MX393177B - Formulacion granulada de 5-metil-1-fenil-2-(1h)-piridona y metodo para elaborarla. - Google Patents

Formulacion granulada de 5-metil-1-fenil-2-(1h)-piridona y metodo para elaborarla.

Info

Publication number
MX393177B
MX393177B MX2018011819A MX2018011819A MX393177B MX 393177 B MX393177 B MX 393177B MX 2018011819 A MX2018011819 A MX 2018011819A MX 2018011819 A MX2018011819 A MX 2018011819A MX 393177 B MX393177 B MX 393177B
Authority
MX
Mexico
Prior art keywords
pyridone
phenyl
methyl
preparing
granulated formulation
Prior art date
Application number
MX2018011819A
Other languages
English (en)
Spanish (es)
Other versions
MX2018011819A (es
Inventor
Siddharthya Krishnachandan Mujumdar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57575344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX393177(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018011819A publication Critical patent/MX2018011819A/es
Publication of MX393177B publication Critical patent/MX393177B/es

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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K9/1605Excipients; Inactive ingredients
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    • A61K9/1629Organic macromolecular compounds
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MX2018011819A 2016-03-29 2017-03-27 Formulacion granulada de 5-metil-1-fenil-2-(1h)-piridona y metodo para elaborarla. MX393177B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662314933P 2016-03-29 2016-03-29
PCT/US2017/024280 WO2017172602A1 (en) 2016-03-29 2017-03-27 Granulate formulation of 5-methy|-1-pheny|-2(1h)-pyridone and method of making the same

Publications (2)

Publication Number Publication Date
MX2018011819A MX2018011819A (es) 2019-07-04
MX393177B true MX393177B (es) 2025-03-24

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Application Number Title Priority Date Filing Date
MX2018011819A MX393177B (es) 2016-03-29 2017-03-27 Formulacion granulada de 5-metil-1-fenil-2-(1h)-piridona y metodo para elaborarla.

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Country Link
US (2) US10188637B2 (https=)
EP (2) EP3435985B1 (https=)
JP (2) JP7456721B2 (https=)
KR (1) KR102552615B1 (https=)
CN (2) CN114533688A (https=)
AR (1) AR107990A1 (https=)
AU (2) AU2017241530B2 (https=)
CA (1) CA2937365C (https=)
ES (1) ES2883595T3 (https=)
IL (1) IL261745B2 (https=)
MX (1) MX393177B (https=)
PL (1) PL3435985T3 (https=)
WO (1) WO2017172602A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180100869A (ko) * 2017-03-02 2018-09-12 영진약품 주식회사 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
US11510877B2 (en) 2017-10-10 2022-11-29 Capsugel Belgium Nv Gelling multiparticulates
ES2886152T3 (es) * 2017-12-11 2021-12-16 Laurus Labs Ltd Un procedimiento mejorado para la preparación de pirfenidona
ES2900457T3 (es) 2018-01-12 2022-03-17 Tiefenbacher Alfred E Gmbh & Co Kg Formulación de comprimidos y cápsulas que contienen pirfenidona
WO2020115774A1 (en) 2018-12-06 2020-06-11 Cipla Limited High drug load extended release formulations
WO2021022033A1 (en) 2019-07-30 2021-02-04 Leung Kai P Layered composite for scar treatment and prevention
CN119909073A (zh) * 2019-07-31 2025-05-02 豪夫迈·罗氏有限公司 新型药物制剂
WO2021057599A1 (zh) * 2019-09-26 2021-04-01 深圳先进技术研究院 吡非尼酮在制备防治类风湿性关节炎的药物中的应用
CN111166748B (zh) * 2019-12-14 2022-06-21 深圳先进技术研究院 吡非尼酮在制备促血管生成药物中的应用
US20230135671A1 (en) 2020-04-01 2023-05-04 Boehringer Ingelheim International Gmbh Use of biomarkers in the treatment of fibrotic conditions
WO2021255159A1 (en) * 2020-06-19 2021-12-23 Glaxosmithkline Intellectual Property (No.2) Limited Formulation comprising daprodustat
WO2022172076A1 (en) * 2021-02-09 2022-08-18 DWIVEDI, Dr. Jayesh Preparation of microwave dried novel co-processed excipient of sucrose and tablet formulation of canagliflozin tablets using co- processed excipient
AU2022269659B2 (en) * 2021-05-07 2025-04-10 Eli Lilly And Company Erodible tablet
US20250161250A1 (en) 2022-02-28 2025-05-22 Nuformix Technologies Limited Compositions and methods for treatment of idiopathic pulmonary fibrosis
WO2026052613A1 (en) * 2024-09-03 2026-03-12 Elanco Us Inc. Pharmaceutical compositions and methods using the same

