WO2008075163A3 - An improved process for the preparation of rizatriptan - Google Patents

An improved process for the preparation of rizatriptan Download PDF

Info

Publication number
WO2008075163A3
WO2008075163A3 PCT/IB2007/003896 IB2007003896W WO2008075163A3 WO 2008075163 A3 WO2008075163 A3 WO 2008075163A3 IB 2007003896 W IB2007003896 W IB 2007003896W WO 2008075163 A3 WO2008075163 A3 WO 2008075163A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved process
rizatriptan
preparation
ethanamine
triazol
Prior art date
Application number
PCT/IB2007/003896
Other languages
French (fr)
Other versions
WO2008075163A2 (en
Inventor
Joseph Prabahar Koilpillai
Magesh Subramanian
Uppalaiah Mallela
Venkata Balaji Boddu
Ramesh Dandala
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Ltd
Joseph Prabahar Koilpillai
Magesh Subramanian
Uppalaiah Mallela
Venkata Balaji Boddu
Ramesh Dandala
Sivakumaran Meenakshisunderam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd, Joseph Prabahar Koilpillai, Magesh Subramanian, Uppalaiah Mallela, Venkata Balaji Boddu, Ramesh Dandala, Sivakumaran Meenakshisunderam filed Critical Aurobindo Pharma Ltd
Priority to EP07859030A priority Critical patent/EP2121663A2/en
Publication of WO2008075163A2 publication Critical patent/WO2008075163A2/en
Publication of WO2008075163A3 publication Critical patent/WO2008075163A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for preparing N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine of Formula (I) and its pharmaceutically acceptable salts.
PCT/IB2007/003896 2006-12-15 2007-12-10 An improved process for the preparation of rizatriptan WO2008075163A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07859030A EP2121663A2 (en) 2006-12-15 2007-12-10 An improved process for the preparation of rizatriptan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2336/CHE/2006 2006-12-15
IN2336CH2006 2006-12-15

Publications (2)

Publication Number Publication Date
WO2008075163A2 WO2008075163A2 (en) 2008-06-26
WO2008075163A3 true WO2008075163A3 (en) 2008-09-25

Family

ID=39265610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003896 WO2008075163A2 (en) 2006-12-15 2007-12-10 An improved process for the preparation of rizatriptan

Country Status (2)

Country Link
EP (1) EP2121663A2 (en)
WO (1) WO2008075163A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103387570A (en) * 2013-08-20 2013-11-13 余鲜红 Preparation method of rizatriptan benzoate
CN103664900B (en) * 2013-11-25 2016-02-24 四川大学 A kind of method preparing rizatriptan benzoate
CN103664901B (en) * 2013-11-25 2016-04-13 四川大学 A kind of rizatriptan benzoate preparation method
CN108892648A (en) * 2018-07-13 2018-11-27 山东贵邦药业有限公司 A kind of Lizakuputan benzoate intermediate process for solid phase synthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053116A2 (en) * 2004-11-10 2006-05-18 Dr. Reddy's Laboratories Ltd. Rizatriptan process

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053116A2 (en) * 2004-11-10 2006-05-18 Dr. Reddy's Laboratories Ltd. Rizatriptan process

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN C-Y ET AL: "SYNTHESIS OF THE 5-HT1D RECEPTOR AGONIST MK-0462 VIA A PD-CATALYZED COUPLING REACTION", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 35, no. 38, 19 September 1994 (1994-09-19), pages 6981 - 6984, XP000608320, ISSN: 0040-4039 *
MAGEDOV I V ET AL: "New Procedure for Obtaining Indomethacin", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, KLUWER ACADEMIC PUBLISHERS-CONSULTANTS BUREAU, NE, vol. 41, no. 4, 1 April 2005 (2005-04-01), pages 449 - 451, XP019276316, ISSN: 1573-8353 *
SUSLOV V V ET AL: "Novel schemes for the synthesis of pyrrolocoumarins", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, KLUWER ACADEMIC PUBLISHERS-CONSULTANTS BUREAU, NE, vol. 40, no. 10, 1 October 2004 (2004-10-01), pages 1315 - 1322, XP019276142, ISSN: 1573-8353 *

Also Published As

Publication number Publication date
WO2008075163A2 (en) 2008-06-26
EP2121663A2 (en) 2009-11-25

Similar Documents

Publication Publication Date Title
WO2008001101A3 (en) Pharmaceutical combinations
WO2008157751A3 (en) Substituted imidazoheterocycles
UA94833C2 (en) Substituted bicyclolactams
MX2010003155A (en) Cyclopropyl aryl amide derivatives and uses thereof.
WO2007062999A3 (en) 1,5-substituted indol-2-yl amide derivatives
WO2009000442A8 (en) Processes for the preparation of pyrazoles
WO2008001195A3 (en) Novel processes for the preparation of dpp iv inhibitors
WO2007135527A3 (en) Benzimidazolyl compounds
WO2007017728A3 (en) Novel heterocyclic compounds
WO2010018549A3 (en) Therapeutic compositions containing macitentan
WO2007013096A8 (en) Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole)
PT2049480E (en) 2-arylindole derivatives as mpges-1 inhibitors
WO2008151828A3 (en) Novel microbiocides
WO2010076810A3 (en) A process for the preparation of gefitinib
EP1831239A1 (en) A process for the preparation of 17-hydroxy-6 beta, 7 beta, 15 beta, 16 beta -bismethylene-17 alpha-pregn-4-ene-3-one-21-carboxylic acid lambda-lactone and key-intermediates for this process
WO2008101247A3 (en) 6 ' substituted indole and indazole derivatives having 5-ht6 receptor affinity
WO2007112913A3 (en) Benzimidazole derivatives
MX2010001938A (en) Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)p yrimidine-based compounds.
WO2007092157A9 (en) 7-(1h-imidazol-4-yl) methyl) -5,6,7,8-tetrahydroquinoline
WO2008075163A3 (en) An improved process for the preparation of rizatriptan
WO2008059514A3 (en) Process for preparing escitalopram
WO2006006040A3 (en) News diamine salts of cephalosporin antibiotics and their preparation
WO2008099416A3 (en) Novel benzothiazole and benzoxazole linked pyrrolo[2,1-c] [1, 4] benzodiazepine hybrids as novel antitumour agents and process for the preparation thereof
WO2009021943A3 (en) Novel preparation process
DE602006013828D1 (en) 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07859030

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007859030

Country of ref document: EP