IL300730A - Pre-HIV vaccine and immunotherapy - Google Patents
Pre-HIV vaccine and immunotherapyInfo
- Publication number
- IL300730A IL300730A IL300730A IL30073023A IL300730A IL 300730 A IL300730 A IL 300730A IL 300730 A IL300730 A IL 300730A IL 30073023 A IL30073023 A IL 30073023A IL 300730 A IL300730 A IL 300730A
- Authority
- IL
- Israel
- Prior art keywords
- hiv
- seq
- cells
- sequence
- vivo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662360185P | 2016-07-08 | 2016-07-08 | |
| US201662385864P | 2016-09-09 | 2016-09-09 | |
| US201662409270P | 2016-10-17 | 2016-10-17 | |
| PCT/US2017/013019 WO2018009246A1 (en) | 2016-07-08 | 2017-01-11 | Hiv pre-immunization and immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL300730A true IL300730A (en) | 2023-04-01 |
Family
ID=60913003
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL300730A IL300730A (en) | 2016-07-08 | 2017-01-11 | Pre-HIV vaccine and immunotherapy |
| IL284348A IL284348B2 (en) | 2016-07-08 | 2017-01-11 | Hiv pre-immunization and immunotherapy |
| IL264064A IL264064B (en) | 2016-07-08 | 2019-01-02 | Hiv pre-immunization and immunotherapy |
| IL276038A IL276038B (en) | 2016-07-08 | 2020-07-14 | Pre-HIV vaccine and immunotherapy |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL284348A IL284348B2 (en) | 2016-07-08 | 2017-01-11 | Hiv pre-immunization and immunotherapy |
| IL264064A IL264064B (en) | 2016-07-08 | 2019-01-02 | Hiv pre-immunization and immunotherapy |
| IL276038A IL276038B (en) | 2016-07-08 | 2020-07-14 | Pre-HIV vaccine and immunotherapy |
Country Status (7)
| Country | Link |
|---|---|
| US (11) | US11911458B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3481418A4 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6971492B2 (cg-RX-API-DMAC7.html) |
| AU (3) | AU2017292582C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3028982A1 (cg-RX-API-DMAC7.html) |
| IL (4) | IL300730A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2018009246A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| JP6890831B2 (ja) | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hiv予備免疫化および免疫療法 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| JP7260898B2 (ja) | 2016-01-15 | 2023-04-19 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | ガンマデルタt細胞の活性化のための方法および組成物 |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hivワクチン接種および免疫療法 |
| EP3426777B1 (en) | 2016-03-09 | 2022-02-16 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| WO2018009246A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| CN118931843A (zh) * | 2017-01-09 | 2024-11-12 | 美国基因技术国际有限公司 | 无预先免疫步骤的hiv免疫疗法 |
| KR102737836B1 (ko) | 2017-04-03 | 2024-12-03 | 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 | 페닐케톤뇨증을 치료하기 위한 조성물 및 방법 |
| US12384830B2 (en) | 2017-06-02 | 2025-08-12 | Regents Of The University Of Minnesota | Compositions and methods for improving immunotherapy |
| WO2019191314A1 (en) * | 2018-03-27 | 2019-10-03 | American Gene Technologies International Inc. | Methods of manufacturing genetically-modified lymphocytes |
| JP7607872B2 (ja) * | 2018-03-30 | 2025-01-06 | ユニバーシティ オブ ジュネーブ | マイクロrna発現構築物及びその使用 |
| WO2020027094A1 (ja) * | 2018-07-31 | 2020-02-06 | サイアス株式会社 | iPS細胞を介して再生T細胞集団を製造する方法 |
| EP3876952A4 (en) | 2018-11-05 | 2022-08-24 | American Gene Technologies International Inc. | VECTOR SYSTEM FOR EXPRESSING REGULATORY RNA |
| US20220211845A1 (en) * | 2019-05-08 | 2022-07-07 | The Wistar Institute Of Anatomy And Biology | Dna encoded il-36 gamma as an adjuvant |
