JP2019501151A5 - - Google Patents

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Publication number
JP2019501151A5
JP2019501151A5 JP2018529176A JP2018529176A JP2019501151A5 JP 2019501151 A5 JP2019501151 A5 JP 2019501151A5 JP 2018529176 A JP2018529176 A JP 2018529176A JP 2018529176 A JP2018529176 A JP 2018529176A JP 2019501151 A5 JP2019501151 A5 JP 2019501151A5
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JP
Japan
Prior art keywords
molar ratio
antibody
motomeko
composition
cancer
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JP2018529176A
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English (en)
Japanese (ja)
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JP2019501151A (ja
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Priority claimed from PCT/EP2016/079517 external-priority patent/WO2017093447A1/en
Publication of JP2019501151A publication Critical patent/JP2019501151A/ja
Publication of JP2019501151A5 publication Critical patent/JP2019501151A5/ja
Priority to JP2022188988A priority Critical patent/JP7679347B2/ja
Withdrawn legal-status Critical Current

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JP2018529176A 2015-12-01 2016-12-01 抗デスレセプター抗体およびその使用方法 Withdrawn JP2019501151A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022188988A JP7679347B2 (ja) 2015-12-01 2022-11-28 抗デスレセプター抗体およびその使用方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
DKPA201500771 2015-12-01
DKPA201500771 2015-12-01
DKPA201500788 2015-12-07
DKPA201500787 2015-12-07
DKPA201500788 2015-12-07
DKPA201500787 2015-12-07
DKPA201600702 2016-11-10
DKPA201600701 2016-11-10
DKPA201600701 2016-11-10
DKPA201600702 2016-11-10
PCT/EP2016/079517 WO2017093447A1 (en) 2015-12-01 2016-12-01 Anti-death receptor antibodies and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022188988A Division JP7679347B2 (ja) 2015-12-01 2022-11-28 抗デスレセプター抗体およびその使用方法

Publications (2)

Publication Number Publication Date
JP2019501151A JP2019501151A (ja) 2019-01-17
JP2019501151A5 true JP2019501151A5 (enExample) 2020-01-16

Family

ID=58796495

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018529087A Active JP7254515B2 (ja) 2015-12-01 2016-12-01 抗dr5抗体およびその使用方法
JP2018529176A Withdrawn JP2019501151A (ja) 2015-12-01 2016-12-01 抗デスレセプター抗体およびその使用方法
JP2022188988A Active JP7679347B2 (ja) 2015-12-01 2022-11-28 抗デスレセプター抗体およびその使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2018529087A Active JP7254515B2 (ja) 2015-12-01 2016-12-01 抗dr5抗体およびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022188988A Active JP7679347B2 (ja) 2015-12-01 2022-11-28 抗デスレセプター抗体およびその使用方法

Country Status (15)

