JP2019536757A5 - - Google Patents
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- Publication number
- JP2019536757A5 JP2019536757A5 JP2019520150A JP2019520150A JP2019536757A5 JP 2019536757 A5 JP2019536757 A5 JP 2019536757A5 JP 2019520150 A JP2019520150 A JP 2019520150A JP 2019520150 A JP2019520150 A JP 2019520150A JP 2019536757 A5 JP2019536757 A5 JP 2019536757A5
- Authority
- JP
- Japan
- Prior art keywords
- muscle
- trans
- thiazole
- carboxamide
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *=C(*C(CC1)CC1Oc1c2nc[s]c2cc(F)c1)NC(CC1)CCN1c(nc1)ncc1F Chemical compound *=C(*C(CC1)CC1Oc1c2nc[s]c2cc(F)c1)NC(CC1)CCN1c(nc1)ncc1F 0.000 description 1
- HEGBXROZTLMDLF-UHFFFAOYSA-N O=C(NC(C1)CN1c(cc1)ncc1F)N(C1)CC1Oc1c2nc[s]c2cc(F)c1 Chemical compound O=C(NC(C1)CN1c(cc1)ncc1F)N(C1)CC1Oc1c2nc[s]c2cc(F)c1 HEGBXROZTLMDLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662407634P | 2016-10-13 | 2016-10-13 | |
| US62/407,634 | 2016-10-13 | ||
| PCT/IB2017/056320 WO2018069863A1 (en) | 2016-10-13 | 2017-10-12 | 1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin d synthase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536757A JP2019536757A (ja) | 2019-12-19 |
| JP2019536757A5 true JP2019536757A5 (enExample) | 2020-12-24 |
| JP6938628B2 JP6938628B2 (ja) | 2021-09-22 |
Family
ID=60320926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520150A Expired - Fee Related JP6938628B2 (ja) | 2016-10-13 | 2017-10-12 | 造血器型プロスタグランジンｄシンターゼ阻害剤としての１，３二置換シクロブタンまたはアゼチジン誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US11053234B2 (enExample) |
| EP (1) | EP3526206A1 (enExample) |
| JP (1) | JP6938628B2 (enExample) |
| KR (1) | KR20190072565A (enExample) |
| CN (1) | CN110072857A (enExample) |
| AR (1) | AR109931A1 (enExample) |
| AU (1) | AU2017342156B2 (enExample) |
| BR (1) | BR112019007609A2 (enExample) |
| CA (1) | CA3038756A1 (enExample) |
| CL (1) | CL2019000986A1 (enExample) |
| CO (1) | CO2019003482A2 (enExample) |
| CR (1) | CR20190174A (enExample) |
| DO (1) | DOP2019000087A (enExample) |
| EA (1) | EA201990904A1 (enExample) |
| IL (1) | IL265597A (enExample) |
| JO (1) | JOP20190072A1 (enExample) |
| MA (1) | MA46531A (enExample) |
| MX (1) | MX2019004320A (enExample) |
| PE (1) | PE20191020A1 (enExample) |
| PH (1) | PH12019500811A1 (enExample) |
| TW (1) | TW201827412A (enExample) |
| UY (1) | UY37440A (enExample) |
| WO (1) | WO2018069863A1 (enExample) |
| ZA (1) | ZA201901848B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| US11149035B2 (en) * | 2017-06-13 | 2021-10-19 | Glaxosmithkline Intellectual Property Dfvelopment Limited | Chemical compounds as H—PGDS inhibitors |
| IL301709B2 (en) * | 2017-08-09 | 2025-07-01 | Denali Therapeutics Inc | Compounds, compositions and methods |
| TW201920129A (zh) | 2017-09-01 | 2019-06-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CR20210426A (es) | 2019-02-13 | 2021-09-30 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| WO2021152113A1 (en) | 2020-01-31 | 2021-08-05 | Bayer Aktiengesellschaft | Substituted 2,3-benzodiazepines derivatives |
| TW202204334A (zh) | 2020-04-08 | 2022-02-01 | 美商阿吉歐斯製藥公司 | Menin抑制劑及治療癌症之使用方法 |
| CN113582880B (zh) * | 2020-04-30 | 2023-11-17 | 南京药石科技股份有限公司 | 一种（3-氨基二环[1.1.1]戊烷-1-基）氨基甲酸叔丁酯的制备方法 |
| CN111574473A (zh) * | 2020-06-04 | 2020-08-25 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 一种氨基噻唑类化合物的合成方法 |
| CA3179059A1 (en) * | 2020-06-09 | 2021-12-16 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
