JOP20170169A1 - مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو - Google Patents

مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو

Info

Publication number
JOP20170169A1
JOP20170169A1 JOP/2017/0169A JOP20170169A JOP20170169A1 JO P20170169 A1 JOP20170169 A1 JO P20170169A1 JO P20170169 A JOP20170169 A JO P20170169A JO P20170169 A1 JOP20170169 A1 JO P20170169A1
Authority
JO
Jordan
Prior art keywords
compounds useful
fused tricyclic
pyridazinone compounds
treat
orthomyxovirus infections
Prior art date
Application number
JOP/2017/0169A
Other languages
Arabic (ar)
English (en)
Inventor
Clifford Sutton James
Jain Rama
Christofer Koester Dennis
R Manning James
Marx Vanessa
Poon Daniel
R Taft Benjamin
Zhao Qian
Wan Lifeng
Yifru Aregahegn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of JOP20170169A1 publication Critical patent/JOP20170169A1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JOP/2017/0169A 2016-08-29 2017-08-24 مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو JOP20170169A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29

Publications (1)

Publication Number Publication Date
JOP20170169A1 true JOP20170169A1 (ar) 2019-01-30

Family

ID=59923494

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2017/0169A JOP20170169A1 (ar) 2016-08-29 2017-08-24 مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو

Country Status (20)

Country Link
US (4) US10160764B2 (enExample)
EP (4) EP4356969B1 (enExample)
JP (3) JP7221861B2 (enExample)
CN (2) CN109863151B (enExample)
AR (1) AR109438A1 (enExample)
CA (1) CA3035302A1 (enExample)
DK (1) DK4356969T3 (enExample)
ES (3) ES2859510T3 (enExample)
FI (1) FI4356969T3 (enExample)
HR (1) HRP20250885T1 (enExample)
HU (1) HUE072776T2 (enExample)
JO (1) JOP20170169A1 (enExample)
LT (1) LT4356969T (enExample)
MX (1) MX383124B (enExample)
PL (3) PL3504214T3 (enExample)
PT (3) PT4356969T (enExample)
SI (3) SI3504214T1 (enExample)
TW (3) TW202517646A (enExample)
UY (2) UY40872A (enExample)
WO (1) WO2018042303A1 (enExample)

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LT4356969T (lt) 2025-09-10
EP3504214A1 (en) 2019-07-03
EP4640279A3 (en) 2025-12-24
US11912715B2 (en) 2024-02-27
US20200123167A1 (en) 2020-04-23
PL3504214T3 (pl) 2021-07-19
SI3848372T1 (sl) 2024-04-30
CN113683614B (zh) 2024-11-08
PL4356969T3 (pl) 2025-10-20
EP4356969B1 (en) 2025-07-09
EP3848372A1 (en) 2021-07-14
TWI869757B (zh) 2025-01-11
HUE072776T2 (hu) 2025-12-28
UY40872A (es) 2024-09-13
MX383124B (es) 2025-03-13
JP2023027102A (ja) 2023-03-01
PT3848372T (pt) 2024-03-22
CN109863151B (zh) 2021-09-10
EP4356969A3 (en) 2024-05-22
EP3848372B1 (en) 2023-12-20
ES2859510T3 (es) 2021-10-04
JP7221861B2 (ja) 2023-02-14
PT4356969T (pt) 2025-10-02
JP2019532033A (ja) 2019-11-07
HRP20250885T1 (hr) 2025-09-26
MX2019002438A (es) 2019-07-08
TW202342482A (zh) 2023-11-01
US20250011334A1 (en) 2025-01-09
TW202517646A (zh) 2025-05-01
AR109438A1 (es) 2018-11-28
US20220041610A1 (en) 2022-02-10
JP2025081322A (ja) 2025-05-27
EP4640279A2 (en) 2025-10-29
US20180057501A1 (en) 2018-03-01
UY37378A (es) 2018-03-23
FI4356969T3 (fi) 2025-08-15
SI4356969T1 (sl) 2025-10-30
WO2018042303A1 (en) 2018-03-08
ES2974494T3 (es) 2024-06-27
TWI803467B (zh) 2023-06-01
EP4356969A2 (en) 2024-04-24
SI3504214T1 (sl) 2021-04-30
EP3504214B1 (en) 2020-12-02
PL3848372T3 (pl) 2024-04-22
CA3035302A1 (en) 2018-03-08
TW201811800A (zh) 2018-04-01
CN109863151A (zh) 2019-06-07
CN113683614A (zh) 2021-11-23
PT3504214T (pt) 2021-03-04
ES3042460T3 (en) 2025-11-20
US11098051B2 (en) 2021-08-24
US10160764B2 (en) 2018-12-25
DK4356969T3 (da) 2025-08-18

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