UY37028A - Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds - Google Patents

Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds

Info

Publication number
UY37028A
UY37028A UY0001037028A UY37028A UY37028A UY 37028 A UY37028 A UY 37028A UY 0001037028 A UY0001037028 A UY 0001037028A UY 37028 A UY37028 A UY 37028A UY 37028 A UY37028 A UY 37028A
Authority
UY
Uruguay
Prior art keywords
pgds
ematopoyética
prostaglandina
sintasa
compound
Prior art date
Application number
UY0001037028A
Other languages
English (en)
Inventor
L Larkin Andrew
Christie Schulte
J Price Daniel
Norman Deaton Dave
Gordon Saxty
Edward David Smith Ian
Wendell Wilson Joseph
T Schaller Lee
N Mortenson Paul
Rodolfo Cadilla
Andrew Thomson Stephen
Heather Hobbs
Paul Hancock Ashley
Teanby Hodgson Simon
Joelle Le
Original Assignee
Astex Therapeutics Ltd
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd, Glaxosmithkline Ip Dev Ltd filed Critical Astex Therapeutics Ltd
Publication of UY37028A publication Critical patent/UY37028A/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Abstract

La presente invención se refiere a compuestos de Fórmula (XI):en donde R1a, R2a, R3a, R4a, R5a, R6a, y Aa son como se definen en la presente memoria, y a sales farmacéuticamente aceptables de los mismos. Los compuestos de la presente invención son inhibidores de prostaglandina D sintasa hematopoyética (H-PGDS) y pueden ser útiles en el tratamiento de la distrofia muscular de Duchenne. Por consiguiente, la invención se refiere adicionalmente a composiciones farmacéuticas que comprenden un compuesto de la invención. Además, la invención también se refiere a métodos para inhibir la actividad de H-PGDS y al tratamiento de trastornos asociados con ella usando un compuesto de la invención o una composición farmacéutica que comprende un compuesto de la invención.
UY0001037028A 2015-12-17 2016-12-15 Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds UY37028A (es)

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US201562268630P 2015-12-17 2015-12-17

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UY37028A true UY37028A (es) 2017-07-31

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UY0001037028A UY37028A (es) 2015-12-17 2016-12-15 Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds

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US (1) US20210238162A1 (es)
EP (1) EP3390384B1 (es)
JP (1) JP2019502691A (es)
KR (1) KR20180095580A (es)
CN (1) CN108430992A (es)
AR (1) AR107044A1 (es)
AU (1) AU2016370779B2 (es)
BR (1) BR112018012469B1 (es)
CA (1) CA3008358A1 (es)
RU (1) RU2018126105A (es)
TW (1) TW201733988A (es)
UY (1) UY37028A (es)
WO (1) WO2017103851A1 (es)

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CA3008358A1 (en) 2017-06-22
BR112018012469B1 (pt) 2020-11-24
BR112018012469A2 (pt) 2018-12-18
US20210238162A1 (en) 2021-08-05
CN108430992A (zh) 2018-08-21
TW201733988A (zh) 2017-10-01
AU2016370779A1 (en) 2018-06-14
AU2016370779B2 (en) 2019-07-25
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AR107044A1 (es) 2018-03-14

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