JP2019514948A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019514948A5 JP2019514948A5 JP2018557408A JP2018557408A JP2019514948A5 JP 2019514948 A5 JP2019514948 A5 JP 2019514948A5 JP 2018557408 A JP2018557408 A JP 2018557408A JP 2018557408 A JP2018557408 A JP 2018557408A JP 2019514948 A5 JP2019514948 A5 JP 2019514948A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- general formula
- methyl
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- -1 phenylhydrazine compound Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 7
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 238000005580 one pot reaction Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940067157 phenylhydrazine Drugs 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021098486A JP2021143193A (ja) | 2016-05-03 | 2021-06-14 | ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16168166 | 2016-05-03 | ||
| EP16168169.7 | 2016-05-03 | ||
| EP16168165 | 2016-05-03 | ||
| EP16168163 | 2016-05-03 | ||
| EP16168166.3 | 2016-05-03 | ||
| EP16168169 | 2016-05-03 | ||
| EP16168172 | 2016-05-03 | ||
| EP16168163.0 | 2016-05-03 | ||
| EP16168172.1 | 2016-05-03 | ||
| EP16168165.5 | 2016-05-03 | ||
| EP17160086 | 2017-03-09 | ||
| EP17160086.9 | 2017-03-09 | ||
| PCT/EP2017/060367 WO2017191104A1 (de) | 2016-05-03 | 2017-05-02 | Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021098486A Division JP2021143193A (ja) | 2016-05-03 | 2021-06-14 | ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514948A JP2019514948A (ja) | 2019-06-06 |
| JP2019514948A5 true JP2019514948A5 (OSRAM) | 2020-06-18 |
| JP6921863B2 JP6921863B2 (ja) | 2021-08-18 |
Family
ID=58633014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557408A Expired - Fee Related JP6921863B2 (ja) | 2016-05-03 | 2017-05-02 | ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法 |
| JP2021098486A Withdrawn JP2021143193A (ja) | 2016-05-03 | 2021-06-14 | ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021098486A Withdrawn JP2021143193A (ja) | 2016-05-03 | 2021-06-14 | ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10703742B2 (OSRAM) |
| EP (1) | EP3452467A1 (OSRAM) |
| JP (2) | JP6921863B2 (OSRAM) |
| KR (1) | KR20190003536A (OSRAM) |
| CN (2) | CN113105403A (OSRAM) |
| AU (2) | AU2017259872B2 (OSRAM) |
| BR (1) | BR112018072528A2 (OSRAM) |
| CA (1) | CA3022789A1 (OSRAM) |
| CL (1) | CL2018003107A1 (OSRAM) |
| CO (1) | CO2018011948A2 (OSRAM) |
| IL (1) | IL262534B (OSRAM) |
| MX (2) | MX391356B (OSRAM) |
| PE (1) | PE20190202A1 (OSRAM) |
| RU (1) | RU2742885C2 (OSRAM) |
| SG (1) | SG11201809672YA (OSRAM) |
| TW (1) | TWI755393B (OSRAM) |
| UY (1) | UY37222A (OSRAM) |
| WO (1) | WO2017191104A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109071464A (zh) * | 2016-05-03 | 2018-12-21 | 拜耳制药股份公司 | 氧代烷基取代的苯基三唑衍生物及其用途 |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CN113105403A (zh) * | 2016-05-03 | 2021-07-13 | 拜耳制药股份公司 | 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法 |
| WO2021259852A1 (en) | 2020-06-25 | 2021-12-30 | Bayer Aktiengesellschaft | Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI490212B (zh) * | 2006-05-25 | 2015-07-01 | Synta Pharmaceuticals Corp | 調節ｈｓｐ９０活性之三唑化合物 |
| EP2341776A4 (en) * | 2008-09-19 | 2012-05-30 | Inst Oneworld Health | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOL AND TRIAZOL DERIVATIVES |
| DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
| JP5826773B2 (ja) | 2010-02-27 | 2015-12-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | ビスアリール−結合アリールトリアゾロン及びその用途 |
| AU2013258107B2 (en) * | 2012-05-08 | 2017-06-22 | Bayer Pharma Aktiengesellschaft | Method for the preparation of triazole compounds |
