ECSP20023056A - Profármacos de derivados de triazol sustituido y sus usos - Google Patents

Profármacos de derivados de triazol sustituido y sus usos

Info

Publication number
ECSP20023056A
ECSP20023056A ECSENADI202023056A ECDI202023056A ECSP20023056A EC SP20023056 A ECSP20023056 A EC SP20023056A EC SENADI202023056 A ECSENADI202023056 A EC SENADI202023056A EC DI202023056 A ECDI202023056 A EC DI202023056A EC SP20023056 A ECSP20023056 A EC SP20023056A
Authority
EC
Ecuador
Prior art keywords
triazole
propharmacs
triazole derivatives
carboxamide
trifluoro
Prior art date
Application number
ECSENADI202023056A
Other languages
English (en)
Inventor
Marie-Pierre Collin-Kroepelin
Chantal Fuerstner
Peter Kolkhof
Thomas Mondritzki
Thomas Neubauer
Carsten Schmeck
Matthias Wittwer
Elisabeth Pook
Heiko Schirmer
Hana Cernecka
Axel Kretschmer
Karoline Droebner
Robert Fricke
Guillaume Levilain
Klemens Lustig
Anja Buchmueller
Hanna Tinel
Ursula Krenz
Norbert Witowski
Pierre Wasnaire
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of ECSP20023056A publication Critical patent/ECSP20023056A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

La presente invención se refiere a profármacos 3-({3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-il}metil)-1-[3-(trifluorometil)-piridin-2-il]-1H-1,2,4-triazol-5-carboxamida, 3-({3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-il}metil)-1-[2-(trifluorometil)-fenil]-1H-1,2,4-triazol-5-carboxamida y 3-({3-(4-clorofenil)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hidroxipropil]-4,5-dihidro-1H-1,2,4-triazol-1-il}metil)-1-(3-cloropiridin-2-il)-1H-1,2,4-triazol-5-carboxamida, a procesos para la preparación de tales compuestos, a composiciones farmacéuticas que contienen tales compuestos, y al uso de tales compuestos o composiciones para el tratamiento y/o prevención de enfermedades, en particular para el tratamiento y/o prevención de enfermedades renales y cardiovasculares.
ECSENADI202023056A 2017-10-24 2020-04-21 Profármacos de derivados de triazol sustituido y sus usos ECSP20023056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17197935 2017-10-24

Publications (1)

Publication Number Publication Date
ECSP20023056A true ECSP20023056A (es) 2020-12-31

Family

ID=60162099

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202023056A ECSP20023056A (es) 2017-10-24 2020-04-21 Profármacos de derivados de triazol sustituido y sus usos

Country Status (38)

Country Link
US (1) US11298367B2 (es)
EP (1) EP3700913B1 (es)
JP (1) JP2021500365A (es)
KR (1) KR20200069361A (es)
CN (1) CN111225921A (es)
AR (1) AR113791A1 (es)
AU (1) AU2018356352A1 (es)
BR (1) BR112020007983A2 (es)
CA (1) CA3079767A1 (es)
CL (1) CL2020001076A1 (es)
CO (1) CO2020004945A2 (es)
CR (1) CR20200176A (es)
CU (1) CU24604B1 (es)
CY (1) CY1124938T1 (es)
DK (1) DK3700913T3 (es)
DO (1) DOP2020000076A (es)
EA (1) EA202091025A1 (es)
EC (1) ECSP20023056A (es)
ES (1) ES2906305T3 (es)
HR (1) HRP20220060T1 (es)
HU (1) HUE057278T2 (es)
IL (1) IL273949A (es)
JO (1) JOP20200099A1 (es)
LT (1) LT3700913T (es)
MA (1) MA50438B1 (es)
MX (1) MX2020004191A (es)
NI (1) NI202000030A (es)
PE (1) PE20210394A1 (es)
PH (1) PH12020550473A1 (es)
PL (1) PL3700913T3 (es)
PT (1) PT3700913T (es)
RS (1) RS62984B1 (es)
SG (1) SG11202003049WA (es)
SI (1) SI3700913T1 (es)
TW (1) TW201932117A (es)
UA (1) UA126456C2 (es)
UY (1) UY37948A (es)
WO (1) WO2019081292A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
WO2022112213A1 (en) 2020-11-30 2022-06-02 Bayer Aktiengesellschaft Crystalline forms of 3-[[3-(4-chlorophenyl)-5-oxo-4-((2s)-3,3,3-trifluoro- 2-hydroxypropyl)-4,5-dihydro-1h-1,2,4-triazol-1-yl]methyl]-1-[3- (trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazole-5-carboxamide

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DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
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MX2016004532A (es) * 2013-10-16 2016-07-22 Bayer Cropscience Ag Combinaciones de compuestos activos que comprenden un derivado de (tio)carboxamida y un compuesto fungicida.
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Also Published As

Publication number Publication date
EP3700913B1 (en) 2021-11-10
CN111225921A (zh) 2020-06-02
CU20200040A7 (es) 2021-03-11
DK3700913T3 (da) 2022-02-07
LT3700913T (lt) 2022-01-25
JP2021500365A (ja) 2021-01-07
PE20210394A1 (es) 2021-03-02
UA126456C2 (uk) 2022-10-05
AU2018356352A1 (en) 2020-04-16
MA50438A (fr) 2020-09-02
ES2906305T3 (es) 2022-04-18
MX2020004191A (es) 2020-08-03
WO2019081292A1 (en) 2019-05-02
UY37948A (es) 2019-05-31
BR112020007983A2 (pt) 2020-10-27
AR113791A1 (es) 2020-06-10
US20200338096A1 (en) 2020-10-29
CO2020004945A2 (es) 2020-05-05
PL3700913T3 (pl) 2022-02-21
PH12020550473A1 (en) 2021-03-08
PT3700913T (pt) 2022-01-31
US11298367B2 (en) 2022-04-12
NI202000030A (es) 2020-10-09
CR20200176A (es) 2020-07-24
SI3700913T1 (sl) 2022-02-28
CL2020001076A1 (es) 2021-02-19
CA3079767A1 (en) 2019-05-02
SG11202003049WA (en) 2020-04-29
DOP2020000076A (es) 2020-08-31
TW201932117A (zh) 2019-08-16
HRP20220060T1 (hr) 2022-04-15
CU24604B1 (es) 2022-06-06
EA202091025A1 (ru) 2020-07-30
RS62984B1 (sr) 2022-03-31
IL273949A (en) 2020-05-31
HUE057278T2 (hu) 2022-04-28
MA50438B1 (fr) 2022-03-31
JOP20200099A1 (ar) 2020-05-06
EP3700913A1 (en) 2020-09-02
CY1124938T1 (el) 2023-01-05
KR20200069361A (ko) 2020-06-16

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