| CN112048523A (zh) * | 2019-06-05 | 2020-12-08 | 南京艾德免疫治疗研究院有限公司 | 一种常规离心制备高滴度慢病毒载体的方法 |
| AU2021232603A1 (en) * | 2020-03-03 | 2022-10-20 | American Gene Technologies International Inc. | On demand expression of exogenous factors in lymphocytes to treat HIV |
| WO2024036217A2 (en) * | 2022-08-09 | 2024-02-15 | Fred Hutchinson Cancer Center | Immunization strategies to more naturally guide the maturation of antibodies against human immunodeficiency virus (hiv) in hiv-infected subjects |
| WO2024155830A2 (en) * | 2023-01-18 | 2024-07-25 | Fred Hutchinson Cancer Center | Viral particle producer cells with landing pad-integrated viral vectors |
| WO2025050047A1 (en) * | 2023-09-01 | 2025-03-06 | American Gene Technologies International Inc. | Combination immunotherapy and antiviral treatment |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668255A (en) | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| PT667912E (pt) | 1993-07-13 | 2008-10-15 | Centelion | Vectores adenovirais deficientes e utilização em terapia génica |
| US20030215422A1 (en) | 1996-09-11 | 2003-11-20 | John A. Chiorini | Aav4 vector and uses thereof |
| EP1012236A1 (en) | 1997-08-15 | 2000-06-28 | Rubicon Laboratory Inc. | Retrovirus and viral vectors |
| US6399383B1 (en) | 1997-10-28 | 2002-06-04 | Maxygen, Inc. | Human papilloma virus vectors |
| WO1999047691A1 (en) | 1998-03-20 | 1999-09-23 | Trustees Of The University Of Pennsylvania | Compositions and methods for helper-free production of recombinant adeno-associated viruses |
| EP1115290B1 (en) | 1998-10-01 | 2009-03-04 | University of Southern California | Retroviral gene delivery system and methods of use |
| US6156514A (en) | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| US6410013B1 (en) | 1999-01-25 | 2002-06-25 | Musc Foundation For Research Development | Viral vectors for use in monitoring HIV drug resistance |
| WO2000072886A1 (en) | 1999-05-26 | 2000-12-07 | Dana-Farber Cancer Institute, Inc. | Episomally replicating lentiviral vectors |
| WO2001083797A2 (en) | 2000-04-28 | 2001-11-08 | Avigen, Inc. | Polynucleotides for use in recombinant adeno-associated virus virion production |
| AU2001261515A1 (en) | 2000-05-12 | 2001-11-26 | The Regents Of The University Of California | Treatment of human papillomavirus (hpv)-infected cells |
| US20060057553A1 (en) | 2000-05-30 | 2006-03-16 | Estuardo Aguilar-Cordova | Chimeric viral vectors for gene therapy |
| NO314588B1 (no) * | 2000-09-04 | 2003-04-14 | Bionor Immuno As | HIV-peptider, antigener, vaksinesammensetning, immunoassay- testsett og en fremgangsmåte for å påvise antistoffer indusert av HIV |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| US20030119770A1 (en) | 2001-08-02 | 2003-06-26 | Zhennan Lai | Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors |
| AU2002323270A1 (en) | 2001-08-18 | 2003-03-03 | Myriad Genetics, Inc | Composition and method for treating hiv infection |
| US7737124B2 (en) | 2001-09-13 | 2010-06-15 | California Institute Of Technology | Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell |
| AU2002363465A1 (en) | 2001-10-25 | 2003-05-19 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human S | Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 |
| US20070203333A1 (en) | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| JP2005521393A (ja) | 2002-03-20 | 2005-07-21 | マサチューセッツ インスティテュート オブ テクノロジー | Hiv治療 |
| WO2003093436A2 (en) | 2002-04-30 | 2003-11-13 | University Of Florida | Treatment for phenylketonuria |