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042699A (en) 1972-12-18 1977-08-16 Affiliated Medical Research, Inc. Method for reducing serum glucose levels
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
US4052509A (en) 1972-12-18 1977-10-04 Affiliated Medical Research, Inc. Method for reducing serum uric acid levels
DE3404810A1 (de) 1984-02-10 1985-08-14 Siemens AG, 1000 Berlin und 8000 München Fensterfunktion fuer ein aperturfenster
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
US4753801A (en) 1985-10-25 1988-06-28 Eli Lilly And Company Sustained release tablets
US5104648A (en) 1989-02-02 1992-04-14 Mallinckrodt Specialty Chemicals Company High ibuprofen content granulations
JPH02215719A (ja) 1989-02-15 1990-08-28 Yamauchi Akitomo 線維化病変組織の修復並びに線維化病変の阻止剤
US5275823A (en) 1989-04-27 1994-01-04 Smith Kline & French Laboratories Ltd. Pharmaceutical compositions
US5716632A (en) 1989-11-22 1998-02-10 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US5518729A (en) 1989-11-22 1996-05-21 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5861172A (en) 1991-05-08 1999-01-19 Laboratorios Beecham Sa Pharmaceutical formulations of compacted granulates of β-lactam antibiotics
WO1993013756A1 (fr) 1992-01-10 1993-07-22 Obschestvo S Ogranichennoy Otvetstvennostyu Meditsinsky Nauchno-Proizvodstvennoy Komplex 'biotiki' Composition pharmaceutique granulee et son procede de production
DK0636023T3 (da) 1992-04-15 1999-12-06 Alteon Inc Fremgangsmåde til spraytørring af aminoguanidin
ES2134796T3 (es) 1992-12-01 1999-10-16 Spirig Ag Pharmazeutische Prap Composiciones farmaceuticas que contienen s(+)-ibuprofeno.
JPH08510251A (ja) 1993-05-07 1996-10-29 ビー マーゴリン、ソロモン 線維症の病変の修復と予防のための組成物および方法
AU680019B2 (en) 1993-08-30 1997-07-17 Warner-Lambert Company Llc Tablet coating based on a melt-spun mixture of a saccharide and apolymer
US5591766A (en) 1993-12-03 1997-01-07 Cheil Foods & Chemicals, Inc. Solid oral formulations of pyridone carboxylic acids
GB9325644D0 (en) 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US5639754A (en) 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
WO1996011210A1 (en) 1994-10-07 1996-04-18 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides having antibiotic activity
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
GB9501127D0 (en) 1995-01-20 1995-03-08 Wellcome Found Tablet
US6090822A (en) 1995-03-03 2000-07-18 Margolin; Solomon B. Treatment of cytokine growth factor caused disorders
CN1134411C (zh) 1995-06-21 2004-01-14 盐野义制药株式会社 双环氨基衍生物及含有此类化合物的前列腺素d2拮抗剂
US5681382A (en) 1995-08-22 1997-10-28 Shin-Etsu Chemical Co., Ltd. Rapidly soluble coating composition and method for preparing same
BR9610480A (pt) 1995-09-19 1999-03-16 Solomon Begelfor Margolin Inibição do fator alfa de necrose tumoral
US5962478A (en) 1995-09-19 1999-10-05 Margolin; Solomon B. Inhibition of tumor necrosis factor α
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6348216B1 (en) 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
DE19628617A1 (de) 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
US7179486B1 (en) 1997-04-01 2007-02-20 Nostrum Pharmaceuticals, Inc. Process for preparing sustained release tablets
TW580397B (en) 1997-05-27 2004-03-21 Takeda Chemical Industries Ltd Solid preparation
ATE241341T1 (de) 1997-09-10 2003-06-15 Takeda Chemical Industries Ltd Stabilisierte pharmazeutische zusammensetzung
DE69934505T2 (de) 1998-05-18 2007-10-04 Takeda Pharmaceutical Co. Ltd. Im munde zerfallende tablette enthaltend ein benzimidazole
