KR20180095580A - H-pgds 억제제로서의 퀴놀린-3-카르복스아미드 - Google Patents

H-pgds 억제제로서의 퀴놀린-3-카르복스아미드 Download PDF

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KR20180095580A
KR20180095580A KR1020187019904A KR20187019904A KR20180095580A KR 20180095580 A KR20180095580 A KR 20180095580A KR 1020187019904 A KR1020187019904 A KR 1020187019904A KR 20187019904 A KR20187019904 A KR 20187019904A KR 20180095580 A KR20180095580 A KR 20180095580A
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carboxamide
quinoline
chloro
difluoromethoxy
trans
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Korean (ko)
Inventor
로돌포 캐딜라
데이브 노먼 대톤
애슐리 폴 핸콕
헤더 홉스
시몬 테안비 호지슨
앤드류 엘. 라킨
조엘 르
폴 엔. 모텐슨
대니얼 제이. 프라이스
고든 삭티
리 티. 샬러
크리스티 셜트
이안 에드워드 데이빗 스미쓰
스티븐 앤드류 톰슨
조셉 웬델 윌슨
Original Assignee
아스텍스 테라퓨틱스 리미티드
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드
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Publication of KR20180095580A publication Critical patent/KR20180095580A/ko
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
KR1020187019904A 2015-12-17 2016-12-15 H-pgds 억제제로서의 퀴놀린-3-카르복스아미드 Withdrawn KR20180095580A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562268630P 2015-12-17 2015-12-17
US62/268,630 2015-12-17
PCT/IB2016/057676 WO2017103851A1 (en) 2015-12-17 2016-12-15 Quinoline-3-carboxamides as h-pgds inhibitors

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KR20180095580A true KR20180095580A (ko) 2018-08-27

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US (1) US20210238162A1 (enExample)
EP (1) EP3390384B1 (enExample)
JP (1) JP2019502691A (enExample)
KR (1) KR20180095580A (enExample)
CN (1) CN108430992A (enExample)
AR (1) AR107044A1 (enExample)
AU (1) AU2016370779B2 (enExample)
BR (1) BR112018012469B1 (enExample)
CA (1) CA3008358A1 (enExample)
RU (1) RU2018126105A (enExample)
TW (1) TW201733988A (enExample)
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EP3781571B1 (en) * 2018-04-20 2024-01-17 F. Hoffmann-La Roche AG N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
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WO2021204930A1 (en) 2020-04-09 2021-10-14 Bayer Animal Health Gmbh Substituted condensed azines as anthelmintic compounds
CN111549000B (zh) * 2020-06-18 2022-07-29 中国医学科学院整形外科医院 一种过表达Hpgds的重组脂肪干细胞、制备方法及其应用
US20230339937A1 (en) 2020-06-19 2023-10-26 Sato Pharmaceutical Co., Ltd. Condensed ring compounds that inhibit h-pgds
US20230348394A1 (en) * 2020-09-11 2023-11-02 The Regents Of The University Of California Compositions and methods for treating muscular dystrophies
JP2024521786A (ja) * 2021-05-28 2024-06-04 メルク・シャープ・アンド・ドーム・エルエルシー Ｂｔｋ阻害剤及びその中間体の合成
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TW201733988A (zh) 2017-10-01
RU2018126105A (ru) 2020-01-17
AU2016370779A1 (en) 2018-06-14
AU2016370779B2 (en) 2019-07-25
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EP3390384B1 (en) 2021-09-15
UY37028A (es) 2017-07-31
CN108430992A (zh) 2018-08-21
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BR112018012469A2 (pt) 2018-12-18
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