| MXPA04010919A (es) | 2002-05-07 | 2005-01-25 | Chiron Corp | Complejos e hibridos de envoltura de vih-cd4. |
| US20040161412A1 (en) | 2002-08-22 | 2004-08-19 | The Cleveland Clinic Foundation | Cell-based VEGF delivery |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| AU2003290586B2 (en) | 2002-11-04 | 2009-07-02 | University Of Massachusetts | Allele-specific RNA interference |
| WO2004053137A2 (en) | 2002-12-11 | 2004-06-24 | Cytos Biotechnology Ag | Method for protein production |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| EP1627231A2 (en) | 2003-05-23 | 2006-02-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Improvements to gamma delta t cell-mediated therapy |
| WO2005005644A1 (en) | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| US20050019927A1 (en) | 2003-07-13 | 2005-01-27 | Markus Hildinger | DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER |
| US20050138677A1 (en) | 2003-09-16 | 2005-06-23 | Pfister Herbert J. | Transgenic animal model for the treatment of skin tumors |
| EP1678292A4 (en) | 2003-09-18 | 2008-05-07 | Univ Emory | IMPROVED MVA VACCINES |
| WO2005033282A2 (en) | 2003-10-01 | 2005-04-14 | Pharmacia & Upjohn Company Llc | Polyamide compositions and therapeutic methods for treatment of human papilloma virus |
| US20080039413A1 (en) | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| JPWO2005051927A1 (ja) | 2003-11-26 | 2007-12-06 | 株式会社クレハ | Hiv−1感染末梢血単核球の刺激培養によるcd4陽性t細胞の培養方法、及びhiv−1の増殖阻害剤 |
| WO2005081911A2 (en) | 2004-02-25 | 2005-09-09 | Dana-Farber Cancer Institute, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HIV INFECTION USING TRIM5α |
| US20060058255A1 (en) | 2004-03-01 | 2006-03-16 | Jianzhu Chen | RNAi-based therapeutics for allergic rhinitis and asthma |
| TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
| US20080227736A1 (en) | 2004-06-03 | 2008-09-18 | Regents Of The University Of California, | Targeting Pseudotyped Retroviral Vectors |
| WO2006012221A2 (en) | 2004-06-25 | 2006-02-02 | The Regents Of The University Of California | Target cell-specific short interfering rna and methods of use thereof |
| EP1789447B1 (en) | 2004-08-16 | 2012-04-25 | Immune Disease Institute, Inc. | Method of delivering rna interference and uses thereof |
| WO2006039721A2 (en) | 2004-10-08 | 2006-04-13 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| EP1647595A1 (en) * | 2004-10-15 | 2006-04-19 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Nucleic acids against viruses, in particular HIV |
| CA2585523A1 (en) | 2004-11-02 | 2006-05-11 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Adenoviral amplicon and producer cells for the production of replication-defective adenoviral vectors, methods of preparation and use thereof |
| US7790446B2 (en) | 2005-02-11 | 2010-09-07 | Kosagen Cell Factory Oü | Vectors, cell lines and their use in obtaining extended episomal maintenance replication of hybrid plasmids and expression of gene products |
| MX2007010008A (es) | 2005-02-16 | 2008-01-18 | Lentigen Corp | Vectores lentivirales y su uso. |
| CN101160055A (zh) | 2005-02-16 | 2008-04-09 | 莱蒂恩公司 | 慢病毒载体及其用途 |
| CN101287834B (zh) | 2005-05-27 | 2016-11-09 | 圣拉法埃莱医院有限公司 | 基因载体 |
| US20070032443A1 (en) | 2005-08-02 | 2007-02-08 | Jaeseob Kim | Therapy for Alzheimer's disease |
| WO2007015122A1 (en) | 2005-08-02 | 2007-02-08 | Genexel, Inc. | Therapy for alzheimer’s disease |
| US20070105835A1 (en) | 2005-11-07 | 2007-05-10 | Kazantsev Aleksey G | Compositions and methods for modulating poly(ADP-ribose) polymerase activity |