Country Link
US (5) US20190202926A1 (enExample)
EP (4) EP3383905A1 (enExample)
JP (3) JP7254515B2 (enExample)
KR (1) KR20180098567A (enExample)
CN (2) CN109476737A (enExample)
AU (2) AU2016363770A1 (enExample)
BR (2) BR112018011058A2 (enExample)
CA (2) CA3007031A1 (enExample)
IL (1) IL259713B1 (enExample)
MA (1) MA43365A (enExample)
MX (1) MX2018006333A (enExample)
SG (1) SG11201803956UA (enExample)
UA (1) UA126897C2 (enExample)
WO (2) WO2017093448A1 (enExample)
ZA (1) ZA201803079B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3960855A1 (en) * 2001-12-28 2022-03-02 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing proteins
UA117901C2 (uk) * 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
US20190202926A1 (en) 2015-12-01 2019-07-04 Genmab B.V. Anti-death receptor antibodies and methods of use thereof
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CN109843916B (zh) 2016-08-12 2023-10-31 詹森生物科技公司 具有增强的激动活性的Fc工程化抗TNFR超家族成员抗体及其使用方法
CN111328335A (zh) * 2017-06-07 2020-06-23 根马布私人有限公司 基于突变igg六聚体的治疗性抗体
EP3710482A4 (en) * 2017-11-14 2021-08-18 University Of Virginia Patent Foundation COMPOSITIONS AND METHODS OF MANUFACTURING AND USE OF BISPECIFIC ANTIBODIES
CN109957020A (zh) * 2017-12-25 2019-07-02 深圳宾德生物技术有限公司 一种靶向dr5的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
WO2019145455A1 (en) 2018-01-24 2019-08-01 Genmab B.V. Polypeptide variants and uses thereof
MA52485A (fr) 2018-05-03 2021-03-10 Genmab Bv Combinaisons de variants d'anticorps et utilisations associées
SG11202012993SA (en) * 2018-07-13 2021-02-25 Genmab As Variants of cd38 antibody and uses thereof
EP3837283B1 (en) * 2018-08-16 2024-04-17 Cantargia AB Anti-il1rap antibody compositions
US20220315661A1 (en) 2019-05-09 2022-10-06 Genmab B.V. Dosage regimens for a combination of anti-dr5 antibodies for use in treating cancer
EP4055046A1 (en) 2019-11-06 2022-09-14 Genmab B.V. Antibody variant combinations and uses thereof
JP2023526224A (ja) * 2020-05-12 2023-06-21 アイジーエム バイオサイエンシズ インコーポレイテッド がんを治療するための、がん治療薬との組合せでの多量体抗dr5結合分子の使用
CN111778333B (zh) * 2020-07-03 2022-11-18 东莞市滨海湾中心医院 测定edar表达水平的试剂的应用和试剂盒
US20230293680A1 (en) 2020-07-23 2023-09-21 Genmab B.V. A composition of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
US20230391881A1 (en) * 2020-10-14 2023-12-07 University Of Virginia Patent Foundation Compositions and methods for overcoming dr5-induced immune evasion by solid tumors
CN112915211B (zh) * 2021-02-07 2022-05-06 成都中医药大学 一种pd-l1靶向肽药物偶联物及其合成方法和应用
WO2023023677A1 (en) * 2021-08-20 2023-02-23 University Of Virginia Patent Foundation Strategy for highly superior dr5 activation including in tumors and cancers
US12410258B2 (en) * 2023-05-12 2025-09-09 Ganmab A/S Antibodies capable of binding to OX40, variants thereof and uses thereof
GB202315963D0 (en) * 2023-10-18 2023-11-29 Cancer Research Tech Ltd Binding molecules
WO2025160152A2 (en) * 2024-01-23 2025-07-31 The Regents Of The University Of California Fas antibody and its use in treating cancers

