JP2019532033A5 - - Google Patents
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- Publication number
- JP2019532033A5 JP2019532033A5 JP2019511749A JP2019511749A JP2019532033A5 JP 2019532033 A5 JP2019532033 A5 JP 2019532033A5 JP 2019511749 A JP2019511749 A JP 2019511749A JP 2019511749 A JP2019511749 A JP 2019511749A JP 2019532033 A5 JP2019532033 A5 JP 2019532033A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- compound according
- acceptable salt
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 COOR Chemical group 0.000 claims description 103
- 150000001875 compounds Chemical class 0.000 claims description 55
- 150000003839 salts Chemical class 0.000 claims description 52
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000005843 halogen group Chemical group 0.000 claims description 39
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 27
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 24
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 229910052717 sulfur Inorganic materials 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 150000001345 alkine derivatives Chemical class 0.000 claims description 12
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 206010022000 influenza Diseases 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 229940127557 pharmaceutical product Drugs 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000004043 oxo group Chemical group O=* 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 2
- 125000006168 tricyclic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- YXKFWFPIHMMZAG-UHFFFAOYSA-N 1h-pyridazine-4,6-dione Chemical compound O=C1CC(=O)C=NN1 YXKFWFPIHMMZAG-UHFFFAOYSA-N 0.000 description 88
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 59
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 16
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 9
- 125000001207 fluorophenyl group Chemical group 0.000 description 7
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical compound O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 description 6
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 5
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 125000004438 haloalkoxy group Chemical group 0.000 description 3
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 2
- WLACIDDVHYDQPV-UHFFFAOYSA-N diazepine-3,5-dione Chemical compound O=C1CC(=O)N=NC=C1 WLACIDDVHYDQPV-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- MXAJVDHGJCYEKL-UHFFFAOYSA-N morpholine-3,5-dione Chemical compound O=C1COCC(=O)N1 MXAJVDHGJCYEKL-UHFFFAOYSA-N 0.000 description 2
- VUAXHMVRKOTJKP-UHFFFAOYSA-M 2,2-dimethylbutanoate Chemical compound CCC(C)(C)C([O-])=O VUAXHMVRKOTJKP-UHFFFAOYSA-M 0.000 description 1
- ZTQYWRVLLZGFFB-UHFFFAOYSA-N 2-pyridazin-4-ylacetic acid Chemical compound OC(=O)CC1=CC=NN=C1 ZTQYWRVLLZGFFB-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- QGSVQSWRNLBJKI-UHFFFAOYSA-N C(C(C)C)(=O)OC1=CN=NC=C1 Chemical compound C(C(C)C)(=O)OC1=CN=NC=C1 QGSVQSWRNLBJKI-UHFFFAOYSA-N 0.000 description 1
- HMYWBBFPSYYQNB-UHFFFAOYSA-N CN(C)C(OC1=CN=NC=C1)=O Chemical compound CN(C)C(OC1=CN=NC=C1)=O HMYWBBFPSYYQNB-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229940126523 co-drug Drugs 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- CEMZBWPSKYISTN-YFKPBYRVSA-N methyl (2s)-2-amino-3-methylbutanoate Chemical compound COC(=O)[C@@H](N)C(C)C CEMZBWPSKYISTN-YFKPBYRVSA-N 0.000 description 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022186394A JP2023027102A (ja) | 2016-08-29 | 2022-11-22 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
| JP2025009843A JP2025081322A (ja) | 2016-08-29 | 2025-01-23 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380712P | 2016-08-29 | 2016-08-29 | |
