BR102013027313A8 - processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso - Google Patents

processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

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Publication number
BR102013027313A8
BR102013027313A8 BR102013027313A BR102013027313A BR102013027313A8 BR 102013027313 A8 BR102013027313 A8 BR 102013027313A8 BR 102013027313 A BR102013027313 A BR 102013027313A BR 102013027313 A BR102013027313 A BR 102013027313A BR 102013027313 A8 BR102013027313 A8 BR 102013027313A8
Authority
BR
Brazil
Prior art keywords
triazol
alkanols
selective preparation
present
intermediates
Prior art date
Application number
BR102013027313A
Other languages
English (en)
Other versions
BR102013027313B1 (pt
BR102013027313A2 (pt
Inventor
Silva De Souza Anderson
Leite De Mattos E Mendes Breno
Original Assignee
Iharabras S A Industrias Quim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iharabras S A Industrias Quim filed Critical Iharabras S A Industrias Quim
Priority to BR102013027313-9A priority Critical patent/BR102013027313B1/pt
Priority to PCT/BR2014/000383 priority patent/WO2015058272A1/pt
Publication of BR102013027313A2 publication Critical patent/BR102013027313A2/pt
Publication of BR102013027313A8 publication Critical patent/BR102013027313A8/pt
Publication of BR102013027313B1 publication Critical patent/BR102013027313B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

processo para a preparação seletiva de ( 1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso. a presente invenção descreve um processo para a preparação seletiva de (1h-1,2,4-triazol-1-ii)alcanóis úteis como intermediários de síntese e como ingredientes ativos farmacêuticos, veterinários e agroquímicos, bem como o uso de seus intermediários, as condições de processamento. de acordo com a presente invenção, oxiranos e halohidrinas reagem com hidrazina (em qualquer forma de apresentação, hidratos ou sais) para originar intermediários do tipo hidrazinilalcanol, os quais são convertidos em (1 h-1 2,4-triazol-1 -ii)alcanóis pela reação com algum reagente formador de 1 2,4-triazolil. a técnica descoberta representa um avanço em relação ao estado da arte por não permitir a formação de isômeros substituidos na posição 4 do anel triazol, os (1h-1,2,4-triazol-4-il)alcanóis. os métodos descritos na presente invenção são particularmente vantajosos em relação ao estado da arte por apresentarem maiores rendimentos, menores tempos de processamento, simplificação das operações unitárias,maior facilidade na recuperação de materiais não reagidos e auxiliares, total seletividade à formação de regioisômero
BR102013027313-9A 2013-10-23 2013-10-23 Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso BR102013027313B1 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR102013027313-9A BR102013027313B1 (pt) 2013-10-23 2013-10-23 Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso
PCT/BR2014/000383 WO2015058272A1 (pt) 2013-10-23 2014-10-22 Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il)alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102013027313-9A BR102013027313B1 (pt) 2013-10-23 2013-10-23 Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

Publications (3)

Publication Number Publication Date
BR102013027313A2 BR102013027313A2 (pt) 2015-09-01
BR102013027313A8 true BR102013027313A8 (pt) 2018-10-23
BR102013027313B1 BR102013027313B1 (pt) 2019-06-18

Family

ID=52992068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR102013027313-9A BR102013027313B1 (pt) 2013-10-23 2013-10-23 Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

Country Status (2)

Country Link
BR (1) BR102013027313B1 (pt)
WO (1) WO2015058272A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019009787A2 (pt) * 2016-11-18 2019-08-06 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro -2-hidróxi-3-(5-mercapto-1h-1,2,4-triazol-1-il)propil) piridina-3-il)óxi)benzonitrila e processos de preparação
CN109020905B (zh) * 2017-06-09 2022-12-23 华东理工大学 两种环丙唑醇的多晶型及其制备方法
CN113666840B (zh) * 2021-10-22 2022-01-11 江苏七洲绿色科技研究院有限公司 一种丙硫菌唑中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069442B1 (en) * 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
US4490539A (en) * 1982-06-22 1984-12-25 Nehezvegyipari Kutato Intezet Process for the preparation of 1,2,4-triazole
CH658654A5 (de) * 1983-03-04 1986-11-28 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und mittel die diese verbindungen enthalten.
IL105200A (en) * 1993-03-29 1997-03-18 Teva Pharma Regiospecific processes for the preparation of 1, 3-bis (1, 2, 4-triazol-1-yl)-propan- 2-ol derivatives
SI9600165A (en) * 1996-05-21 1997-12-31 Krka Tovarna Zdravil D D Novo Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
US5710280A (en) * 1996-07-09 1998-01-20 Development Center For Biotechnology Preparation of fluconazole and pharmaceutically acceptable salts thereof
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법

Also Published As

Publication number Publication date
BR102013027313B1 (pt) 2019-06-18
BR102013027313A2 (pt) 2015-09-01
WO2015058272A1 (pt) 2015-04-30

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: reinstatement - article 33, solely paragraph, of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B06I Technical and formal requirements: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B03H Publication of an application: rectification

Free format text: REFERENTE AO CODIGO 3.1 PUBLICADO NA RPI2330 DE 01/09/2015 RELATIVO AO CAMPO INID (72) NOME DO INVENTOR. CONSIDEREM-SE OS DADOS ATUAIS.

B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
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B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/10/2013, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/10/2013, OBSERVADAS AS CONDICOES LEGAIS