EA201791530A1 - НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ - Google Patents

НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ

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Publication number
EA201791530A1
EA201791530A1 EA201791530A EA201791530A EA201791530A1 EA 201791530 A1 EA201791530 A1 EA 201791530A1 EA 201791530 A EA201791530 A EA 201791530A EA 201791530 A EA201791530 A EA 201791530A EA 201791530 A1 EA201791530 A1 EA 201791530A1
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Eurasian Patent Office
Prior art keywords
inhibitors
new
aminoacyl
trna
synthetasis
Prior art date
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EA201791530A
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English (en)
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EA036995B1 (ru
Inventor
Айгарс Йиргенсонс
Эйнарс Лоза
Майкл Чарльтон
Пол Уильям Финн
Де Поуплана Луис Рибас
Аделаида Сен-Леже
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Оксфорд Драг Дизайн Лимитед
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Priority claimed from LVP-15-14A external-priority patent/LV15146B/lv
Priority claimed from LVP-16-06A external-priority patent/LV15257A/lv
Application filed by Оксфорд Драг Дизайн Лимитед filed Critical Оксфорд Драг Дизайн Лимитед
Publication of EA201791530A1 publication Critical patent/EA201791530A1/ru
Publication of EA036995B1 publication Critical patent/EA036995B1/ru

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Abstract

Изобретение относится к новым N-ацилдиарисульфонамидам, выступающим в качестве ингибиторов бактериальной аминоацил-тРНК синтетазы. Указанные соединения можно применять в качестве лекарственных средств или в составе лекарственных средств для лечения бактериальных инфекций.
EA201791530A 2015-02-13 2016-02-11 НОВЫЕ N-АЦИЛАРИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ АМИНОАЦИЛ-тРНК СИНТЕТАЗЫ EA036995B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LVP-15-14A LV15146B (lv) 2015-02-13 2015-02-13 N-acil-diarilsulfonamīda atvasinājumi kā aminoacil-t-RNS sintetāžu inhibitori
LVP-16-06A LV15257A (lv) 2016-02-10 2016-02-10 Jauni N-acil-arilsulfonamīda atvasinājumi kā aminoacil-tRNS sintetāzes inhibitori
PCT/LV2016/000001 WO2016129983A1 (en) 2015-02-13 2016-02-11 Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors

Publications (2)

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EA201791530A1 true EA201791530A1 (ru) 2018-01-31
EA036995B1 EA036995B1 (ru) 2021-01-25

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US (1) US11072581B2 (ru)
EP (1) EP3259250A1 (ru)
JP (1) JP6740256B2 (ru)
KR (1) KR102568859B1 (ru)
CN (1) CN107257789B (ru)
AU (1) AU2016216782C1 (ru)
CA (1) CA2975682A1 (ru)
EA (1) EA036995B1 (ru)
IL (1) IL253886B (ru)
MA (1) MA41542A (ru)
MX (1) MX2017010357A (ru)
NZ (1) NZ735398A (ru)
WO (1) WO2016129983A1 (ru)
ZA (1) ZA201706108B (ru)

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CN107257789B (zh) 2015-02-13 2021-06-29 牛津药物设计有限公司 作为氨酰-trna合成酶抑制剂的新型n-酰基-芳基磺酰胺衍生物
GB201617064D0 (en) * 2016-10-07 2016-11-23 Inhibox Limited And Latvian Institute Of Organic Synthesis The Compounds and their therapeutic use
CN107033093B (zh) * 2017-06-07 2019-09-03 浙江工业大学 N-取代磺酰胺类化合物及其制备方法与应用
TW202120490A (zh) 2019-07-30 2021-06-01 德商拜耳動物保健有限公司 新穎異喹啉衍生物
CN112759542B (zh) * 2019-11-04 2022-04-01 上海现代制药股份有限公司 一种药物中间体及其制备和应用
CN110950863B (zh) * 2019-11-15 2021-04-02 中山大学 一种喹唑啉酮类化合物及其制备方法和应用
AU2020409713A1 (en) * 2019-12-19 2022-06-02 Oxford Drug Design Limited 2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use

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EP3259250A1 (en) 2017-12-27
CN107257789A (zh) 2017-10-17
CA2975682A1 (en) 2016-08-18
JP2018507257A (ja) 2018-03-15
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IL253886B (en) 2020-01-30
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WO2016129983A1 (en) 2016-08-18
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