CA3035302A1 - Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections - Google Patents

Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections Download PDF

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Publication number
CA3035302A1
CA3035302A1 CA3035302A CA3035302A CA3035302A1 CA 3035302 A1 CA3035302 A1 CA 3035302A1 CA 3035302 A CA3035302 A CA 3035302A CA 3035302 A CA3035302 A CA 3035302A CA 3035302 A1 CA3035302 A1 CA 3035302A1
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CA
Canada
Prior art keywords
methyl
hydroxy
dione
tetrahydro
pyrazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3035302A
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English (en)
French (fr)
Inventor
Rama Jain
Dennis Christofer KOESTER
James R. MANNING
Vanessa Marx
Daniel Poon
James Clifford Sutton
Benjamin R. TAFT
Lifeng Wan
Aregahegn Yifru
Qian Zhao
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Novartis AG
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Novartis AG
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Publication of CA3035302A1 publication Critical patent/CA3035302A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3035302A 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections Pending CA3035302A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29
US62/380,712 2016-08-29
PCT/IB2017/055137 WO2018042303A1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Publications (1)

Publication Number Publication Date
CA3035302A1 true CA3035302A1 (en) 2018-03-08

Family

ID=59923494

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3035302A Pending CA3035302A1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

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EP (4) EP4356969B1 (enExample)
JP (3) JP7221861B2 (enExample)
CN (2) CN109863151B (enExample)
AR (1) AR109438A1 (enExample)
CA (1) CA3035302A1 (enExample)
DK (1) DK4356969T3 (enExample)
ES (3) ES2859510T3 (enExample)
FI (1) FI4356969T3 (enExample)
HR (1) HRP20250885T1 (enExample)
HU (1) HUE072776T2 (enExample)
JO (1) JOP20170169A1 (enExample)
LT (1) LT4356969T (enExample)
MX (1) MX383124B (enExample)
PL (3) PL3504214T3 (enExample)
PT (3) PT4356969T (enExample)
SI (3) SI3504214T1 (enExample)
TW (3) TW202517646A (enExample)
UY (2) UY40872A (enExample)
WO (1) WO2018042303A1 (enExample)

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LT4356969T (lt) 2025-09-10
EP3504214A1 (en) 2019-07-03
EP4640279A3 (en) 2025-12-24
US11912715B2 (en) 2024-02-27
JOP20170169A1 (ar) 2019-01-30
US20200123167A1 (en) 2020-04-23
PL3504214T3 (pl) 2021-07-19
SI3848372T1 (sl) 2024-04-30
CN113683614B (zh) 2024-11-08
PL4356969T3 (pl) 2025-10-20
EP4356969B1 (en) 2025-07-09
EP3848372A1 (en) 2021-07-14
TWI869757B (zh) 2025-01-11
HUE072776T2 (hu) 2025-12-28
UY40872A (es) 2024-09-13
MX383124B (es) 2025-03-13
JP2023027102A (ja) 2023-03-01
PT3848372T (pt) 2024-03-22
CN109863151B (zh) 2021-09-10
EP4356969A3 (en) 2024-05-22
EP3848372B1 (en) 2023-12-20
ES2859510T3 (es) 2021-10-04
JP7221861B2 (ja) 2023-02-14
PT4356969T (pt) 2025-10-02
JP2019532033A (ja) 2019-11-07
HRP20250885T1 (hr) 2025-09-26
MX2019002438A (es) 2019-07-08
TW202342482A (zh) 2023-11-01
US20250011334A1 (en) 2025-01-09
TW202517646A (zh) 2025-05-01
AR109438A1 (es) 2018-11-28
US20220041610A1 (en) 2022-02-10
JP2025081322A (ja) 2025-05-27
EP4640279A2 (en) 2025-10-29
US20180057501A1 (en) 2018-03-01
UY37378A (es) 2018-03-23
FI4356969T3 (fi) 2025-08-15
SI4356969T1 (sl) 2025-10-30
WO2018042303A1 (en) 2018-03-08
ES2974494T3 (es) 2024-06-27
TWI803467B (zh) 2023-06-01
EP4356969A2 (en) 2024-04-24
SI3504214T1 (sl) 2021-04-30
EP3504214B1 (en) 2020-12-02
PL3848372T3 (pl) 2024-04-22
TW201811800A (zh) 2018-04-01
CN109863151A (zh) 2019-06-07
CN113683614A (zh) 2021-11-23
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