| CN111549000B (zh) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用 |
| JP7734129B2 (ja) | 2020-06-19 | 2025-09-04 | 佐藤製薬株式会社 | Ｈ－ｐｇｄｓを阻害する縮環化合物 |
| TW202241857A (zh) | 2020-12-18 | 2022-11-01 | 美商戴納立製藥公司 | 化合物之固體形式 |
| CN114085167A (zh) * | 2021-12-13 | 2022-02-25 | 华中药业股份有限公司 | 一种杂质ts-3a的制备方法 |
| EP4448492B1 (en) | 2021-12-17 | 2026-03-04 | Reglagene, Inc. | Compositions and methods of making and using small molecules in the treatment of cancer |
| CA3240926A1 (en) | 2021-12-17 | 2023-06-22 | Sato Pharmaceutical Co., Ltd. | Azaindole derivative inhibiting h-pgds |
| US20250250265A1 (en) * | 2022-04-15 | 2025-08-07 | Vanderbilt University | Benzothiazole-phenylsulfonyl-piperidine analogs as activators of nacylphosphatidylethanolamine hydrolyzing phospholipase d |
| JP7894535B2 (ja) * | 2023-02-28 | 2026-07-23 | レグラジーン、インコーポレイテッド | 健康状態の治療のための小分子を作製および使用するための組成物および方法 |
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| US4031221A (en) * | 1974-06-17 | 1977-06-21 | American Hoechst Corporation | Method of treating pain and hypertension |
| US4956359A (en) | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
| IE58943B1 (en) | 1985-02-28 | 1993-12-01 | Robins Co Inc A H | 3-Aryloxy-azetidine-carboxamides |
| US6809088B2 (en) * | 1997-03-24 | 2004-10-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
| GB9801501D0 (en) * | 1998-01-23 | 1998-03-18 | Cerebrus Ltd | Chemical compounds - II |
| GB9917385D0 (en) | 1999-07-23 | 1999-09-22 | Cerebrus Ltd | Chemical compounds-I |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| JP2007522233A (ja) * | 2004-02-11 | 2007-08-09 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び治療におけるそれらの使用 |
| WO2005094805A1 (ja) | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| US20070225333A1 (en) * | 2004-04-28 | 2007-09-27 | Bryans Justin S | 3-Heterocyclyl-4-Phenyl-Triazole Derivatives as Inhibitors of the Vasopressin Via Receptor |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| JP2008545008A (ja) | 2005-06-30 | 2008-12-11 | プロシディオン・リミテッド | Ｇｐｃｒアゴニスト |
| GB0514017D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
| JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| DOP2006000210A (es) | 2005-10-04 | 2007-06-15 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| US20070208426A1 (en) * | 2006-03-03 | 2007-09-06 | Sdgi Holdings, Inc. | Spinal implant with improved surface properties for delivery |
| WO2007106705A1 (en) | 2006-03-10 | 2007-09-20 | Boehringer Ingelheim International Gmbh | Soluble epoxide hydrolase inhibitors and methods of using same |
| JPWO2008023720A1 (ja) | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
| JP2010513458A (ja) | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| NZ579892A (en) | 2007-03-30 | 2012-03-30 | Sanofi Aventis | Pyrimidine hydrazide compounds as prostaglandin D synthase inhibitors |
| GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| CN102015635B (zh) * | 2008-03-04 | 2013-05-08 | 弗奈利斯（R&D）有限公司 | 氮杂环丁烷衍生物 |
| EP2307378A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| EP2307377A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| WO2010024903A1 (en) * | 2008-08-29 | 2010-03-04 | Yangbo Feng | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS |
| MY154000A (en) | 2008-09-22 | 2015-04-30 | Cayman Chem Co | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| CN102341385B (zh) | 2009-03-09 | 2014-01-15 | 大鹏药品工业株式会社 | 能够抑制前列腺素d合酶的哌嗪化合物 |
| WO2011043359A1 (ja) | 2009-10-06 | 2011-04-14 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