DE69934582T2 (de) 1998-06-11 2007-10-04 Pharmacia & Upjohn Co. Llc, Kalamazoo Delavirdin tablettenformulierung
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
US6599530B2 (en) 1998-09-14 2003-07-29 Orion Corporation Oral compacted composition comprising catechol derivatives
IT1311907B1 (it) 1999-04-06 2002-03-20 Zambon Spa Compresse deglutibili ad alto contenuto di n-acetilcisteina.
US6262072B1 (en) 1999-10-12 2001-07-17 Yung Shin Pharmaceutical Industrial Co. Ltd. Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin
US8124124B2 (en) 1999-12-09 2012-02-28 Reckitt Benckiser Healthcare (Uk) Limited Compressed tablet formulation comprising non-steroidal anti-inflammatory drugs and methods
US6956044B1 (en) 2000-02-21 2005-10-18 Margolin Solomon B Compositions and methods for treatment of epilepsy
PL365072A1 (en) 2000-03-07 2004-12-27 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
CA2403594A1 (en) 2000-03-27 2002-09-18 Kyowa Hakko Kogyo Co., Ltd. Granules having good taking property
EP1301484A2 (en) 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
AU2001288102A1 (en) 2000-09-22 2002-04-02 Takeda Chemical Industries Ltd. Solid preparations
WO2002060446A1 (fr) * 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Preparation medicamenteuse contenant du 5-methyle-1-phenyle-2-(1h)-pyridone en tant que principe actif
ATE460163T1 (de) 2001-04-12 2010-03-15 Pharmacopeia Llc Arly und diaryl piperidinderivate verwendbar als mch-hemmer
WO2002087549A1 (fr) 2001-04-25 2002-11-07 Taisho Pharmaceutical Co., Ltd. Comprimes a liberation prolongee du type a unites multiples
US6761905B2 (en) 2001-05-01 2004-07-13 Wei Ming Pharmaceutical Mfg. Co., Ltd. Process for the preparation of direct tabletting formulations and aids
AU2002352878B2 (en) 2001-11-27 2007-11-22 Merck Sharp & Dohme Corp. 2-Aminoquinoline compounds
US7071335B2 (en) 2002-02-01 2006-07-04 Euro-Celtique S.A. 2-pyridinyl-1-piperazine therapeutic agents useful for treating pain
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
US8911781B2 (en) 2002-06-17 2014-12-16 Inventia Healthcare Private Limited Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides
EA200500114A1 (ru) 2002-06-28 2005-06-30 Еуро-Селтик, С. А. Терапевтические агенты, используемые для лечения боли
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
AU2003262811A1 (en) 2002-08-27 2004-03-19 Intermune, Inc. Methods of treating idiopathic pulmonary fibrosis
EP1551369A4 (en) 2002-08-28 2007-05-09 Intermune Inc COMBINATION THERAPY FOR THE TREATMENT OF FIBROTIC DISEASES
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
PL377215A1 (pl) 2002-10-17 2006-01-23 Amgen Inc. Pochodne benzimidazolu oraz ich zastosowanie w charakterze ligandów receptora waniloidowego
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
JP4542743B2 (ja) 2002-12-26 2010-09-15 Kdl株式会社 ピリドン誘導体の溶液状医薬組成物
WO2004075826A2 (en) 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Extended release, multiple unit dosage forms of phenytoin sodium and processes for their preparation
UA80872C2 (uk) 2003-03-31 2007-11-12 Пліва-Лахема А.С. Фармацевтична композиція, що містить як активну речовину платиновий комплекс, і спосіб її виготовлення
AU2003236336A1 (en) 2003-04-01 2004-11-01 Ohara Chmical Industries, Ltd. Process for producing tablet
BRPI0410098A (pt) 2003-05-06 2006-05-16 Nirmal Mulye formulação de liberação controlada de derivados de eritromicina
US20050008691A1 (en) 2003-05-14 2005-01-13 Arturo Siles Ortega Bicalutamide compositions
CA2525647A1 (en) 2003-05-16 2005-02-24 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
WO2004103296A2 (en) 2003-05-16 2004-12-02 Intermune, Inc. Methods of treating idiopathic pulmonary fibrosis
HUP0301537A3 (en) 2003-06-03 2005-07-28 Egis Gyogyszergyar Nyilvanosan Deramcyclane fumarate tablets and process for producing them
TWI287010B (en) 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
WO2005004763A1 (en) 2003-07-01 2005-01-20 Pharmacia & Upjohn Company Llc. Diffusion layer modulated solids
US7632521B2 (en) 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
GEP20094676B (en) 2003-07-24 2009-05-10 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
DE602004017316D1 (de) 2003-07-24 2008-12-04 Euro Celtique Sa Heteroaryl-tetrahydropyridylverbindungen, die sich für die behandlung bzw. die prävention von schmerzen eignen
WO2005012287A1 (en) 2003-08-01 2005-02-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
SI1664016T1 (sl) 2003-09-22 2009-04-30 Euro Celtique Sa Terapevtska sredstva, uporabna za zdravljenje bolečine
PL1664041T3 (pl) 2003-09-22 2008-12-31 Euro Celtique Sa Przydatne do leczenia bólu związki fenylowo-karboksyamidowe
US20050079221A1 (en) 2003-10-10 2005-04-14 Groenewoud Pieter Jurjen Ibuprofen narcotic composition and method for making same
WO2005039598A1 (en) 2003-10-24 2005-05-06 Intermune, Inc. Method of treating alcoholic liver disease
US7407973B2 (en) 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
CN100358872C (zh) 2003-11-14 2008-01-02 上海睿星基因技术有限公司 吡啶酮衍生物及其应用
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
PL1727801T3 (pl) 2003-12-30 2009-08-31 Euro Celtique Sa Piperazyny użyteczne do leczenia bólu
SE0400235D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
US8642079B2 (en) 2004-02-23 2014-02-04 Hormos Medical Corporation Solid formulations of ospemifene
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
PE20142101A1 (es) 2004-03-17 2014-12-27 Novartis Ag Composiciones farmaceuticas de aliskiren
RU2361872C2 (ru) 2004-05-26 2009-07-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Циннамидное соединение
AR049142A1 (es) 2004-06-07 2006-06-28 Wyeth Corp Composiciones para recubrimientos de azucar,composiciones recubiertas y metodos para la fabricacion de los mismos
WO2006007095A2 (en) 2004-06-30 2006-01-19 Albemarle Corporation High ibuprofen content granules and their preparation and use
CN101111245A (zh) 2005-01-27 2008-01-23 阿雷姆贝克有限公司 左乙拉西坦延长释放制剂
US8846088B2 (en) 2005-02-03 2014-09-30 Takeda Nycomed As Melt granulation of a composition containing a calcium-containing compound
US20070009591A1 (en) 2005-07-07 2007-01-11 Trivedi Jay S ACE inhibitor formulation
MX2008001166A (es) 2005-07-25 2008-03-18 Intermune Inc Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c.
NZ591443A (en) 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
US20070203202A1 (en) 2005-12-02 2007-08-30 Robinson Cynthia Y Methods of reducing adverse events associated with pirfenidone therapy
WO2007069773A1 (en) 2005-12-15 2007-06-21 Shionogi & Co., Ltd. A pharmaceutical composition comprising an amide derivative
JP2009525953A (ja) 2006-01-11 2009-07-16 テバ ファーマシューティカル インダストリーズ リミティド ジバルプロ酸及びその誘導体の徐放性製剤
ZA200807571B (en) 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
CZ300698B6 (cs) 2006-06-16 2009-07-22 Zentiva, A. S. Tableta s obsahem metforminu
JP5475443B2 (ja) 2006-06-28 2014-04-16 エミスフェアー・テクノロジーズ・インク 硝酸ガリウム製剤
US20080254118A1 (en) 2007-04-11 2008-10-16 Hans-Werner Wernersbach Process for preparing pramipexole dihydrochloride tablets
WO2008062446A2 (en) 2006-09-14 2008-05-29 Alembic Limited An extended release composition of levetiracetam, which exhibits no adverse food effect
CA2563690C (en) 2006-10-12 2014-10-07 Pharmascience Inc. Pharmaceutical compositions comprising intra- and extra- granular fractions
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
EP2471534A1 (en) 2006-12-18 2012-07-04 Intermune, Inc. Method of providing pirfenidone therapy to a patient
EP1952803A1 (en) 2007-01-23 2008-08-06 KTB-Tumorforschungs GmbH Solid pharmaceutical dosage form containing hydrogenated phospholipids
CA2685266C (en) 2007-04-27 2014-01-28 Purdue Pharma L.P. Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal
MX2009011601A (es) 2007-04-27 2009-11-10 Purdue Pharma Lp Agentes terapeuticos utiles para tratar el dolor.
EP1987814A1 (en) 2007-04-30 2008-11-05 Exelgyn Mifepristone pharmaceutical compositions and their methods of preparation
US20080287508A1 (en) 2007-05-18 2008-11-20 Intermune, Inc. Altering pharmacokinetics of pirfenidone therapy
WO2008157786A1 (en) 2007-06-20 2008-12-24 Auspex Pharmaceutical, Inc. Substituted n-aryl pyridinones as fibrotic inhibitors
JP2010530892A (ja) 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
CN101778624A (zh) 2007-06-22 2010-07-14 百时美施贵宝公司 含有阿扎那韦的压片组合物
DE602008005316D1 (de) 2007-06-22 2011-04-14 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
UA102825C2 (ru) 2007-11-07 2013-08-27 Райджел Фармасьютикалз, Инк. Фармацевтическая композиция, полученная влажным гранулированием с использованием вещества, которое связывает воду
US20110053950A1 (en) 2008-04-17 2011-03-03 Pfizer, Inc. 4-benzylidene-3-methylpiperidine aryl carboxamide compounds useful as faah inhibitors
PE20100083A1 (es) 2008-06-05 2010-02-17 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
GB0813929D0 (en) 2008-07-30 2008-09-03 Glaxo Group Ltd Novel method
WO2010035282A1 (en) 2008-09-24 2010-04-01 Matrix Laboratories Limited Pharmaceutical compositions comprising deferasirox
US8546388B2 (en) 2008-10-24 2013-10-01 Purdue Pharma L.P. Heterocyclic TRPV1 receptor ligands
US8703962B2 (en) 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
US8759362B2 (en) 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
CA2741954A1 (en) 2008-10-29 2010-05-06 Pacific Therapeutics Ltd. Composition and method for treating fibrosis
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US7566729B1 (en) 2008-11-10 2009-07-28 Intermune, Inc. Modifying pirfenidone treatment for patients with atypical liver function
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
US20100166861A1 (en) 2008-12-29 2010-07-01 Kelly Noel Lynch Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone
CA2755274C (en) 2009-03-13 2017-02-28 Sahoe Kakuda Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
WO2010135470A1 (en) 2009-05-19 2010-11-25 Intermune, Inc. Pifenidone derivatives for treating bronchial asthma
TWI434833B (zh) 2009-06-03 2014-04-21 Intermune Inc 用於合成吡非尼酮(pirfenidone)的改良方法
CN101921225B (zh) 2009-06-11 2013-04-03 北京凯得尔森生物技术有限公司 吡啡尼酮类化合物、其制备方法和应用
AU2010316683B2 (en) * 2009-11-09 2015-10-08 Wyeth Llc Tablet formulations of neratinib maleate
US7816383B1 (en) 2009-12-04 2010-10-19 Intermune, Inc. Methods of administering pirfenidone therapy
US8084475B2 (en) 2009-12-04 2011-12-27 Intermune, Inc. Pirfenidone therapy and inducers of cytochrome P450
EP2338474A1 (de) * 2009-12-23 2011-06-29 Ratiopharm GmbH Oral dispersible Tablette enthaltend kompaktierte Sildenafil-Base
IL210279A0 (en) 2009-12-25 2011-03-31 Dexcel Pharma Technologies Ltd Extended release compositions for high solubility, high permeability acdtive pharmaceutical ingredients
EP2359814A1 (en) 2010-02-11 2011-08-24 Laboratorios Liconsa, S.A. Pharmaceutical mini-tablets for sustained release of flecainide acetate
WO2011121593A1 (en) 2010-03-29 2011-10-06 Hetero Research Foundation Stable pharmaceutical composition of imatinib
US8921373B2 (en) 2010-06-22 2014-12-30 Shionogi & Co., Ltd. Compounds having TRPV1 antagonistic activity and uses thereof
WO2012029074A2 (en) 2010-09-02 2012-03-08 Hetero Research Foundation Pharmaceutical compositions of linezolid
CN101972236A (zh) 2010-10-13 2011-02-16 北京诚创康韵医药科技有限公司 一种含吡非尼酮的缓释制剂
TR201011148A1 (tr) 2010-12-30 2012-07-23 Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Levetirasetam farmasötik bileşimleri.
WO2012097222A1 (en) 2011-01-14 2012-07-19 Bristol-Myers Squibb Company High drug load tablet formulation of brivanib alaninate
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CA2827747A1 (en) 2011-02-21 2012-08-30 Hetero Research Foundation Pharmaceutical compositions of maraviroc and process for the preparation thereof
JP2014507474A (ja) 2011-03-08 2014-03-27 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換n−アリールピリジノン
MX2011007675A (es) * 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
US20130064888A1 (en) 2011-08-08 2013-03-14 Roey Solomonovich Pharmaceutical formulations
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
EP2838380B1 (en) 2012-04-20 2018-04-18 DSM IP Assets B.V. Solid, color-stable l-ascorbic acid compositions
US20150224086A1 (en) 2012-08-23 2015-08-13 Hetero Research Foundation Pharmaceutical Formulations of Rufinamide
CA2819967C (en) 2012-08-31 2016-03-22 Intermune, Inc. Use of pirfenidone concomitantly with ciprofloxacin
CN102846569A (zh) 2012-09-06 2013-01-02 北京万全德众医药生物技术有限公司 一种含吡非尼酮的药物组合物及其制备方法
WO2014063101A1 (en) 2012-10-18 2014-04-24 Abbvie Inc. Formulations of pyrimidinedione derivative compounds
CN104271134B (zh) 2013-01-15 2016-06-29 富士胶片株式会社 含有5-羟基-1h-咪唑-4-甲酰胺的片剂
WO2014115082A1 (en) 2013-01-22 2014-07-31 Dr. Reddys Laboratories Limited Pharmaceutical formulations of imatinib
WO2014130553A2 (en) 2013-02-20 2014-08-28 Abbvie Inc. Tablet dosage forms
HRP20190173T1 (hr) 2013-03-08 2019-03-22 Novartis Ag Oralne formulacije deferasiroksa
GB201304699D0 (en) 2013-03-15 2013-05-01 Remedica Ltd Pharmaceutical compositions
CN103271886B (zh) 2013-05-29 2014-08-13 南京正大天晴制药有限公司 一种吡非尼酮片剂及其制备方法
HK1220390A1 (zh) 2013-08-29 2017-05-05 Teva Pharmaceutical Industries Ltd. 包括恩曲他滨,替诺福韦,达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂
CN105555261B (zh) 2013-09-20 2020-02-11 灿盛制药有限公司荷兰公司 包含交聚维酮的片剂
EP3421033B1 (en) 2013-10-07 2022-07-27 Bristol-Myers Squibb Holdings Ireland Unlimited Company Hiv treatment formulation of atazanavir and cobicistat
LT3250182T (lt) 2015-01-27 2023-07-10 Janssen Pharmaceutica Nv Dispersinės kompozicijos

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IL261745A (en) 2018-10-31
EP3435985B1 (en) 2021-05-12
KR102552615B1 (ko) 2023-07-06
EP3435985A1 (en) 2019-02-06
AU2022275529A1 (en) 2023-01-19
US10188637B2 (en) 2019-01-29
AR107990A1 (es) 2018-07-04
CN108883072A (zh) 2018-11-23
US20180243277A1 (en) 2018-08-30

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