CO2018011948A2 - Procedimiento para la preparación de derivados de 1-fenilo-1,2,4- triazol sustituidos por 5-hidroxialquilo - Google Patents

Procedimiento para la preparación de derivados de 1-fenilo-1,2,4- triazol sustituidos por 5-hidroxialquilo

Info

Publication number
CO2018011948A2
CO2018011948A2 CONC2018/0011948A CO2018011948A CO2018011948A2 CO 2018011948 A2 CO2018011948 A2 CO 2018011948A2 CO 2018011948 A CO2018011948 A CO 2018011948A CO 2018011948 A2 CO2018011948 A2 CO 2018011948A2
Authority
CO
Colombia
Prior art keywords
preparation
hydroxyalkyl
phenyl
triazole derivatives
derivatives substituted
Prior art date
Application number
CONC2018/0011948A
Other languages
English (en)
Inventor
Heiko Schirmer
Hans-Christian Militzer
Philipp Rubenbauer
Marie-Pierre Collin-Kröpelin
Frank Süssmeier
Kersten Matthias Gericke
Thomas Neubauer
Chantal Fürstner
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CO2018011948A2 publication Critical patent/CO2018011948A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente solicitud se refiere a un procedimiento novedoso y mejorado para la preparación de derivados de 5-(hidroxialquilo)-1-fenilo-1,2,4-triazol de la fórmula (I) (I), en la que R1A y R1B se seleccionan independientemente del grupo que consiste en hidrógeno, flúor, cloro, metilo, monofluormetilo, difluormetilo, trifluormetilo, etilo, metoxi, difluormetoxi y trifluormetoxi, nuevas fases previas para su preparación y la preparación y el uso de la modificación cristalina I de (5-(4-clorofenil)-2-({1-(3-clorofenil)-5-[(1S)-1-hidroxietil]-1H-1,2,4-triazol-3-ilo}metilo)-4-[(2S)-3,3,3-tri¬fluor-2-hidroxipropil]-2,4-dihidro-3H-1,2,4-triazol-3-ona de la fórmula (I-A-1).
CONC2018/0011948A 2016-05-03 2018-11-02 Procedimiento para la preparación de derivados de 1-fenilo-1,2,4- triazol sustituidos por 5-hidroxialquilo CO2018011948A2 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16168165 2016-05-03
EP16168166 2016-05-03
EP16168169 2016-05-03
EP16168163 2016-05-03
EP16168172 2016-05-03
EP17160086 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (de) 2016-05-03 2017-05-02 Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen

Publications (1)

Publication Number Publication Date
CO2018011948A2 true CO2018011948A2 (es) 2018-11-22

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0011948A CO2018011948A2 (es) 2016-05-03 2018-11-02 Procedimiento para la preparación de derivados de 1-fenilo-1,2,4- triazol sustituidos por 5-hidroxialquilo

Country Status (18)

Country Link
US (2) US10703742B2 (es)
EP (1) EP3452467A1 (es)
JP (2) JP6921863B2 (es)
KR (1) KR20190003536A (es)
CN (2) CN109071500B (es)
AU (2) AU2017259872B2 (es)
BR (1) BR112018072528A2 (es)
CA (1) CA3022789A1 (es)
CL (1) CL2018003107A1 (es)
CO (1) CO2018011948A2 (es)
IL (1) IL262534B (es)
MX (2) MX2018013336A (es)
PE (1) PE20190202A1 (es)
RU (1) RU2742885C2 (es)
SG (1) SG11201809672YA (es)
TW (1) TWI755393B (es)
UY (1) UY37222A (es)
WO (1) WO2017191104A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
SG11201809672YA (en) * 2016-05-03 2018-11-29 Bayer Pharma AG Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives
WO2017191115A1 (en) * 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2653332A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
DE102010001064A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
RS56312B1 (sr) * 2010-02-27 2017-12-29 Bayer Ip Gmbh Ariltriazoloni spojeni sa bis-arilom i njihova upotreba
HUE034430T2 (en) * 2012-05-08 2018-02-28 Bayer Pharma AG Process for the preparation of triazole compounds
SG11201703199UA (en) * 2014-11-03 2017-05-30 Bayer Pharma AG Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
SG11201809672YA (en) * 2016-05-03 2018-11-29 Bayer Pharma AG Process For Preparing 5-Hydroxyalkyl-Substituted 1-Phenyl-1,2,4-Triazole Derivatives
WO2017191115A1 (en) * 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof

Also Published As

Publication number Publication date
UY37222A (es) 2017-11-30
CA3022789A1 (en) 2017-11-09
IL262534B (en) 2021-04-29
TWI755393B (zh) 2022-02-21
CN109071500A (zh) 2018-12-21
JP2019514948A (ja) 2019-06-06
US20200299271A1 (en) 2020-09-24
CN109071500B (zh) 2021-05-18
RU2018142264A3 (es) 2020-08-19
AU2017259872A1 (en) 2018-11-22
IL262534A (en) 2018-12-31
KR20190003536A (ko) 2019-01-09
WO2017191104A1 (de) 2017-11-09
US10703742B2 (en) 2020-07-07
JP6921863B2 (ja) 2021-08-18
EP3452467A1 (de) 2019-03-13
BR112018072528A2 (pt) 2019-03-26
MX2018013336A (es) 2019-05-09
PE20190202A1 (es) 2019-02-05
AU2017259872B2 (en) 2021-06-24
SG11201809672YA (en) 2018-11-29
CL2018003107A1 (es) 2019-02-22
JP2021143193A (ja) 2021-09-24
AU2021236502A1 (en) 2021-10-21
CN113105403A (zh) 2021-07-13
US20190144431A1 (en) 2019-05-16
MX2020010365A (es) 2022-04-06
TW201815782A (zh) 2018-05-01
RU2742885C2 (ru) 2021-02-11
RU2018142264A (ru) 2020-06-03

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