HUE072776T2 - Ortomixovírus-fertõzések kezelésére alkalmas kondenzált triciklusos piridazinon vegyületek - Google Patents

Ortomixovírus-fertõzések kezelésére alkalmas kondenzált triciklusos piridazinon vegyületek

Info

Publication number
HUE072776T2
HUE072776T2 HUE23217305A HUE23217305A HUE072776T2 HU E072776 T2 HUE072776 T2 HU E072776T2 HU E23217305 A HUE23217305 A HU E23217305A HU E23217305 A HUE23217305 A HU E23217305A HU E072776 T2 HUE072776 T2 HU E072776T2
Authority
HU
Hungary
Prior art keywords
compounds useful
fused tricyclic
pyridazinone compounds
treat
orthomyxovirus infections
Prior art date
Application number
HUE23217305A
Other languages
English (en)
Hungarian (hu)
Inventor
Rama Jain
Dennis Christofer Koester
James R Manning
Vanessa Marx
Daniel Poon
James Clifford Sutton
Benjamin R Taft
Lifeng Wan
Aregahegn Yifru
Qian Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HUE072776T2 publication Critical patent/HUE072776T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE23217305A 2016-08-29 2017-08-25 Ortomixovírus-fertõzések kezelésére alkalmas kondenzált triciklusos piridazinon vegyületek HUE072776T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29

Publications (1)

Publication Number Publication Date
HUE072776T2 true HUE072776T2 (hu) 2025-12-28

Family

ID=59923494

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE23217305A HUE072776T2 (hu) 2016-08-29 2017-08-25 Ortomixovírus-fertõzések kezelésére alkalmas kondenzált triciklusos piridazinon vegyületek

Country Status (20)

Country Link
US (4) US11098051B2 (enExample)
EP (4) EP4356969B1 (enExample)
JP (3) JP7221861B2 (enExample)
CN (2) CN109863151B (enExample)
AR (1) AR109438A1 (enExample)
CA (1) CA3035302A1 (enExample)
DK (1) DK4356969T3 (enExample)
ES (3) ES2974494T3 (enExample)
FI (1) FI4356969T3 (enExample)
HR (1) HRP20250885T1 (enExample)
HU (1) HUE072776T2 (enExample)
JO (1) JOP20170169A1 (enExample)
LT (1) LT4356969T (enExample)
MX (1) MX383124B (enExample)
PL (3) PL4356969T3 (enExample)
PT (3) PT3504214T (enExample)
SI (3) SI3504214T1 (enExample)
TW (3) TWI869757B (enExample)
UY (2) UY37378A (enExample)
WO (1) WO2018042303A1 (enExample)

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JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
CN111848615B (zh) 2018-01-17 2022-05-17 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
HUE069183T2 (hu) * 2018-02-28 2025-02-28 Novartis Ag 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7H--pirrolo[1',2':4,5]pirazino[1,2-b]piridazin-3,5-dion származékok és kapcsolódó vegyületek mint orthomyxovírus repikáció gátlók influenza kezelésére
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康(无锡)生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药
TW202035424A (zh) * 2018-10-10 2020-10-01 美商健生生物製藥公司 大環流感內切核酸酶抑制劑
CN111909174B (zh) 2019-05-08 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物的晶型及制备方法和应用
CN115135646B (zh) * 2019-12-23 2024-05-17 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
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WO2022105669A1 (zh) * 2020-11-17 2022-05-27 南京明德新药研发有限公司 含Se大环类化合物
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HUE069183T2 (hu) 2018-02-28 2025-02-28 Novartis Ag 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7H--pirrolo[1',2':4,5]pirazino[1,2-b]piridazin-3,5-dion származékok és kapcsolódó vegyületek mint orthomyxovírus repikáció gátlók influenza kezelésére

Also Published As

Publication number Publication date
PT4356969T (pt) 2025-10-02
LT4356969T (lt) 2025-09-10
ES3042460T3 (en) 2025-11-20
EP4356969B1 (en) 2025-07-09
US20220041610A1 (en) 2022-02-10
JP2023027102A (ja) 2023-03-01
HRP20250885T1 (hr) 2025-09-26
US11912715B2 (en) 2024-02-27
US20250011334A1 (en) 2025-01-09
JP7221861B2 (ja) 2023-02-14
US11098051B2 (en) 2021-08-24
TWI803467B (zh) 2023-06-01
MX2019002438A (es) 2019-07-08
TW201811800A (zh) 2018-04-01
ES2859510T3 (es) 2021-10-04
JOP20170169A1 (ar) 2019-01-30
SI3504214T1 (sl) 2021-04-30
UY40872A (es) 2024-09-13
UY37378A (es) 2018-03-23
EP4640279A2 (en) 2025-10-29
EP4640279A3 (en) 2025-12-24
TW202342482A (zh) 2023-11-01
DK4356969T3 (da) 2025-08-18
US20200123167A1 (en) 2020-04-23
PL3848372T3 (pl) 2024-04-22
EP3504214B1 (en) 2020-12-02
AR109438A1 (es) 2018-11-28
EP3504214A1 (en) 2019-07-03
US20180057501A1 (en) 2018-03-01
TW202517646A (zh) 2025-05-01
EP4356969A2 (en) 2024-04-24
CN109863151A (zh) 2019-06-07
FI4356969T3 (fi) 2025-08-15
PL4356969T3 (pl) 2025-10-20
CN113683614A (zh) 2021-11-23
PL3504214T3 (pl) 2021-07-19
JP2025081322A (ja) 2025-05-27
WO2018042303A1 (en) 2018-03-08
PT3504214T (pt) 2021-03-04
EP3848372A1 (en) 2021-07-14
US10160764B2 (en) 2018-12-25
SI4356969T1 (sl) 2025-10-30
CN113683614B (zh) 2024-11-08
TWI869757B (zh) 2025-01-11
JP2019532033A (ja) 2019-11-07
EP4356969A3 (en) 2024-05-22
EP3848372B1 (en) 2023-12-20
SI3848372T1 (sl) 2024-04-30
CA3035302A1 (en) 2018-03-08
ES2974494T3 (es) 2024-06-27
CN109863151B (zh) 2021-09-10
PT3848372T (pt) 2024-03-22
MX383124B (es) 2025-03-13

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