| WO2007133674A2 (en) | 2006-05-12 | 2007-11-22 | Lentigen Corporation | Lentiviral vector compositions, methods and applications |
| WO2007149476A2 (en) | 2006-06-19 | 2007-12-27 | Trustees Of Columbia University In The City Of New York | Assays for non-apoptotic cell death and uses thereof |
| US20080003225A1 (en) | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| WO2008008719A2 (en) | 2006-07-10 | 2008-01-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the myc gene |
| EP1878440A1 (en) | 2006-07-13 | 2008-01-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for increasing the efficiency of therapeutic antibodies using gamma delta cell activator compounds |
| AU2007276808A1 (en) | 2006-07-26 | 2008-01-31 | Novartis Ag | Inhibitors of undecaprenyl pyrophosphate synthase |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| US8052968B2 (en) | 2006-10-16 | 2011-11-08 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| US8338101B2 (en) * | 2007-01-23 | 2012-12-25 | Virco Bvba | Method for designing a drug regime for HIV-infected patients |
| JP2010523709A (ja) | 2007-04-12 | 2010-07-15 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | Fpps、ggpps及びdppsを含む複数の標的に対して高い効能を有するビスホスホネート化合物及び方法 |
| US20080293142A1 (en) | 2007-04-19 | 2008-11-27 | The Board Of Regents For Oklahoma State University | Multiple shRNA Expression Vectors and Methods of Construction |
| EP2008656A1 (en) | 2007-06-28 | 2008-12-31 | Bergen Teknologioverforing AS | Compositions for the treatment of hyperphenylalaninemia |
| WO2009026328A2 (en) * | 2007-08-21 | 2009-02-26 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| US20110008417A1 (en) | 2008-01-16 | 2011-01-13 | Opal Therapeutics Pty Ltd | Immunomodulating compositions and uses therefor |
| GB0802754D0 (en) | 2008-02-14 | 2008-03-26 | Inst Superiore Di Sanito | Antisense RNA targetting CXCR4 |
| EP2090659A1 (en) | 2008-02-14 | 2009-08-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Infectious particle, process for its preparation and use thereof |
| WO2009120947A1 (en) | 2008-03-28 | 2009-10-01 | Virxsys Corporation | Lentivirus-based immunogenic vectors |
| GB0810209D0 (en) | 2008-06-04 | 2008-07-09 | Cambridge Entpr Ltd | Pluripotency associated epigenetic factor |
| CA2727266A1 (en) | 2008-06-16 | 2010-01-14 | Polyplus Battery Company | Aqueous lithium/air battery cells |
| US8629334B2 (en) | 2008-07-16 | 2014-01-14 | University Of Florida Research Foundation, Inc. | Viral-based transient-expression vector system for trees |
| US20110207226A1 (en) | 2008-08-20 | 2011-08-25 | Virxsys Corporation | Non-integrating lenti/adeno-associated virus hybrid vector system |
| US8871515B2 (en) | 2008-09-17 | 2014-10-28 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
| US20100183558A1 (en) | 2008-10-17 | 2010-07-22 | Zhennan Lai | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| JP2012507299A (ja) | 2008-10-31 | 2012-03-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Light標的分子およびその使用 |
| WO2010051521A1 (en) | 2008-10-31 | 2010-05-06 | Lentigen Corporation | Cell therapy product for the treatment of hiv infection |
| JP2012508591A (ja) | 2008-11-14 | 2012-04-12 | ライフ テクノロジーズ コーポレーション | 細胞を操作するための組成物および方法 |
| EP2191834A1 (en) | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| CN102438631A (zh) | 2009-04-09 | 2012-05-02 | 史坦赛特股份有限公司 | 抗hiv干细胞及其用途 |
| SG175127A1 (en) | 2009-04-13 | 2011-11-28 | Apceth Gmbh & Co Kg | Engineered mesenchymal stem cells and method of using same to treat tumors |
