SG11201809672YA - Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives - Google Patents

Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives

Info

Publication number
SG11201809672YA
SG11201809672YA SG11201809672YA SG11201809672YA SG11201809672YA SG 11201809672Y A SG11201809672Y A SG 11201809672YA SG 11201809672Y A SG11201809672Y A SG 11201809672YA SG 11201809672Y A SG11201809672Y A SG 11201809672YA SG 11201809672Y A SG11201809672Y A SG 11201809672YA
Authority
SG
Singapore
Prior art keywords
hydroxyalkyl
preparing
triazole derivatives
phenyl
substituted
Prior art date
Application number
SG11201809672YA
Inventor
Heiko Schirmer
Philipp Rubenbauer
Hans-Christian Militzer
Marie-Pierre Collin-Kröpelin
Frank Süssmeier
Kersten Gericke
Thomas Neubauer
Chantal Fürstner
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of SG11201809672YA publication Critical patent/SG11201809672YA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for preparing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4-triazole derivatives The present application relates to a novel and improved process for preparing 5- (hydroxyalkyl)-1-pheny1-1,2,4-triazole derivatives of the formula (I) HO OHO,,F / N—N N R IAIF 1B d ilk R CI (I) 5 in which RIA and RIB are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline 10 polymorph I of (5-(4-chloropheny1)-24(1-(3-chloropheny1)-5-[(1 S)- 1-hydroxyethy1]-1H- 1 ,2,4-triazol-3 -yl}methyl)-4-[(28)-3,3,3 -trifluoro-2-hydroxypropy1]-2,4-dihydro-3 H- 1,2,4 - triazol-3 -one of the formula (I-A-1). No suitable figure
SG11201809672YA 2016-05-03 2017-05-02 Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives SG11201809672YA (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16168169 2016-05-03
EP16168172 2016-05-03
EP16168165 2016-05-03
EP16168166 2016-05-03
EP16168163 2016-05-03
EP17160086 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (en) 2016-05-03 2017-05-02 Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4- triazole derivatives

Publications (1)

Publication Number Publication Date
SG11201809672YA true SG11201809672YA (en) 2018-11-29

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201809672YA SG11201809672YA (en) 2016-05-03 2017-05-02 Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives

Country Status (18)

Country Link
US (2) US10703742B2 (en)
EP (1) EP3452467A1 (en)
JP (2) JP6921863B2 (en)
KR (1) KR20190003536A (en)
CN (2) CN109071500B (en)
AU (2) AU2017259872B2 (en)
BR (1) BR112018072528A2 (en)
CA (1) CA3022789A1 (en)
CL (1) CL2018003107A1 (en)
CO (1) CO2018011948A2 (en)
IL (1) IL262534B (en)
MX (2) MX2018013336A (en)
PE (1) PE20190202A1 (en)
RU (1) RU2742885C2 (en)
SG (1) SG11201809672YA (en)
TW (1) TWI755393B (en)
UY (1) UY37222A (en)
WO (1) WO2017191104A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2017191104A1 (en) * 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4- triazole derivatives
EP3452457B1 (en) * 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490212B (en) * 2006-05-25 2015-07-01 Synta Pharmaceuticals Corp Triazole compounds that modulate hsp90 activity
JP2012503005A (en) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス Compounds, compositions and methods comprising imidazole derivatives and triazole derivatives.
DE102010001064A1 (en) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituted 2-acetamido-5-aryl-1,2,4-triazolones and their use
BR112012021498B8 (en) * 2010-02-27 2020-04-14 Bayer Ip Gmbh Bisaryl-linked aryltriazolones and their use
AU2013258107B2 (en) * 2012-05-08 2017-06-22 Bayer Pharma Aktiengesellschaft Method for the preparation of triazole compounds
PE20170945A1 (en) 2014-11-03 2017-07-13 Bayer Pharma AG HYDROXYALKYL SUBSTITUTED PHENYLTRIAZOLE DERIVATIVES AND THEIR USES
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
WO2017191104A1 (en) * 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4- triazole derivatives
EP3452457B1 (en) * 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof

Also Published As

Publication number Publication date
TWI755393B (en) 2022-02-21
WO2017191104A1 (en) 2017-11-09
UY37222A (en) 2017-11-30
JP6921863B2 (en) 2021-08-18
CN113105403A (en) 2021-07-13
TW201815782A (en) 2018-05-01
MX2018013336A (en) 2019-05-09
US20200299271A1 (en) 2020-09-24
IL262534A (en) 2018-12-31
CO2018011948A2 (en) 2018-11-22
AU2017259872A1 (en) 2018-11-22
EP3452467A1 (en) 2019-03-13
PE20190202A1 (en) 2019-02-05
CL2018003107A1 (en) 2019-02-22
MX2020010365A (en) 2022-04-06
RU2018142264A (en) 2020-06-03
CN109071500B (en) 2021-05-18
JP2021143193A (en) 2021-09-24
CN109071500A (en) 2018-12-21
US20190144431A1 (en) 2019-05-16
CA3022789A1 (en) 2017-11-09
RU2742885C2 (en) 2021-02-11
KR20190003536A (en) 2019-01-09
US10703742B2 (en) 2020-07-07
AU2017259872B2 (en) 2021-06-24
JP2019514948A (en) 2019-06-06
AU2021236502A1 (en) 2021-10-21
BR112018072528A2 (en) 2019-03-26
RU2018142264A3 (en) 2020-08-19
IL262534B (en) 2021-04-29

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