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077A (en) 1849-01-30 Improved hinged claw-wrench
US835A (en) 1838-07-12 X i i i x
US761218A (en) 1899-10-05 1904-05-31 U S Standard Voting Machine Co Register or counter.
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6284236B1 (en) 1995-06-29 2001-09-04 Immunex Corporation Cytokine that induces apoptosis
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
CA2249206A1 (en) 1996-04-01 1997-10-09 Genentech, Inc. Apo-2li and apo-3 apoptosis polypeptides
EP1012274B2 (en) 1997-01-28 2011-06-15 Human Genome Sciences, Inc. Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l)
US20050233958A1 (en) 1997-03-17 2005-10-20 Human Genome Sciences, Inc. Death domain containing receptor 5
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
ES2246069T3 (es) 1997-05-02 2006-02-01 Genentech, Inc. Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
PT1045906E (pt) 1998-01-15 2009-01-27 Genentech Inc Ligando apo-2
JP2003524587A (ja) 1998-06-05 2003-08-19 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ 多発性骨髄腫を処置するための、cd38に対する、遺伝子操作した抗体の使用
PT1150918E (pt) 1999-02-03 2005-01-31 Biosante Pharmaceuticals Inc Metodo de fabrico de particulas terapeuticas de fosfato de calcio
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
AU5596500A (en) 1999-06-09 2000-12-28 Genentech Inc. Apo-2l receptor agonist and cpt-11 synergism
US6444640B1 (en) 1999-09-30 2002-09-03 Ludwig Institute For Cancer Research Compositions of trail and DNA damaging drugs and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
DE10043437A1 (de) 2000-09-04 2002-03-28 Horst Lindhofer Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites
US20020155109A1 (en) 2001-04-20 2002-10-24 Lynch David H. Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
US7115717B2 (en) 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
NZ529359A (en) * 2001-05-25 2007-04-27 Human Genome Sciences Inc Antibodies that immunospecifically bind to a TR4 polypeptide or polypeptide fragment or variant of TR4 and their use in a medicament for treating cancer
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
CA2451680C (en) 2001-07-03 2011-04-19 Genentech, Inc. Human dr4 antibodies and uses thereof
ATE491019T1 (de) 2001-11-01 2010-12-15 Uab Research Foundation Kombinationen aus anti-dr5-antikörpern und anti- dr4-antikörpern und weiteren therapeutischen agentien
US20040019915A1 (en) 2002-04-01 2004-01-29 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer
MXPA05004022A (es) 2002-10-17 2005-10-05 Genmab As Anticuerpos monoclonales humanos contra cd20.
US20050266008A1 (en) 2004-03-29 2005-12-01 Medarex, Inc. Human anti-IRTA-5 antibodies
KR20070010046A (ko) 2004-04-06 2007-01-19 제넨테크, 인크. Dr5 항체 및 그의 용도
CA2573192C (en) * 2004-08-04 2013-09-10 Applied Molecular Evolution Inc. Variant fc regions
US7741568B2 (en) 2005-01-13 2010-06-22 The Wiremold Company Downward facing receptacle assembly for cable raceway
EP1853313B1 (en) 2005-03-03 2018-01-24 Immunomedics Inc. Humanized l243 antibodies
CA2603408C (en) 2005-03-31 2018-08-21 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
WO2008157379A2 (en) 2007-06-21 2008-12-24 Macrogenics, Inc. Covalent diabodies and uses thereof
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
JP5374359B2 (ja) 2006-03-17 2013-12-25 バイオジェン・アイデック・エムエイ・インコーポレイテッド 安定化されたポリペプチド化合物
PT1999154E (pt) 2006-03-24 2013-01-24 Merck Patent Gmbh Domínios proteicos heterodiméricos modificados
AT503902B1 (de) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von immunglobulinen
KR100847010B1 (ko) 2006-07-05 2008-07-17 아주대학교산학협력단 세포사멸 수용체 5 (dr5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물
TW200904072A (en) 2007-07-05 2009-01-16 Ic Plus Corp System and method for generating interrupt
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
PL2235064T3 (pl) 2008-01-07 2016-06-30 Amgen Inc Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
WO2010003766A2 (en) 2008-06-17 2010-01-14 Apogenix Gmbh Multimeric tnf receptors
EP2166021A1 (en) * 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
SI2786762T1 (sl) 2008-12-19 2019-07-31 Macrogenics, Inc. Kovalentna diatelesa in njihove uporabe
US9067986B2 (en) 2009-04-27 2015-06-30 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
WO2010138725A1 (en) 2009-05-28 2010-12-02 Amgen Inc. Treatment of pancreatic cancer using a dr5 agonist in combination with gemcitabine
MY199658A (en) 2009-06-26 2023-11-14 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
JP6040148B2 (ja) 2010-04-20 2016-12-07 ゲンマブ エー/エス ヘテロ二量体抗体Fc含有タンパク質およびその産生方法
JP6022444B2 (ja) 2010-05-14 2016-11-09 ライナット ニューロサイエンス コーポレイション ヘテロ二量体タンパク質ならびにそれを生産および精製するための方法
ES2537207T3 (es) 2010-08-16 2015-06-03 Novimmune S.A. Métodos para la generación de anticuerpos multiespecíficos y multivalentes
CN103068847B (zh) 2010-08-24 2019-05-07 罗切格利卡特公司 可活化的双特异性抗体
JP5758004B2 (ja) 2010-08-24 2015-08-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ジスルフィドによって安定化されたFv断片を含む二重特異性抗体
US8993727B2 (en) * 2010-09-22 2015-03-31 Amgen Inc. Carrier immunoglobulins and uses thereof
SG189456A1 (en) * 2010-10-29 2013-05-31 Daiichi Sankyo Co Ltd Novel anti-dr5 antibody
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
CN102250246A (zh) 2011-06-10 2011-11-23 常州亚当生物技术有限公司 抗VEGF/PDGFRβ双特异性抗体及其应用
UA117901C2 (uk) * 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
CN102654260B (zh) 2011-09-29 2014-09-03 北京京东方光电科技有限公司 一种背光源和液晶显示器
CN104011221B (zh) 2011-12-20 2019-01-08 米迪缪尼有限公司 用于双特异性抗体支架的经修饰的多肽
CA2870821C (en) 2012-04-20 2022-06-14 Merus B.V. Methods and means for the production of ig-like molecules
ES2758979T3 (es) 2012-07-06 2020-05-07 Genmab Bv Proteína dimérica con mutaciones triples
SG11201408646VA (en) 2012-07-06 2015-01-29 Genmab Bv Dimeric protein with triple mutations
EP2684896A1 (en) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof
SG11201505286TA (en) 2013-01-10 2015-08-28 Genmab Bv Human igg1 fc region variants and uses thereof
EP3048116A1 (en) * 2015-01-23 2016-07-27 International-Drug-Development-Biotech Anti-dr5 antibodies with enhanced apoptosis potency
US20190202926A1 (en) 2015-12-01 2019-07-04 Genmab B.V. Anti-death receptor antibodies and methods of use thereof
CN110461868A (zh) 2016-11-01 2019-11-15 根马布私人有限公司 多肽变体及其用途
UA128814C2 (uk) 2017-02-10 2024-10-30 Генмаб Б.В. Поліпептид та його застосування

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