JP2019525914A5 - - Google Patents

Info

Publication number

JP2019525914A5

JP2019525914A5 JP2019500423A JP2019500423A JP2019525914A5 JP 2019525914 A5 JP2019525914 A5 JP 2019525914A5 JP 2019500423 A JP2019500423 A JP 2019500423A JP 2019500423 A JP2019500423 A JP 2019500423A JP 2019525914 A5 JP2019525914 A5 JP 2019525914A5

Authority

JP

Japan

Prior art keywords

seq

composition

stimulant

pbmc

hiv

Prior art date

2017-07-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 37
• 238000000034 method Methods 0.000 claims description 36
• 230000002068 genetic effect Effects 0.000 claims description 24
• 108700011259 MicroRNAs Proteins 0.000 claims description 12
• 239000002679 microRNA Substances 0.000 claims description 12
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 11
• 229960005486 vaccine Drugs 0.000 claims description 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
• 229940033330 HIV vaccine Drugs 0.000 claims description 8
• 230000003612 virological effect Effects 0.000 claims description 8
• 238000012258 culturing Methods 0.000 claims description 7
• 230000002463 transducing effect Effects 0.000 claims description 7
• 108700011778 CCR5 Proteins 0.000 claims description 5
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
• 230000002401 inhibitory effect Effects 0.000 claims description 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 238000010187 selection method Methods 0.000 claims description 4
• 208000031886 HIV Infections Diseases 0.000 claims description 3
• 208000037357 HIV infectious disease Diseases 0.000 claims description 3
• 108091027967 Small hairpin RNA Proteins 0.000 claims description 3
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 3
• 210000000265 leukocyte Anatomy 0.000 claims description 3
• 239000002245 particle Substances 0.000 claims description 3
• 239000004055 small Interfering RNA Substances 0.000 claims description 3
• 210000004027 cell Anatomy 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 35
• AWGBKZRMLNVLAF-UHFFFAOYSA-N 3,5-dibromo-n,2-dihydroxybenzamide Chemical compound ONC(=O)C1=CC(Br)=CC(Br)=C1O AWGBKZRMLNVLAF-UHFFFAOYSA-N 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 108091032955 Bacterial small RNA Proteins 0.000 description 5
• 230000008685 targeting Effects 0.000 description 3
• 230000003053 immunization Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1