| US8728458B2 (en) | 2009-04-30 | 2014-05-20 | The Regents Of The University Of California | Combination anti-HIV vectors, targeting vectors, and methods of use |
| WO2011008348A2 (en) | 2009-07-15 | 2011-01-20 | Calimmune Inc. | Dual vector for inhibition of human immunodeficiency virus |
| KR20120093941A (ko) * | 2009-10-08 | 2012-08-23 | 버베리안 노딕 에이/에스 | 인간에서 hiv에 대한 광범위한 t-세포 반응의 생성 |
| WO2011066578A1 (en) | 2009-11-30 | 2011-06-03 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules to treat liver cancer |
| CN101805750B (zh) | 2009-12-29 | 2011-11-30 | 浙江大学 | 法呢基焦磷酸合成酶rna干扰重组慢病毒载体构建及用途 |
| CN102782136A (zh) * | 2010-02-18 | 2012-11-14 | 爱默蕾大学 | 表达hiv抗原和gm-csf的载体和用于产生免疫应答的相关方法 |
| WO2011119942A1 (en) | 2010-03-25 | 2011-09-29 | Vistagen Therapeutics, Inc. | Induction of ips cells using transient episomal vectors |
| WO2011133687A2 (en) | 2010-04-20 | 2011-10-27 | President And Fellows Of Harvard College | Methods and compositions for inhibition of beta2-adrenergic receptor degradation |
| AU2011242576B2 (en) | 2010-04-23 | 2016-03-31 | Cold Spring Harbor Laboratory | Novel structurally designed shRNAs |
| DK2575894T3 (en) | 2010-05-28 | 2015-05-26 | Oxford Biomedica Ltd | FEED lentiviral vectors FOR BRAIN |
| WO2012020757A1 (ja) | 2010-08-10 | 2012-02-16 | タカラバイオ株式会社 | 細胞集団の製造方法 |
| EP2625294A4 (en) | 2010-10-07 | 2014-03-26 | Univ Columbia | PROCESS FOR TREATING TUMORS WITH A P53 MUTATION |
| WO2012061075A2 (en) | 2010-10-25 | 2012-05-10 | The Regents Of The University Of California | Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells |
| CN103492574B (zh) | 2011-02-22 | 2015-12-09 | 加州理工学院 | 使用腺相关病毒(aav)载体递送蛋白 |
| WO2012140127A2 (en) | 2011-04-13 | 2012-10-18 | Immunicum Ab | Method for priming of t cells |
| CA2870511C (en) | 2011-04-21 | 2023-08-08 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| EP2782596A4 (en) | 2011-11-22 | 2015-07-29 | Philadelphia Children Hospital | VIRUS VECTORS FOR HIGHLY EFFICIENT TRANSGENIC ADMINISTRATION |
| US9745631B2 (en) | 2011-12-20 | 2017-08-29 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
| BR112014019431A8 (pt) | 2012-02-07 | 2017-07-11 | Global Bio Therapeutics Usa Inc | Método compartimentalizado de distribuição de ácido nucleico e composições e usos desses |
| WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| EP2858667A1 (en) | 2012-06-06 | 2015-04-15 | Bionor Immuno AS | Hiv vaccine |
| JP2015524264A (ja) | 2012-07-17 | 2015-08-24 | ユニベルシテ ドゥ ジュネーブ | 遺伝子発現の下方制御のための核酸 |
| CA2922005A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| EP3415627A1 (en) | 2012-11-13 | 2018-12-19 | Codiak BioSciences, Inc. | Delivery of therapeutic agent |
| HK1215873A1 (zh) | 2012-12-05 | 2016-09-23 | 桑格摩治疗股份有限公司 | 調整代謝紊亂的方法及組合物 |
| US9642921B2 (en) | 2012-12-20 | 2017-05-09 | Tocagen Inc. | Cancer combination therapy and recombinant vectors |
| WO2014117050A2 (en) | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| CN103184224A (zh) | 2013-04-03 | 2013-07-03 | 衡阳师范学院 | 一种抗艾滋病病毒感染的三联miRNA及构建方法 |
| WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
| EP2999797B1 (en) | 2013-05-21 | 2018-07-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Isoforms of gata6 and nkx2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy |
| EP3027755B1 (en) | 2013-08-02 | 2019-10-09 | The Regents of The University of California | Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors |
| WO2015042308A2 (en) | 2013-09-18 | 2015-03-26 | City Of Hope | Rna-based hiv inhibitors |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| EP2878674A1 (en) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| EP3134514B1 (en) | 2014-04-23 | 2019-09-18 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| FI3851537T3 (fi) | 2014-04-25 | 2024-03-21 | Genethon | Hyperbilirubinemian hoito |
| SMT202000203T1 (it) | 2014-04-25 | 2020-05-08 | Bluebird Bio Inc | Recettori antigenici chimerici con promotore mnd |
| WO2016033163A1 (en) | 2014-08-29 | 2016-03-03 | Immunomedics, Inc. | Identification of cancer genes by in-vivo fusion of human cancer cells and animal cells |
| LT3197472T (lt) | 2014-09-22 | 2021-11-10 | Tanea Medical Ab | Rekombinantinių baltymų be fenilalanino naudojimas gydant fenilketonuriją |
| MA40783A (fr) * | 2014-10-03 | 2017-08-08 | Los Alamos Nat Security Llc | Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population |
| AU2015329696A1 (en) | 2014-10-10 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting CD47 |
| CN107405357B (zh) * | 2014-10-14 | 2021-12-31 | 德克萨斯科技大学系统 | 多重shRNAs及其应用 |
| WO2016069518A2 (en) * | 2014-10-27 | 2016-05-06 | International Aids Vaccine Initiative | Genetically stable replication competent sendai virus vector(s) containing and expressing optimized hiv genes |
| WO2016069716A1 (en) | 2014-10-30 | 2016-05-06 | The Scripps Research Institute | Compositions and methods comprising tyrosyl-trna synthetases and resveratrol compounds |
| JP2018518196A (ja) | 2015-05-18 | 2018-07-12 | カリミューン, インコーポレーティッド | Hivの治療のための遺伝子治療法およびその使用 |
| GB201509202D0 (en) | 2015-05-28 | 2015-07-15 | Ge Healthcare Bio Sciences Ab | Semi-static cell culture |
| EP3307894A4 (en) | 2015-06-10 | 2019-01-16 | American Gene Technologies International, Inc. | SYSTEM AND METHOD FOR NONINTEGRAL VIRAL OUTPUT AND METHOD FOR USE THEREOF |
| JP6890831B2 (ja) * | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hiv予備免疫化および免疫療法 |
| AU2016305705B2 (en) | 2015-08-13 | 2019-06-13 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced extended pluripotent stem cells, methods of making and using |
| CN105112370B (zh) | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| KR20180050413A (ko) | 2015-09-22 | 2018-05-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Hiv 감염을 치료하기 위해 t 세포를 리디렉션시키는 방법 |
| WO2017068077A1 (en) | 2015-10-20 | 2017-04-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and products for genetic engineering |
| WO2017100551A1 (en) | 2015-12-09 | 2017-06-15 | Alexion Pharmaceuticals, Inc. | HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| JP7260898B2 (ja) | 2016-01-15 | 2023-04-19 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | ガンマデルタt細胞の活性化のための方法および組成物 |
| JP7153332B2 (ja) | 2016-02-08 | 2022-10-14 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Hivワクチン接種および免疫療法 |
| EP3426777B1 (en) | 2016-03-09 | 2022-02-16 | American Gene Technologies International Inc. | Combination vectors and methods for treating cancer |
| WO2017173453A1 (en) | 2016-04-01 | 2017-10-05 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
| EP3468617A4 (en) | 2016-06-08 | 2020-01-22 | American Gene Technologies International Inc. | INTEGRATED VIRAL ADMINISTRATION SYSTEM AND RELATED METHODS |
| WO2018009246A1 (en) | 2016-07-08 | 2018-01-11 | American Gene Technologies International Inc. | Hiv pre-immunization and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| JP6923215B2 (ja) | 2016-08-03 | 2021-08-18 | 国立大学法人 鹿児島大学 | 抗htlv−1剤、htlv−1関連脊髄症(ham/tsp)治療薬 |
| EP3562494A4 (en) | 2016-12-30 | 2020-08-19 | The Trustees Of The University Of Pennsylvania | GENE THERAPY FOR THE TREATMENT OF PHENYLKETONURIS |
| CN118931843A (zh) | 2017-01-09 | 2024-11-12 | 美国基因技术国际有限公司 | 无预先免疫步骤的hiv免疫疗法 |
| EP3579847A4 (en) | 2017-02-08 | 2020-12-09 | Dana Farber Cancer Institute, Inc. | MODULAR DEGRADATION OF ENDOGENOUS PROTEIN WITH HETEROBIFUNCTIONAL COMPOUNDS |
| KR102737836B1 (ko) | 2017-04-03 | 2024-12-03 | 아메리칸 진 테크놀로지스 인터내셔널 인코포레이티드 | 페닐케톤뇨증을 치료하기 위한 조성물 및 방법 |
| US20200181645A1 (en) | 2017-06-16 | 2020-06-11 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| WO2019070674A2 (en) | 2017-10-02 | 2019-04-11 | American Gene Technologies International Inc. | VECTORS COMPRISING PROMOTER AND ACTIVATOR COMBINATIONS FOR THE TREATMENT OF PHENYLCETONURIA |
| WO2019191314A1 (en) | 2018-03-27 | 2019-10-03 | American Gene Technologies International Inc. | Methods of manufacturing genetically-modified lymphocytes |
| JP7447388B2 (ja) | 2018-07-13 | 2024-03-12 | ナンジン レジェンド バイオテック カンパニー,リミテッド | 感染性疾患の治療のための共受容体システム |
| EP3876952A4 (en) | 2018-11-05 | 2022-08-24 | American Gene Technologies International Inc. | VECTOR SYSTEM FOR EXPRESSING REGULATORY RNA |
| US20220162643A1 (en) | 2019-05-31 | 2022-05-26 | American Gene Technologies International Inc. | Optimized phenylananine hydroxylase expression |
-
2017
- 2017-01-11 WO PCT/US2017/013019 patent/WO2018009246A1/en not_active Ceased
- 2017-01-11 CA CA3028982A patent/CA3028982A1/en active Pending
- 2017-01-11 JP JP2019500475A patent/JP6971492B2/ja active Active
- 2017-01-11 IL IL300730A patent/IL300730A/en unknown
- 2017-01-11 AU AU2017292582A patent/AU2017292582C1/en active Active
- 2017-01-11 IL IL284348A patent/IL284348B2/en unknown
- 2017-01-11 EP EP17824652.6A patent/EP3481418A4/en active Pending
- 2017-07-07 WO PCT/US2017/041168 patent/WO2018009847A1/en not_active Ceased
- 2017-07-07 EP EP17825011.4A patent/EP3481435A4/en active Pending
- 2017-07-07 JP JP2019500423A patent/JP7162895B2/ja active Active
- 2017-07-07 US US16/312,056 patent/US11911458B2/en active Active
- 2017-08-03 US US15/668,223 patent/US10036038B2/en active Active
-
2018
- 2018-06-18 US US16/011,550 patent/US10233464B2/en active Active
- 2018-12-12 US US16/218,010 patent/US10494647B2/en active Active
-
2019
- 2019-01-02 IL IL264064A patent/IL264064B/en active IP Right Grant
- 2019-10-04 US US16/593,882 patent/US11090379B2/en active Active
-
2020
- 2020-07-14 IL IL276038A patent/IL276038B/en unknown
-
2021
- 2021-01-14 AU AU2021200210A patent/AU2021200210A1/en not_active Abandoned
- 2021-02-12 US US17/175,278 patent/US11612649B2/en active Active
- 2021-10-26 JP JP2021174409A patent/JP2022028677A/ja active Pending
-
2022
- 2022-08-24 JP JP2022133225A patent/JP2022166288A/ja active Pending
-
2023
- 2023-02-10 US US18/108,148 patent/US20230241200A1/en not_active Abandoned
- 2023-07-28 US US18/227,796 patent/US12370253B2/en active Active
- 2023-07-28 US US18/227,761 patent/US20240091339A1/en not_active Abandoned
- 2023-12-14 US US18/540,621 patent/US20240238406A1/en active Pending
-
2024
- 2024-05-16 JP JP2024080081A patent/JP2024099855A/ja active Pending
- 2024-07-10 AU AU2024204743A patent/AU2024204743A1/en active Pending
- 2024-10-22 US US18/923,461 patent/US20250121051A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12370253B2 (en) | Pre-immunization and immunotherapy | |
| US20250121050A1 (en) | Methods of producing cells resistant to hiv infection | |
| US20200384021A1 (en) | Hiv immunotherapy with no pre-immunization step | |
| US20240115604A1 (en) | Methods of manufacturing genetically-modified lymphocytes | |
| WO2025050047A1 (en) | Combination immunotherapy and antiviral treatment |