JP2019502691A5 - - Google Patents
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- Publication number
- JP2019502691A5 JP2019502691A5 JP2018531378A JP2018531378A JP2019502691A5 JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5 JP 2018531378 A JP2018531378 A JP 2018531378A JP 2018531378 A JP2018531378 A JP 2018531378A JP 2019502691 A5 JP2019502691 A5 JP 2019502691A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- quinoline
- difluoromethoxy
- trans
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268630P | 2015-12-17 | 2015-12-17 | |
| US62/268,630 | 2015-12-17 | ||
| PCT/IB2016/057676 WO2017103851A1 (en) | 2015-12-17 | 2016-12-15 | Quinoline-3-carboxamides as h-pgds inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019502691A JP2019502691A (ja) | 2019-01-31 |
| JP2019502691A5 true JP2019502691A5 (enExample) | 2020-02-06 |
Family
ID=57589094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531378A Pending JP2019502691A (ja) | 2015-12-17 | 2016-12-15 | Ｈ−ｐｇｄｓ阻害剤としてのキノリン−３−カルボキサミド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210238162A1 (enExample) |
| EP (1) | EP3390384B1 (enExample) |
| JP (1) | JP2019502691A (enExample) |
| KR (1) | KR20180095580A (enExample) |
| CN (1) | CN108430992A (enExample) |
| AR (1) | AR107044A1 (enExample) |
| AU (1) | AU2016370779B2 (enExample) |
| BR (1) | BR112018012469B1 (enExample) |
| CA (1) | CA3008358A1 (enExample) |
| RU (1) | RU2018126105A (enExample) |
| TW (1) | TW201733988A (enExample) |
| UY (1) | UY37028A (enExample) |
| WO (1) | WO2017103851A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2716136C2 (ru) | 2015-07-02 | 2020-03-06 | Ф. Хоффманн-Ля Рош Аг | Бициклические лактамы и способы их применения |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| JP7349359B2 (ja) | 2016-10-17 | 2023-09-22 | エフ． ホフマン－ラ ロシュ アーゲー | 二環式ピリドンラクタム及びその使用方法。 |
| MY196327A (en) | 2016-11-11 | 2023-03-24 | Bayer Animal Health Gmbh | New Anthelmintic Quinoline-3-Carboxamide Derivative |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| WO2018195123A1 (en) | 2017-04-18 | 2018-10-25 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| US11149035B2 (en) | 2017-06-13 | 2021-10-19 | Glaxosmithkline Intellectual Property Dfvelopment Limited | Chemical compounds as H—PGDS inhibitors |
| US11254661B2 (en) | 2017-08-04 | 2022-02-22 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| TW201920129A (zh) | 2017-09-01 | 2019-06-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| US20210139507A1 (en) * | 2017-12-13 | 2021-05-13 | Glaxosmithkline Intellectual Property Development Limited | Fused pyridines which act as inhibitors of h pgds |
| MX2020006185A (es) | 2017-12-15 | 2020-09-03 | Bayer Animal Health Gmbh | Proceso para la preparacion de derivados de quinolina. |
| CN112313208B (zh) * | 2018-04-17 | 2024-04-19 | 泰普斯特医疗公司 | 双环羧酰胺及其使用方法 |
| EP3781571B1 (en) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
| CN112074514B (zh) | 2018-05-09 | 2024-10-29 | 礼蓝动物保健有限公司 | 新的喹啉衍生物 |
| US20220177456A1 (en) * | 2019-03-06 | 2022-06-09 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| WO2021204930A1 (en) | 2020-04-09 | 2021-10-14 | Bayer Animal Health Gmbh | Substituted condensed azines as anthelmintic compounds |
| CN111549000B (zh) * | 2020-06-18 | 2022-07-29 | 中国医学科学院整形外科医院 | 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用 |
| JP7734129B2 (ja) | 2020-06-19 | 2025-09-04 | 佐藤製薬株式会社 | Ｈ－ｐｇｄｓを阻害する縮環化合物 |
| MX2023002947A (es) * | 2020-09-11 | 2023-06-06 | Univ California | Composiciones y métodos para el tratamiento de distrofias musculares. |