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| JP5677325B2 (ja) | 2010-01-22 | 2015-02-25 | 大鵬薬品工業株式会社 | Ｐｇｄｓ阻害作用を有するピペラジン化合物 |
| EP2569302A1 (en) * | 2010-05-13 | 2013-03-20 | Amgen, Inc | Heteroaryloxyheterocyclyl compounds as pde10 inhibitors |
| US8952037B2 (en) * | 2010-05-13 | 2015-02-10 | Amgen Inc. | Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors |
| WO2012009649A1 (en) * | 2010-07-16 | 2012-01-19 | Anderson Gaweco | Mif inhibitors and their uses |
| DK2616465T3 (da) * | 2010-09-13 | 2016-02-01 | Novartis Ag | Triazin-oxadiazoler |
| KR101400192B1 (ko) | 2010-12-31 | 2014-05-27 | 제일모직 주식회사 | 포지티브형 감광성 수지 조성물, 이를 사용하여 제조된 감광성 수지막 및 상기 감광성 수지막을 포함하는 반도체 소자 |
| US9133164B2 (en) * | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| SG194625A1 (en) | 2011-05-23 | 2013-12-30 | Sanofi Sa | Process for the preparation of deuterated compounds containing n-alkyl groups |
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| US9499533B2 (en) * | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
| TWI585088B (zh) * | 2012-06-04 | 2017-06-01 | 第一三共股份有限公司 | 作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物 |
| US20150376198A1 (en) | 2013-02-18 | 2015-12-31 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
| WO2014179144A1 (en) | 2013-04-29 | 2014-11-06 | E. I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
| NZ726874A (en) | 2014-05-19 | 2018-03-23 | Merial Inc | Anthelmintic compounds |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| LT3277677T (lt) * | 2015-03-30 | 2021-05-25 | Mission Therapeutics Limited | 1-ciano-pirolidino junginiai kaip usp30 inhibitoriai |
| AU2016370779B2 (en) | 2015-12-17 | 2019-07-25 | Astex Therapeutics Limited | Quinoline-3-carboxamides as H-PGDS inhibitors |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
-
2017
- 2017-06-16 JO JOP/2019/0072A patent/JOP20190072A1/ar unknown
- 2017-10-11 UY UY0001037440A patent/UY37440A/es unknown
- 2017-10-11 AR ARP170102843A patent/AR109931A1/es unknown
- 2017-10-11 TW TW106134668A patent/TW201827412A/zh unknown
- 2017-10-12 PE PE2019000741A patent/PE20191020A1/es unknown
- 2017-10-12 US US16/341,113 patent/US11053234B2/en not_active Expired - Fee Related
- 2017-10-12 EA EA201990904A patent/EA201990904A1/ru unknown
- 2017-10-12 WO PCT/IB2017/056320 patent/WO2018069863A1/en not_active Ceased
- 2017-10-12 EP EP17797738.6A patent/EP3526206A1/en not_active Withdrawn
- 2017-10-12 BR BR112019007609A patent/BR112019007609A2/pt not_active Application Discontinuation
- 2017-10-12 CA CA3038756A patent/CA3038756A1/en not_active Abandoned
- 2017-10-12 MX MX2019004320A patent/MX2019004320A/es unknown
- 2017-10-12 JP JP2019520150A patent/JP6938628B2/ja not_active Expired - Fee Related
- 2017-10-12 KR KR1020197013195A patent/KR20190072565A/ko not_active Ceased
- 2017-10-12 MA MA046531A patent/MA46531A/fr unknown
- 2017-10-12 CR CR20190174A patent/CR20190174A/es unknown
- 2017-10-12 AU AU2017342156A patent/AU2017342156B2/en not_active Ceased
- 2017-10-12 CN CN201780075127.1A patent/CN110072857A/zh active Pending
-
2019
- 2019-03-25 IL IL265597A patent/IL265597A/en unknown
- 2019-03-26 ZA ZA2019/01848A patent/ZA201901848B/en unknown
- 2019-04-08 DO DO2019000087A patent/DOP2019000087A/es unknown
- 2019-04-08 CO CONC2019/0003482A patent/CO2019003482A2/es unknown
- 2019-04-11 CL CL2019000986A patent/CL2019000986A1/es unknown
- 2019-04-12 PH PH12019500811A patent/PH12019500811A1/en unknown
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