JP2009509928A5 - - Google Patents

Download PDF

Info

Publication number
JP2009509928A5
JP2009509928A5 JP2008529292A JP2008529292A JP2009509928A5 JP 2009509928 A5 JP2009509928 A5 JP 2009509928A5 JP 2008529292 A JP2008529292 A JP 2008529292A JP 2008529292 A JP2008529292 A JP 2008529292A JP 2009509928 A5 JP2009509928 A5 JP 2009509928A5
Authority
JP
Japan
Prior art keywords
alkyl
group
phenyl
halogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008529292A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009509928A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/034128 external-priority patent/WO2007027959A1/en
Publication of JP2009509928A publication Critical patent/JP2009509928A/ja
Publication of JP2009509928A5 publication Critical patent/JP2009509928A5/ja
Pending legal-status Critical Current

Links

JP2008529292A 2005-09-01 2006-08-30 カリウムチャンネル開口剤としての新規ベンゾピラン誘導体 Pending JP2009509928A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71332305P 2005-09-01 2005-09-01
PCT/US2006/034128 WO2007027959A1 (en) 2005-09-01 2006-08-30 Novel benzopyran derivatives as potassium channel openers

Publications (2)

Publication Number Publication Date
JP2009509928A JP2009509928A (ja) 2009-03-12
JP2009509928A5 true JP2009509928A5 (enExample) 2009-10-01

Family

ID=37401455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008529292A Pending JP2009509928A (ja) 2005-09-01 2006-08-30 カリウムチャンネル開口剤としての新規ベンゾピラン誘導体

Country Status (13)

Country Link
US (1) US7838553B2 (enExample)
EP (1) EP1937669B9 (enExample)
JP (1) JP2009509928A (enExample)
CN (1) CN101296925A (enExample)
AT (1) ATE543813T1 (enExample)
AU (1) AU2006284675A1 (enExample)
CA (1) CA2620894A1 (enExample)
DK (1) DK1937669T3 (enExample)
ES (1) ES2379098T3 (enExample)
PL (1) PL1937669T3 (enExample)
PT (1) PT1937669E (enExample)
SI (1) SI1937669T1 (enExample)
WO (1) WO2007027959A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2620846A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers
CA2816753A1 (en) 2010-11-08 2012-05-18 Lycera Corporation N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases
MX367341B (es) 2012-05-08 2019-08-14 Merck Sharp & Dohme Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades.
MX363350B (es) 2012-05-08 2019-03-20 Merck Sharp & Dohme COMPUESTOS DE SULFONA BICÍCLICA PARA LA INHIBICIÓN DE LA ACTIVIDAD RORgamma Y EL TRATAMIENTO DE ENFERMEDADES.
US9394315B2 (en) 2012-05-08 2016-07-19 Lycera Corporation Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
WO2015095792A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease
US9663502B2 (en) 2013-12-20 2017-05-30 Lycera Corporation 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease
WO2015095795A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
JP2017507950A (ja) 2014-02-27 2017-03-23 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法
US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
WO2016130818A1 (en) 2015-02-11 2016-08-18 Merck Sharp & Dohme Corp. SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
AU2016257997A1 (en) 2015-05-05 2017-11-09 Lycera Corporation Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
AU2016276947A1 (en) 2015-06-11 2017-12-14 Lycera Corporation Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
MX2018005004A (es) 2015-10-27 2018-09-12 Merck Sharp & Dohme Compuestos de indazol substituidos como inhibidores de rorgammat y sus usos.
EP3368535B1 (en) 2015-10-27 2020-12-02 Merck Sharp & Dohme Corp. Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
EP3368516B1 (en) 2015-10-27 2020-07-15 Merck Sharp & Dohme Corp. SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
CN116535379B (zh) * 2023-06-29 2023-09-19 希格生科（深圳）有限公司 化合物及其医药用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH594675A5 (enExample) * 1976-01-30 1978-01-13 Ciba Geigy Ag
DE3579390D1 (de) 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
EP0218373B1 (en) * 1985-09-11 1990-03-07 Beecham Group Plc Chroman derivatives and analogues having antihypertensive activity
DE3726261A1 (de) 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US4971982A (en) 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
DE3732146A1 (de) * 1987-09-24 1989-04-06 Merck Patent Gmbh Azachromanderivate
US5254557A (en) * 1988-05-09 1993-10-19 Beecham Group P.L.C. Compound and treatment
DE3823533A1 (de) 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
DE68921972T2 (de) * 1988-12-13 1995-11-16 Beecham Group Plc Benzopyran und verwandte Verbindungen.
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
DE3922392A1 (de) * 1989-07-07 1991-01-17 Merck Patent Gmbh Chromanderivate
GB8916683D0 (en) 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
US4983612A (en) * 1989-10-05 1991-01-08 American Home Products Corporation Antihypertensive benzopyran derivatives
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
US5171857A (en) * 1990-03-29 1992-12-15 American Home Products Corporation Antihypertensive benzopyran derivatives
GB2242628A (en) 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
US5254578A (en) * 1990-10-24 1993-10-19 Sankyo Company, Limited Benzopyran derivatives having anti-hypertensive and vasodilatory activity and their therapeutic use
US5310932A (en) * 1991-04-15 1994-05-10 E. R. Squibb & Sons, Inc. Chromanyl substituted indole potassium channel openers
US5225566A (en) 1992-05-08 1993-07-06 American Home Products Corporation Indazolanonyl derivative of benzopyran
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US6253627B1 (en) * 2000-06-12 2001-07-03 The United States Of America As Represented By The Secretary Of The Navy Thin-line towed-array force measurement apparatus and method
BRPI0415165A (pt) 2003-10-01 2007-01-09 Adolor Corp composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem
CA2620846A1 (en) * 2005-09-01 2007-03-08 Janssen Pharmaceutica N.V. Benzopyran and pyranopyridine derivatives as potassium channel openers

Similar Documents

Publication Publication Date Title
JP2009509928A5 (enExample)
WO2004074270A3 (en) Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
JP2009538897A5 (enExample)
RU2007119562A (ru) Тетрациклические производные индолов в качестве противовирусных агентов
RU2011116227A (ru) Пиразолопиридиновые производные как ингибиторы надфн-оксидазы
JP2018533611A5 (enExample)
JP2008526999A5 (enExample)
RU2012110246A (ru) Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
JP2014037426A5 (enExample)
CA2492723A1 (en) Novel 2,5-disubstituted pyrimidine derivatives
JP2011509309A5 (enExample)
CA2628131A1 (en) Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods
WO2008147557A3 (en) Heteroaryl substituted thiazoles and their use as antiviral agents
RU2014121205A (ru) Производные азолов
JP2006502119A5 (enExample)
WO2010042684A4 (en) Pyrrolotriazine kinase inhibitors
RU2009123525A (ru) ПРОИЗВОДНЫЕ 5-СУЛЬФАНИЛМЕТИЛ[1,2,4}ТРИАЗОЛ[1,5-а]ПИРИМИДИН-7-ОЛА В КАЧЕСТВЕ АНТАГОНИСТОВ CXCR2
CA2728098A1 (en) Pyrazole-containing tricyclic compounds as_antagonits of an ep1 receptor
JP2013508382A5 (enExample)
JP2015535834A5 (enExample)
RU2007108863A (ru) Производные пиразола для лечения состояний, опосредованных активацией рецептора аденозина а2в или а3
JP2006511446A5 (enExample)
JP2005538111A5 (enExample)
RU2009103300A (ru) Производные 2-бензоилимидазопиридинов, их получение и их применение в терапии
RU2435760C2 (ru) 1н-хиназолин-2,4-дионы