JP2017524348A5 - - Google Patents
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- Publication number
- JP2017524348A5 JP2017524348A5 JP2016572566A JP2016572566A JP2017524348A5 JP 2017524348 A5 JP2017524348 A5 JP 2017524348A5 JP 2016572566 A JP2016572566 A JP 2016572566A JP 2016572566 A JP2016572566 A JP 2016572566A JP 2017524348 A5 JP2017524348 A5 JP 2017524348A5
- Authority
- JP
- Japan
- Prior art keywords
- ptpn2
- leukocytes
- cell
- inhibitor
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 16
- 101001135572 Homo sapiens Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 claims 14
- 102100033141 Tyrosine-protein phosphatase non-receptor type 2 Human genes 0.000 claims 13
- 210000000265 leukocyte Anatomy 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 230000002452 interceptive effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108091033409 CRISPR Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 108700010039 chimeric receptor Proteins 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014902203 | 2014-06-10 | ||
| AU2014902203A AU2014902203A0 (en) | 2014-06-10 | Method of producing cells for adoptive cell transfer | |
| AU2015901171 | 2015-03-31 | ||
| AU2015901171A AU2015901171A0 (en) | 2015-03-31 | Method of producing cells for adoptive cell transfer (2) | |
| PCT/AU2015/050318 WO2015188228A1 (en) | 2014-06-10 | 2015-06-10 | Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017524348A JP2017524348A (ja) | 2017-08-31 |
| JP2017524348A5 true JP2017524348A5 (cg-RX-API-DMAC7.html) | 2018-06-07 |
Family
ID=54832624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572566A Pending JP2017524348A (ja) | 2014-06-10 | 2015-06-10 | 養子細胞移入のためのｐｔｐｎ２阻害を用いた白血球の産生方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20170224731A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3154555A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017524348A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015274242A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015188228A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2592821B (en) | 2015-07-31 | 2022-01-12 | Univ Minnesota | Modified cells and methods of therapy |
| CA3041068A1 (en) | 2016-10-18 | 2018-04-26 | Regents Of The University Of Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
| US11261428B2 (en) | 2018-03-15 | 2022-03-01 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| WO2018148378A1 (en) * | 2017-02-08 | 2018-08-16 | Dana-Farber Cancer Institute, Inc. | Modulating biomarkers to increase tumor immunity and improve the efficiacy of cancer immunotherapy |
| CN111511375A (zh) | 2017-06-30 | 2020-08-07 | 因提玛生物科学公司 | 用于基因治疗的腺相关病毒载体 |
| WO2019036815A1 (en) * | 2017-08-24 | 2019-02-28 | The Royal Institution For The Advancement Of Learning/Mcgill University | ENHANCEMENT OF CD8 + T LYMPHOCYTES FOR ADOPTIVE CELL THERAPY BY INHIBITING PTPN1 (PTP1B) AND PTPN2 (TC-PTP)) |
| JP2021518162A (ja) * | 2018-03-15 | 2021-08-02 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| JP7558563B2 (ja) | 2018-03-15 | 2024-10-01 | ケーエスキュー セラピューティクス， インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
| WO2019227176A1 (en) * | 2018-06-01 | 2019-12-05 | Monash University | Methods of activating cells via ptp 1b inhibition |
| EP3810580A1 (en) | 2018-06-21 | 2021-04-28 | Calico Life Sciences LLC | Protein tyrosine phosphatase inhibitors and methods of use thereof |
| US20220081691A1 (en) * | 2018-08-07 | 2022-03-17 | Dana-Farber Cancer Institute, Inc | Modulating ptpn2 to increase immune responses and perturbing gene expression in hematopoietic stem cell lineages |
| CN113396216A (zh) * | 2019-02-04 | 2021-09-14 | Ksq治疗公司 | 用于改进的免疫疗法的组合基因靶标 |
| MA55301A (fr) | 2019-03-14 | 2022-01-19 | Abbvie Inc | Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation |
| US12188045B2 (en) | 2019-06-07 | 2025-01-07 | KSQ Therapeutics, Inc. | Guide RNA combinations and methods of use |
| US20240376428A1 (en) * | 2019-11-25 | 2024-11-14 | KSQ Therapeutics, Inc. | Methods for activation and expansion of tumor infiltrating lymphocytes |
| WO2021108867A1 (en) * | 2019-12-04 | 2021-06-10 | Monash University | Methods of activating cytotoxic leukocytes using ptp1b and ptpn2 inhibitors |
| CA3163012A1 (en) * | 2019-12-12 | 2021-06-17 | Yi Liu | Compositions and methods for potentiating immune activity |
| CN113827727B (zh) * | 2020-06-24 | 2025-04-29 | 上海交通大学医学院附属瑞金医院 | Ptpn2抑制剂在kras突变肿瘤中的应用 |
| WO2023064928A2 (en) | 2021-10-14 | 2023-04-20 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| IL322949A (en) | 2023-03-03 | 2025-10-01 | Arsenal Biosciences Inc | Systems targeting PSMA and CA9 |
| AU2024276994A1 (en) | 2023-05-24 | 2025-10-23 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| WO2025075947A1 (en) * | 2023-10-06 | 2025-04-10 | Purdue Research Foundation | Selective tc-ptp degraders for cancer immunotherapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008043181A1 (en) * | 2006-10-12 | 2008-04-17 | Mcgill University | Augmenting stem cell populations by modulating t-cell protein tyrosine phosphatase (tc-ptp) |
| WO2010118241A2 (en) * | 2009-04-08 | 2010-10-14 | Indiana University Research & Technology Corporation | Inhibitors of protein tyrosine phosphatases |
| US9937205B2 (en) * | 2012-09-04 | 2018-04-10 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive T cell transfer |
| AR092745A1 (es) * | 2012-10-01 | 2015-04-29 | Univ Pennsylvania | Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer |
| US20150275209A1 (en) * | 2012-10-22 | 2015-10-01 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Service | Compositions and methods for enhancing cancer immunotherapy |
| JP2016524464A (ja) * | 2013-05-13 | 2016-08-18 | セレクティスＣｅｌｌｅｃｔｉｓ | 免疫療法のために高活性ｔ細胞を操作するための方法 |
| KR20210115051A (ko) * | 2013-06-10 | 2021-09-24 | 다나-파버 캔서 인스티튜트 인크. | 종양 세포에 의한 면역 억제를 감소시키기 위한 방법 및 조성물 |
| CN106471004A (zh) * | 2014-02-28 | 2017-03-01 | 麦吉尔大学学术发展皇家学院 | 作为用于免疫疗法的apc活化剂的tc‑ptp抑制剂 |
| RU2752933C2 (ru) * | 2014-03-11 | 2021-08-11 | Селлектис | Способ создания т-клеток, пригодных для аллогенной трансплантации |
-
2015
- 2015-06-10 US US15/317,197 patent/US20170224731A1/en not_active Abandoned
- 2015-06-10 AU AU2015274242A patent/AU2015274242A1/en not_active Abandoned
- 2015-06-10 JP JP2016572566A patent/JP2017524348A/ja active Pending
- 2015-06-10 WO PCT/AU2015/050318 patent/WO2015188228A1/en not_active Ceased
- 2015-06-10 EP EP15807341.1A patent/EP3154555A4/en not_active Withdrawn
-
2020
- 2020-09-08 US US17/014,737 patent/US20210052648A1/en active Pending
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