MX2020004191A - Profarmacos de derivados de triazol sustituido y sus usos. - Google Patents

Profarmacos de derivados de triazol sustituido y sus usos.

Info

Publication number
MX2020004191A
MX2020004191A MX2020004191A MX2020004191A MX2020004191A MX 2020004191 A MX2020004191 A MX 2020004191A MX 2020004191 A MX2020004191 A MX 2020004191A MX 2020004191 A MX2020004191 A MX 2020004191A MX 2020004191 A MX2020004191 A MX 2020004191A
Authority
MX
Mexico
Prior art keywords
triazol
prodrugs
trifluoro
chlorophenyl
dihydro
Prior art date
Application number
MX2020004191A
Other languages
English (en)
Inventor
Ursula Krenz
Klemens Lustig
Axel Kretschmer
Carsten Schmeck
Hanna Tinel
Pierre Wasnaire
Peter Kolkhof
Thomas Mondritzki
Elisabeth Pook
Heiko Schirmer
Matthias Beat Wittwer
Thomas Neubauer
Hana Cernecka
Marie-Pierre Collin-Kroepelin
Chantal Fuerstner
Karoline Droebner
Anja Buchmueller
Robert Fricke
Guillaume Levilain
Norbert Witowski
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020004191A publication Critical patent/MX2020004191A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

La presente invención se refiere a profármacos 3-({3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropi l]-4,5-dihidro-1H-1,2,4-triazol-1-il}metil)-1-[3-(trifluorometil) -piridin-2-il]-1H-1,2,4-triazol-5-carboxamida, 3-({3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropi l]-4,5-dihidro-1H-1,2,4-triazol-1-il}metil)-1-[2-(trifluorometil) -fenil]-1H-1,2,4-triazol-5-carboxamida y 3-({3-(4-clorofenil)-5-ox o-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-t riazol-1-il}metil)-1-(3-cloropiridin-2-il)-1H-1,2,4-triazol-5-car boxamida, a procesos para la preparación de tales compuestos, a composiciones farmacéuticas que contienen tales compuestos, y al uso de tales compuestos o composiciones para el tratamiento y/o prevención de enfermedades, en particular para el tratamiento y/o prevención de enfermedades renales y cardiovasculares.
MX2020004191A 2017-10-24 2018-10-17 Profarmacos de derivados de triazol sustituido y sus usos. MX2020004191A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24
PCT/EP2018/078364 WO2019081292A1 (en) 2017-10-24 2018-10-17 PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

Publications (1)

Publication Number Publication Date
MX2020004191A true MX2020004191A (es) 2020-08-03

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004191A MX2020004191A (es) 2017-10-24 2018-10-17 Profarmacos de derivados de triazol sustituido y sus usos.

Country Status (38)

Country Link
US (1) US11298367B2 (es)
EP (1) EP3700913B1 (es)
JP (1) JP2021500365A (es)
KR (1) KR20200069361A (es)
CN (1) CN111225921A (es)
AR (1) AR113791A1 (es)
AU (1) AU2018356352A1 (es)
BR (1) BR112020007983A2 (es)
CA (1) CA3079767A1 (es)
CL (1) CL2020001076A1 (es)
CO (1) CO2020004945A2 (es)
CR (1) CR20200176A (es)
CU (1) CU24604B1 (es)
CY (1) CY1124938T1 (es)
DK (1) DK3700913T3 (es)
DO (1) DOP2020000076A (es)
EA (1) EA202091025A1 (es)
EC (1) ECSP20023056A (es)
ES (1) ES2906305T3 (es)
HR (1) HRP20220060T1 (es)
HU (1) HUE057278T2 (es)
IL (1) IL273949A (es)
JO (1) JOP20200099A1 (es)
LT (1) LT3700913T (es)
MA (1) MA50438B1 (es)
MX (1) MX2020004191A (es)
NI (1) NI202000030A (es)
PE (1) PE20210394A1 (es)
PH (1) PH12020550473A1 (es)
PL (1) PL3700913T3 (es)
PT (1) PT3700913T (es)
RS (1) RS62984B1 (es)
SG (1) SG11202003049WA (es)
SI (1) SI3700913T1 (es)
TW (1) TW201932117A (es)
UA (1) UA126456C2 (es)
UY (1) UY37948A (es)
WO (1) WO2019081292A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
WO2022112213A1 (en) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Crystalline forms of 3-[[3-(4-chlorophenyl)-5-oxo-4-((2s)-3,3,3-trifluoro- 2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]methyl]-1-[3- (trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

