PL4356969T3 - Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami - Google Patents

Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami

Info

Publication number
PL4356969T3
PL4356969T3 PL23217305.4T PL23217305T PL4356969T3 PL 4356969 T3 PL4356969 T3 PL 4356969T3 PL 23217305 T PL23217305 T PL 23217305T PL 4356969 T3 PL4356969 T3 PL 4356969T3
Authority
PL
Poland
Prior art keywords
orthomyxoviral
infections
treatment
compounds useful
pyridazinone compounds
Prior art date
Application number
PL23217305.4T
Other languages
English (en)
Inventor
Rama Jain
Dennis Christofer KOESTER
James R. MANNING
Vanessa Marx
Daniel Poon
James Clifford Sutton
Benjamin R. TAFT
Lifeng Wan
Aregahegn Yifru
Qian Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL4356969T3 publication Critical patent/PL4356969T3/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL23217305.4T 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami PL4356969T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29

Publications (1)

Publication Number Publication Date
PL4356969T3 true PL4356969T3 (pl) 2025-10-20

Family

ID=59923494

Family Applications (3)

Application Number Title Priority Date Filing Date
PL17771587T PL3504214T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami
PL23217305.4T PL4356969T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami
PL20210329.7T PL3848372T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami

Family Applications Before (1)

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PL17771587T PL3504214T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami

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Country Status (20)

Country Link
US (4) US10160764B2 (pl)
EP (4) EP4356969B1 (pl)
JP (3) JP7221861B2 (pl)
CN (2) CN109863151B (pl)
AR (1) AR109438A1 (pl)
CA (1) CA3035302A1 (pl)
DK (1) DK4356969T3 (pl)
ES (3) ES2859510T3 (pl)
FI (1) FI4356969T3 (pl)
HR (1) HRP20250885T1 (pl)
HU (1) HUE072776T2 (pl)
JO (1) JOP20170169A1 (pl)
LT (1) LT4356969T (pl)
MX (1) MX383124B (pl)
PL (3) PL3504214T3 (pl)
PT (3) PT4356969T (pl)
SI (3) SI3504214T1 (pl)
TW (3) TW202517646A (pl)
UY (2) UY40872A (pl)
WO (1) WO2018042303A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102323515B1 (ko) * 2013-09-12 2021-11-05 얀센 바이오파마, 인코퍼레이트. 아자-피리돈 화합물 및 이의 용도
JP6323860B2 (ja) 2015-12-15 2018-05-16 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
AU2017310774B2 (en) 2016-08-10 2023-01-19 Shionogi & Co., Ltd. Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof
JOP20170169A1 (ar) * 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
CN111848616B (zh) 2018-01-17 2021-11-23 江西彩石医药科技有限公司 吡啶酮衍生物及其用于制备抗流感病毒药物的用途
EA202091696A1 (ru) * 2018-02-28 2021-01-27 Новартис Аг ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康(无锡)生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药
KR20210074329A (ko) * 2018-10-10 2021-06-21 얀센 바이오파마, 인코퍼레이트. 매크로사이클릭 플루 엔도뉴클레아제 억제제
CN111909174B (zh) 2019-05-08 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物的晶型及制备方法和应用
WO2021129602A1 (zh) * 2019-12-23 2021-07-01 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
WO2022105669A1 (zh) * 2020-11-17 2022-05-27 南京明德新药研发有限公司 含Se大环类化合物
WO2024228401A1 (ja) * 2023-05-02 2024-11-07 国立大学法人 大分大学 新型コロナウイルス感染症の処置または予防用医薬としての置換三環式複素環化合物

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2225112A (en) 1938-07-09 1940-12-17 Wright Aeronautical Corp Air cleaner
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
AUPM354694A0 (en) 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
DK3042894T1 (da) 2001-08-10 2016-11-07 Shionogi & Co Antiviralt middel
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CA2557926A1 (en) 2004-03-09 2005-09-22 Monica Donghi Hiv integrase inhibitors
FR2901795A1 (fr) 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
MX2011004636A (es) 2008-10-31 2011-06-20 Shionogi & Co Cefarosporinas que tienen un grupo catecol.
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
WO2010110231A1 (ja) 2009-03-26 2010-09-30 塩野義製薬株式会社 置換された3-ヒドロキシ-4-ピリドン誘導体
DK2444400T3 (en) 2009-06-15 2018-06-18 Shionogi & Co SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
CA2783258A1 (en) 2009-12-23 2011-06-30 Elan Pharmaceuticals, Inc. Pteridinones as inhibitors of polo-like kinase
US8541407B2 (en) 2010-03-31 2013-09-24 Arqule, Inc. Substituted benzo-pyrido-triazolo-diazepine compounds
US20120195857A1 (en) 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
CA2812363C (en) 2010-09-24 2019-04-02 Shionogi & Co., Ltd. Substituted polycyclic carbamoyl pyridone derivative prodrug
WO2012151567A1 (en) 2011-05-05 2012-11-08 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for preventing and treating influenza
CA2851218A1 (en) 2011-10-12 2013-04-18 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
ES2604766T3 (es) 2012-09-20 2017-03-09 Celltrion, Inc. Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo
PE20151722A1 (es) 2013-01-08 2015-11-19 European Molecular Biology Lab Embl Derivados de pirimidona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral
PH12021550330A1 (en) 2013-08-21 2022-09-28 Janssen Biopharma Inc Antiviral compounds
WO2015038665A1 (en) 2013-09-11 2015-03-19 University Of Southern California A composition of stem cells having highly expressed fas ligand
KR102323515B1 (ko) 2013-09-12 2021-11-05 얀센 바이오파마, 인코퍼레이트. 아자-피리돈 화합물 및 이의 용도
LT3030549T (lt) 2013-09-12 2019-06-25 Janssen Biopharma, Inc. Piridazinono junginiai ir jų panaudojimas
JP2017521424A (ja) 2014-07-07 2017-08-03 ザヴィラ ファーマシューティカルズ ゲーエムベーハー ウイルス疾患の治療、改善又は予防におけるジヒドロピリドピラジン−1,8−ジオン及びそれらの使用
EA036776B1 (ru) 2015-03-11 2020-12-21 Янссен Байофарма, Инк. Соединения азапиридона и способы их применения
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
WO2017156407A1 (en) 2016-03-10 2017-09-14 Alios Biopharma, Inc. Method of preparing aza-pyridone compounds
BR112018077136A2 (pt) 2016-07-01 2019-04-30 G1 Therapeutics, Inc. composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis.
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
AU2017310774B2 (en) 2016-08-10 2023-01-19 Shionogi & Co., Ltd. Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof
JOP20170169A1 (ar) * 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
JP2019059697A (ja) * 2017-09-28 2019-04-18 塩野義製薬株式会社 置換された多環性ピリダジン誘導体およびそのプロドラッグ
CN111848616B (zh) 2018-01-17 2021-11-23 江西彩石医药科技有限公司 吡啶酮衍生物及其用于制备抗流感病毒药物的用途
CN110041327B (zh) 2018-01-17 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
RU2020131405A (ru) 2018-02-28 2022-03-24 Джапан Тобакко Инк. Сконденсированные с насыщенным кольцом дигидропиримидиноновые или дигидротриазиноновые соединения и их применение в фармацевтике
EA202091696A1 (ru) 2018-02-28 2021-01-27 Новартис Аг ПРОИЗВОДНЫЕ 10-(ДИ(ФЕНИЛ)МЕТИЛ)-4-ГИДРОКСИ-8,9,9a,10-ТЕТРАГИДРО-7H-ПИРРОЛО[1',2':4,5]ПИРАЗИНО[1,2-b]ПИРИДАЗИН-3,5-ДИОНА И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ РЕПЛИКАЦИИ ОРТОМИКСОВИРУСА ДЛЯ ЛЕЧЕНИЯ ГРИППА
WO2019166432A1 (en) 2018-02-28 2019-09-06 F. Hoffmann-La Roche Ag 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer
SG11202007117RA (en) 2018-02-28 2020-08-28 Japan Tobacco Inc 4-methyldihydropyrimidinone compounds and pharmaceutical use thereof

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Publication number Publication date
LT4356969T (lt) 2025-09-10
EP3504214A1 (en) 2019-07-03
EP4640279A3 (en) 2025-12-24
US11912715B2 (en) 2024-02-27
JOP20170169A1 (ar) 2019-01-30
US20200123167A1 (en) 2020-04-23
PL3504214T3 (pl) 2021-07-19
SI3848372T1 (sl) 2024-04-30
CN113683614B (zh) 2024-11-08
EP4356969B1 (en) 2025-07-09
EP3848372A1 (en) 2021-07-14
TWI869757B (zh) 2025-01-11
HUE072776T2 (hu) 2025-12-28
UY40872A (es) 2024-09-13
MX383124B (es) 2025-03-13
JP2023027102A (ja) 2023-03-01
PT3848372T (pt) 2024-03-22
CN109863151B (zh) 2021-09-10
EP4356969A3 (en) 2024-05-22
EP3848372B1 (en) 2023-12-20
ES2859510T3 (es) 2021-10-04
JP7221861B2 (ja) 2023-02-14
PT4356969T (pt) 2025-10-02
JP2019532033A (ja) 2019-11-07
HRP20250885T1 (hr) 2025-09-26
MX2019002438A (es) 2019-07-08
TW202342482A (zh) 2023-11-01
US20250011334A1 (en) 2025-01-09
TW202517646A (zh) 2025-05-01
AR109438A1 (es) 2018-11-28
US20220041610A1 (en) 2022-02-10
JP2025081322A (ja) 2025-05-27
EP4640279A2 (en) 2025-10-29
US20180057501A1 (en) 2018-03-01
UY37378A (es) 2018-03-23
FI4356969T3 (fi) 2025-08-15
SI4356969T1 (sl) 2025-10-30
WO2018042303A1 (en) 2018-03-08
ES2974494T3 (es) 2024-06-27
TWI803467B (zh) 2023-06-01
EP4356969A2 (en) 2024-04-24
SI3504214T1 (sl) 2021-04-30
EP3504214B1 (en) 2020-12-02
PL3848372T3 (pl) 2024-04-22
CA3035302A1 (en) 2018-03-08
TW201811800A (zh) 2018-04-01
CN109863151A (zh) 2019-06-07
CN113683614A (zh) 2021-11-23
PT3504214T (pt) 2021-03-04
ES3042460T3 (en) 2025-11-20
US11098051B2 (en) 2021-08-24
US10160764B2 (en) 2018-12-25
DK4356969T3 (da) 2025-08-18

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