JP2020506208A5 - - Google Patents
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- JP2020506208A5 JP2020506208A5 JP2019543208A JP2019543208A JP2020506208A5 JP 2020506208 A5 JP2020506208 A5 JP 2020506208A5 JP 2019543208 A JP2019543208 A JP 2019543208A JP 2019543208 A JP2019543208 A JP 2019543208A JP 2020506208 A5 JP2020506208 A5 JP 2020506208A5
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- polypeptide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000006467 substitution reaction Methods 0.000 claims description 133
- 229920001184 polypeptide Polymers 0.000 claims description 113
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 113
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 113
- 238000000034 method Methods 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 30
- 239000001354 calcium citrate Substances 0.000 claims description 26
- 239000000427 antigen Substances 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 239000001825 Polyoxyethene (8) stearate Substances 0.000 claims description 8
- 239000004337 magnesium citrate Substances 0.000 claims description 8
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 6
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- -1 RANK Proteins 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 2
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims description 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 2
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 2
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 claims description 2
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims description 2
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 101000679921 Homo sapiens Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 claims description 2
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims description 2
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims description 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 2
- 101000920026 Homo sapiens Tumor necrosis factor receptor superfamily member EDAR Proteins 0.000 claims description 2
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims description 2
- 108010052562 RELT Proteins 0.000 claims description 2
- 102000018795 RELT Human genes 0.000 claims description 2
- 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 claims description 2
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims description 2
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims description 2
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 2
- 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 claims description 2
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 2
- 102100030810 Tumor necrosis factor receptor superfamily member EDAR Human genes 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 102200000984 rs557327165 Human genes 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024084876A JP2024105709A (ja) | 2017-02-10 | 2024-05-24 | ポリペプチドバリアントおよびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201700097 | 2017-02-10 | ||
| DKPA201700097 | 2017-02-10 | ||
| PCT/EP2018/053464 WO2018146317A1 (en) | 2017-02-10 | 2018-02-12 | Polypeptide variants and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084876A Division JP2024105709A (ja) | 2017-02-10 | 2024-05-24 | ポリペプチドバリアントおよびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506208A JP2020506208A (ja) | 2020-02-27 |
| JP2020506208A5 true JP2020506208A5 (enExample) | 2021-03-25 |
| JP7577446B2 JP7577446B2 (ja) | 2024-11-05 |
Family
ID=61226568
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543208A Active JP7577446B2 (ja) | 2017-02-10 | 2018-02-12 | ポリペプチドバリアントおよびそれらの使用 |
| JP2024084876A Pending JP2024105709A (ja) | 2017-02-10 | 2024-05-24 | ポリペプチドバリアントおよびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024084876A Pending JP2024105709A (ja) | 2017-02-10 | 2024-05-24 | ポリペプチドバリアントおよびそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US12173076B2 (enExample) |
| EP (1) | EP3580233A1 (enExample) |
| JP (2) | JP7577446B2 (enExample) |
| KR (3) | KR20250140128A (enExample) |
| CN (1) | CN110945021B (enExample) |
| AU (1) | AU2018218345B2 (enExample) |
| BR (1) | BR112019015900A2 (enExample) |
| CA (1) | CA3053222A1 (enExample) |
| EA (1) | EA201991879A1 (enExample) |
| IL (1) | IL268593B2 (enExample) |
| MA (1) | MA47449A (enExample) |
| MX (1) | MX2019009346A (enExample) |
| SG (1) | SG11201906961UA (enExample) |
| UA (1) | UA128814C2 (enExample) |
| WO (1) | WO2018146317A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| US10323081B2 (en) * | 2011-07-06 | 2019-06-18 | Genmag A/S | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains |
| MX2018006333A (es) | 2015-12-01 | 2018-08-01 | Genmab Bv | Anticuerpos anti-receptor de muerte 5 (dr5) y metodos de uso de los mismos. |
| US10882907B2 (en) | 2017-06-21 | 2021-01-05 | Gilead Sciences, Inc. | Multispecific antibodies that target HIV GP120 and CD3 |
| KR20200138741A (ko) | 2018-04-02 | 2020-12-10 | 내셔널 유니버시티 오브 싱가포르 | 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화 |
| MX2020011552A (es) | 2018-05-03 | 2020-11-24 | Genmab Bv | Combinaciones de variantes de anticuerpos y usos de las mismas. |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| CA3146987A1 (en) * | 2019-07-17 | 2021-01-21 | National University Of Singapore | Functional binders synthesized and secreted by immune cells |
| GB201910900D0 (en) | 2019-07-31 | 2019-09-11 | Scancell Ltd | Modified fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof |
| CN113484512B (zh) * | 2021-06-01 | 2023-06-27 | 中国农业科学院油料作物研究所 | 黄曲霉毒素风险预警智能感知卡及其应用 |
| US12448451B2 (en) | 2021-06-25 | 2025-10-21 | Chugai Seiyaku Kabushiki Kaisha | Anti-CTLA-4 antibody and use thereof |
| KR20240051280A (ko) | 2021-09-06 | 2024-04-19 | 젠맵 에이/에스 | Cd27과 결합할 수 있는 항체, 그의 변이체 및 그의 용도 |
| WO2023206347A1 (zh) * | 2022-04-29 | 2023-11-02 | 苏州瀛创生物科技有限公司 | 作为早老性痴呆诊断标志物的ddit4l剪切产物 |
| WO2023218051A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| IL316628A (en) | 2022-05-12 | 2024-12-01 | Genmab As | Binding agents capable of binding to CD27 in combination therapy |
| CN115368467A (zh) * | 2022-07-19 | 2022-11-22 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| AR132668A1 (es) | 2023-05-12 | 2025-07-16 | Genmab As | Anticuerpos capaces de unirse a ox40, variantes de los mismos y usos de los mismos |
| WO2025114541A1 (en) | 2023-11-30 | 2025-06-05 | Genmab A/S | Antibodies capable of binding to ox40 in combination therapy |
| WO2025229159A1 (en) * | 2024-05-01 | 2025-11-06 | Commit Biologics Aps | Antibodies and antibody constructs against cd20 |
| CN118598996B (zh) * | 2024-08-08 | 2024-11-01 | 康立泰生物医药(青岛)有限公司 | 一种抗人白介素8抗体及其应用 |
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-
2018
- 2018-02-12 KR KR1020257030938A patent/KR20250140128A/ko active Pending
- 2018-02-12 KR KR1020197026071A patent/KR20190115057A/ko not_active Ceased
- 2018-02-12 EA EA201991879A patent/EA201991879A1/ru unknown
- 2018-02-12 MX MX2019009346A patent/MX2019009346A/es unknown
- 2018-02-12 UA UAA201909718A patent/UA128814C2/uk unknown
- 2018-02-12 KR KR1020247020823A patent/KR20240101717A/ko not_active Ceased
- 2018-02-12 IL IL268593A patent/IL268593B2/en unknown
- 2018-02-12 MA MA047449A patent/MA47449A/fr unknown
- 2018-02-12 EP EP18705367.3A patent/EP3580233A1/en active Pending
- 2018-02-12 CA CA3053222A patent/CA3053222A1/en active Pending
- 2018-02-12 JP JP2019543208A patent/JP7577446B2/ja active Active
- 2018-02-12 US US16/482,747 patent/US12173076B2/en active Active
- 2018-02-12 SG SG11201906961UA patent/SG11201906961UA/en unknown
- 2018-02-12 WO PCT/EP2018/053464 patent/WO2018146317A1/en not_active Ceased
- 2018-02-12 BR BR112019015900A patent/BR112019015900A2/pt unknown
- 2018-02-12 CN CN201880019701.6A patent/CN110945021B/zh active Active
- 2018-02-12 AU AU2018218345A patent/AU2018218345B2/en active Active
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2024
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- 2024-11-06 US US18/938,588 patent/US20250326854A1/en active Pending
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