JP2019513009A5 - - Google Patents
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- JP2019513009A5 JP2019513009A5 JP2018545230A JP2018545230A JP2019513009A5 JP 2019513009 A5 JP2019513009 A5 JP 2019513009A5 JP 2018545230 A JP2018545230 A JP 2018545230A JP 2018545230 A JP2018545230 A JP 2018545230A JP 2019513009 A5 JP2019513009 A5 JP 2019513009A5
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- immune cell
- modified immune
- cdr
- antibody
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- 210000002865 immune cell Anatomy 0.000 claims 10
- 102000004965 antibodies Human genes 0.000 claims 9
- 108090001123 antibodies Proteins 0.000 claims 9
- 102100007290 CD274 Human genes 0.000 claims 3
- 101710012053 CD274 Proteins 0.000 claims 3
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 2
- 102100002977 CDR1 Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 102100013078 CD47 Human genes 0.000 claims 1
- 101700033237 CD47 Proteins 0.000 claims 1
- 102100019451 CD80 Human genes 0.000 claims 1
- 101700080477 CD80 Proteins 0.000 claims 1
- 102100005310 CTLA4 Human genes 0.000 claims 1
- 101700054183 CTLA4 Proteins 0.000 claims 1
- 101700079540 FAS Proteins 0.000 claims 1
- 101710004393 HAVCR2 Proteins 0.000 claims 1
- 102100016384 HAVCR2 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 102100017213 LAG3 Human genes 0.000 claims 1
- 108060004270 LAG3 Proteins 0.000 claims 1
- 101710040448 TNFRSF4 Proteins 0.000 claims 1
- 102100013135 TNFRSF4 Human genes 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N Tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 101700008936 Tim8 Proteins 0.000 claims 1
- 241000424123 Trachinotus baillonii Species 0.000 claims 1
- 101710019504 XAB2 Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 230000000139 costimulatory Effects 0.000 claims 1
- 238000000375 direct analysis in real time Methods 0.000 claims 1
- 101700068417 fol1 Proteins 0.000 claims 1
- 230000001506 immunosuppresive Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 230000002147 killing Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 101700050775 oct-1 Proteins 0.000 claims 1
- 231100000205 reproductive and developmental toxicity Toxicity 0.000 claims 1
Claims (10)
- ｉ）抗原レセプター、及び
ｉｉ）ＰＤ−Ｌ１を結合する抗体
を発現する、ナチュラルキラーＴ（ＮＫＴ）細胞である改変免疫細胞。 - 前記抗体が、ＣＤ８０及びＰＤ−１の両方とのＰＤ−Ｌ１相互作用を阻害する、請求項１に記載の改変免疫細胞。
- 前記ＣＡＲが、１つ以上の共刺激ドメイン、例えばＣＤ２８，４−１ＢＢ（ＣＤ１３７）、ＩＣＯＳ、もしくはＯＸ４０（ＣＤ１３４）、又はそれらの機能的フラグメントそれぞれをさらに含む、請求項１に記載の改変免疫細胞。
- 前記抗原レセプターが内因性ＴＣＲ又は改変ＴＣＲなどのＴＣＲである、請求項１〜３のいずれか一項に記載の改変免疫細胞。
- 前記抗体が、Ｆｃドメインを含まない、例えばＦａｂ、Ｆａｂ’、ｓｃＦａｂ、ｓｃＦｖ、Ｆｖフラグメント、ナノボディ、ＶＨＨ、ｄＡｂ、最小認識ユニット、ダイアボディ、単鎖ダイアボディ（ｓｃＤｂ）、ＢｉＴＥ、又はＤＡＲＴからなる群から選択される抗体フラグメントである、請求項１〜４に記載の改変免疫細胞。
- 前記抗体が、１００ｐＭ未満のＫＤでヒトＰＤ−Ｌ１に結合する、請求項１〜５のいずれか一項に記載の改変免疫細胞。
- 前記抗体が、
ｉ）配列番号６、７、及び８それぞれ、又は配列番号６、７、及び８と少なくとも９０％同一性を有する配列に示される可変重鎖（ＶＨ）ＣＤＲ配列ＣＤＲ−Ｈ１、ＣＤＲ−Ｈ２、及びＣＤＲ−Ｈ３、
ｉｉ）配列番号３、４、及び５それぞれ、又は配列番号３、４、及び５と少なくとも９０％同一性を有する配列に示される可変軽鎖（ＶＬ）ＣＤＲ配列ＣＤＲ−Ｌ１、ＣＤＲ−Ｌ２、及びＣＤＲ−Ｌ３、
を含む、請求項１〜６のいずれか一項に記載の改変免疫細胞。 - 前記抗体が、
ｉ）配列番号２のＶＨ配列、又は配列番号２と少なくとも９０％同一性を有する配列、及び
ｉｉ）配列番号１のＶＨ配列、又は配列番号１と少なくとも９０％同一性を有する配列
を含む、請求項１〜７のいずれか一項に記載の改変免疫細胞。 - 前記抗体が、配列番号９又は配列番号９と少なくとも９０％同一性を有する配列を含む、請求項１〜８のいずれか一項に記載の改変免疫細胞。
- 前記細胞が、ＩＬ−２、ＩＬ−４、ＩＬ−７、ＩＬ−１２、ＩＬ−１５、ＩＬ−２１、及び／又はＭＩＰ−１アルファなどの１つ以上のサイトカイン、好ましくはヒトサイトカインをさらに発現し、及び／又は
トランスフォーミング増殖因子−ベータ（ＴＧＦ−β）、ＩＬ−１０、Ｆａｓ、ＣＤ４７、ＣＴＬＡ−４、Ｔｉｍ−３、ＬＡＧ−３、及びそれらのリガンドなどの免疫抑制分子を標的とする１つ以上の抗体をさらに発現する、
請求項１〜９のいずれか一項に記載の改変免疫細胞。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022088103A JP2022116230A (ja) | 2016-02-25 | 2022-05-30 | 免疫療法用改変細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16020057.2 | 2016-02-25 | ||
| EP16020057 | 2016-02-25 | ||
| PCT/US2017/019301 WO2017147383A1 (en) | 2016-02-25 | 2017-02-24 | Modified cells for immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022088103A Division JP2022116230A (ja) | 2016-02-25 | 2022-05-30 | 免疫療法用改変細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019513009A JP2019513009A (ja) | 2019-05-23 |
| JP2019513009A5 true JP2019513009A5 (ja) | 2020-04-02 |
| JP7082574B2 JP7082574B2 (ja) | 2022-06-08 |
Family
ID=55446573
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545230A Active JP7082574B2 (ja) | 2016-02-25 | 2017-02-24 | 免疫療法用改変細胞 |
| JP2018544554A Active JP7080819B2 (ja) | 2016-02-25 | 2017-02-24 | Ｐｄ－ｌ１に対する結合メンバー |
| JP2022088103A Pending JP2022116230A (ja) | 2016-02-25 | 2022-05-30 | 免疫療法用改変細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544554A Active JP7080819B2 (ja) | 2016-02-25 | 2017-02-24 | Ｐｄ－ｌ１に対する結合メンバー |
| JP2022088103A Pending JP2022116230A (ja) | 2016-02-25 | 2022-05-30 | 免疫療法用改変細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20190048085A1 (ja) |
| EP (3) | EP3420001B1 (ja) |
| JP (3) | JP7082574B2 (ja) |
| KR (2) | KR20190003938A (ja) |
| CN (3) | CN116082505A (ja) |
| AU (2) | AU2017223846A1 (ja) |
| BR (2) | BR112018067696A2 (ja) |
| CA (2) | CA3014001A1 (ja) |
| ES (1) | ES2903408T3 (ja) |
| RU (2) | RU2018128464A (ja) |
| SG (2) | SG11201807188VA (ja) |
| WO (2) | WO2017147383A1 (ja) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| KR20180069903A (ko) | 2015-11-02 | 2018-06-25 | 파이브 프라임 테라퓨틱스, 인크. | Cd80 세포외 도메인 폴리펩타이드 및 이들의 암 치료에서의 용도 |
| CN116082505A (zh) * | 2016-02-25 | 2023-05-09 | 细胞医学公司 | Pd-l1的结合成员 |
| TWI786044B (zh) | 2016-05-13 | 2022-12-11 | 美商再生元醫藥公司 | 藉由投予ｐｄ-１抑制劑治療皮膚癌之方法 |
| GB201617714D0 (en) * | 2016-10-19 | 2016-11-30 | Ucl Business Plc | T Cell receptor |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3555273B1 (en) | 2016-12-16 | 2024-05-22 | B-Mogen Biotechnologies, Inc. | ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS |
| AU2018225102A1 (en) | 2017-02-21 | 2019-09-05 | Regeneron Pharmaceuticals, Inc. | Anti-PD-1 antibodies for treatment of lung cancer |
| EP4317422A3 (en) | 2017-04-13 | 2024-05-01 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| WO2018201014A1 (en) | 2017-04-28 | 2018-11-01 | Five Prime Therapeutics, Inc. | Methods of treatment with cd80 extracellular domain polypeptides |
| US20210139557A1 (en) * | 2017-12-20 | 2021-05-13 | Poseida Therapeutics, Inc. | Vcar compositions and methods for use |
| US20200353004A1 (en) * | 2018-01-19 | 2020-11-12 | Miltenyi Biotec B.V. & Co. KG | Regulatory T Cell Expressing a Chimeric Antigen Receptor |
| KR20210028140A (ko) | 2018-03-02 | 2021-03-11 | 씨디알-라이프 아게 | 삼중특이성 항원 결합 단백질 |
| KR20210016514A (ko) * | 2018-03-29 | 2021-02-16 | 아다진 인크. | 항-pd-l1 항체 및 그의 용도 |
| CA3104288A1 (en) | 2018-06-21 | 2019-12-26 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US11945864B2 (en) | 2018-06-29 | 2024-04-02 | Y-Biologics Inc. | Monoclonal antibody specifically binding to LAG-3 and use thereof |
| CN112672753A (zh) | 2018-07-09 | 2021-04-16 | 普瑞赛格恩公司 | 融合构建体及其使用方法 |
| CN113272016A (zh) * | 2018-10-01 | 2021-08-17 | 阿迪塞特生物股份有限公司 | 关于治疗实体肿瘤的工程化和非工程化γδ-T细胞的组合物和方法 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP3866813A4 (en) | 2018-10-17 | 2022-08-03 | Senti Biosciences, Inc. | COMBINATORY CANCER IMMUNOTHERAPY |
| SG11202105975SA (en) * | 2018-12-06 | 2021-07-29 | Guangdong Tcrcure Biopharma Technology Co Ltd | Combinational tcr-t cell therapy targeting tumor antigens, tgf-beta, and immune checkpoints |
| CN113195542B (zh) * | 2018-12-26 | 2024-05-24 | 南京传奇生物科技有限公司 | Cd30-结合部分、嵌合抗原受体及其用途 |
| CN109652379B (zh) * | 2018-12-29 | 2022-08-16 | 博生吉医药科技(苏州)有限公司 | Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用 |
| CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
| JP2022523696A (ja) * | 2019-01-28 | 2022-04-26 | サイフォス、バイオサイエンシズ、インコーポレイテッド | Ｃａｒ細胞上の非天然ｎｋｇ２ｄ受容体に、結合した異種分子を選択的に送達する改変非天然ｎｋｇ２ｄリガンド |
| JP2022527081A (ja) * | 2019-03-26 | 2022-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血液がんおよび固形がんの治療のためのキメラ抗原受容体改変ｔ細胞（ｃａｒ－ｔ） |
| CN110402892A (zh) * | 2019-04-30 | 2019-11-05 | 梁廷波 | 选择性敲除胰腺上皮细胞程序性死亡配体1分子的自发胰腺癌小鼠模型的建立方法 |
| CN112079924B (zh) * | 2019-06-12 | 2024-02-06 | 苏州工业园区唯可达生物科技有限公司 | Pd-l1靶向结合剂及其用途 |
| MX2021015670A (es) * | 2019-07-02 | 2022-04-18 | Telix Int Pty Ltd | Anticuerpos contra caix con afinidad reducida por el receptor de fc neonatal. |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药（上海）有限公司 | 表达il-15的免疫效应细胞 |
| WO2021092019A1 (en) * | 2019-11-04 | 2021-05-14 | Inovio Pharmaceuticals, Inc. | Combination therapy to treat brain cancer |
| RU2733430C1 (ru) * | 2019-11-19 | 2020-10-01 | Общество с ограниченной ответственностью «Реал Таргет» | Создание конъюгатов gd2-специфичных антител и фрагментов gd2-специфичных антител с препаратами |
| CN115925976A (zh) * | 2019-11-21 | 2023-04-07 | 博生吉医药科技(苏州)有限公司 | Cd7-car-t细胞及其制备和应用 |
| CA3159308A1 (en) * | 2019-12-02 | 2021-06-10 | Wayne A. Marasco | Antibodies against pd-l1 and methods of use thereof |
| EP4123021A4 (en) * | 2020-03-23 | 2024-05-15 | Curigin Co Ltd | STRUCTURE OF AN ONCOLYTIC VIRUS WITH BISPECIFIC NUCLEIC ACID MOLECULE |
| KR20230038139A (ko) * | 2020-05-14 | 2023-03-17 | 버투오소 빈코, 인크. | 인간화 cd38 및 icam1 항체 및 이의 용도 |
| WO2021252654A1 (en) * | 2020-06-11 | 2021-12-16 | Innovative Cellular Therapeutics Holdings, Ltd. | Cell/gene therapies targeting mage-a4 peptide |
| CN115916828A (zh) * | 2020-06-25 | 2023-04-04 | 普洛迈博生物技术公司 | Pd-l1-特异性抗体和抗pd-l1-car-t细胞 |
| AU2021376208A1 (en) * | 2020-11-04 | 2023-06-22 | Senti Biosciences, Inc. | Protein payload release |
| CN112375743A (zh) * | 2020-11-20 | 2021-02-19 | 山东省医学科学院附属医院 | 一种分泌型靶向her2抗原的嵌合抗原受体t细胞及其应用 |
| WO2022115719A1 (en) * | 2020-11-30 | 2022-06-02 | Fred Hutchinson Cancer Research Center | Pd-l1 binding peptides and peptide complexes and methods of use thereof |
| CN113234152B (zh) * | 2021-06-03 | 2023-05-02 | 天津科技大学 | 程序性死亡受体-配体1(pd-l1)特异性结合多肽及应用 |
| WO2023274387A1 (zh) * | 2021-07-01 | 2023-01-05 | 宁波茂行生物医药科技有限公司 | 靶向gd2的通用型car-t细胞及其制备方法和应用 |
| WO2023009891A2 (en) * | 2021-07-30 | 2023-02-02 | Janssen Biotech, Inc. | Materials and methods of making or using il-23r binding proteins |
| WO2023072043A1 (zh) * | 2021-10-26 | 2023-05-04 | 正大天晴药业集团股份有限公司 | 治疗肿瘤的联用药物 |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
| WO2023147564A2 (en) * | 2022-01-28 | 2023-08-03 | The University Of North Carolina At Chapel Hill | Natural killer t-cells and methods of using the same |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4237113B4 (de) | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| US20040241745A1 (en) | 2001-07-31 | 2004-12-02 | Tasuku Honjo | Substance specific to pd-1 |
| ES2399617T3 (es) | 2002-05-22 | 2013-04-02 | Esbatech - A Novartis Company Llc | Regiones de marco de inmunoglobulina que demuestran estabilidad potenciada en el entorno intracelulcar y métodos de identificación de las mismas |
| GB0328363D0 (en) | 2003-12-06 | 2004-01-14 | Imp College Innovations Ltd | Therapeutically useful molecules |
| JP5563194B2 (ja) | 2004-06-29 | 2014-07-30 | イムノコア リミテッド | 改変ｔ細胞レセプターを発現する細胞 |
| WO2008083174A2 (en) | 2006-12-27 | 2008-07-10 | Emory University | Compositions and methods for the treatment of infections and tumors |
| CA2689941C (en) | 2007-06-25 | 2019-10-29 | Esbatech Ag | Methods of modifying antibodies, and modified antibodies with improved functional properties |
| CN102164958A (zh) | 2008-06-25 | 2011-08-24 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| CA2728829C (en) | 2008-06-25 | 2018-01-02 | Esbatech, An Alcon Biomedical Research Unit Llc | Solubility optimization of immunobinders |
| TWI686405B (zh) * | 2008-12-09 | 2020-03-01 | 建南德克公司 | 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途 |
| RS60033B1 (sr) | 2009-11-24 | 2020-04-30 | Medimmune Ltd | Ciljano vezujući agensi usmereni na b7-h1 |
| US9493740B2 (en) | 2010-09-08 | 2016-11-15 | Baylor College Of Medicine | Immunotherapy of cancer using genetically engineered GD2-specific T cells |
| ES2795023T3 (es) | 2011-09-16 | 2020-11-20 | Baylor College Medicine | Reconocimiento específico del microambiente tumoral mediante el uso de células NKT manipuladas |
| BR112014012819B1 (pt) | 2011-11-28 | 2022-08-16 | Merck Patent Gmbh | Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição |
| US9175082B2 (en) * | 2012-05-31 | 2015-11-03 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| MX368513B (es) * | 2012-06-06 | 2019-10-07 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Métodos in vitro para el pronóstico, diagnóstico y diseño de una terapia de metástasis de cáncer de pulmón. |
| CN113684185A (zh) | 2013-02-26 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| EP3013864A1 (en) | 2013-06-26 | 2016-05-04 | Numab AG | Novel antibody frameworks |
| WO2015038538A1 (en) | 2013-09-10 | 2015-03-19 | Medimmune, Llc | Compositions and methods for treating sepsis |
| US20160376375A1 (en) | 2013-11-27 | 2016-12-29 | Baylor College Of Medicine | CSGP4 - Specific Chimeric Antigen Receptor for Cancer |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| EP3593812A3 (en) * | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| ES2928000T3 (es) * | 2014-06-06 | 2022-11-14 | Memorial Sloan Kettering Cancer Center | Receptores de antígeno quimérico dirigidos a mesotelina y usos de los mismos |
| EP3166974A1 (en) * | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Anti-pd-l1 antibodies and diagnostic uses thereof |
| WO2016034666A1 (en) | 2014-09-04 | 2016-03-10 | Cellectis | Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy |
| WO2016049459A1 (en) | 2014-09-26 | 2016-03-31 | Baylor College Of Medicine | Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy |
| CA2965521A1 (en) | 2014-10-31 | 2016-05-06 | Baylor College Of Medicine | Survivin specific t-cell receptor targeting tumor but not t cells |
| JP2018504894A (ja) | 2014-12-19 | 2018-02-22 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | キメラ抗原受容体およびその使用方法 |
| GB201506642D0 (en) | 2015-04-20 | 2015-06-03 | Ucl Business Plc | T cell receptor |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药（上海）有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| CN116082505A (zh) * | 2016-02-25 | 2023-05-09 | 细胞医学公司 | Pd-l1的结合成员 |
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2017
- 2017-02-24 CN CN202211150762.0A patent/CN116082505A/zh active Pending
- 2017-02-24 ES ES17711573T patent/ES2903408T3/es active Active
- 2017-02-24 BR BR112018067696A patent/BR112018067696A2/pt not_active Application Discontinuation
- 2017-02-24 RU RU2018128464A patent/RU2018128464A/ru not_active Application Discontinuation
- 2017-02-24 JP JP2018545230A patent/JP7082574B2/ja active Active
- 2017-02-24 SG SG11201807188VA patent/SG11201807188VA/en unknown
- 2017-02-24 EP EP17711573.0A patent/EP3420001B1/en active Active
- 2017-02-24 EP EP21209739.8A patent/EP4086285A1/en active Pending
- 2017-02-24 CA CA3014001A patent/CA3014001A1/en active Pending
- 2017-02-24 AU AU2017223846A patent/AU2017223846A1/en active Pending
- 2017-02-24 CA CA3014067A patent/CA3014067A1/en active Pending
- 2017-02-24 US US16/079,202 patent/US20190048085A1/en not_active Abandoned
- 2017-02-24 EP EP17710091.4A patent/EP3420000A1/en not_active Withdrawn
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- 2017-02-24 RU RU2018128462A patent/RU2018128462A/ru not_active Application Discontinuation
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- 2017-02-24 CN CN201780012727.3A patent/CN108699153B/zh active Active
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- 2017-02-24 CN CN201780012682.XA patent/CN108884164B/zh active Active
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