| CA3217271A1 (en) * | 2021-05-28 | 2022-12-01 | Yonggang Chen | Synthesis of btk inhibitor and intermediates thereof |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| CA3240926A1 (en) | 2021-12-17 | 2023-06-22 | Sato Pharmaceutical Co., Ltd. | Azaindole derivative inhibiting h-pgds |
| CN117562559A (zh) * | 2023-12-04 | 2024-02-20 | 东华大学 | 基于功率和力矩输出的上臂肱二头肌疲劳识别与预测方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100321649B1 (ko) | 1993-03-17 | 2002-07-22 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제 |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| CH1196397H1 (de) * | 1999-06-02 | 2007-05-31 | Nps Pharma Inc | Metabotrope Glutamatrezeptorantagonisten zur Behandlung von Krankheiten des zentralen Nervensystems. |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| WO2005094805A1 (ja) * | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| TW200720255A (en) | 2005-07-13 | 2007-06-01 | Taiho Pharmaceutical Co Ltd | Benzoimidazole compound capable of inhibiting prostaglandin d synthetase |
| JP2007051121A (ja) | 2005-07-22 | 2007-03-01 | Taiho Yakuhin Kogyo Kk | プロスタグランジンｄ合成酵素を阻害するピリミジン化合物 |
| DOP2006000210A (es) | 2005-10-04 | 2007-06-15 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| JP2010513458A (ja) | 2006-12-19 | 2010-04-30 | ファイザー・プロダクツ・インク | Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンｄ２の仲介による疾患を治療するためのその使用 |
| NZ579892A (en) | 2007-03-30 | 2012-03-30 | Sanofi Aventis | Pyrimidine hydrazide compounds as prostaglandin D synthase inhibitors |
| GB0706793D0 (en) | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
| EP2231666B1 (en) * | 2007-12-12 | 2015-07-29 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| EP2307378A1 (en) * | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| EP2307377A1 (en) | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| MY154000A (en) | 2008-09-22 | 2015-04-30 | Cayman Chem Co | Multiheteroaryl compounds as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| CN102341385B (zh) | 2009-03-09 | 2014-01-15 | 大鹏药品工业株式会社 | 能够抑制前列腺素d合酶的哌嗪化合物 |
| WO2011043359A1 (ja) | 2009-10-06 | 2011-04-14 | 協和発酵キリン株式会社 | 芳香族複素環化合物を含有する医薬 |
| CA2776242C (en) | 2009-10-08 | 2014-09-02 | Sanofi | Phenyloxadiazole derivatives as pgds inhibitors |
| JP5677325B2 (ja) | 2010-01-22 | 2015-02-25 | 大鵬薬品工業株式会社 | Ｐｇｄｓ阻害作用を有するピペラジン化合物 |
| US9212209B2 (en) * | 2012-07-13 | 2015-12-15 | Indiana University Research And Technology Corporation | Screening methods for spinal muscular atrophy |
-
2016
- 2016-12-15 AU AU2016370779A patent/AU2016370779B2/en not_active Expired - Fee Related
- 2016-12-15 WO PCT/IB2016/057676 patent/WO2017103851A1/en not_active Ceased
- 2016-12-15 KR KR1020187019904A patent/KR20180095580A/ko not_active Withdrawn
- 2016-12-15 AR ARP160103847A patent/AR107044A1/es unknown
- 2016-12-15 CN CN201680074158.0A patent/CN108430992A/zh active Pending
- 2016-12-15 UY UY0001037028A patent/UY37028A/es unknown
- 2016-12-15 TW TW105141512A patent/TW201733988A/zh unknown
- 2016-12-15 CA CA3008358A patent/CA3008358A1/en not_active Abandoned
- 2016-12-15 RU RU2018126105A patent/RU2018126105A/ru not_active Application Discontinuation
- 2016-12-15 BR BR112018012469-9A patent/BR112018012469B1/pt not_active IP Right Cessation
- 2016-12-15 JP JP2018531378A patent/JP2019502691A/ja active Pending
- 2016-12-15 US US16/062,223 patent/US20210238162A1/en not_active Abandoned
- 2016-12-15 EP EP16815960.6A patent/EP3390384B1/en active Active
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