| US62/380,712 | 2016-08-29 | ||
| PCT/IB2017/055137 WO2018042303A1 (en) | 2016-08-29 | 2017-08-25 | Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022186394A Division JP2023027102A (ja) | 2016-08-29 | 2022-11-22 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532033A JP2019532033A (ja) | 2019-11-07 |
| JP2019532033A5 true JP2019532033A5 (enExample) | 2020-10-01 |
| JP7221861B2 JP7221861B2 (ja) | 2023-02-14 |
Family
ID=59923494
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511749A Active JP7221861B2 (ja) | 2016-08-29 | 2017-08-25 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
| JP2022186394A Withdrawn JP2023027102A (ja) | 2016-08-29 | 2022-11-22 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
| JP2025009843A Pending JP2025081322A (ja) | 2016-08-29 | 2025-01-23 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022186394A Withdrawn JP2023027102A (ja) | 2016-08-29 | 2022-11-22 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
| JP2025009843A Pending JP2025081322A (ja) | 2016-08-29 | 2025-01-23 | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10160764B2 (enExample) |
| EP (4) | EP4356969B1 (enExample) |
| JP (3) | JP7221861B2 (enExample) |
| CN (2) | CN109863151B (enExample) |
| AR (1) | AR109438A1 (enExample) |
| CA (1) | CA3035302A1 (enExample) |
| DK (1) | DK4356969T3 (enExample) |
| ES (3) | ES2859510T3 (enExample) |
| FI (1) | FI4356969T3 (enExample) |
| HR (1) | HRP20250885T1 (enExample) |
| HU (1) | HUE072776T2 (enExample) |
| JO (1) | JOP20170169A1 (enExample) |
| LT (1) | LT4356969T (enExample) |
| MX (1) | MX383124B (enExample) |
| PL (3) | PL3504214T3 (enExample) |
| PT (3) | PT4356969T (enExample) |
| SI (3) | SI3504214T1 (enExample) |
| TW (3) | TW202517646A (enExample) |
| UY (2) | UY40872A (enExample) |
| WO (1) | WO2018042303A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102323515B1 (ko) * | 2013-09-12 | 2021-11-05 | 얀센 바이오파마, 인코퍼레이트. | 아자-피리돈 화합물 및 이의 용도 |
| JP6323860B2 (ja) | 2015-12-15 | 2018-05-16 | 塩野義製薬株式会社 | キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬 |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| AU2017310774B2 (en) | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| CN111848616B (zh) | 2018-01-17 | 2021-11-23 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及其用于制备抗流感病毒药物的用途 |
| EA202091696A1 (ru) * | 2018-02-28 | 2021-01-27 | Новартис Аг | ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА |
| CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
| KR20210074329A (ko) * | 2018-10-10 | 2021-06-21 | 얀센 바이오파마, 인코퍼레이트. | 매크로사이클릭 플루 엔도뉴클레아제 억제제 |
| CN111909174B (zh) | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| WO2022105669A1 (zh) * | 2020-11-17 | 2022-05-27 | 南京明德新药研发有限公司 | 含Se大环类化合物 |
| WO2024228401A1 (ja) * | 2023-05-02 | 2024-11-07 | 国立大学法人 大分大学 | 新型コロナウイルス感染症の処置または予防用医薬としての置換三環式複素環化合物 |
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| US2225112A (en) | 1938-07-09 | 1940-12-17 | Wright Aeronautical Corp | Air cleaner |
| GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
| AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| DK3042894T1 (da) | 2001-08-10 | 2016-11-07 | Shionogi & Co | Antiviralt middel |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| CA2557926A1 (en) | 2004-03-09 | 2005-09-22 | Monica Donghi | Hiv integrase inhibitors |
| FR2901795A1 (fr) | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| MX2011004636A (es) | 2008-10-31 | 2011-06-20 | Shionogi & Co | Cefarosporinas que tienen un grupo catecol. |
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| WO2010110231A1 (ja) | 2009-03-26 | 2010-09-30 | 塩野義製薬株式会社 | 置換された３－ヒドロキシ－４－ピリドン誘導体 |
| DK2444400T3 (en) | 2009-06-15 | 2018-06-18 | Shionogi & Co | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE |
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| WO2012151567A1 (en) | 2011-05-05 | 2012-11-08 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
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| PE20151722A1 (es) | 2013-01-08 | 2015-11-19 | European Molecular Biology Lab Embl | Derivados de pirimidona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral |
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| KR102323515B1 (ko) | 2013-09-12 | 2021-11-05 | 얀센 바이오파마, 인코퍼레이트. | 아자-피리돈 화합물 및 이의 용도 |
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| JP2017521424A (ja) | 2014-07-07 | 2017-08-03 | ザヴィラ ファーマシューティカルズ ゲーエムベーハー | ウイルス疾患の治療、改善又は予防におけるジヒドロピリドピラジン−１，８−ジオン及びそれらの使用 |
| EA036776B1 (ru) | 2015-03-11 | 2020-12-21 | Янссен Байофарма, Инк. | Соединения азапиридона и способы их применения |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
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| BR112018077136A2 (pt) | 2016-07-01 | 2019-04-30 | G1 Therapeutics, Inc. | composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis. |
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| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| JP2019059697A (ja) * | 2017-09-28 | 2019-04-18 | 塩野義製薬株式会社 | 置換された多環性ピリダジン誘導体およびそのプロドラッグ |
| CN111848616B (zh) | 2018-01-17 | 2021-11-23 | 江西彩石医药科技有限公司 | 吡啶酮衍生物及其用于制备抗流感病毒药物的用途 |
| CN110041327B (zh) | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
| RU2020131405A (ru) | 2018-02-28 | 2022-03-24 | Джапан Тобакко Инк. | Сконденсированные с насыщенным кольцом дигидропиримидиноновые или дигидротриазиноновые соединения и их применение в фармацевтике |
| EA202091696A1 (ru) | 2018-02-28 | 2021-01-27 | Новартис Аг | ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА |
| WO2019166432A1 (en) | 2018-02-28 | 2019-09-06 | F. Hoffmann-La Roche Ag | 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer |
| SG11202007117RA (en) | 2018-02-28 | 2020-08-28 | Japan Tobacco Inc | 4-methyldihydropyrimidinone compounds and pharmaceutical use thereof |
-
2017
- 2017-08-24 JO JOP/2017/0169A patent/JOP20170169A1/ar unknown
- 2017-08-25 SI SI201730650T patent/SI3504214T1/sl unknown
- 2017-08-25 PT PT232173054T patent/PT4356969T/pt unknown
- 2017-08-25 CN CN201780065653.XA patent/CN109863151B/zh active Active
- 2017-08-25 EP EP23217305.4A patent/EP4356969B1/en active Active
- 2017-08-25 CA CA3035302A patent/CA3035302A1/en active Pending
- 2017-08-25 EP EP25187556.3A patent/EP4640279A3/en active Pending
- 2017-08-25 DK DK23217305.4T patent/DK4356969T3/da active
- 2017-08-25 EP EP20210329.7A patent/EP3848372B1/en active Active
- 2017-08-25 MX MX2019002438A patent/MX383124B/es unknown
- 2017-08-25 US US15/686,652 patent/US10160764B2/en active Active
- 2017-08-25 PL PL17771587T patent/PL3504214T3/pl unknown
- 2017-08-25 PL PL23217305.4T patent/PL4356969T3/pl unknown
- 2017-08-25 ES ES17771587T patent/ES2859510T3/es active Active
- 2017-08-25 FI FIEP23217305.4T patent/FI4356969T3/fi active
- 2017-08-25 ES ES23217305T patent/ES3042460T3/es active Active
- 2017-08-25 SI SI201731620T patent/SI4356969T1/sl unknown
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- 2017-08-25 JP JP2019511749A patent/JP7221861B2/ja active Active
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- 2017-08-25 WO PCT/IB2017/055137 patent/WO2018042303A1/en not_active Ceased
- 2017-08-25 EP EP17771587.7A patent/EP3504214B1/en active Active
- 2017-08-25 PL PL20210329.7T patent/PL3848372T3/pl unknown
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