PE20190202A1 - Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo - Google Patents

Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo

Info

Publication number
PE20190202A1
PE20190202A1 PE2018002254A PE2018002254A PE20190202A1 PE 20190202 A1 PE20190202 A1 PE 20190202A1 PE 2018002254 A PE2018002254 A PE 2018002254A PE 2018002254 A PE2018002254 A PE 2018002254A PE 20190202 A1 PE20190202 A1 PE 20190202A1
Authority
PE
Peru
Prior art keywords
formula
compound
procedure
hydroxialkyl
phenyl
Prior art date
Application number
PE2018002254A
Other languages
English (en)
Inventor
Heiko Schirmer
Philipp Rubenbauer
Hans-Christian Militzer
Marie-Pierre Collin-Kropelin
Frank Sussmeier
Kersten Matthias Gericke
Thomas Neubauer
Chantal Furstner
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of PE20190202A1 publication Critical patent/PE20190202A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 5-(HIDROXIALQUILO)-1-FENILO-1,2,4-TRIAZOL DE FORMULA (I) DONDE R1A Y R1B SON CADA UNO H, FLUOR, CLORO, METILO, MONOFLUORMETILO, ENTRE OTROS, EN DONDE DICHO PROCEDIMIENTO COMPRENDE: C-1) HACER REACCIONAR UN COMPUESTO DE FORMULA (XI) EN PRESENCIA DE UNA BASE CLORURO DE ACIDO DE FORMULA (XII) DONDE R2 ES ALQUILO C1-C4 Y PG ES UN GRUPO PROTECTOR TAL COMO ACETILO; C-2) EL PRODUCTO RESULTANTE SE HACE REACCIONAR CON UN COMPUESTO DE FENILHIDRAZINA DE FORMULA (XIII) EN PRESENCIA DE UNA BASE, DONDE R1A Y R1B SON H, F, METILO, ENTRE OTROS, PARA OBTENER UN COMPUESTO 1,2,4-TRIAZOLILO DE FORMULA (XIV); Y D) POR ESCISION DEL GRUPO PROTECTOR PG DEL COMPUESTO (XIV) SE OBTIENE EL COMPUESTO DE FORMULA (I)
PE2018002254A 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo PE20190202A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16168163 2016-05-03
EP16168169 2016-05-03
EP16168166 2016-05-03
EP16168172 2016-05-03
EP16168165 2016-05-03
EP17160086 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (de) 2016-05-03 2017-05-02 Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen

Publications (1)

Publication Number Publication Date
PE20190202A1 true PE20190202A1 (es) 2019-02-05

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018002254A PE20190202A1 (es) 2016-05-03 2017-05-02 Procedimiento para la preparacion de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo

Country Status (18)

Country Link
US (2) US10703742B2 (es)
EP (1) EP3452467A1 (es)
JP (2) JP6921863B2 (es)
KR (1) KR20190003536A (es)
CN (2) CN109071500B (es)
AU (2) AU2017259872B2 (es)
BR (1) BR112018072528A2 (es)
CA (1) CA3022789A1 (es)
CL (1) CL2018003107A1 (es)
CO (1) CO2018011948A2 (es)
IL (1) IL262534B (es)
MX (2) MX2018013336A (es)
PE (1) PE20190202A1 (es)
RU (1) RU2742885C2 (es)
SG (1) SG11201809672YA (es)
TW (1) TWI755393B (es)
UY (1) UY37222A (es)
WO (1) WO2017191104A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10800746B2 (en) * 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
CN109071500B (zh) * 2016-05-03 2021-05-18 拜耳制药股份公司 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2038262B1 (en) * 2006-05-25 2014-11-12 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
US20110237528A1 (en) * 2008-09-19 2011-09-29 Institute For Oneworld Health Compositions and methods comprising imidazole and triazole derivatives
DE102010001064A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
LT2539326T (lt) * 2010-02-27 2017-08-10 Bayer Intellectual Property Gmbh Sujungti bisariliniai ariltriazolonai ir jų panaudojimas
PT2847183T (pt) * 2012-05-08 2017-10-02 Bayer Pharma AG Processo para preparação de compostos de triazol
JP6623220B2 (ja) * 2014-11-03 2019-12-18 バイエル ファーマ アクチエンゲゼルシャフト ヒドロキシアルキル置換フェニルトリアゾール誘導体およびその使用
US10800746B2 (en) * 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
CN109071500B (zh) * 2016-05-03 2021-05-18 拜耳制药股份公司 制备5-羟基烷基-取代的1-苯基-1,2,4-三唑衍生物的方法

Also Published As

Publication number Publication date
AU2021236502A1 (en) 2021-10-21
EP3452467A1 (de) 2019-03-13
MX2018013336A (es) 2019-05-09
TWI755393B (zh) 2022-02-21
IL262534A (en) 2018-12-31
KR20190003536A (ko) 2019-01-09
JP6921863B2 (ja) 2021-08-18
TW201815782A (zh) 2018-05-01
RU2018142264A3 (es) 2020-08-19
US10703742B2 (en) 2020-07-07
AU2017259872A1 (en) 2018-11-22
SG11201809672YA (en) 2018-11-29
CN109071500B (zh) 2021-05-18
UY37222A (es) 2017-11-30
WO2017191104A1 (de) 2017-11-09
US20200299271A1 (en) 2020-09-24
CA3022789A1 (en) 2017-11-09
RU2018142264A (ru) 2020-06-03
US20190144431A1 (en) 2019-05-16
JP2019514948A (ja) 2019-06-06
RU2742885C2 (ru) 2021-02-11
JP2021143193A (ja) 2021-09-24
CN109071500A (zh) 2018-12-21
AU2017259872B2 (en) 2021-06-24
IL262534B (en) 2021-04-29
CL2018003107A1 (es) 2019-02-22
CO2018011948A2 (es) 2018-11-22
MX2020010365A (es) 2022-04-06
BR112018072528A2 (pt) 2019-03-26
CN113105403A (zh) 2021-07-13

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