-11-01 | 2017-11-01 | Polypeptide variants and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076427A Division JP7695293B2 (ja) | 2016-11-01 | 2023-05-08 | ポリペプチド変異体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502046A JP2020502046A (ja) | 2020-01-23 |
| JP2020502046A5 true JP2020502046A5 (enExample) | 2020-12-10 |
| JP7277363B2 JP7277363B2 (ja) | 2023-05-18 |
Family
ID=60450591
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523105A Active JP7277363B2 (ja) | 2016-11-01 | 2017-11-01 | ポリペプチド変異体およびその使用 |
| JP2023076427A Active JP7695293B2 (ja) | 2016-11-01 | 2023-05-08 | ポリペプチド変異体およびその使用 |
| JP2025094622A Pending JP2025124873A (ja) | 2016-11-01 | 2025-06-06 | ポリペプチド変異体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076427A Active JP7695293B2 (ja) | 2016-11-01 | 2023-05-08 | ポリペプチド変異体およびその使用 |
| JP2025094622A Pending JP2025124873A (ja) | 2016-11-01 | 2025-06-06 | ポリペプチド変異体およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190276549A1 (enExample) |
| EP (1) | EP3535291A1 (enExample) |
| JP (3) | JP7277363B2 (enExample) |
| KR (1) | KR20190070977A (enExample) |
| CN (1) | CN110461868A (enExample) |
| BR (1) | BR112019008702A2 (enExample) |
| CA (1) | CA3041988A1 (enExample) |
| MA (1) | MA46700A (enExample) |
| SG (1) | SG11201903693QA (enExample) |
| WO (1) | WO2018083126A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| US10323081B2 (en) * | 2011-07-06 | 2019-06-18 | Genmag A/S | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains |
| MX2018006333A (es) | 2015-12-01 | 2018-08-01 | Genmab Bv | Anticuerpos anti-receptor de muerte 5 (dr5) y metodos de uso de los mismos. |
| CA3049689A1 (en) * | 2017-02-06 | 2018-08-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for augmenting antibody mediated receptor signaling |
| KR20250140128A (ko) | 2017-02-10 | 2025-09-24 | 젠맵 비. 브이 | 폴리펩티드 변이체 및 그의 용도 |
| CA3127624A1 (en) * | 2019-01-23 | 2020-07-30 | Millennium Pharmaceuticals, Inc. | Anti-cd38 antibodies |
| GB2600834B (en) * | 2019-04-30 | 2024-07-17 | Myeloid Therapeutics Inc | Engineered chimeric fusion protein compositions and methods of use thereof |
| GB201910900D0 (en) | 2019-07-31 | 2019-09-11 | Scancell Ltd | Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof |
| KR20220097875A (ko) | 2019-09-03 | 2022-07-08 | 마이얼로이드 테라퓨틱스, 인크. | 게놈 통합을 위한 방법 및 조성물 |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| US20230302168A1 (en) * | 2020-06-23 | 2023-09-28 | Actinium Pharmaceuticals, Inc. | Dr5 radioimmunotherapy in the treatment of solid cancers |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| MX2023005201A (es) | 2020-11-04 | 2023-06-28 | Myeloid Therapeutics Inc | Composiciones de proteinas de fusion quimerica modificadas por ingenieria y metodos de uso de las mismas. |
| CN112851794B (zh) * | 2021-02-04 | 2023-05-23 | 苏州铂维生物科技有限公司 | 一种基于cd271的抗原表位及其应用 |
| BR112023018832A2 (pt) | 2021-03-17 | 2023-12-26 | Myeloid Therapeutics Inc | Composições de proteínas de fusão quiméricas modificadas e métodos de uso das mesmas |
| EP4337268A4 (en) | 2021-05-11 | 2025-06-04 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| KR20240051280A (ko) * | 2021-09-06 | 2024-04-19 | 젠맵 에이/에스 | Cd27과 결합할 수 있는 항체, 그의 변이체 및 그의 용도 |
| WO2023218051A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| IL316628A (en) | 2022-05-12 | 2024-12-01 | Genmab As | Binding agents capable of binding to CD27 in combination therapy |
| AR132668A1 (es) | 2023-05-12 | 2025-07-16 | Genmab As | Anticuerpos capaces de unirse a ox40, variantes de los mismos y usos de los mismos |
| WO2025114541A1 (en) | 2023-11-30 | 2025-06-05 | Genmab A/S | Antibodies capable of binding to ox40 in combination therapy |
| EP4644413A1 (en) | 2024-05-03 | 2025-11-05 | Genmab B.V. | Binding agents having altered fc-mediated effector functions |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
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2017
- 2017-11-01 EP EP17803807.1A patent/EP3535291A1/en active Pending
- 2017-11-01 SG SG11201903693QA patent/SG11201903693QA/en unknown
- 2017-11-01 MA MA046700A patent/MA46700A/fr unknown
- 2017-11-01 CA CA3041988A patent/CA3041988A1/en active Pending
- 2017-11-01 CN CN201780081545.1A patent/CN110461868A/zh active Pending
- 2017-11-01 KR KR1020197015386A patent/KR20190070977A/ko active Pending
- 2017-11-01 JP JP2019523105A patent/JP7277363B2/ja active Active
- 2017-11-01 BR BR112019008702A patent/BR112019008702A2/pt unknown
- 2017-11-01 US US16/345,044 patent/US20190276549A1/en not_active Abandoned
- 2017-11-01 WO PCT/EP2017/077971 patent/WO2018083126A1/en not_active Ceased
-
2022
- 2022-05-16 US US17/745,667 patent/US20230107363A1/en active Pending
-
2023
- 2023-05-08 JP JP2023076427A patent/JP7695293B2/ja active Active
-
2025
- 2025-06-06 JP JP2025094622A patent/JP2025124873A/ja active Pending
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