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DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
KR100854872B1 (ko) 2003-12-22 2008-08-28 화이자 인코포레이티드 바소프레신 길항제로서의 트리아졸 유도체
MXPA06012510A (es) 2004-04-28 2006-12-15 Pfizer Derivados de 3-heterociclil-4-fenil-triazol como inhibidores del receptor de vasopresina via.
AR069206A1 (es) * 2007-11-06 2010-01-06 Astrazeneca Ab Derivados de 2-pirazinona, proceso para preparalos, composiciones farmaceuticas que los comprenden, proceso de preparacion de las mismas y usos en el tratamiento de trastornos osteoarticularesy del aparato respiratorio, entre otros.
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
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DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
BR112016007643B1 (pt) * 2013-10-16 2021-03-23 Bayer Cropscience Aktiengesellschaft Composições fungicidas com derivado de carboxamida e composto fungicida, seus processos de produção, seus usos e método para o controle de fungos nocivos fitopatogênicos
HUE040696T2 (hu) 2014-11-03 2019-03-28 Bayer Pharma AG Hidroxialkil-szubsztituált feniltriazol-származékok és alkalmazásuk
UY36571A (es) * 2015-03-05 2016-09-30 Bayer Cropscience Ag Combinaciones de compuestos activos
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WO2017191115A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
US10525041B2 (en) 2016-05-03 2020-01-07 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
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WO2018073144A1 (en) 2016-10-20 2018-04-26 Bayer Pharma Aktiengesellschaft Hydroxyalkyl-substituted triazole derivatives and uses thereof

Also Published As

Publication number Publication date
EP3700913A1 (en) 2020-09-02
CL2020001076A1 (es) 2021-02-19
LT3700913T (lt) 2022-01-25
IL273949A (en) 2020-05-31
AU2018356352A1 (en) 2020-04-16
WO2019081292A1 (en) 2019-05-02
BR112020007983A2 (pt) 2020-10-27
MA50438B1 (fr) 2022-03-31
HRP20220060T1 (hr) 2022-04-15
MA50438A (fr) 2020-09-02
CU24604B1 (es) 2022-06-06
CY1124938T1 (el) 2023-01-05
SG11202003049WA (en) 2020-04-29
UY37948A (es) 2019-05-31
DOP2020000076A (es) 2020-08-31
JOP20200099A1 (ar) 2020-05-06
CA3079767A1 (en) 2019-05-02
JP2021500365A (ja) 2021-01-07
PH12020550473A1 (en) 2021-03-08
CO2020004945A2 (es) 2020-05-05
US11298367B2 (en) 2022-04-12
CR20200176A (es) 2020-07-24
NI202000030A (es) 2020-10-09
PL3700913T3 (pl) 2022-02-21
SI3700913T1 (sl) 2022-02-28
EA202091025A1 (ru) 2020-07-30
CU20200040A7 (es) 2021-03-11
PE20210394A1 (es) 2021-03-02
AR113791A1 (es) 2020-06-10
HUE057278T2 (hu) 2022-04-28
ES2906305T3 (es) 2022-04-18
PT3700913T (pt) 2022-01-31
DK3700913T3 (da) 2022-02-07
ECSP20023056A (es) 2020-12-31
CN111225921A (zh) 2020-06-02
TW201932117A (zh) 2019-08-16
EP3700913B1 (en) 2021-11-10
UA126456C2 (uk) 2022-10-05
KR20200069361A (ko) 2020-06-16
US20200338096A1 (en) 2020-10-29
RS62984B1 (sr) 2022-03-31

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