NI202000030A - Profármacos de derivados de triazol sustituido y sus usos - Google Patents

Profármacos de derivados de triazol sustituido y sus usos

Info

Publication number
NI202000030A
NI202000030A NI202000030A NI202000030A NI202000030A NI 202000030 A NI202000030 A NI 202000030A NI 202000030 A NI202000030 A NI 202000030A NI 202000030 A NI202000030 A NI 202000030A NI 202000030 A NI202000030 A NI 202000030A
Authority
NI
Nicaragua
Prior art keywords
triazole
propharmacs
triazole derivatives
carboxamide
trifluoro
Prior art date
Application number
NI202000030A
Other languages
English (en)
Inventor
Collin-Kröpelin Marie-Pierre
Kolkhof Peter
Neubauer Thomas
Fürstner Chantal
Pook Elisabeth
Beat Wittwer Matthias
Schmeck Carsten
Wasnaire Pierre
Schirmer Heiko
Cernecka Hana
Dröbner Karoline
Tinel Hanna
Buchmüller Anja
Mondritzki Thomas
Kretschmer Axel
Lustig Klemens
Fricke Robert
Levilain Guillaume
Krenz Ursula
Witowski Norbert
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NI202000030A publication Critical patent/NI202000030A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a profármacos 3 - ({3 - (4 - clorofenil) - 5 - oxo - 4 - [(2S) - 3,3,3 - trifluoro - 2 - hidroxipropil] - 4, 5-dihidro - 1H - 1,2,4-triazol - 1- il} metil) - 1 - [3 - (trifluorometil) - piridin - 2 - il] - 1H - 1,2,4 - triazol - 5 - carboxamida, 3 - ({3 - (4 - clorofenil) - 5 - oxo - 4 - [(2S) - 3,3,3 - trifluoro - 2 - hidroxipropil] - 4,5 - dihidro - 1H - 1,2,4 - triazol - 1 - il} metil) - 1 - [2 - (trifluorometil) - fenil] - 1H - 1,2,4 - triazol - 5 - carboxamida y 3 - ({3 - (4 - clorofenil) - 5 - oxo - 4 - [(2S) - 3,3,3 - trifluoro - 2 - hidroxipropil] - 4,5 - dihidro - 1H - 1,2,4 - triazol - 1 - il} metil) - 1 - (3-cloropiridin - 2 - il) - 1H - 1,2,4 - triazol - 5 - carboxamida, a procesos para la preparación de tales compuestos, a composiciones farmacéuticas que contienen tales compuestos, y al uso de tales compuestos o composiciones para el tratamiento y/o prevención de enfermedades, en particular para el tratamiento y/o prevención de enfermedades renales y cardiovasculares.
NI202000030A 2017-10-24 2020-04-23 Profármacos de derivados de triazol sustituido y sus usos NI202000030A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24

Publications (1)

Publication Number Publication Date
NI202000030A true NI202000030A (es) 2020-10-09

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
NI202000030A NI202000030A (es) 2017-10-24 2020-04-23 Profármacos de derivados de triazol sustituido y sus usos

Country Status (38)

Country Link
US (1) US11298367B2 (es)
EP (1) EP3700913B1 (es)
JP (1) JP2021500365A (es)
KR (1) KR20200069361A (es)
CN (1) CN111225921A (es)
AR (1) AR113791A1 (es)
AU (1) AU2018356352A1 (es)
BR (1) BR112020007983A2 (es)
CA (1) CA3079767A1 (es)
CL (1) CL2020001076A1 (es)
CO (1) CO2020004945A2 (es)
CR (1) CR20200176A (es)
CU (1) CU24604B1 (es)
CY (1) CY1124938T1 (es)
DK (1) DK3700913T3 (es)
DO (1) DOP2020000076A (es)
EA (1) EA202091025A1 (es)
EC (1) ECSP20023056A (es)
ES (1) ES2906305T3 (es)
HR (1) HRP20220060T1 (es)
HU (1) HUE057278T2 (es)
IL (1) IL273949A (es)
JO (1) JOP20200099A1 (es)
LT (1) LT3700913T (es)
MA (1) MA50438B1 (es)
MX (1) MX2020004191A (es)
NI (1) NI202000030A (es)
PE (1) PE20210394A1 (es)
PH (1) PH12020550473A1 (es)
PL (1) PL3700913T3 (es)
PT (1) PT3700913T (es)
RS (1) RS62984B1 (es)
SG (1) SG11202003049WA (es)
SI (1) SI3700913T1 (es)
TW (1) TW201932117A (es)
UA (1) UA126456C2 (es)
UY (1) UY37948A (es)
WO (1) WO2019081292A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
WO2022112213A1 (en) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Crystalline forms of 3-[[3-(4-chlorophenyl)-5-oxo-4-((2s)-3,3,3-trifluoro- 2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]methyl]-1-[3- (trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
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DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
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BR112016007643B1 (pt) * 2013-10-16 2021-03-23 Bayer Cropscience Aktiengesellschaft Composições fungicidas com derivado de carboxamida e composto fungicida, seus processos de produção, seus usos e método para o controle de fungos nocivos fitopatogênicos
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EP3452470B1 (en) 2016-05-03 2020-03-18 Bayer Pharma Aktiengesellschaft Amide-substituted phenyltriazole derivatives and uses thereof
JP6911052B2 (ja) 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用
EP3452472A1 (en) 2016-05-03 2019-03-13 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
US10525041B2 (en) 2016-05-03 2020-01-07 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
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EP3529244A1 (en) 2016-10-20 2019-08-28 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof

Also Published As

Publication number Publication date
PT3700913T (pt) 2022-01-31
CA3079767A1 (en) 2019-05-02
CN111225921A (zh) 2020-06-02
HUE057278T2 (hu) 2022-04-28
ECSP20023056A (es) 2020-12-31
DOP2020000076A (es) 2020-08-31
CU24604B1 (es) 2022-06-06
US11298367B2 (en) 2022-04-12
UY37948A (es) 2019-05-31
PL3700913T3 (pl) 2022-02-21
CU20200040A7 (es) 2021-03-11
WO2019081292A1 (en) 2019-05-02
HRP20220060T1 (hr) 2022-04-15
EP3700913A1 (en) 2020-09-02
AU2018356352A1 (en) 2020-04-16
IL273949A (en) 2020-05-31
US20200338096A1 (en) 2020-10-29
CY1124938T1 (el) 2023-01-05
UA126456C2 (uk) 2022-10-05
PH12020550473A1 (en) 2021-03-08
JP2021500365A (ja) 2021-01-07
MA50438B1 (fr) 2022-03-31
SG11202003049WA (en) 2020-04-29
SI3700913T1 (sl) 2022-02-28
ES2906305T3 (es) 2022-04-18
KR20200069361A (ko) 2020-06-16
EA202091025A1 (ru) 2020-07-30
CO2020004945A2 (es) 2020-05-05
LT3700913T (lt) 2022-01-25
PE20210394A1 (es) 2021-03-02
EP3700913B1 (en) 2021-11-10
BR112020007983A2 (pt) 2020-10-27
JOP20200099A1 (ar) 2020-05-06
AR113791A1 (es) 2020-06-10
DK3700913T3 (da) 2022-02-07
RS62984B1 (sr) 2022-03-31
MX2020004191A (es) 2020-08-03
CL2020001076A1 (es) 2021-02-19
TW201932117A (zh) 2019-08-16
CR20200176A (es) 2020-07-24
MA50438A (fr) 2020-09-02

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