AR112278A1 - Proceso mejorado para la preparación de productos intermedios - Google Patents

Proceso mejorado para la preparación de productos intermedios

Info

Publication number
AR112278A1
AR112278A1 ARP180102002A AR112278A1 AR 112278 A1 AR112278 A1 AR 112278A1 AR P180102002 A ARP180102002 A AR P180102002A AR 112278 A1 AR112278 A1 AR 112278A1
Authority
AR
Argentina
Prior art keywords
chlorocyclopropyl
chlorophenyl
chloro
reacting
prothioconazole
Prior art date
Application number
Other languages
English (en)
Inventor
Jaidev Rajnikant Shroff
Vikram Rajnikant Shroff
Talati Paresh Vithaldas
Santosh Ganpat Shelke
Original Assignee
Upl Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upl Ltd filed Critical Upl Ltd
Publication of AR112278A1 publication Critical patent/AR112278A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/27—Condensation of epihalohydrins or halohydrins with compounds containing active hydrogen atoms
    • C07D301/28—Condensation of epihalohydrins or halohydrins with compounds containing active hydrogen atoms by reaction with hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
    • C07D301/26—Y being hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente solicitud se describe un proceso para preparar 1-cloro-2-(1-clorociclopropil)-3-(2-clorofenil)propan-2-ol y 2-(1-clorociclopropil)-2-[(2-clorofenil)metil]oxirano. Reivindicación 1: Un proceso para la preparación de 1-cloro-2-(1-clorociclopropil)-3-(2-clorofenil)propan-2-ol y 2-(1-clorociclopropil)-2-[(2-clorofenil)metil]oxirano o una mezcla de estos al hacer reaccionar haluro de 2-clorobencilo con 1-cloro-1-cloroacetilciclopropano caracterizado porque la reacción se lleva a cabo en un sistema solvente que comprende metil tetrahidrofurano. Reivindicación 6: Un proceso para preparar protioconazol caracterizado porque comprende: (a) hacer reaccionar haluro de 2-clorobencilo con 1-cloro-1-cloroacetilciclopropano en un sistema solvente que comprende metil tetrahidrofurano; y (b) usar el producto de la etapa (a) para preparar protioconazol. Reivindicación 7: Un proceso para preparar protioconazol caracterizado porque comprende: (a) hacer reaccionar haluro de 2-clorobencilo con 1-cloro-1-cloroacetilciclopropano en un sistema solvente que comprende tetrahidrofurano de metilo; (a) hacer reaccionar el producto de la etapa (a) con 1,2,4-triazol para producir 2-(1-clorociclopropil)-1-(2-clorofenil)-3-(1H-1,2,4-triazol-1-il)propan-2-ol; y (c) hacer reaccionar el producto de la etapa (b) con azufre para producir protioconazol.
ARP180102002 2018-03-06 2018-07-18 Proceso mejorado para la preparación de productos intermedios AR112278A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201831008255 2018-03-06

Publications (1)

Publication Number Publication Date
AR112278A1 true AR112278A1 (es) 2019-10-09

Family

ID=67512127

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102002 AR112278A1 (es) 2018-03-06 2018-07-18 Proceso mejorado para la preparación de productos intermedios

Country Status (9)

Country Link
US (1) US20200399236A1 (es)
EP (2) EP3762356A4 (es)
CN (1) CN112399967A (es)
AR (1) AR112278A1 (es)
CA (1) CA3093047A1 (es)
EA (1) EA202091920A1 (es)
UA (1) UA127895C2 (es)
UY (1) UY37792A (es)
WO (1) WO2019171161A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN201921042108A (es) * 2019-10-17 2021-04-23
CN114085126B (zh) * 2021-10-09 2023-09-29 张北北九食品检验技术有限公司 放射性同位素碳-14标记的苄基化合物、丙硫菌唑及其制备方法和在代谢实验中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3812967A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Azolylmethyl-cyclopropyl-derivate
DE3942240A1 (de) * 1989-12-21 1991-06-27 Bayer Ag Azolylmethyl-cyclopropyl-saccharinaddukte
DE4027608A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Verfahren zur herstellung von 1-chlor-2-(1-chlor-cyclopropyl)-3-(2-chlor-phenyl)-propan-2-ol und/oder 2-(1-chlor-cyclopropyl)-2-(2-chlor-benzyl)-oxiran
DE4030039A1 (de) * 1990-09-22 1992-03-26 Bayer Ag Verfahren zur herstellung von 2-(1-chlor-cyclopropyl)-1- (2-chlor-phenyl)-3-(1,2,4-triazol-1-yl- propan-2-ol
DE19808570C1 (de) 1998-02-28 1999-03-04 Metallgesellschaft Ag Benzylmagnesiumhalogenide oder Allylmagnesiumhalogenide enthaltende Synthesemittel und Verfahren zu deren Herstellung
DE10233171A1 (de) * 2002-07-22 2004-02-12 Bayer Cropscience Ag Kristallmodifikation II des 2-[2-(Chlor-cyclopropyl)-3-(2-chlorphenyl)-2-hydroxy-propyl]-2,4dihydro-3H-1,2,4-triazol-3-thions
CN105263911A (zh) * 2012-12-21 2016-01-20 巴斯夫欧洲公司 取代[1,2,4]三唑和咪唑化合物
CN104557742A (zh) 2013-10-15 2015-04-29 上海生华化学科技有限公司 一种丙硫菌唑类似物的制备方法
CN106749057B (zh) * 2016-12-30 2019-07-30 南京工业大学 一种中间体化合物以及丙硫菌唑的合成方法
CN106928041A (zh) 2017-03-02 2017-07-07 芮城县斯普伦迪生物工程有限公司 一种2‑氯苄基‑（1‑氯环丙基）酮的制备方法
CN107628928A (zh) * 2017-09-27 2018-01-26 长治市晋宁化工有限公司 2‑(1‑氯‑环丙烷‑1‑基)‑3‑氯‑1‑(2‑氯‑苯基)‑2‑丙醇的制备方法

Also Published As

Publication number Publication date
CA3093047A1 (en) 2019-09-12
EP3762356A1 (en) 2021-01-13
EP3762356A4 (en) 2021-09-29
EP4385329A2 (en) 2024-06-19
US20200399236A1 (en) 2020-12-24
UA127895C2 (uk) 2024-02-07
BR102018015115A2 (pt) 2019-09-17
AU2018411552A1 (en) 2020-10-08
UY37792A (es) 2019-04-30
EA202091920A1 (ru) 2020-10-27
WO2019171161A8 (en) 2020-11-05
CN112399967A (zh) 2021-02-23
WO2019171161A1 (en) 2019-09-12

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