MD4505C1 - Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei - Google Patents
Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-oneiInfo
- Publication number
- MD4505C1 MD4505C1 MDA20160146A MD20160146A MD4505C1 MD 4505 C1 MD4505 C1 MD 4505C1 MD A20160146 A MDA20160146 A MD A20160146A MD 20160146 A MD20160146 A MD 20160146A MD 4505 C1 MD4505 C1 MD 4505C1
- Authority
- MD
- Moldova
- Prior art keywords
- butan
- dimethyl
- acetone
- triazol
- synthesis
- Prior art date
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Invenţia se referă la chimia organică, şi anume la un procedeu de obţinere a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei - un intermediat pentru sinteza substanţelor cu activitate biologică antituberculoasă sau fungicidă.Esenţa invenţiei revendicate constă în aceea că se alchilează 1,2,4-triazolul cu 1-clor-3,3-dimetil-2-butan-2-onă în sistemul acetonă/K2CO3, conform schemei:Amestecul reactant se fierbe timp de 5…7 ore, se separă soluţia acetonică de precipitatul format, se distilează acetona, reziduul se extrage cu hexan la fierbere, din care la răcire se sedimentează produsul pur 1.Reacţia decurge într-o singură etapă, într-un timp mai scurt şi cu un randament mai mare (99%) faţă de procedeele analogice.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160146A MD4505C1 (ro) | 2016-12-21 | 2016-12-21 | Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160146A MD4505C1 (ro) | 2016-12-21 | 2016-12-21 | Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4505B1 MD4505B1 (ro) | 2017-08-31 |
MD4505C1 true MD4505C1 (ro) | 2018-03-31 |
Family
ID=59759576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160146A MD4505C1 (ro) | 2016-12-21 | 2016-12-21 | Procedeu de sinteză a 3,3-dimetil-1-(1H-1,2,4-triazol-1-il)butan-2-onei |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4505C1 (ro) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1464224A (en) * | 1974-06-29 | 1977-02-09 | Bayer Ag | Triazolyl-alkanones and triazolylalkanols processes for their preparation and their use as fungicides |
US4079143A (en) * | 1975-08-26 | 1978-03-14 | Imperial Chemical Industries Limited | Fungicidal 1H-1,2,4-triazoles |
US4243405A (en) * | 1976-08-19 | 1981-01-06 | Imperial Chemical Industries Limited | Fungicidal compounds |
CA1168248A (en) * | 1980-07-25 | 1984-05-29 | Erik Regel | Triazolylpropenol derivatives, a process for their preparation and their use as plant growth regulators and fungicides |
CA1179352A (en) * | 1980-07-25 | 1984-12-11 | Erik Regel | Triazolylpropenone derivatives, a process for their preparation and their use as intermediates |
US4554007A (en) * | 1979-03-20 | 1985-11-19 | Sumitomo Chemical Company, Limited | Geometrical isomer of 1-substituted-1-triazolylstyrenes, and their production and use as fungicide, herbicide and/or plant growth regulant |
CN102351803A (zh) * | 2011-11-18 | 2012-02-15 | 苏州诚和医药化学有限公司 | 一种合成3,3-二甲基-1-(1h-1,2,4三唑)丁酮-2的方法 |
-
2016
- 2016-12-21 MD MDA20160146A patent/MD4505C1/ro not_active IP Right Cessation
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1464224A (en) * | 1974-06-29 | 1977-02-09 | Bayer Ag | Triazolyl-alkanones and triazolylalkanols processes for their preparation and their use as fungicides |
US4079143A (en) * | 1975-08-26 | 1978-03-14 | Imperial Chemical Industries Limited | Fungicidal 1H-1,2,4-triazoles |
US4243405A (en) * | 1976-08-19 | 1981-01-06 | Imperial Chemical Industries Limited | Fungicidal compounds |
US4554007A (en) * | 1979-03-20 | 1985-11-19 | Sumitomo Chemical Company, Limited | Geometrical isomer of 1-substituted-1-triazolylstyrenes, and their production and use as fungicide, herbicide and/or plant growth regulant |
US4749716A (en) * | 1979-03-20 | 1988-06-07 | Sumitomo Chemical Company, Limited | Geometrical isomer of 1-substituted-1-triazolystyrenes |
CA1168248A (en) * | 1980-07-25 | 1984-05-29 | Erik Regel | Triazolylpropenol derivatives, a process for their preparation and their use as plant growth regulators and fungicides |
CA1179352A (en) * | 1980-07-25 | 1984-12-11 | Erik Regel | Triazolylpropenone derivatives, a process for their preparation and their use as intermediates |
CN102351803A (zh) * | 2011-11-18 | 2012-02-15 | 苏州诚和医药化学有限公司 | 一种合成3,3-二甲基-1-(1h-1,2,4三唑)丁酮-2的方法 |
Non-Patent Citations (3)
Title |
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Funaki Y. et al. Structure-activity relationships of vinyl triazole fungicides. J. Pesticide Sci., 1984, 9, 229-236 * |
Pawan Kumar Mishra, Jaya Dwivedi, Rajani Chauhan. Triazoles as potential antitubercular agent: a review. Journal of Advanced Scientific Research, 2016, 7(1), 9-13. * |
Rangappa S. Keri, Siddappa A. Patil, Srinivasa, Budagumpi, Bhari Mallanna Nagaraja. Triazole: A Promising Antitubercular Agent. Chem Biol Drug Des 2015, 86, 410-423 * |
Also Published As
Publication number | Publication date |
---|---|
MD4505B1 (ro) | 2017-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |