JP2019513145A5 - - Google Patents

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JP2019513145A5
JP2019513145A5 JP2018551222A JP2018551222A JP2019513145A5 JP 2019513145 A5 JP2019513145 A5 JP 2019513145A5 JP 2018551222 A JP2018551222 A JP 2018551222A JP 2018551222 A JP2018551222 A JP 2018551222A JP 2019513145 A5 JP2019513145 A5 JP 2019513145A5
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JP2019513145A (ja
JP7456721B2 (ja
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Priority claimed from PCT/US2017/024280 external-priority patent/WO2017172602A1/en
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Priority to JP2022041514A priority Critical patent/JP2022087115A/ja
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JP2018551222A 2016-03-29 2017-03-27 5-メチル-1-フェニル-2-(1h)-ピリドンの顆粒製剤及びその製造方法 Active JP7456721B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022041514A JP2022087115A (ja) 2016-03-29 2022-03-16 5-メチル-1-フェニル-2-(1h)-ピリドンの顆粒製剤及びその製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662314933P 2016-03-29 2016-03-29
US62/314,933 2016-03-29
PCT/US2017/024280 WO2017172602A1 (en) 2016-03-29 2017-03-27 Granulate formulation of 5-methy|-1-pheny|-2(1h)-pyridone and method of making the same

Related Child Applications (1)

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JP2022041514A Division JP2022087115A (ja) 2016-03-29 2022-03-16 5-メチル-1-フェニル-2-(1h)-ピリドンの顆粒製剤及びその製造方法

Publications (3)

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JP2019513145A JP2019513145A (ja) 2019-05-23
JP2019513145A5 true JP2019513145A5 (https=) 2020-05-07
JP7456721B2 JP7456721B2 (ja) 2024-03-27

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JP2018551222A Active JP7456721B2 (ja) 2016-03-29 2017-03-27 5-メチル-1-フェニル-2-(1h)-ピリドンの顆粒製剤及びその製造方法
JP2022041514A Pending JP2022087115A (ja) 2016-03-29 2022-03-16 5-メチル-1-フェニル-2-(1h)-ピリドンの顆粒製剤及びその製造方法

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Country Status (13)

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US (2) US10188637B2 (https=)
EP (2) EP3435985B1 (https=)
JP (2) JP7456721B2 (https=)
KR (1) KR102552615B1 (https=)
CN (2) CN108883072A (https=)
AR (1) AR107990A1 (https=)
AU (2) AU2017241530B2 (https=)
CA (1) CA2937365C (https=)
ES (1) ES2883595T3 (https=)
IL (1) IL261745B2 (https=)
MX (1) MX393177B (https=)
PL (1) PL3435985T3 (https=)
WO (1) WO2017172602A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180100869A (ko) * 2017-03-02 2018-09-12 영진약품 주식회사 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
US11510877B2 (en) 2017-10-10 2022-11-29 Capsugel Belgium Nv Gelling multiparticulates
ES2886152T3 (es) * 2017-12-11 2021-12-16 Laurus Labs Ltd Un procedimiento mejorado para la preparación de pirfenidona
ES2900457T3 (es) 2018-01-12 2022-03-17 Tiefenbacher Alfred E Gmbh & Co Kg Formulación de comprimidos y cápsulas que contienen pirfenidona
WO2020115774A1 (en) 2018-12-06 2020-06-11 Cipla Limited High drug load extended release formulations
WO2021022033A1 (en) 2019-07-30 2021-02-04 Leung Kai P Layered composite for scar treatment and prevention
AU2020319662B2 (en) * 2019-07-31 2024-02-29 F. Hoffmann-La Roche Ag New pharmaceutical formulation
WO2021057599A1 (zh) * 2019-09-26 2021-04-01 深圳先进技术研究院 吡非尼酮在制备防治类风湿性关节炎的药物中的应用
CN111166748B (zh) * 2019-12-14 2022-06-21 深圳先进技术研究院 吡非尼酮在制备促血管生成药物中的应用
WO2021198253A1 (en) 2020-04-01 2021-10-07 Boehringer Ingelheim International Gmbh Use of biomarkers in the treatment of fibrotic conditions
US20230225977A1 (en) * 2020-06-19 2023-07-20 Glaxosmithkline Intellectual Property (No.2) Limited Formulation comprising daprodustat
WO2022172076A1 (en) * 2021-02-09 2022-08-18 DWIVEDI, Dr. Jayesh Preparation of microwave dried novel co-processed excipient of sucrose and tablet formulation of canagliflozin tablets using co- processed excipient
CN117642153A (zh) * 2021-05-07 2024-03-01 伊莱利利公司 易蚀片剂
CN119630395A (zh) 2022-02-28 2025-03-14 努福米克斯技术有限公司 用于治疗特发性肺纤维化的组合物和方法
WO2026052613A1 (en) * 2024-09-03 2026-03-12 Elanco Us Inc. Pharmaceutical compositions and methods using the same

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042699A (en) 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
US4052509A (en) 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
DE3404810A1 (de) 1984-02-10 1985-08-14 Siemens AG, 1000 Berlin und 8000 München Fensterfunktion fuer ein aperturfenster
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
US4753801A (en) 1985-10-25 1988-06-28 Eli Lilly And Company Sustained release tablets
US5104648A (en) 1989-02-02 1992-04-14 Mallinckrodt Specialty Chemicals Company High ibuprofen content granulations
JPH02215719A (ja) 1989-02-15 1990-08-28 Yamauchi Akitomo 線維化病変組織の修復並びに線維化病変の阻止剤
US5275823A (en) 1989-04-27 1994-01-04 Smith Kline & French Laboratories Ltd. Pharmaceutical compositions
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US5716632A (en) 1989-11-22 1998-02-10 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5518729A (en) 1989-11-22 1996-05-21 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5861172A (en) 1991-05-08 1999-01-19 Laboratorios Beecham Sa Pharmaceutical formulations of compacted granulates of β-lactam antibiotics
AU1193092A (en) 1992-01-10 1993-08-03 Obschestvo S Ogranichennoi Otvetstvennostju Meditsinsky Nauchno-Proizvodstvenny Komplex Biotiki Granulated pharmaceutical composition and method of obtaining it
NZ251806A (en) 1992-04-15 1996-01-26 Marion Merrell Dow Inc Making compressed tablets containing aminoguanidine or a salt thereof and a binder, by first spray-drying an aqueous solution to form a powder
ATE180668T1 (de) 1992-12-01 1999-06-15 Spirig Ag S(+)-ibuprofen enthaltende arzneimittel
JPH08510251A (ja) 1993-05-07 1996-10-29 ビー マーゴリン、ソロモン 線維症の病変の修復と予防のための組成物および方法
EP0716597A1 (en) 1993-08-30 1996-06-19 Warner-Lambert Company Tablet coating based on a melt-spun mixture of a saccharide and apolymer
US5591766A (en) 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
GB9325644D0 (en) 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US5639754A (en) 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
RU2165423C2 (ru) 1994-10-07 2001-04-20 Фудзисава Фармасьютикал Ко., Лтд. Полипептидное соединение, способ его получения и фармацевтическая композиция
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
GB9501127D0 (en) 1995-01-20 1995-03-08 Wellcome Found Tablet
US6090822A (en) 1995-03-03 2000-07-18 Margolin; Solomon B. Treatment of cytokine growth factor caused disorders
EP0837052B1 (en) 1995-06-21 2006-08-23 Shionogi & Co., Ltd. Bicyclic amino derivatives and pgd 2 antagonist containing the same
US5681382A (en) 1995-08-22 1997-10-28 Shin-Etsu Chemical Co., Ltd. Rapidly soluble coating composition and method for preparing same
EP0866656B1 (en) 1995-09-19 2007-04-25 MARGOLIN, Solomon B. Use of n-substituted pyridones as tumor necrosis factor alpha inhibitors
US5962478A (en) 1995-09-19 1999-10-05 Margolin; Solomon B. Inhibition of tumor necrosis factor α
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6348216B1 (en) 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
DE19628617A1 (de) 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
TW580397B (en) 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
EP0901787B1 (en) 1997-09-10 2003-05-28 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
DK2263660T3 (en) 1998-05-18 2018-01-02 Takeda Pharmaceuticals Co Orally disintegrating tablets.
DK1083885T3 (da) 1998-06-11 2007-02-26 Pharmacia & Upjohn Co Llc Delavirdintabletformulering
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
US6599530B2 (en) 1998-09-14 2003-07-29 Orion Corporation Oral compacted composition comprising catechol derivatives
IT1311907B1 (it) 1999-04-06 2002-03-20 Zambon Spa Compresse deglutibili ad alto contenuto di n-acetilcisteina.
US6262072B1 (en) 1999-10-12 2001-07-17 Yung Shin Pharmaceutical Industrial Co. Ltd. Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin
DK1235558T3 (da) 1999-12-09 2006-10-09 Reckitt Benckiser Healthcare Sammenpresset tabletsammensætning, der omfatter et NSAID
US6956044B1 (en) 2000-02-21 2005-10-18 Margolin Solomon B Compositions and methods for treatment of epilepsy
PL365072A1 (en) 2000-03-07 2004-12-27 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
AU4278301A (en) 2000-03-27 2001-10-08 Kyowa Hakko Kogyo Co. Ltd. Easy-to-take granule
JP2004525071A (ja) 2000-07-20 2004-08-19 ニューロジェン コーポレイション カプサイシン受容体リガンド
EP1319409A4 (en) 2000-09-22 2006-05-03 Takeda Pharmaceutical SOLID PREPARATIONS
KR100891887B1 (ko) 2001-01-29 2009-04-03 시오노기세이야쿠가부시키가이샤 5-메틸-1-페닐-2-(1h)-피리돈을 활성 성분으로서 함유하는의약 제제
PE20021081A1 (es) 2001-04-12 2002-12-18 Pharmacopeia Drug Discovery Aril y biaril piperidinas con actividad moduladora mch
JP4280074B2 (ja) 2001-04-25 2009-06-17 大正製薬株式会社 マルチプルユニット型徐放性錠剤
US6761905B2 (en) 2001-05-01 2004-07-13 Wei Ming Pharmaceutical Mfg. Co., Ltd. Process for the preparation of direct tabletting formulations and aids
CA2468015A1 (en) 2001-11-27 2003-06-05 Merck & Co., Inc. 2-aminoquinoline compounds
WO2003066595A2 (en) 2002-02-01 2003-08-14 Euro-Celtique S.A. 2 - piperazine - pyridines useful for treating pain
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
PT1556354E (pt) 2002-06-28 2008-04-17 Euro Celtique Sa Derivados de piperazina úteis como agentes terapêuticos para o tratamento da dor
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
AU2003262811A1 (en) 2002-08-27 2004-03-19 Intermune, Inc. Methods of treating idiopathic pulmonary fibrosis
EP1551369A4 (en) 2002-08-28 2007-05-09 Intermune Inc COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
EP1551811A1 (en) 2002-10-17 2005-07-13 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
JP4542743B2 (ja) 2002-12-26 2010-09-15 Kdl株式会社 ピリドン誘導体の溶液状医薬組成物
WO2004075826A2 (en) 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Extended release, multiple unit dosage forms of phenytoin sodium and processes for their preparation
HRP20050902A2 (en) 2003-03-31 2005-12-31 Pliva-Lachema A.S. Pharmaceutical composition containing platinum complex as active substance and method of manufacturing thereof
AU2003236336A1 (en) 2003-04-01 2004-11-01 Ohara Chmical Industries, Ltd. Process for producing tablet
US8507000B2 (en) 2003-05-06 2013-08-13 Nostrum Pharmaceuticals, Inc. Controlled release formulation of erythromycin derivatives
US20050008691A1 (en) 2003-05-14 2005-01-13 Arturo Siles Ortega Bicalutamide compositions
US20070092488A1 (en) 2003-05-16 2007-04-26 Intermune Inc. Methods of treating idiopathic pulmonary fibrosis
CN101039957A (zh) 2003-05-16 2007-09-19 因特缪恩公司 合成的趋化因子受体配体及其使用方法
HUP0301537A3 (en) 2003-06-03 2005-07-28 Egis Gyogyszergyar Nyilvanosan Deramcyclane fumarate tablets and process for producing them
MY142655A (en) 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
CA2531116A1 (en) 2003-07-01 2005-01-20 Michael Hawley Diffusion layer modulated solids
US7632521B2 (en) 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
SI1867644T1 (sl) 2003-07-24 2009-10-31 Euro Celtique Sa Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine
AU2004259357B2 (en) 2003-07-24 2010-02-18 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
PL1942106T3 (pl) 2003-08-01 2012-02-29 Euro Celtique Sa Środki lecznicze użyteczne do leczenia bólu
PL1664016T3 (pl) 2003-09-22 2009-04-30 Euro Celtique Sa Środki terapeutyczne przydatne do leczenia bólu
EP1664041B1 (en) 2003-09-22 2008-07-02 Euro-Celtique S.A. Phenyl-carboxamide compounds useful for treating pain
US20050079221A1 (en) 2003-10-10 2005-04-14 Groenewoud Pieter Jurjen Ibuprofen narcotic composition and method for making same
WO2005039598A1 (en) 2003-10-24 2005-05-06 Intermune, Inc. Method of treating alcoholic liver disease
US7407973B2 (en) 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
JP4614884B2 (ja) 2003-11-14 2011-01-19 シャンハイ ゲノミックス インク ピリドンの誘導体とその使用
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
ES2322907T3 (es) 2003-12-30 2009-07-01 Euro-Celtique S.A. Piperazinas utiles para el tratamiento de dolor.
SE0400235D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8642079B2 (en) 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
MY148773A (en) 2004-03-17 2013-05-31 Novartis Ag Galenic formulations of organic compounds
MY149038A (en) 2004-05-26 2013-07-15 Eisai R&D Man Co Ltd Cinnamide compound
BRPI0511663A (pt) 2004-06-07 2008-01-02 Wyeth Corp composição compreendendo água e um componente de sólidos, processo, e, tablete revestido
BRPI0512900A (pt) 2004-06-30 2008-04-15 Albemarle Corp composição farmacêutica compreendendo de ibuprofeno, processo de preparação dos gránulos enriquecidos em ibuprofeno e os gránulos secos feitos por este processo
EA014249B1 (ru) 2005-01-27 2010-10-29 Алембик Лимитед Формуляция леветирацетама длительного высвобождения
DE602006001295D1 (de) 2005-02-03 2008-07-03 Nycomed Pharma As Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung
US20070009591A1 (en) 2005-07-07 2007-01-11 Trivedi Jay S ACE inhibitor formulation
AU2006276246B2 (en) 2005-07-25 2012-09-27 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis C virus replication
NZ591443A (en) * 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
US20070203202A1 (en) 2005-12-02 2007-08-30 Robinson Cynthia Y Methods of reducing adverse events associated with pirfenidone therapy
WO2007069773A1 (en) 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
AU2006335344A1 (en) 2006-01-11 2007-07-19 Teva Pharmaceutical Industries Ltd. Controlled release formulation of divalproic acid and its derivatives
ZA200807571B (en) 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
CZ300698B6 (cs) 2006-06-16 2009-07-22 Zentiva, A. S. Tableta s obsahem metforminu
JP5475443B2 (ja) 2006-06-28 2014-04-16 エミスフェアー・テクノロジーズ・インク 硝酸ガリウム製剤
US20080254118A1 (en) 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
WO2008062446A2 (en) 2006-09-14 2008-05-29 Alembic Limited An extended release composition of levetiracetam, which exhibits no adverse food effect
CA2563690C (en) 2006-10-12 2014-10-07 Pharmascience Inc. Pharmaceutical compositions comprising intra- and extra- granular fractions
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
SI2124945T1 (sl) 2006-12-18 2011-08-31 Intermune Inc Postopek dajanja terapije s pirfenidonom pacientu
EP1952803A1 (en) 2007-01-23 2008-08-06 KTB-Tumorforschungs GmbH Solid pharmaceutical dosage form containing hydrogenated phospholipids
DK2142529T3 (da) 2007-04-27 2014-02-10 Purdue Pharma Lp Trpv1-antagonister og anvendelser deraf
WO2008133973A1 (en) 2007-04-27 2008-11-06 Purdue Pharma L.P. Therapeutic agents useful for treating pain
EP1987814A1 (en) 2007-04-30 2008-11-05 Exelgyn Mifepristone pharmaceutical compositions and their methods of preparation
US20080287508A1 (en) 2007-05-18 2008-11-20 Intermune, Inc. Altering pharmacokinetics of pirfenidone therapy
JP5587184B2 (ja) 2007-06-20 2014-09-10 オースペックス・ファーマシューティカルズ・インコーポレイテッド 繊維症阻害剤としての置換n−アリールピリジノン
SI2178513T1 (sl) 2007-06-22 2011-05-31 Bristol Myers Squibb Co Tabletni sestavki vsebujoäśi atazanavir
ES2360336T3 (es) 2007-06-22 2011-06-03 Bristol-Myers Squibb Company Composiciones en comprimidos que contienen atazanavir.
DK2170292T3 (da) 2007-06-22 2014-04-07 Bristol Myers Squibb Holdings Ireland Atazanavirholdige sammensætninger i tabletform
US20090131485A1 (en) 2007-09-10 2009-05-21 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
MY169761A (en) 2007-11-07 2019-05-15 Rigel Pharmaceuticals Inc Wet granulation using a water sequestering agent
EP2276734A1 (en) 2008-04-17 2011-01-26 Pfizer Inc. 4-benzylidene-3-methylpiperidine aryl carboxamide compounds useful as faah inhibitors
ES2617619T3 (es) 2008-06-05 2017-06-19 Janssen Pharmaceutica, N.V. Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
GB0813929D0 (en) 2008-07-30 2008-09-03 Glaxo Group Ltd Novel method
WO2010035282A1 (en) 2008-09-24 2010-04-01 Matrix Laboratories Limited Pharmaceutical compositions comprising deferasirox
US8546388B2 (en) 2008-10-24 2013-10-01 Purdue Pharma L.P. Heterocyclic TRPV1 receptor ligands
US8759362B2 (en) 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
US8703962B2 (en) 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
WO2010048716A1 (en) 2008-10-29 2010-05-06 Pacific Therapeutics Ltd. Composition and method for treating fibrosis
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US7566729B1 (en) 2008-11-10 2009-07-28 Intermune, Inc. Modifying pirfenidone treatment for patients with atypical liver function
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
US20100166861A1 (en) 2008-12-29 2010-07-01 Kelly Noel Lynch Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone
US8513261B2 (en) 2009-03-13 2013-08-20 Toyama Chemical Co., Ltd. Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
WO2010135470A1 (en) 2009-05-19 2010-11-25 Intermune, Inc. Pifenidone derivatives for treating bronchial asthma
TWI434833B (zh) 2009-06-03 2014-04-21 Intermune Inc 用於合成吡非尼酮(pirfenidone)的改良方法
CN101921225B (zh) 2009-06-11 2013-04-03 北京凯得尔森生物技术有限公司 吡啡尼酮类化合物、其制备方法和应用
AU2010316683B2 (en) * 2009-11-09 2015-10-08 Wyeth Llc Tablet formulations of neratinib maleate
US7816383B1 (en) 2009-12-04 2010-10-19 Intermune, Inc. Methods of administering pirfenidone therapy
US8084475B2 (en) 2009-12-04 2011-12-27 Intermune, Inc. Pirfenidone therapy and inducers of cytochrome P450
EP2338474A1 (de) * 2009-12-23 2011-06-29 Ratiopharm GmbH Oral dispersible Tablette enthaltend kompaktierte Sildenafil-Base
IL210279A0 (en) 2009-12-25 2011-03-31 Dexcel Pharma Technologies Ltd Extended release compositions for high solubility, high permeability acdtive pharmaceutical ingredients
EP2359814A1 (en) 2010-02-11 2011-08-24 Laboratorios Liconsa, S.A. Pharmaceutical mini-tablets for sustained release of flecainide acetate
EP2552447A4 (en) 2010-03-29 2013-09-11 Hetero Research Foundation STABLE PHARMACEUTICAL COMPOSITION OF IMATINIB
WO2011162409A1 (en) 2010-06-22 2011-12-29 Shionogi & Co., Ltd. Compounds having trpv1 antagonistic activity and uses thereof
WO2012029074A2 (en) 2010-09-02 2012-03-08 Hetero Research Foundation Pharmaceutical compositions of linezolid
CN101972236A (zh) 2010-10-13 2011-02-16 北京诚创康韵医药科技有限公司 一种含吡非尼酮的缓释制剂
TR201011148A1 (tr) 2010-12-30 2012-07-23 Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Levetirasetam farmasötik bileşimleri.
EP2663283B1 (en) 2011-01-14 2017-05-10 Bristol-Myers Squibb Company High drug load tablet formulation of brivanib alaninate
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012114352A2 (en) 2011-02-21 2012-08-30 Hetero Research Foundation Pharmaceutical compositions of maraviroc and process for the preparation thereof
JP2014507474A (ja) 2011-03-08 2014-03-27 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換n−アリールピリジノン
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
WO2013022924A1 (en) 2011-08-08 2013-02-14 Teva Pharmaceutical Industries Ltd. Pharmaceutical formulations
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
KR102121082B1 (ko) 2012-04-20 2020-06-10 디에스엠 아이피 어셋츠 비.브이. 색 안정성을 갖는 고형 l-아스코르브산 조성물
US20150224086A1 (en) 2012-08-23 2015-08-13 Hetero Research Foundation Pharmaceutical Formulations of Rufinamide
CA2819967C (en) 2012-08-31 2016-03-22 Intermune, Inc. Use of pirfenidone concomitantly with ciprofloxacin
CN102846569A (zh) 2012-09-06 2013-01-02 北京万全德众医药生物技术有限公司 一种含吡非尼酮的药物组合物及其制备方法
EA032913B1 (ru) 2012-10-18 2019-08-30 Эббви Инк. Препараты производных пиримидиндиона
BR112014027231A2 (pt) 2013-01-15 2017-06-27 Fujifilm Corp comprimido contendo 5-hidróxi-1h-imidazola-4-carboxamida
WO2014115082A1 (en) 2013-01-22 2014-07-31 Dr. Reddys Laboratories Limited Pharmaceutical formulations of imatinib
EP2958563A2 (en) 2013-02-20 2015-12-30 AbbVie Inc. Tablet dosage form comprising ritonavir and lopinavir
ME03297B (me) 2013-03-08 2019-07-20 Novartis Ag Oralne formulacije deferasiroksa
GB201304699D0 (en) 2013-03-15 2013-05-01 Remedica Ltd Pharmaceutical compositions
CN103271886B (zh) 2013-05-29 2014-08-13 南京正大天晴制药有限公司 一种吡非尼酮片剂及其制备方法
HK1220390A1 (zh) 2013-08-29 2017-05-05 Teva Pharmaceutical Industries Ltd. 包括恩曲他滨,替诺福韦,达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂
WO2015040093A1 (en) 2013-09-20 2015-03-26 Dsm Sinochem Pharmaceuticals Netherlands B.V. Tablet comprising crospovidone
KR102286386B1 (ko) 2013-10-07 2021-08-05 브리스톨-마이어스 스퀴브 홀딩스 아일랜드 언리미티드 컴퍼니 아타자나비르 및 코비시스타트의 hiv 치료 제제
IL310920A (en) 2015-01-27 2024-04-01 Janssen Pharmaceutica Nv Dispersible compositions

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