| PE20170945A1 (es) | 2014-11-03 | 2017-07-13 | Bayer Pharma AG | Derivados de feniltriazol sustituido con hidroxialquilo y sus usos |
| CN109071464A (zh) * | 2016-05-03 | 2018-12-21 | 拜耳制药股份公司 | 氧代烷基取代的苯基三唑衍生物及其用途 |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| CN113105403A (zh) * | 2016-05-03 | 2021-07-13 | 拜耳制药股份公司 | 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法 |
-
2017
- 2017-05-02 CN CN202110424553.XA patent/CN113105403A/zh active Pending
- 2017-05-02 BR BR112018072528-5A patent/BR112018072528A2/pt active Search and Examination
- 2017-05-02 MX MX2020010365A patent/MX391356B/es unknown
- 2017-05-02 KR KR1020187031568A patent/KR20190003536A/ko not_active Ceased
- 2017-05-02 CN CN201780027607.0A patent/CN109071500B/zh not_active Expired - Fee Related
- 2017-05-02 RU RU2018142264A patent/RU2742885C2/ru active
- 2017-05-02 EP EP17719636.7A patent/EP3452467A1/de not_active Withdrawn
- 2017-05-02 AU AU2017259872A patent/AU2017259872B2/en not_active Ceased
- 2017-05-02 PE PE2018002254A patent/PE20190202A1/es unknown
- 2017-05-02 UY UY0001037222A patent/UY37222A/es not_active Application Discontinuation
- 2017-05-02 US US16/098,238 patent/US10703742B2/en not_active Expired - Fee Related
- 2017-05-02 MX MX2018013336A patent/MX379555B/es unknown
- 2017-05-02 SG SG11201809672YA patent/SG11201809672YA/en unknown
- 2017-05-02 CA CA3022789A patent/CA3022789A1/en active Pending
- 2017-05-02 JP JP2018557408A patent/JP6921863B2/ja not_active Expired - Fee Related
- 2017-05-02 TW TW106114435A patent/TWI755393B/zh not_active IP Right Cessation
- 2017-05-02 WO PCT/EP2017/060367 patent/WO2017191104A1/de not_active Ceased
-
2018
- 2018-10-23 IL IL262534A patent/IL262534B/en active IP Right Grant
- 2018-10-31 CL CL2018003107A patent/CL2018003107A1/es unknown
- 2018-11-02 CO CONC2018/0011948A patent/CO2018011948A2/es unknown
-
2020
- 2020-05-21 US US16/880,933 patent/US20200299271A1/en not_active Abandoned
-
2021
- 2021-06-14 JP JP2021098486A patent/JP2021143193A/ja not_active Withdrawn
- 2021-09-22 AU AU2021236502A patent/AU2021236502A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100889937B1 (ko) | 보리코나졸의 제조방법 | |
| FI96859B (fi) | Menetelmä terapeuttisesti käyttökelpoisten fungisidisten triatsoliyhdisteiden valmistamiseksi | |
| JP2019514948A5 (OSRAM) | ||
| PL169332B1 (pl) | Sposób wytwarzania pochodnych triazolu PL PL PL PL PL | |
| JP6108112B2 (ja) | 改良されたルフィナミド調製プロセス | |
| PL181193B1 (pl) | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków | |
| JP2015096515A (ja) | ルフィナマイドの製造方法 | |
| FR2542315A1 (fr) | Nouveaux composes azoliques, leur preparation et leur utilisation comme antifongiques et fongicides | |
| CN104817508B (zh) | 一种三氮唑醇类衍生物及其制备方法和应用 | |
| JPH07502022A (ja) | トリアゾール抗真菌剤 | |
| JP2017519796A5 (OSRAM) | ||
| CN114901644B (zh) | 制备右美托咪定的方法 | |
| RU2018142264A (ru) | Способ получения 5-гидроксиалкилзамещенных производных 1-фенил-1,2,4-триазола | |
| JP2016540793A5 (OSRAM) | ||
| EP2909177B1 (en) | Process for preparing roflumilast | |
| EP3915981B1 (en) | Method for preparation of efinaconazole in ionic liquid medium | |
| JP6851149B2 (ja) | ピペリジン化合物の製造方法 | |
| JP7311520B2 (ja) | スルフェントラゾンの合成のための方法 | |
| JP6251197B2 (ja) | 置換フェニルプロパノンを調製するためのプロセス | |
| JP2009530256A (ja) | ４−［１−（４−シアノフェニル）−１−（１，２，４−トリアゾール−１−イル）メチル］ベンゾニトリルおよび４−［１−（１ｈ−１，２，４−トリアゾール−１−イル）メチレンベンゾニトリル中間体 | |
| JPS62230742A (ja) | １，１−ジ置換シクロプロパン誘導体 | |
| AU2012269895B2 (en) | Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation | |
| JP3622882B2 (ja) | トリアゾール誘導体を含有する医薬 | |
| JP4125672B2 (ja) | アゾール誘導体製造方法における中間体ハロフェニル誘導体およびそれらの使用 | |
| CN104220430A (zh) | 三唑基甲基环烷醇衍生物的制造方法及含有三唑基甲基环烷醇衍生物的组合物 |